Traditional Chinese medicine extracting and filtering method

Abstract

The invention belongs to the technical field of traditional Chinese medicine extraction, and particularly relates to a traditional Chinese medicine extraction and filtration method which comprises the following steps: adding traditional Chinese medicine raw materials and water into an extraction tank through a feeding port, connecting a vacuumizing device through a gas pipeline interface, vacuumizing the interior of the extraction tank, and then connecting a protective atmosphere pipeline through the gas pipeline interface, introducing a protective atmosphere into the extraction tank, opening a steam adjusting valve, introducing high-pressure steam into the extraction tank, starting extraction of traditional Chinese medicine components, filtering traditional Chinese medicine residues in an extracting solution through a stainless steel filter element filter after extraction of the traditional Chinese medicine components is completed, and storing the extracting solution through a third liquid storage tank. Steam can be introduced into the extraction tank, namely, the extraction temperature in the extraction tank is adjusted according to the temperatures required by different traditional Chinese medicines, so that thermosensitive and soluble medicinal components can be extracted at a low temperature, insoluble medicinal components can be extracted under the protection of nitrogen and in a subcritical state of water, and the extraction rate of the medicinal components in the traditional Chinese medicines or formulas is increased.

Description

Technical Field

[0001] The invention belongs to the technical field of traditional Chinese medicine extraction, and particularly relates to a traditional Chinese medicine extraction and filtering method. Background Art

[0002] Chinese medicine extraction is the primary link of Chinese medicine preparation and an important part of Chinese medicine preparation production. It is generally composed of extraction, filtration, concentration, drying and other operation units. The quality of Chinese medicine extraction process directly affects the quality of medicine and therapeutic effect. Chinese medicine pieces or prescriptions have complex ingredients. Some active ingredients are severely damaged and lost during high-temperature extraction. Some active ingredients must be at high temperature to improve their dissolution rate. In addition, improper extraction methods will directly reduce the therapeutic effect.

[0003] In recent years, membrane separation technologies, including ceramic membranes, nanofiltration and reverse osmosis, have been widely used in the field of plant extraction and separation due to their unique separation advantages. However, they are rarely used in the production of Chinese patent medicines. Chinese patent medicines, especially the production of solid preparations of Chinese medicines, almost all face the problem of high paste yield and large deviation from the registered process during the extraction process. Although the existing membrane separation equipment can effectively remove large suspended solids, the transfer rate of active ingredients, especially those whose solubility is greatly affected by temperature, is very low. Summary of the invention

[0004] In view of the above problems, the present invention provides a method for extracting and filtering traditional Chinese medicine.

[0005] To achieve the above object, the present invention adopts the following technical solutions:

[0006] A Chinese medicine extraction and filtration method uses a Chinese medicine extraction and filtration system, including an extraction tank, a feeding port is provided on the extraction tank, Chinese medicine raw materials and water are added to the extraction tank through the feeding port, a gas pipeline interface is provided at the upper end of the extraction tank, a vacuum operation is performed on the extraction tank or a protective atmosphere is introduced into the extraction tank through the gas pipeline interface, a steam inlet is provided on one side of the extraction tank for introducing steam into the extraction tank, a steam regulating valve is provided at the steam inlet, a No. 3 temperature sensor is provided on the extraction tank, the inlet of the volatile oil collector is connected to the hot end outlet of the condenser, the hot end inlet of the condenser is communicated with the upper part of the extraction tank, and the condensed water outlet of the volatile oil collector is connected to the extraction tank The upper part of the extraction tank is connected to the upper part of the extraction tank, which is used to return the condensed water collected by the volatile oil collector to the extraction tank. The extraction liquid outlet of the extraction tank is connected to the inlet of the No. 1 circulation pump, and the outlet of the No. 1 circulation pump is connected to the inlet of the stainless steel filter element filter. A No. 4 temperature sensor is arranged at the inlet of the stainless steel filter element filter. The reflux port of the stainless steel filter element filter is connected to the inlet of the No. 1 circulation pump, and the outlet of the stainless steel filter element filter is connected to the hot end inlet of the No. 1 heat exchanger. The hot end outlet of the No. 1 heat exchanger is connected to the inlet of the No. 3 liquid storage tank. A No. 5 temperature sensor is arranged at the hot end outlet of the No. 1 heat exchanger. An air pressure regulating port is arranged at the upper end of the No. 3 liquid storage tank, and the No. 3 liquid storage tank is evacuated through the air pressure regulating port. Operate or introduce compressed air into the No. 3 liquid storage tank, the outlet of the No. 3 liquid storage tank is connected to the inlet of the No. 2 liquid storage tank, the outlet of the No. 2 liquid storage tank is connected to the inlet of the No. 1 centrifugal pump, the outlet of the No. 1 centrifugal pump is connected to the inlet of the No. 1 plunger pump, the outlet of the No. 1 plunger pump is connected to the cold end inlet of the No. 3 heat exchanger, the No. 1 centrifugal pump is used to control the flow rate of the extract, the No. 1 plunger pump is used to control the pressure of the extract, the cold end outlet of the No. 3 heat exchanger is connected to the inlet of the ceramic microfiltration membrane assembly, a No. 1 temperature sensor and a No. 1 pressure sensor are arranged at the inlet of the ceramic microfiltration membrane assembly, the reflux port of the ceramic microfiltration membrane assembly is connected to the inlet of the No. 2 liquid storage tank, the outlet of the ceramic microfiltration membrane assembly is connected to the No. 2 exchanger, and the No. 3 heat exchanger is connected to the No. 3 heat exchanger. The hot end inlet of the heat exchanger No. 4 is connected, the hot end outlet of the heat exchanger No. 2 is connected to the inlet of the liquid storage tank No. 1, a flow regulating valve is arranged at the hot end outlet of the heat exchanger No. 2, a liquid level sensor is arranged on the liquid storage tank No. 1, the outlet of the liquid storage tank No. 1 is connected to the inlet of the centrifugal pump No. 2, the outlet of the centrifugal pump No. 2 is connected to the inlet of the plunger pump No. 2, the outlet of the plunger pump No. 2 is connected to the hot end inlet of the heat exchanger No. 4, the hot end outlet of the heat exchanger No. 4 is connected to the inlet of the nanofiltration membrane assembly, the reflux port of the nanofiltration membrane assembly is connected to the inlet of the liquid storage tank No. 1, the outlet of the nanofiltration membrane assembly is connected to the inlet of the filtrate storage tank, and a No. 2 pressure sensor and a No. 2 temperature sensor are arranged at the inlet of the nanofiltration membrane assembly,A No. 2 flow regulating valve is provided at the reflux port of the nanofiltration membrane assembly, and a No. 3 flow regulating valve is provided at the outlet of the nanofiltration membrane assembly;

[0007] The method comprises the following steps: adding Chinese medicine raw materials and water into the extraction tank through a feeding port, connecting a vacuum pumping device through a gas pipeline interface to vacuumize the inside of the extraction tank, then connecting a protective atmosphere pipeline through the gas pipeline interface to introduce a protective atmosphere into the extraction tank, opening a steam regulating valve, introducing high-pressure steam into the extraction tank, and starting to extract Chinese medicine components. During this process, if it is necessary to extract volatile oil, the valve at the hot end inlet of the condenser and the valve at the condensate outlet of the volatile oil collector are opened, and the volatile oil is extracted through the condenser and the volatile oil collector. If it is not necessary to extract volatile oil, the valve at the hot end inlet of the condenser and the valve at the condensate outlet of the volatile oil collector are closed, and the extraction of Chinese medicine components is completed. After the extraction, the No. 3 liquid storage tank is evacuated through the air pressure regulating port at the upper end of the No. 3 liquid storage tank to form a pressure difference between the extraction tank and the No. 3 liquid storage tank, and the extract is discharged through the extract outlet below the extraction tank. Under the pressure difference between the extraction tank and the No. 3 liquid storage tank and the action of the No. 1 circulation pump, the extract passes through the stainless steel filter element filter and the No. 1 heat exchanger in turn and enters the No. 3 liquid storage tank. The Chinese medicine residue in the extract is filtered through the stainless steel filter element filter, the extract is cooled through the No. 1 heat exchanger, and the extract is stored in the No. 3 liquid storage tank. When the extract needs to be filtered for the second time, compressed air is introduced into the No. 3 liquid storage tank through the air pressure regulating port at the upper end of the No. 3 liquid storage tank. Under the pressure of the gas, the extract in the No. 3 liquid storage tank enters the No. 2 liquid storage tank, and then flows out from the outlet at the lower end of the No. 2 liquid storage tank. Under the joint action of the No. 1 centrifugal pump and the No. 1 plunger pump, it enters the No. 3 heat exchanger. The extract is heated by the No. 3 heat exchanger to increase the solubility of the Chinese medicine components and prevent some of the Chinese medicine components from precipitating due to the decrease in temperature. After that, the extract enters the ceramic microfiltration membrane assembly for filtration. The extract flowing out of the reflux port of the ceramic microfiltration membrane assembly flows back to the No. 2 liquid storage tank and is filtered again. The filtered extract is cooled by the No. 2 heat exchanger and then enters the No. 1 liquid storage tank for storage. When it is necessary to concentrate the extract in the No. 1 liquid storage tank, the extract flows out from the outlet at the lower end of the No. 1 liquid storage tank and enters the No. 2 liquid storage tank. The extract enters the No. 4 heat exchanger under the joint action of the centrifugal pump and the No. 2 plunger pump, and the extract is cooled by the No. 4 heat exchanger. By cooling the extract, the Chinese medicinal ingredients in the extract are separated out, and then the extract is filtered through the nanofiltration membrane assembly, wherein the filtrate without Chinese medicinal ingredients is discharged from the outlet of the nanofiltration membrane assembly and collected in the filtrate storage tank, and the filtered Chinese medicinal ingredients are refluxed to the No. 1 liquid storage tank along with part of the extract through the reflux port of the nanofiltration membrane assembly, and filtered again, and the liquid level in the No. 1 liquid storage tank is observed by the liquid level sensor. When the liquid level in the No. 1 liquid storage tank drops to the set height, the concentration of the extract is completed, and the concentrated extract can be discharged from the outlet of the No. 1 liquid storage tank for subsequent processing.

[0008] Furthermore, the operating pressure of the extraction tank is 0-5 MPa, and the operating temperature is 50-200°C.

[0009] Furthermore, the operating pressure of the stainless steel filter element filter is 0-5 MPa, the operating temperature is 50-200° C., and the filter pore size on the stainless steel filter element filter is 1-50 μm.

[0010] Furthermore, the operating pressure of the ceramic microfiltration membrane assembly is 0-5 MPa, the operating temperature is 50-200° C., and the filtration pore size of the ceramic microfiltration membrane assembly is 50-200 nm.

[0011] Furthermore, the molecular weight cut-off range of the nanofiltration membrane assembly is 200Da to 1000Da.

[0012] Furthermore, the Chinese medicine extraction and filtration system also includes a No. 1 cleaning tank, which is used to store cleaning water. The outlet of the No. 1 cleaning tank is connected to the inlet of the No. 1 centrifugal pump for cleaning the No. 2 liquid storage tank and the ceramic microfiltration membrane assembly.

[0013] Furthermore, the Chinese medicine extraction and filtration system also includes a No. 2 cleaning tank, which is used to store cleaning water. The outlet of the No. 2 cleaning tank is connected to the inlet of the No. 2 centrifugal pump for cleaning the No. 1 liquid storage tank and the nanofiltration membrane assembly.

[0014] Compared with the prior art, the present invention has the following advantages:

[0015] The invention can introduce steam into the extraction tank, that is, adjust the extraction temperature in the extraction tank according to the temperature required by different Chinese medicines, so that heat-sensitive and easily soluble medicinal ingredients can be extracted at low temperature, and insoluble medicinal ingredients can be extracted under nitrogen protection and subcritical state of water, thereby improving the extraction rate of medicinal ingredients in Chinese medicines or prescriptions; by adjusting the temperature of the extract entering the stainless steel filter element filter, the solubility of the insoluble medicinal ingredients in the Chinese medicine or prescription is increased, thereby improving the extraction rate; at the same time, before the extract enters the ceramic microfiltration membrane component, The extract is heated by the No. 3 heat exchanger to ensure the solubility of the Chinese medicinal ingredients and prevent the ceramic microfiltration membrane component from filtering out the effective Chinese medicinal ingredients. Before the extract of the present invention enters the nanofiltration membrane component, the extract is cooled by the No. 4 heat exchanger to precipitate the effective Chinese medicinal ingredients in the extract, and the effective Chinese medicinal ingredients are filtered out by the nanofiltration membrane component, and the filtered waste liquid is collected in the filtrate storage tank. The effective Chinese medicinal ingredients are filtered by the nanofiltration membrane component, which can reduce the paste output rate of the Chinese patent medicine and improve the efficacy of the Chinese patent medicine. BRIEF DESCRIPTION OF THE DRAWINGS

[0016] Figure 1 It is a process structure diagram of the present invention;

[0017] In the figure, extraction tank 1, feeding port 2, gas pipeline interface 3, steam inlet 4, steam regulating valve 5, No. 3 temperature sensor 6, No. 1 circulation pump 7, stainless steel filter element filter 8, No. 4 temperature sensor 9, No. 1 heat exchanger 10, No. 3 liquid storage tank 11, No. 5 temperature sensor 12, air pressure regulating port 13, No. 2 liquid storage tank 14, No. 1 centrifugal pump 15, No. 1 plunger pump 16, No. 3 heat exchanger 17, ceramic microfiltration membrane assembly 18, No. 1 temperature sensor 19, No. 1 pressure sensor 20, No. 2 heat exchanger 21, No. 1 liquid storage tank 22, No. 2 centrifugal pump 23, No. 2 plunger pump 24, No. 4 heat exchanger 25, nanofiltration membrane assembly 26, filtrate storage tank 27, No. 2 pressure sensor 28, No. 2 temperature sensor 29, No. 2 flow regulating valve 30, No. 3 flow regulating valve 31, volatile oil collector 32, condenser 33, No. 1 cleaning tank 34, No. 2 cleaning tank 35, No. 1 flow regulating valve 36, liquid level sensor 37. DETAILED DESCRIPTION

[0018] In order to further illustrate the technical solution of the present invention, the present invention is further described below through embodiments.

[0019] Example 1

[0020] like Figure 1As shown, a Chinese medicine extraction and filtration method uses a Chinese medicine extraction and filtration system, including an extraction tank 1, the operating pressure of the extraction tank 1 is 0-5MPa, the operating temperature is 50-200°C, a feeding port 2 is provided on the extraction tank 1, and Chinese medicine raw materials and water are added to the extraction tank 1 through the feeding port 2, a gas pipeline interface 3 is provided at the upper end of the extraction tank 1, and a vacuum operation is performed on the extraction tank 1 or a protective atmosphere is introduced into the extraction tank 1 through the gas pipeline interface 3, a steam inlet 4 is provided on one side of the extraction tank 1 for introducing steam into the extraction tank 1, a steam regulating valve 5 is provided at the steam inlet 4, a No. 3 temperature sensor 6 is provided on the extraction tank 1, and the inlet of the volatile oil collector 32 is connected to the cold The hot end outlet of the condenser 33 is connected, the hot end inlet of the condenser 33 is connected to the upper part of the extraction tank 1, the condensate outlet of the volatile oil collector 32 is connected to the upper part of the extraction tank 1, and is used to return the condensate collected by the volatile oil collector 32 to the extraction tank 1, the extract outlet of the extraction tank 1 is connected to the inlet of the No. 1 circulation pump 7, the outlet of the No. 1 circulation pump 7 is connected to the inlet of the stainless steel filter element filter 8, and a No. 4 temperature sensor 9 is arranged at the inlet of the stainless steel filter element filter 8, the operating pressure of the stainless steel filter element filter 8 is 0-5MPa, the operating temperature is 50-200℃, the filtration pore size on the stainless steel filter element filter 8 is 1-50μm, and the reflux port of the stainless steel filter element filter 8 is connected to the No. 1 circulation pump 7. The inlet of the pump 7 is connected, the outlet of the stainless steel filter element filter 8 is connected to the hot end inlet of the No. 1 heat exchanger 10, the hot end outlet of the No. 1 heat exchanger 10 is connected to the inlet of the No. 3 liquid storage tank 11, a No. 5 temperature sensor 12 is arranged at the hot end outlet of the No. 1 heat exchanger 10, and an air pressure regulating port 13 is arranged at the upper end of the No. 3 liquid storage tank 11, through which the No. 3 liquid storage tank 11 is vacuumed or compressed air is introduced into the No. 3 liquid storage tank 11, the outlet of the No. 3 liquid storage tank 11 is connected to the inlet of the No. 2 liquid storage tank 14, the outlet of the No. 2 liquid storage tank 14 is connected to the inlet of the No. 1 centrifugal pump 15, the outlet of the No. 1 centrifugal pump 15 is connected to the inlet of the No. 1 plunger pump 16, and the No. 1 plunger pump 16 is connected to the No. 1 plunger pump 16. The outlet of the No. 3 heat exchanger 17 is connected to the cold end inlet of the No. 3 heat exchanger 17, the No. 1 centrifugal pump 15 is used to control the flow rate of the extract, the No. 1 plunger pump 16 is used to control the pressure of the extract, the cold end outlet of the No. 3 heat exchanger 17 is connected to the inlet of the ceramic microfiltration membrane assembly 18, and a No. 1 temperature sensor 19 and a No. 1 pressure sensor 20 are arranged at the inlet of the ceramic microfiltration membrane assembly 18. The operating pressure of the ceramic microfiltration membrane assembly 18 is 0-5MPa, the operating temperature is 50-200°C, the filtration pore size of the ceramic microfiltration membrane assembly 18 is 50-200nm, the reflux port of the ceramic microfiltration membrane assembly 18 is connected to the inlet of the No. 2 liquid storage tank 14, and the outlet of the ceramic microfiltration membrane assembly 18 is connected to the hot end inlet of the No. 2 heat exchanger 21.The hot end outlet of the No. 2 heat exchanger 21 is connected to the inlet of the No. 1 liquid storage tank 22. A No. 1 flow regulating valve 36 is provided at the hot end outlet of the No. 2 heat exchanger 21. A liquid level sensor 37 is provided on the No. 1 liquid storage tank 22. The outlet of the No. 1 liquid storage tank 22 is connected to the inlet of the No. 2 centrifugal pump 23. The outlet of the No. 2 centrifugal pump 23 is connected to the inlet of the No. 2 plunger pump 24. The outlet of the No. 2 plunger pump 24 is connected to the hot end inlet of the No. 4 heat exchanger 25. The hot end outlet of the No. 4 heat exchanger 25 is connected to the outlet of the nanofiltration membrane assembly 26. The inlet of the nanofiltration membrane assembly 26 is connected, the molecular weight cutoff range of the nanofiltration membrane assembly 26 is 200Da to 1000Da, the reflux port of the nanofiltration membrane assembly 26 is connected to the inlet of the No. 1 liquid storage tank 22, the outlet of the nanofiltration membrane assembly 26 is connected to the inlet of the filtrate storage tank 27, a No. 2 pressure sensor 28 and a No. 2 temperature sensor 29 are arranged at the inlet of the nanofiltration membrane assembly 26, a No. 2 flow regulating valve 30 is arranged at the reflux port of the nanofiltration membrane assembly 26, and a No. 3 flow regulating valve 31 is arranged at the outlet of the nanofiltration membrane assembly 26;

[0021] The method comprises the following steps: adding Chinese medicine raw materials and water into the extraction tank 1 through the feeding port 2, connecting the vacuum device through the gas pipeline interface 3, vacuumizing the inside of the extraction tank 1, then connecting the protective atmosphere pipeline through the gas pipeline interface 3, introducing the protective atmosphere into the extraction tank 1, opening the steam regulating valve 5, introducing high-pressure steam into the extraction tank 1, and starting the extraction of Chinese medicine components. During this process, if it is necessary to extract volatile oil, the valve at the hot end inlet of the condenser 33 and the valve at the condensate outlet of the volatile oil collector 32 are opened, and the volatile oil is extracted through the condenser 33 and the volatile oil collector 32. If it is not necessary to extract volatile oil, the valve at the hot end inlet of the condenser 33 and the valve at the condensate outlet of the volatile oil collector 32 are closed, and the extraction is completed. After the extraction of the Chinese medicinal ingredients, the No. 3 liquid storage tank 11 is evacuated through the air pressure regulating port 13 at the upper end of the No. 3 liquid storage tank 11, so that a pressure difference is formed between the extraction tank 1 and the No. 3 liquid storage tank 11, and the extract is discharged through the extract outlet below the extraction tank 1. Under the pressure difference between the extraction tank 1 and the No. 3 liquid storage tank 11 and the action of the No. 1 circulation pump 7, the extract passes through the stainless steel filter element filter 8 and the No. 1 heat exchanger 10 in sequence and enters the No. 3 liquid storage tank 11, and the Chinese medicinal residue in the extract is filtered through the stainless steel filter element filter 8, the extract is cooled through the No. 1 heat exchanger 10, and the extract is stored in the No. 3 liquid storage tank 11. When the extract needs to be filtered for the second time, the air pressure regulating port 13 at the upper end of the No. 3 liquid storage tank 11 is used to cool the extract. Compressed air is introduced into the No. 3 liquid storage tank 11. Under the pressure of the compressed air, the extract in the No. 3 liquid storage tank 11 enters the No. 2 liquid storage tank 14, and then flows out from the outlet at the lower end of the No. 2 liquid storage tank 14. Under the joint action of the No. 1 centrifugal pump 15 and the No. 1 plunger pump 16, it enters the No. 3 heat exchanger 17. The extract is heated by the No. 3 heat exchanger 17 to improve the solubility of the Chinese medicine components and prevent some of the Chinese medicine components from precipitating due to the decrease in temperature. After that, the extract enters the ceramic microfiltration membrane assembly 18 for filtration. The extract flowing out of the reflux port of the ceramic microfiltration membrane assembly 18 flows back to the No. 2 liquid storage tank 14 and is filtered again. The filtered extract is cooled by the No. 2 heat exchanger 21 and then enters the No. 1 liquid storage tank 22 for storage. When it is necessary to filter the extract in the No. 1 liquid storage tank 22, When the extract is concentrated, the extract flows out from the outlet at the lower end of the No. 1 liquid storage tank 22, and enters the No. 4 heat exchanger 25 under the joint action of the No. 2 centrifugal pump 23 and the No. 2 plunger pump 24. The extract is cooled by the No. 4 heat exchanger 25. By cooling the extract, the Chinese medicine components in the extract are separated out, and then the extract is filtered through the nanofiltration membrane assembly 26, wherein the filtrate without Chinese medicine components is discharged from the outlet of the nanofiltration membrane assembly 26 and collected in the filtrate storage tank 27. The filtered Chinese medicine components are refluxed to the No. 1 liquid storage tank 22 along with part of the extract through the reflux port of the nanofiltration membrane assembly 26, and filtered again. The liquid level in the No. 1 liquid storage tank 22 is observed by the liquid level sensor 37. When the liquid level in the No. 1 liquid storage tank 22 drops to the set height,That is, the concentration of the extract is completed, and the concentrated extract can be discharged from the outlet of the first liquid storage tank 22 for subsequent processing.

[0022] The Chinese medicine extraction and filtration system also includes a No. 1 cleaning tank 34 and a No. 2 cleaning tank 35, wherein the No. 1 cleaning tank 34 and the No. 2 cleaning tank 35 are used to store cleaning water, the outlet of the No. 1 cleaning tank 34 is connected to the inlet of the No. 1 centrifugal pump 15, and is used to clean the No. 2 liquid storage tank 14 and the ceramic microfiltration membrane assembly 18, and the outlet of the No. 2 cleaning tank 35 is connected to the inlet of the No. 2 centrifugal pump 23, and is used to clean the No. 1 liquid storage tank 22 and the nanofiltration membrane assembly 26.

[0023] Huoxiang Zhengqi Capsule (Specification: 0.3g / capsule) Standard prescription and preparation method:

[0024] Prescription: Patchouli 780g Angelica dahurica 260g Atractylodes macrocephala (fried) 520g Perilla leaf 260g

[0025] French Pinellia 520g Tangerine Peel 520g Magnolia Officinalis (Ginger Juice) 520g Poria 260g

[0026] Platycodon grandiflorum 520g Licorice root 520g Dictyophora japonica peel 260g Jujube 130g

[0027] 78g ginger

[0028] Preparation method: The above thirteen ingredients are crushed into fine powder and sieved; after extracting volatile oil from patchouli, perilla leaf, tangerine peel, and ginger, they are decocted twice with water, Poria, big belly peel, platycodon, licorice, and jujube, each time for 2 hours, filtered, and the filtrate is combined; Angelica dahurica, Atractylodes macrocephala, and Magnolia officinalis are used according to the percolation method under the extract and extract (General Principle 0189 of the 2020 edition of the Chinese Pharmacopoeia), using 70% ethanol as a solvent, percolating, collecting the filtrate, and recovering ethanol. Combine the above liquid medicines, decompress and concentrate into a thick paste, add the fine powder of the French pinellia and an appropriate amount of auxiliary materials, mix well, make granules, dry below 60°C, spray with volatile oils such as patchouli, mix well, put into capsules, and make 4000 capsules.

[0029] Problems with the standard preparation method of Huoxiang Zhengqi Capsules (Specification: 0.3g / capsule):

[0030] The production volume is too high, which is inconsistent with the current standards;

[0031] The amount of volatile oil extracted is insufficient, and the stability during storage is poor;

[0032] The migration rate of hesperidin is low;

[0033] In short, Huoxiang Zhengqi Capsules produced according to the current process are at least inferior drugs and carry extremely high risks.

[0034] Example 2

[0035] The method of the invention is adopted to prepare Huoxiangzhengqi capsule.

[0036] S1, patchouli, perilla leaves, tangerine peel, and ginger are put into the extraction tank 1, purified water is added, and the extraction tank 1 is soaked for 2 hours; the extraction tank 1 is evacuated through the gas pipeline interface 3 at the upper end of the extraction tank 1, and then nitrogen is injected through the gas pipeline interface 3; the steam regulating valve 5 is opened, the temperature and steam pressure of the condenser 33 are adjusted, the volatile oil is extracted for 3 hours, and the volatile oil is collected; the pressure difference between the extraction tank 1 and the third liquid storage tank 11 is adjusted to be not less than 5kpa, the temperature of the extract in the stainless steel filter element filter 8 is maintained above 95°C, and the temperature of the extract after heat exchange through the first heat exchanger 10 is not higher than 60°C;

[0037] S2, the extract is transferred to the second liquid storage tank 14, and the extract is heated to above 95°C by the third heat exchanger 17. The pore size of the filter pores on the ceramic microfiltration membrane assembly 18 is 50nm. The system parameters of the ceramic microfiltration membrane assembly 18 are adjusted to keep the extract above 95°C before filtration and the extract temperature after filtration is not higher than 60°C;

[0038] S3, the filtered extract is transferred to the first liquid storage tank 22, the cut-off molecular weight of the nanofiltration membrane assembly 26 is 500Da, the system parameters of the nanofiltration membrane assembly 26 are adjusted so that the system temperature is not higher than 40°C, and the extract is concentrated to a specified relative density for standby use;

[0039] S4, put Poria cocos, dried tangerine peel, Platycodon grandiflorum, licorice and jujube into the extraction tank 1, mix with patchouli, perilla leaf and other drug residues, add purified water, soak for 2 hours, evacuate the extraction tank 1 through the gas pipeline interface 3 at the upper end of the extraction tank 1, and then inject nitrogen through the gas pipeline interface 3; open the steam regulating valve 5 to keep the temperature in the extraction tank 1 between 120°C and 125°C, and extract twice continuously, each time for 2 hours; adjust the pressure difference between the extraction tank 1 and the No. 3 liquid storage tank 11 to be not less than 5kpa, keep the temperature of the extract in the stainless steel filter element filter 8 above 110°C, and the temperature of the extract after heat exchange through the No. 1 heat exchanger 10 is not higher than 60°C;

[0040] S5, the extract is transferred to the second liquid storage tank 14, and the extract is heated to 115°C by the third heat exchanger 17. The pore size of the filter pores on the ceramic microfiltration membrane assembly 18 is 50nm. The system parameters of the ceramic microfiltration membrane assembly 18 are adjusted so that the extract is maintained between 110°C and 115°C before filtration, and the temperature of the extract after filtration is not higher than 60°C;

[0041] S6, the filtered extract is transferred to the first liquid storage tank 22, the cut-off molecular weight of the nanofiltration membrane assembly 26 is 500Da, the system parameters of the nanofiltration membrane assembly 26 are adjusted so that the system temperature is not higher than 40°C, and the extract is concentrated to a specified relative density for standby use;

[0042] S7, Angelica dahurica, Atractylodes macrocephala, and Magnolia officinalis were filtered using 70% ethanol as solvent according to the percolation method under the fluid extract and extract (General Rule 0189 of the 2020 edition of the Chinese Pharmacopoeia), and the filtrate was collected to recover the ethanol;

[0043] S8, crushing the French pinellia into a fine powder of 120 mesh and sieving;

[0044] S9, all the concentrated liquids are combined with the percolated liquids of Angelica dahurica, Atractylodes macrocephala and Magnolia officinalis, and the fine powder of Pinellia ternata is added, mixed evenly, made into granules, dried below 60°C, sprayed with volatile oils such as Patchouli, mixed evenly, and put into capsules.

[0045] By adopting the traditional Chinese medicine extraction and filtration method of the present invention, the hesperidin transfer rate of Huoxiang Zhengqi Capsule can be increased from 9% to 28%, and the paste yield rate can be reduced by about 30%, which meets the standard requirements.

[0046] The above shows and describes the main features and advantages of the present invention. It is obvious to those skilled in the art that the present invention is not limited to the details of the above exemplary embodiments, and that the present invention can be implemented in other specific forms without departing from the spirit or essential features of the present invention. Therefore, no matter from which point of view, the embodiments should be regarded as exemplary and non-restrictive. The scope of the present invention is defined by the appended claims rather than the above description, and it is intended that all changes that fall within the meaning and scope of the equivalent elements of the claims are included in the present invention.

[0047] In addition, it should be understood that although the present specification is described according to implementation modes, not every implementation mode contains only one independent technical solution. This description of the specification is only for the sake of clarity. Those skilled in the art should regard the specification as a whole. The technical solutions in each embodiment may also be appropriately combined to form other implementation modes that can be understood by those skilled in the art.

Claims

1. A method for extracting and filtering traditional Chinese medicine, characterized in that: A Chinese medicine extraction and filtration system is used, comprising an extraction tank (1), wherein a feeding port (2) is provided on the extraction tank (1), and Chinese medicine raw materials and water are added to the extraction tank (1) through the feeding port (2); a gas pipeline interface (3) is provided at the upper end of the extraction tank (1), and a vacuum operation is performed on the extraction tank (1) or a protective atmosphere is introduced into the extraction tank (1) through the gas pipeline interface (3); a steam inlet (4) is provided on one side of the extraction tank (1) for introducing steam into the extraction tank (1); a steam regulating valve (5) is provided at the steam inlet (4); a No. 3 temperature sensor (6) is provided on the extraction tank (1); an inlet of the volatile oil collector (32) and a condenser (33) are connected The hot end outlet of the condenser (33) is connected to the upper part of the extraction tank (1), the hot end inlet of the condenser (33) is connected to the upper part of the extraction tank (1), the condensate outlet of the volatile oil collector (32) is connected to the upper part of the extraction tank (1), and is used to return the condensate collected by the volatile oil collector (32) to the extraction tank (1), the extract outlet of the extraction tank (1) is connected to the inlet of the No. 1 circulation pump (7), the outlet of the No. 1 circulation pump (7) is connected to the inlet of the stainless steel filter element filter (8), a No. 4 temperature sensor (9) is arranged at the inlet of the stainless steel filter element filter (8), the reflux port of the stainless steel filter element filter (8) is connected to the inlet of the No. 1 circulation pump (7), and the outlet of the stainless steel filter element filter (8) is connected to the outlet of the No. 1 heat exchanger (10). The hot end inlet of the first heat exchanger (10) is connected, the hot end outlet of the first heat exchanger (10) is connected to the inlet of the third liquid storage tank (11), a fifth temperature sensor (12) is arranged at the hot end outlet of the first heat exchanger (10), an air pressure regulating port (13) is arranged at the upper end of the third liquid storage tank (11), and a vacuum operation is performed on the third liquid storage tank (11) or compressed air is introduced into the third liquid storage tank (11) through the air pressure regulating port (13), the outlet of the third liquid storage tank (11) is connected to the inlet of the second liquid storage tank (14), the outlet of the second liquid storage tank (14) is connected to the inlet of the first centrifugal pump (15), the outlet of the first centrifugal pump (15) is connected to the inlet of the first plunger pump (16), and the first plunger pump The outlet of the heat exchanger (16) is connected to the cold end inlet of the third heat exchanger (17), the first centrifugal pump (15) is used to control the flow rate of the extract, the first plunger pump (16) is used to control the pressure of the extract, the cold end outlet of the third heat exchanger (17) is connected to the inlet of the ceramic microfiltration membrane assembly (18), a first temperature sensor (19) and a first pressure sensor (20) are provided at the inlet of the ceramic microfiltration membrane assembly (18), the reflux port of the ceramic microfiltration membrane assembly (18) is connected to the inlet of the second liquid storage tank (14), the outlet of the ceramic microfiltration membrane assembly (18) is connected to the hot end inlet of the second heat exchanger (21), and the hot end outlet of the second heat exchanger (21) is connected to the inlet of the first liquid storage tank (22),A first flow regulating valve (36) is provided at the hot end outlet of the second heat exchanger (21), a liquid level sensor (37) is provided on the first liquid storage tank (22), the outlet of the first liquid storage tank (22) is connected to the inlet of the second centrifugal pump (23), the outlet of the second centrifugal pump (23) is connected to the inlet of the second plunger pump (24), the outlet of the second plunger pump (24) is connected to the hot end inlet of the fourth heat exchanger (25), the hot end outlet of the fourth heat exchanger (25) is connected to the nanofiltration membrane assembly (2 6), the reflux port of the nanofiltration membrane assembly (26) is connected to the inlet of the first liquid storage tank (22), the outlet of the nanofiltration membrane assembly (26) is connected to the inlet of the filtrate storage tank (27), a second pressure sensor (28) and a second temperature sensor (29) are arranged at the inlet of the nanofiltration membrane assembly (26), a second flow regulating valve (30) is arranged at the reflux port of the nanofiltration membrane assembly (26), and a third flow regulating valve (31) is arranged at the outlet of the nanofiltration membrane assembly (26); The method The method comprises the following steps: adding Chinese medicine raw materials and water into an extraction tank (1) through a feeding port (2); connecting a vacuum pumping device through a gas pipeline interface (3) to vacuumize the interior of the extraction tank (1); then connecting a protective atmosphere pipeline through the gas pipeline interface (3) to introduce a protective atmosphere into the interior of the extraction tank (1); opening a steam regulating valve (5) to introduce high-pressure steam into the interior of the extraction tank (1) to start extracting Chinese medicine components; during this process, if volatile oil needs to be extracted, opening a valve at the hot end inlet of a condenser (33) and a valve at the condensate outlet of a volatile oil collector (32) to extract volatile oil through the condenser (33) and the volatile oil collector (32); if volatile oil does not need to be extracted, closing a valve at the hot end inlet of the condenser (33) to extract volatile oil; The valve and the valve at the condensate outlet of the volatile oil collector (32) are closed. After the extraction of the Chinese medicine components is completed, the No. 3 liquid storage tank (11) is evacuated through the air pressure regulating port (13) at the upper end of the No. 3 liquid storage tank (11), so that a pressure difference is formed between the extraction tank (1) and the No. 3 liquid storage tank (11), and the extract is discharged through the extract outlet below the extraction tank (1). Under the action of the pressure difference between the extraction tank (1) and the No. 3 liquid storage tank (11) and the No. 1 circulation pump (7), the extract passes through the stainless steel filter element filter (8) and the No. 1 heat exchanger (10) in sequence and enters the No. 3 liquid storage tank (11). The Chinese medicine residue in the extract is filtered through the stainless steel filter element filter (8), and the extract is cooled through the No. 1 heat exchanger (10). The extract is stored in the No. 3 liquid storage tank (11). When the extract needs to be filtered for a second time, compressed air is introduced into the No. 3 liquid storage tank (11) through the air pressure regulating port (13) at the upper end of the No. 3 liquid storage tank (11). Under the pressure of the compressed air, the extract in the No. 3 liquid storage tank (11) enters the No. 2 liquid storage tank (14), and then flows out from the outlet at the lower end of the No. 2 liquid storage tank (14). Under the joint action of the No. 1 centrifugal pump (15) and the No. 1 plunger pump (16), the extract enters the No. 3 heat exchanger (17). The extract is heated by the No. 3 heat exchanger (17) to increase the solubility of the Chinese medicinal ingredients and prevent some of the Chinese medicinal ingredients from precipitating due to the decrease in temperature. After that, the extract enters the ceramic microfiltration membrane assembly (18) for filtration. The extract flowing out of the reflux port of the microfiltration membrane assembly (18) flows back into the second liquid storage tank (14) and is filtered again. The filtered extract is cooled by the second heat exchanger (21) and then enters the first liquid storage tank (22) for storage. When it is necessary to concentrate the extract in the first liquid storage tank (22), the extract flows out from the outlet at the lower end of the first liquid storage tank (22) and enters the fourth heat exchanger (25) under the joint action of the second centrifugal pump (23) and the second plunger pump (24). The extract is cooled by the fourth heat exchanger (25). By cooling the extract, the Chinese medicine components in the extract are separated out. The extract is then filtered by the nanofiltration membrane assembly (26), wherein the filtrate without Chinese medicine components is discharged from the outlet of the nanofiltration membrane assembly (26).The filtered Chinese medicinal ingredients are returned to the No. 1 liquid storage tank (22) along with part of the extract through the reflux port of the nanofiltration membrane assembly (26) and filtered again. The liquid level in the No. 1 liquid storage tank (22) is observed by the liquid level sensor (37). When the liquid level in the No. 1 liquid storage tank (22) drops to a set height, the concentration of the extract is completed. The concentrated extract can be discharged from the outlet of the No. 1 liquid storage tank (22) for subsequent processing.

2. A Chinese medicine extraction and filtration method according to claim 1, characterized in that: The operating pressure of the extraction tank (1) is 0-5 MPa, and the operating temperature is 50-200°C.

3. A Chinese medicine extraction and filtration method according to claim 1, characterized in that: The operating pressure of the stainless steel filter element filter (8) is 0-5 MPa, the operating temperature is 50-200° C., and the filter pore size on the stainless steel filter element filter (8) is 1-50 μm.

4. A Chinese medicine extraction and filtration method according to claim 1, characterized in that: The operating pressure of the ceramic microfiltration membrane assembly (18) is 0-5 MPa, the operating temperature is 50-200° C., and the filtration pore size of the ceramic microfiltration membrane assembly (18) is 50-200 nm.

5. A Chinese medicine extraction and filtration method according to claim 1, characterized in that: The molecular weight cut-off range of the nanofiltration membrane component (26) is 200Da to 1000Da.

6. A Chinese medicine extraction and filtration method according to claim 1, characterized in that: The Chinese medicine extraction and filtration system further comprises a No. 1 cleaning tank (34), wherein the No. 1 cleaning tank (34) is used to store cleaning water, and the outlet of the No. 1 cleaning tank (34) is connected to the inlet of the No. 1 centrifugal pump (15) for cleaning the No. 2 liquid storage tank (14) and the ceramic microfiltration membrane assembly (18).

7. A Chinese medicine extraction and filtration method according to claim 1, characterized in that: The Chinese medicine extraction and filtration system also includes a No. 2 cleaning tank (35), which is used to store cleaning water. The outlet of the No. 2 cleaning tank (35) is connected to the inlet of the No. 2 centrifugal pump (23) and is used to clean the No. 1 liquid storage tank (22) and the nanofiltration membrane assembly (26).

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