Three-dimensional bone scanning total index calculation method, electronic equipment and storage medium

Abstract

The invention relates to the technical field of medical image processing, and particularly provides a three-dimensional bone scanning total index calculation method, electronic equipment and a storage medium, and the method comprises the following steps: S1, carrying out focus segmentation on SPECT (Single Photon Emission Computed Tomography) tomographic bone scanning data to obtain a plurality of focus areas, each focus area corresponding to a bone metastasis focus; s2, performing skeleton segmentation and SPECT spatial conversion on the CT fault data to obtain a plurality of skeleton regions; s3, calculating a three-dimensional bone scanning index of each bone metastasis focus according to a proportional relation between the focus area and a bone area to which the focus area belongs, and then calculating a total three-dimensional bone scanning index according to all the three-dimensional bone scanning indexes; the method can effectively solve the problem of low acquisition precision of the total area of the bone region to which the focus belongs due to insufficient segmentation precision of the bone region.

Description

Technical Field

[0001] The present application relates to the technical field of medical image processing, and in particular to a method for calculating a total index of three-dimensional bone scanning, an electronic device and a storage medium. Background Art

[0002] In order to monitor the disease progression and treatment effect of cancer patients, the relevant technology needs to calculate the bone scan index. Specifically, the process of calculating the relevant bone scan index is: obtaining the lesion area and the total area of ​​the bone area to which the lesion belongs according to the SPECT plane image; calculating the bone scan index according to the lesion area, the total area of ​​the corresponding bone area, and the preset bone weight percentage corresponding to the bone area to which the lesion belongs. Since the relevant technology needs to obtain the bone scan index according to the SPECT plane image, and the SPECT plane image has the problem of insufficient accuracy in bone area segmentation, for example, the sternum and the spine overlap in the SPECT plane image, and the sternum and the spine cannot be accurately distinguished, the relevant technology has the problem of low accuracy in obtaining the total area of ​​the bone area to which the lesion belongs due to insufficient accuracy in bone area segmentation, which leads to insufficient accuracy of the bone scan index, and the existing bone scan index calculation is only applicable to SPECT plane images.

[0003] There is currently no effective technical solution to the above problems. Summary of the invention

[0004] The purpose of the present application is to provide a three-dimensional bone scan total index calculation method, electronic device and storage medium, which can effectively solve the problem of low accuracy in obtaining the total area of ​​the bone region to which the lesion belongs due to insufficient accuracy in bone region segmentation.

[0005] In a first aspect, the present application provides a method for calculating a total index of a three-dimensional bone scan, which comprises the following steps: S1. Segmenting the SPECT bone scan data to obtain a plurality of lesion regions, each of which corresponds to a bone metastasis lesion; S2, performing bone segmentation and SPECT space conversion on the CT tomographic data to obtain multiple bone regions; S3. Calculate the three-dimensional bone scanning index of each bone metastasis lesion according to the proportional relationship between the lesion area and the bone area to which the lesion area belongs, and then calculate the three-dimensional bone scanning total index according to all the three-dimensional bone scanning indices.

[0006] The present application provides a method for calculating a total three-dimensional bone scan index, which can obtain the lesion area of ​​a bone metastasis lesion by performing lesion segmentation on SPECT tomographic bone scan data and obtain multiple bone areas by performing bone segmentation and SPECT space conversion on CT tomographic data. Since CT tomographic data can clearly display the bone structure, the present application can accurately divide the bone area by performing bone segmentation on CT tomographic data, that is, compared with dividing the bone area according to SPECT planar images, the present application can effectively improve the accuracy of bone area segmentation, thereby effectively solving the problem of low accuracy in obtaining the total area of ​​the bone area to which the lesion belongs due to insufficient accuracy in bone area segmentation, thereby effectively improving the accuracy of the bone scan index, and the three-dimensional bone scan total index calculation method of the present application can be applicable to SPECT planar images and SPECT three-dimensional images.

[0007] Optionally, the proportional relationship includes a volumetric proportion and a weight proportion, the three-dimensional bone scan total index includes a volumetric bone scan total index and a weight bone scan total index, and step S3 includes: S31, acquiring lesion volume information and lesion weight information of each bone metastasis lesion according to the lesion area, and acquiring bone volume information and bone weight information corresponding to each bone area; S32, calculating the volume bone scan index of each bone metastasis lesion according to the lesion volume information and the bone volume information, and calculating the total volume bone scan index according to all the volume bone scan indices, wherein the volume bone scan index is the ratio of the lesion volume information corresponding to the lesion area to the bone volume information corresponding to the bone area to which the lesion area belongs; S33. Calculate the weight bone scan index of each bone metastasis lesion based on the lesion weight information and the bone weight information, and calculate the total weight bone scan index based on all the weight bone scan indices. The weight bone scan index is the ratio of the lesion weight information corresponding to the lesion area to the bone weight information corresponding to the bone area to which the lesion area belongs.

[0008] Optionally, the lesion volume information is the product of the sum of the pixels occupied by the lesion area in each slice and the unit pixel volume, the lesion weight information is the product of the average number of photons per unit volume in the lesion area and the lesion volume information, the bone volume information is the product of the total number of voxels in the bone area and the unit voxel volume, and the bone weight information is the product of the average linear absorption coefficient of the bone area and the bone volume information.

[0009] Optionally, the calculation formula of bone volume information is as shown in formula (1): (1); Among them, V bone Represents the bone volume information, N label Represents the total number of voxels in the bone region, Vvoxel Represents the unit voxel volume; The calculation formula of bone weight information is shown in formula (2): (2); Among them, W bone Indicates the weight and volume information of the bone area, HU bone represents the average linear absorption coefficient corresponding to the bone area.

[0010] Optionally, the calculation formula of the total volumetric bone scan index is as shown in formula (3): (3); Among them, VSBI 总 represents the volumetric bone scan total index, n represents the total number of bone metastatic lesions, VSBI i represents the volumetric bone scan index corresponding to the i-th bone metastasis lesion; The calculation formula of volumetric bone scan index is shown in formula (4): (4); Among them, V lessioni represents the lesion volume information of the lesion area corresponding to the i-th bone metastasis lesion, V totalbonei Represents the bone volume information of the bone area corresponding to the i-th bone metastasis lesion.

[0011] Optionally, the calculation formula of the total weight bone scan index is as shown in formula (5): (5); Among them, WSBI 总 represents the total weight bone scan index, n represents the total number of bone metastatic lesions, WSBI i represents the weight bone scan index corresponding to the i-th bone metastasis lesion; The calculation formula of the weight bone scan index is shown in formula (6): (6); Among them, W lessioni represents the lesion weight information of the lesion area corresponding to the i-th bone metastasis lesion, W totalbonei Represents the bone weight information of the bone area corresponding to the i-th bone metastasis lesion.

[0012] Optionally, step S2 includes: S21, performing bone segmentation on the CT tomographic data based on a pre-trained first segmentation network to obtain a plurality of bone segmentation results; S22. Convert all bone segmentation results into SPECT space to obtain multiple bone regions.

[0013] Optionally, step S1 includes: S11. Acquire several lesion areas according to SPECT bone scan data based on a pre-trained second segmentation network.

[0014] In a second aspect, the present application provides an electronic device, including a processor and a memory, wherein the memory stores computer-readable instructions. When the computer-readable instructions are executed by the processor, the steps in the three-dimensional bone scan total index calculation method provided in the first aspect are executed.

[0015] In a third aspect, the present application provides a computer-readable storage medium having a computer program stored thereon. When the computer program is executed by a processor, the steps in the method for calculating the total index of three-dimensional bone scanning provided in the first aspect are executed.

[0016] As can be seen from the above, the present application provides a three-dimensional bone scan total index calculation method, electronic device and storage medium, which can obtain the lesion area of ​​the bone metastasis lesion by performing lesion segmentation on the SPECT tomographic bone scan data and obtain multiple bone areas by performing bone segmentation and SPECT space conversion on the CT tomographic data. Since the CT tomographic data can clearly display the bone structure, the present application can accurately divide the bone area by performing bone segmentation on the CT tomographic data, that is, compared with the bone area division according to the SPECT plane image, the present application can effectively improve the bone area segmentation accuracy, thereby effectively solving the problem of low acquisition accuracy of the total area of ​​the bone area to which the lesion belongs due to insufficient bone area segmentation accuracy, thereby effectively improving the accuracy of the bone scan index, and the three-dimensional bone scan total index calculation method of the present application can be applicable to SPECT plane images and SPECT three-dimensional images. BRIEF DESCRIPTION OF THE DRAWINGS

[0017] Figure 1 A flowchart of a method for calculating a total index of three-dimensional bone scanning provided in an embodiment of the present application.

[0018] Figure 2 A schematic diagram of the structure of an electronic device provided in an embodiment of the present application.

[0019] Reference numerals: 101, processor; 102, memory; 103, communication bus. DETAILED DESCRIPTION

[0020] The technical solutions in the embodiments of the present application will be clearly and completely described below in conjunction with the drawings in the embodiments of the present application. Obviously, the described embodiments are only a part of the embodiments of the present application, rather than all of the embodiments. The components of the embodiments of the present application described and shown in the drawings here can be arranged and designed in various different configurations. Therefore, the following detailed description of the embodiments of the present application provided in the drawings is not intended to limit the scope of the application claimed for protection, but merely represents the selected embodiments of the present application. Based on the embodiments of the present application, all other embodiments obtained by those skilled in the art without making creative work belong to the scope of protection of the present application.

[0021] It should be noted that similar reference numerals and letters represent similar items in the following drawings, so once an item is defined in one drawing, it does not need to be further defined and explained in subsequent drawings. At the same time, in the description of this application, the terms "first", "second", etc. are only used to distinguish the description and cannot be understood as indicating or implying relative importance.

[0022] First, as Figure 1 As shown, the present application provides a method for calculating the total index of three-dimensional bone scanning, which comprises the following steps: S1. Segmenting the SPECT bone scan data to obtain a plurality of lesion regions, each of which corresponds to a bone metastasis lesion; S2, performing bone segmentation and SPECT space conversion on the CT tomographic data to obtain multiple bone regions; S3. Calculate the three-dimensional bone scanning index of each bone metastasis lesion according to the proportional relationship between the lesion area and the bone area to which the lesion area belongs, and then calculate the three-dimensional bone scanning total index according to all the three-dimensional bone scanning indices.

[0023] The SPECT tomographic bone scan data of step S1 is preferably data obtained after scanning a patient using a single photon emission tomography technology device (SPECT device). The SPECT tomographic bone scan data is data about bone metastasis lesions, that is, the SPECT tomographic bone scan data can accurately reflect the relevant information of bone metastasis lesions (such as the location and size of bone metastasis lesions). Step S1 can manually segment the SPECT tomographic bone scan data to obtain a plurality of lesion areas, each of which corresponds to a bone metastasis lesion.

[0024] The CT slice data of step S2 is preferably data obtained by scanning a patient using an X-ray scanning imaging device. Since the CT device has the advantages of high resolution and the ability to clearly display the bone structure, step S2 can accurately divide the bone region in the CT slice data by performing bone segmentation on the CT slice data. Since the size of the CT slice data is usually 512×512×N, and the size of the SPECT tomographic bone scan data is usually 128×128×N, in order to make the data obtained after the bone segmentation of the CT slice data applicable to the SPECT tomographic bone scan data, step S2 needs to perform SPECT space conversion on the data obtained after the bone segmentation of the CT slice data to obtain multiple bone regions applicable to the SPECT tomographic bone scan data. It should be understood that the bone region of this embodiment is CT data with the same resolution as the resolution of the SPECT tomographic bone scan data. Since the SPECT space conversion of this embodiment is equivalent to adjusting the resolution of the data obtained after the bone segmentation of the CT slice data to be consistent with the resolution of the SPECT tomographic bone scan data, the bone region of this embodiment can match the bone region in the SPECT tomographic bone scan data.

[0025] Step S3 can analyze which bone region the lesion region belongs to by analyzing which bone region has an intersection with the lesion region. This embodiment can also analyze which bone region the lesion region belongs to by first obtaining the position of the lesion region and then analyzing which bone region the position is located in. The three-dimensional bone scan total index of step S3 can reflect the percentage of all bone metastasis lesions in the bone, so step S3 can first calculate the three-dimensional bone scan index of each bone metastasis lesion according to the proportional relationship between the lesion region and the bone region to which the lesion region belongs, and then calculate the three-dimensional bone scan total index according to all three-dimensional bone scan indices. Specifically, step S3 can obtain the three-dimensional bone scan total index by summing all three-dimensional bone scan indices. It should be understood that since SPECT tomographic bone scan data can accurately reflect the relevant information of bone metastasis lesions, CT tomographic data can accurately reflect the bone structure, and this application is based on SPECT tomographic bone scan data to obtain the lesion region and based on CT tomographic data to obtain the bone region, so this application is equivalent to using the respective advantages of SPECT tomographic bone scan data and CT tomographic data to calculate an accurate three-dimensional bone scan total index.

[0026] The present application provides a method for calculating a total three-dimensional bone scan index, which can obtain the lesion area of ​​a bone metastasis lesion by performing lesion segmentation on SPECT tomographic bone scan data and obtain multiple bone areas by performing bone segmentation and SPECT space conversion on CT tomographic data. Since CT tomographic data can clearly display the bone structure, the present application can accurately divide the bone area by performing bone segmentation on CT tomographic data, that is, compared with dividing the bone area according to SPECT planar images, the present application can effectively improve the accuracy of bone area segmentation, thereby effectively solving the problem of low accuracy in obtaining the total area of ​​the bone area to which the lesion belongs due to insufficient accuracy in bone area segmentation, thereby effectively improving the accuracy of the bone scan index, and the three-dimensional bone scan total index calculation method of the present application can be applicable to SPECT planar images and SPECT three-dimensional images. In addition, since the prior art requires the use of a preset bone weight percentage to calculate the bone scan index, the preset bone weight percentage is the percentage of the weight of a certain bone area to the total weight of all bones, and the preset bone weight percentage is obtained by comprehensively analyzing the bone weight ratios of multiple patients collected in advance. Therefore, the preset bone weight percentage may not accurately reflect the actual situation of the patient who needs to calculate the bone scan index. Since the present application obtains multiple bone areas based on CT tomography data, the present application can obtain accurate bone weight percentages based on the patient's own multiple bone areas, that is, the bone weight percentage of the present application can accurately reflect the actual situation of the patient who needs to calculate the bone scan index, thereby effectively avoiding the situation where the preset bone weight percentage may not accurately reflect the actual situation of the patient who needs to calculate the bone scan index.

[0027] In some preferred embodiments, the proportional relationship includes a volumetric ratio and a weight ratio, the three-dimensional bone scan total index includes a volumetric bone scan total index and a weight bone scan total index, and step S3 includes: S31, acquiring lesion volume information and lesion weight information of each bone metastasis lesion according to the lesion area, and acquiring bone volume information and bone weight information corresponding to each bone area; S32, calculating the volume bone scan index of each bone metastasis lesion according to the lesion volume information and the bone volume information, and calculating the total volume bone scan index according to all the volume bone scan indices, wherein the volume bone scan index is the ratio of the lesion volume information corresponding to the lesion area to the bone volume information corresponding to the bone area to which the lesion area belongs; S33. Calculate the weight bone scan index of each bone metastasis lesion based on the lesion weight information and the bone weight information, and calculate the total weight bone scan index based on all the weight bone scan indices. The weight bone scan index is the ratio of the lesion weight information corresponding to the lesion area to the bone weight information corresponding to the bone area to which the lesion area belongs.

[0028] Since each bone metastasis lesion corresponds to a lesion volume information and a lesion weight information, each bone region corresponds to a bone volume information and a bone weight information, and each bone metastasis lesion corresponds to a bone region, after executing step S31, each lesion volume information of this embodiment corresponds to a bone volume information, each lesion weight information of this embodiment corresponds to a bone weight information, the bone weight information of this embodiment is the relative weight of the bone region, and the lesion weight information of this embodiment is the relative weight of the lesion region. Step S32 can calculate the volume bone scan index by summing all volume bone scan indices, and step S33 can calculate the total weight bone scan index by summing all weight bone scan indices.

[0029] In some preferred embodiments, the lesion volume information is the product of the sum of the pixels occupied by the lesion area in each slice and the unit pixel volume, the lesion weight information is the product of the average number of photons per unit volume in the lesion area and the lesion volume information, the bone volume information is the product of the total number of voxels in the bone area and the unit voxel volume, and the bone weight information is the product of the average linear absorption coefficient of the bone area and the bone volume information. It should be understood that since the average number of photons per unit volume in the lesion area is affected by the tissue density of the bone metastasis lesion, this embodiment can use the product of the average number of photons per unit volume in the lesion area and the lesion volume information as the lesion weight information, and since the average linear absorption coefficient is affected by the bone density of the bone area, this embodiment can use the product of the average linear absorption coefficient of the bone area and the bone volume information as the bone weight information. It should also be understood that, since the patient will be injected with a contrast agent containing a radioactive isotope before obtaining the SPECT tomographic bone scan data, and the radioactive isotope will emit photons during the decay process, and the photons will be captured by the SPECT device, this embodiment can use the SPECT device to obtain the total number of photons in a certain area, that is, this embodiment can obtain the average number of photons per unit volume in the lesion area by dividing the total number of photons in a certain area in the lesion area by the volume of the area.

[0030] In some preferred embodiments, the calculation formula of bone volume information is as shown in formula (1): (1); Among them, V bone Represents the bone volume information, N label Represents the total number of voxels in the bone region, V voxel Represents the unit voxel volume; The calculation formula of bone weight information is shown in formula (2): (2); Among them, W bone Indicates the weight and volume information of the bone area, HU bone represents the average linear absorption coefficient corresponding to the bone area.

[0031] This embodiment may also first calculate the product of each voxel in the bone region and the corresponding linear absorption coefficient to obtain the weight of each voxel in the bone region, and then sum the weights of all voxels to obtain the bone weight information.

[0032] In some preferred embodiments, the calculation formula of the volumetric bone scan total index is as shown in formula (3): (3); Among them, VSBI 总 represents the volumetric bone scan total index, n represents the total number of bone metastatic lesions, VSBI i represents the volumetric bone scan index corresponding to the i-th bone metastasis lesion; The calculation formula of volumetric bone scan index is shown in formula (4): (4); Among them, V lessioni represents the lesion volume information of the lesion area corresponding to the i-th bone metastasis lesion, V totalbonei represents the bone volume information of the bone region corresponding to the i-th bone metastasis lesion. totalbonei V is the bone region corresponding to the i-th bone metastasis lesion bone .

[0033] In some preferred embodiments, the calculation formula of the total weight bone scan index is as shown in formula (5): (5); Among them, WSBI 总 represents the total weight bone scan index, n represents the total number of bone metastatic lesions, WSBI i represents the weight bone scan index corresponding to the i-th bone metastasis lesion; The calculation formula of the weight bone scan index is shown in formula (6): (6); Among them, W lessioni represents the lesion weight information of the lesion area corresponding to the i-th bone metastasis lesion, W totalbonei W represents the bone weight information of the bone region corresponding to the i-th bone metastasis lesion. totalbonei is the W corresponding to the bone region corresponding to the i-th bone metastasis lesion bone .

[0034] In some preferred embodiments, step S2 comprises: S21, performing bone segmentation on the CT tomographic data based on a pre-trained first segmentation network to obtain a plurality of bone segmentation results; S22. Convert all bone segmentation results into SPECT space to obtain multiple bone regions.

[0035] The first segmentation network of this embodiment is preferably an existing open source segmentation algorithm nnUNet. The first segmentation network can perform bone segmentation on CT cross-sectional data to accurately divide the bones in the CT cross-sectional data into regions. The difference between the bone segmentation result of this embodiment and the bone region is that the corresponding resolutions of the two are different.

[0036] In some preferred embodiments, step S22 includes: S221. Based on the registration algorithm and CT data resampling technology, all bone segmentation results are converted into SPECT space to obtain multiple bone regions.

[0037] The registration algorithm of this embodiment can align the data in the CT space with the SPECT space, and the CT data resampling technology of this embodiment can adjust the resolution of the bone segmentation result to match the SPECT space.

[0038] In some preferred embodiments, step S1 comprises: S11. Perform lesion segmentation on the SPECT bone scan data based on a pre-trained second segmentation network to obtain a plurality of lesion regions.

[0039] The second segmentation network of this embodiment is preferably an existing open source segmentation algorithm nnUNet. The difference between the second segmentation network of this embodiment and the first segmentation network of the above embodiment is that the network parameters of the two are different. Since this embodiment obtains a plurality of lesion regions by performing lesion segmentation on SPECT bone scan data based on the pre-trained second segmentation network, this embodiment can effectively avoid the situation that the labor intensity is high and the calculation efficiency of the bone scan index is low due to the need to perform lesion segmentation on SPECT bone scan data manually.

[0040] As can be seen from the above, the three-dimensional bone scan total index calculation method provided by the present application can obtain the lesion area of ​​the bone metastasis lesion by performing lesion segmentation on the SPECT tomographic bone scan data and obtain multiple bone areas by performing bone segmentation and SPECT space conversion on the CT tomographic data. Since the CT tomographic data can clearly display the bone structure, the present application can accurately divide the bone area by performing bone segmentation on the CT tomographic data, that is, compared with the bone area division according to the SPECT plane image, the present application can effectively improve the bone area segmentation accuracy, thereby effectively solving the problem of low acquisition accuracy of the total area of ​​the bone area to which the lesion belongs due to insufficient bone area segmentation accuracy, thereby effectively improving the accuracy of the bone scan index, and the three-dimensional bone scan total index calculation method of the present application can be applicable to SPECT plane images and SPECT three-dimensional images.

[0041] Please refer to Figure 2 , Figure 2 The present invention provides a structural schematic diagram of an electronic device provided in an embodiment of the present application. The present application provides an electronic device, including: a processor 101 and a memory 102. The processor 101 and the memory 102 are interconnected and communicate with each other through a communication bus 103 and / or other forms of connection mechanisms (not shown). The memory 102 stores computer-readable instructions executable by the processor 101. When the electronic device is running, the processor 101 executes the computer-readable instructions to execute the method in any optional implementation of the above embodiment to achieve the following functions: step S1, performing lesion segmentation on SPECT tomographic bone scan data to obtain a plurality of lesion areas, each of which corresponds to a bone metastasis lesion; step S2, performing bone segmentation and SPECT space conversion on CT tomographic data to obtain a plurality of bone areas; step S3, calculating the three-dimensional bone scan index of each bone metastasis lesion according to the proportional relationship between the lesion area and the bone area to which the lesion area belongs, and then calculating the three-dimensional bone scan total index according to all the three-dimensional bone scan indices.

[0042] The embodiment of the present application also provides a computer-readable storage medium having a computer program stored thereon. When the computer program is executed by a processor, the method in any optional implementation of the above embodiment is executed to achieve the following functions: step S1, lesion segmentation is performed on the SPECT tomographic bone scanning data to obtain a plurality of lesion areas, each lesion area corresponds to a bone metastasis lesion; step S2, bone segmentation and SPECT space conversion are performed on the CT tomographic data to obtain multiple bone areas; step S3, the three-dimensional bone scanning index of each bone metastasis lesion is calculated according to the proportional relationship between the lesion area and the bone area to which the lesion area belongs, and then the three-dimensional bone scanning total index is calculated according to all the three-dimensional bone scanning indices. Among them, the computer-readable storage medium can be implemented by any type of volatile or non-volatile storage device or a combination thereof, such as static random access memory (SRAM), electrically erasable programmable read-only memory (EEPROM), erasable programmable read-only memory (EPROM), programmable red-only memory (PROM), read-only memory (ROM), magnetic storage, flash memory, magnetic disk or optical disk.

[0043] As can be seen from the above, the present application provides a three-dimensional bone scan total index calculation method, electronic device and storage medium, which can obtain the lesion area of ​​the bone metastasis lesion by performing lesion segmentation on the SPECT tomographic bone scan data and obtain multiple bone areas by performing bone segmentation and SPECT space conversion on the CT tomographic data. Since the CT tomographic data can clearly display the bone structure, the present application can accurately divide the bone area by performing bone segmentation on the CT tomographic data, that is, compared with the bone area division according to the SPECT plane image, the present application can effectively improve the bone area segmentation accuracy, thereby effectively solving the problem of low acquisition accuracy of the total area of ​​the bone area to which the lesion belongs due to insufficient bone area segmentation accuracy, thereby effectively improving the accuracy of the bone scan index, and the three-dimensional bone scan total index calculation method of the present application can be applicable to SPECT plane images and SPECT three-dimensional images.

[0044] In the embodiments provided in the present application, it should be understood that, herein, relational terms such as first and second, etc. are merely used to distinguish one entity or operation from another entity or operation, and do not necessarily require or imply any such actual relationship or order between these entities or operations.

[0045] The above description is only an embodiment of the present application and is not intended to limit the protection scope of the present application. For those skilled in the art, the present application may have various modifications and variations. Any modification, equivalent replacement, improvement, etc. made within the spirit and principle of the present application shall be included in the protection scope of the present application.

Claims

1. A method for calculating a total index of three-dimensional bone scanning, characterized in that: The three-dimensional bone scanning total index calculation method comprises the following steps: S1. Segmenting the SPECT bone scan data to obtain a plurality of lesion regions, each of which corresponds to a bone metastasis lesion; S2, performing bone segmentation and SPECT space conversion on the CT tomographic data to obtain multiple bone regions; S3. Calculate the three-dimensional bone scanning index of each bone metastasis lesion according to the proportional relationship between the lesion area and the bone area to which the lesion area belongs, and then calculate the three-dimensional bone scanning total index according to all the three-dimensional bone scanning indices.

2. The method for calculating the total index of three-dimensional bone scanning according to claim 1, characterized in that: The proportional relationship includes a volume ratio and a weight ratio, and the three-dimensional bone scan total index includes a volume bone scan total index and a weight bone scan total index. Step S3 includes: S31, acquiring the lesion volume information and lesion weight information of each bone metastasis lesion according to the lesion area, and acquiring the bone volume information and bone weight information corresponding to each bone area; S32, calculating the volume bone scan index of each bone metastasis lesion according to the lesion volume information and the bone volume information, and calculating the total volume bone scan index according to all the volume bone scan indices, wherein the volume bone scan index is the ratio of the lesion volume information corresponding to the lesion area to the bone volume information corresponding to the bone area to which the lesion area belongs; S33. Calculate the weight bone scan index of each bone metastasis lesion based on the lesion weight information and the bone weight information, and calculate the total weight bone scan index based on all the weight bone scan indices, wherein the weight bone scan index is the ratio of the lesion weight information corresponding to the lesion area to the bone weight information corresponding to the bone area to which the lesion area belongs.

3. The method for calculating the total index of three-dimensional bone scanning according to claim 2, characterized in that: The lesion volume information is the product of the sum of the pixels occupied by the lesion area in each slice and the unit pixel volume, the lesion weight information is the product of the average number of photons per unit volume in the lesion area and the lesion volume information, the bone volume information is the product of the total number of voxels in the bone area and the unit voxel volume, and the bone weight information is the product of the average linear absorption coefficient of the bone area and the bone volume information.

4. The method for calculating the total index of three-dimensional bone scanning according to claim 3, characterized in that: The calculation formula of the bone volume information is as follows: ； Among them, V bone Represents the bone volume information, N label Represents the total number of voxels in the bone region, V voxel Represents the unit voxel volume; The calculation formula of the bone weight information is as follows: ； Among them, W bone Indicates the weight and volume information of the bone area, HU bone represents the average linear absorption coefficient corresponding to the bone area.

5. The method for calculating the total index of three-dimensional bone scanning according to claim 2, characterized in that: The calculation formula of the volumetric bone scan total index is as follows: ； Among them, VSBI 总 represents the volumetric bone scan total index, n represents the total number of bone metastatic lesions, VSBI i represents the volumetric bone scan index corresponding to the i-th bone metastasis lesion; The calculation formula of the volumetric bone scan index is shown below: ； Among them, V lessioni represents the lesion volume information of the lesion area corresponding to the i-th bone metastasis lesion, V totalbonei Represents the bone volume information of the bone area corresponding to the i-th bone metastasis lesion.

6. The method for calculating the total index of three-dimensional bone scanning according to claim 2, characterized in that: The calculation formula of the total weight bone scan index is as follows: ； Among them, WSBI 总 represents the total weight bone scan index, n represents the total number of bone metastatic lesions, WSBI i represents the weight bone scan index corresponding to the i-th bone metastasis lesion; The calculation formula of the weight bone scan index is shown below: ； Among them, W lessioni represents the lesion weight information of the lesion area corresponding to the i-th bone metastasis lesion, W totalbonei Represents the bone weight information of the bone area corresponding to the i-th bone metastasis lesion.

7. The method for calculating the total index of three-dimensional bone scanning according to claim 5, characterized in that: Step S2 includes: S21, performing bone segmentation on the CT tomographic data based on a pre-trained first segmentation network to obtain a plurality of bone segmentation results; S22. Convert all the bone segmentation results into SPECT space to obtain multiple bone regions.

8. The method for calculating the total index of three-dimensional bone scanning according to claim 1, characterized in that: Step S1 includes: S11. Acquire several lesion areas according to SPECT bone scan data based on a pre-trained second segmentation network.

9. An electronic device, characterized in that: The method comprises a processor and a memory, wherein the memory stores computer-readable instructions. When the computer-readable instructions are executed by the processor, the steps in the method according to any one of claims 1 to 8 are executed.

10. A computer-readable storage medium having a computer program stored thereon, characterized in that: When the computer program is executed by a processor, the steps of the method according to any one of claims 1 to 8 are executed.

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