Chromatographic column sealing assembly

Abstract

The invention relates to the technical field of chromatographic column sealing assemblies, in particular to a chromatographic column sealing assembly which comprises a cylinder, a fixing ring is arranged outside the cylinder in a sleeving mode and fixedly connected with the cylinder, a lifting mechanism is arranged at the upper end of the cylinder, a pressing mechanism is arranged at the end, close to the cylinder, of the upper end of the cylinder, and two pressing plates are arranged in the cylinder. A water filling mechanism is arranged between the two pressing plates, a wrapping mechanism is arranged on the sides, close to the inner wall of the cylinder body, of the pressing plates, and by means of the arranged structure, when the column head pressing ring moves downwards, a first arc-shaped rubber plate bends outwards to drive a rubber ball to move outwards to be attached to the inner side wall of the cylinder body; the two rubber rings and the rubber ball in the middle of the two rubber rings are attached to the barrel at the same time, so that the sealing effect can be improved, and the sealing effect on the barrel can be better through three-position sealing of the two rubber rings and the rubber ball in the middle of the two rubber rings.

Description

Technical Field

[0001] The invention relates to the technical field of chromatography column sealing components, in particular to a chromatography column sealing component. Background Art

[0002] The chromatography column sealing assembly is a vital part of the chromatography column. Its main function is to ensure that the liquid or particulate matter in the chromatography column will not leak, thereby maintaining the stable operation and separation effect of the chromatography system. The chromatography column sealing assembly is usually composed of multiple components, including but not limited to a distributor plate, a distributor plate back plate, a clamping plate, an elastic device, a gear device, and a screw located in the axial position of the cylindrical shell. These components work together to achieve effective sealing between the chromatography column adapter and the inner wall of the cylindrical shell. The chromatography column sealing assembly is an indispensable key component in the chromatography column. Its good sealing performance is of great significance for ensuring the stable operation and separation effect of the chromatography system.

[0003] The existing chromatography column sealing assembly rotates the gear device to cause the compression plate to rotate, thereby changing the relative distance between the distributor plate and the distributor plate back plate. During this process, the elastic device is compressed, so that it is in close contact with the inner wall of the cylindrical shell, forming a reliable sealing effect. The design of the sealing assembly effectively avoids the leakage of liquid or particulate matter in the chromatography column, ensuring the purity and stability of the internal environment of the chromatography column.

[0004] The chromatography column sealing component plays a vital role in the chromatography system, and its sealing performance directly affects the stability of the chromatography process and the separation effect. However, the chromatography column sealing component also has some potential disadvantages, which may gradually appear during use, affecting the efficiency and results of the experiment or production. If the sealing performance of the sealing component is poor or there is a risk of leakage during use, the sample or solvent in the chromatography process will be contaminated, affecting the experimental results or product quality. The performance problems of the sealing component may also affect the separation effect of the chromatography column, resulting in reduced separation purity or slower separation speed. The seals of the chromatography column sealing component, such as O-rings, U-rings, etc., will reduce the sealing performance due to aging, hardening or wear after long-term use or frequent operation, resulting in insufficient sealing pressure and leakage. Summary of the invention

[0005] In view of the problems in the prior art, the present invention provides a chromatography column sealing assembly.

[0006] The technical solution adopted by the present invention to solve its technical problems is: a chromatography column sealing assembly, including a cylinder, a fixing ring is sleeved on the outside of the cylinder and fixedly connected to the cylinder, a lifting mechanism is arranged on the upper end of the cylinder, a pressing mechanism is arranged on the end of the upper end of the cylinder close to the cylinder, two pressing plates are arranged inside the cylinder, a water filling mechanism is arranged between the two pressing plates, and a wrapping mechanism is arranged on the side of the pressing plate close to the inner wall of the cylinder.

[0007] Preferably, brackets are rotatably connected to both sides of the fixing ring.

[0008] Preferably, the lifting mechanism includes a cover, the lower end of the cover is fixedly connected to the cylinder, the interior of the cover is provided with a thread, the upper end of the cover is rotatably connected to the outer ring of the first bearing, and the upper end of the inner ring of the first bearing is fixedly connected to the first nut.

[0009] Preferably, the lifting mechanism further comprises a screw, the first nut is internally threadedly engaged with the screw, the surface thread of the screw is engaged with the internal thread of the cover, a slide groove is provided inside the screw, and the lower end of the screw is fixedly connected to a dispenser.

[0010] Preferably, the pressing mechanism comprises a second nut, the internal thread of the second nut is engaged with the screw rod, and the upper end of the second nut is fixedly connected to the outer ring of the second bearing.

[0011] Preferably, the pressing mechanism further comprises a sliding rod, the inner ring of the second bearing is fixedly connected with the sliding rod, the surface of the sliding rod is fixedly connected with a connecting block, and one end of the connecting block is fixedly connected with a column head pressure ring.

[0012] Preferably, one end of the pressure plate is fixedly connected to a first arc-shaped rubber plate, one pressure plate at the upper end of the two pressure plates is fixedly connected to the column head pressure ring, one pressure plate at the lower end of the two pressure plates is fixedly connected to the distributor, and one end of the two first arc-shaped rubber plates is fixedly connected to a rubber ball.

[0013] Preferably, the water filling mechanism includes an airbag, the upper end of the airbag is fixedly connected to the bottom surface of a pressure plate at the upper ends of the two pressure plates, the lower end of the airbag is fixedly connected to the top surface of a pressure plate at the lower ends of the two pressure plates, the upper end of the airbag is fixedly connected to the pressure plate, and one end of the hose is fixedly connected to the rubber ball.

[0014] Preferably, the wrapping mechanism includes a fixed block, one end of which is fixedly connected to the top surface of the column head pressure ring, the lower end of the fixed block is fixedly connected to a sleeve, a telescopic rod is slidably connected inside the sleeve, the lower end of the telescopic rod is fixedly connected to a second arc-shaped rubber plate, and the lower end of the fixed block is fixedly connected to a spring.

[0015] Preferably, the wrapping mechanism further comprises a second arc-shaped rubber plate, the lower end of the spring is fixedly connected to the second arc-shaped rubber plate, and one end of the second arc-shaped rubber plate away from the spring is fixedly connected to a rubber ring.

[0016] Beneficial effects of the present invention: 1. A chromatography column sealing assembly described in the present invention adopts a structure that is set up. When the column head pressure ring moves downward, the first curved rubber plate bends outward, which drives the rubber ball to move outward and fit the inner side wall of the cylinder. At the same time, when the pressure plate moves downward, the air inside the cavity surrounded by the two pressure plates, the two first curved rubber plates and the rubber balls is compressed. The compressed air inside the cavity will further drive the first curved rubber plate to continue to fit against the inner side wall of the cylinder. When the first curved rubber plate bends outward, it will also drive the two second curved rubber plates wrapped on the outside thereof to move outward and close to the cylinder. The outward movement of the two second curved rubber plates close to the cylinder will drive the rubber rings at the ends of the two second curved rubber plates to fit the cylinder. The two rubber rings and the rubber balls at the middle positions of the two rubber rings fit the cylinder at the same time, which can improve the sealing effect. The three-point sealing of the two rubber rings and the rubber balls at the middle positions of the two rubber rings can achieve a better sealing effect on the cylinder.

[0017] 2. A chromatography column sealing assembly described in the present invention has an airbag filled with one-third of water. When the column head pressure ring moves downward, the airbag is driven to compress downward. The airbag is compressed downward to fill the water inside the airbag into the rubber ball. The rubber ball expands and becomes larger when a certain amount of water is filled inside the rubber ball. The expanded and larger rubber ball fits the inner side wall of the cylinder. The rubber ball fits the inner side wall of the cylinder to seal the cylinder. At the same time, the inside of the rubber ball is filled with water, which is difficult to compress. Therefore, when the rubber ball moves outward, it will fit more tightly to the inner side wall of the cylinder under the action of the water inside the rubber ball.

[0018] 3. A chromatography column sealing assembly described in the present invention adopts a structure that drives the second curved rubber plate to move downward to wrap the first curved rubber plate while the column head pressure ring moves downward. The second curved rubber plate is made of hard rubber material. The second curved rubber plate moves downward to wrap the first curved rubber plate to reduce the degree of expansion of the first curved rubber plate to both sides of the rubber ball under pressure. BRIEF DESCRIPTION OF THE DRAWINGS

[0019] The present invention is further described below in conjunction with the accompanying drawings and embodiments.

[0020] Figure 1 A schematic diagram of the overall structure provided by the present invention; Figure 2 It is a schematic diagram of the cylinder structure; Figure 3It is a schematic diagram of the connection structure between the fixing ring and the bracket; Figure 4 It is a schematic diagram of the connection structure between the cover and the first bearing; Figure 5 Schematic diagram of the screw structure; Figure 6 It is a schematic diagram of the distributor structure; Figure 7 It is a schematic diagram of the connection structure between the connection block and the column head pressure ring; Figure 8 It is a schematic diagram of the pressure plate structure; Fig. 9 Schematic diagram of the airbag structure Fig.10 for Figure 8 A schematic diagram of the enlarged structure of part A is shown.

[0021] In the figure: 100, cylinder; 200, fixing ring; 201, bracket; 300, lifting mechanism; 301, cover; 302, first bearing; 303, first nut; 304, screw; 305, slide; 306, distributor; 400, pressing mechanism; 401, second nut; 402, second bearing; 403, sliding rod; 404, connecting block; 405, column head pressure ring; 500, pressing plate; 501, first arc-shaped rubber sheet; 502, rubber ball; 600, water filling mechanism; 601, air bag; 602, hose; 700, wrapping mechanism; 701, fixing block; 702, sleeve; 703, telescopic rod; 704, spring; 705, second arc-shaped rubber sheet; 706, rubber ring. DETAILED DESCRIPTION

[0022] In order to make the technical means, creative features, objectives and effects achieved by the present invention easy to understand, the present invention is further explained below in conjunction with specific implementation methods.

[0023] like Figure 1-Figure 10As shown, a chromatography column sealing assembly of the present invention comprises a barrel 100, a fixing ring 200 is sleeved on the outer side of the barrel 100 and fixedly connected thereto, a lifting mechanism 300 is arranged on the upper end of the barrel 100, a pressing mechanism 400 is arranged on the upper end of the barrel 100 close to the barrel 100, two pressing plates 500 are arranged inside the barrel 100, a water filling mechanism 600 is arranged between the two pressing plates 500, and a packing mechanism 600 is arranged on one side of the pressing plate 500 close to the inner wall of the barrel 100. Wrapping mechanism 700; the structure is set up so that when the column head pressure ring 405 moves downward, the first arc-shaped rubber plate 501 bends outward, which will drive the rubber ball 502 to move outward and fit the inner side wall of the cylinder 100. The two rubber rings 706 and the rubber ball 502 in the middle of the two rubber rings 706 are simultaneously fitted to the cylinder 100 to improve the sealing effect. The three-point sealing of the two rubber rings 706 and the rubber ball 502 in the middle of the two rubber rings 706 can achieve a better sealing effect on the cylinder 100.

[0024] Preferably, brackets 201 are rotatably connected to both sides of the fixing ring 200 .

[0025] Furthermore, the lifting mechanism 300 includes a cover 301, the lower end of the cover 301 is fixedly connected to the cylinder 100, the cover 301 is provided with a thread inside, the upper end of the cover 301 is rotatably connected to the outer ring of the first bearing 302, the upper end of the inner ring of the first bearing 302 is fixedly connected to the first nut 303, the internal thread of the first nut 303 is meshed with a screw 304, the screw 304 is set to a hollow structure for easy liquid injection, the surface thread of the screw 304 is meshed with the internal thread of the cover 301, the screw 304 is provided with a slide groove 305, and the lower end of the screw 304 is fixedly connected to a dispenser 306.

[0026] Specifically, the pressing mechanism 400 includes a second nut 401, the internal thread of the second nut 401 is meshed with the screw rod 304, the upper end of the second nut 401 is fixedly connected to the outer ring of the second bearing 402, the inner ring of the second bearing 402 is fixedly connected to the sliding rod 403, the surface of the sliding rod 403 is fixedly connected to the connecting block 404, and one end of the connecting block 404 is fixedly connected to the column head pressing ring 405;At this time, rotating the second nut 401 downward, the downward movement of the second nut 401 will drive the second bearing 402 to move downward, the downward movement of the second bearing 402 will drive the sliding rod 403 to move downward, the downward movement of the sliding rod 403 will drive the connecting block 404 to move downward, the downward movement of the connecting block 404 will drive the column head pressing ring 405 to move downward, the downward movement of the column head pressing ring 405 will drive the pressing plate 500 to move downward, the downward movement of the pressing plate 500 will drive the first arc-shaped rubber plates 501 on both sides to bend outward, the outward bending of the first arc-shaped rubber plates 501 on both sides will drive the rubber balls 502 to move outward to fit the inner side walls of the cylinder 100, and at the same time, when the pressing plate 500 moves downward, the two pressing plates 500 and The air inside the cavity surrounded by the two first curved rubber plates 501 and the rubber ball 502 is compressed, and the compressed air inside the cavity will further drive the first curved rubber plate 501 to continue to fit against the inner side wall of the cylinder 100. When the first curved rubber plate 501 bends outward, it will also drive the two second curved rubber plates 705 wrapped outside thereof to move outward and close to the cylinder 100. The outward movement of the two second curved rubber plates 705 close to the cylinder 100 will drive the rubber rings 706 at the ends of the two second curved rubber plates 705 to fit against the cylinder 100. The rubber rings 706 at the ends of the two second curved rubber plates 705 fit against the cylinder 100, thereby further sealing the cylinder 100. The sealing effect can be improved by having the two rubber rings 706 and the rubber ball 502 in the middle of the two rubber rings 706 fit the cylinder 100 at the same time. The sealing effect of the cylinder 100 can be better achieved by the three-point sealing of the two rubber rings 706 and the rubber ball 502 in the middle of the two rubber rings 706. The structure is set so that when the column head pressure ring 405 moves downward, the first arc rubber plate 501 bends outward, which will drive the rubber ball 502 to move outward and fit the inner side wall of the cylinder 100. At the same time, when the pressing plate 500 moves downward, the air inside the cavity surrounded by the two pressing plates 500, the two first arc rubber plates 501 and the rubber ball 502 will be compressed. The air inside the cavity is compressed. The air will further drive the first curved rubber sheet 501 to continue to fit against the inner side wall of the cylinder 100. When the first curved rubber sheet 501 bends outward, it will also drive the two second curved rubber sheets 705 wrapped outside it to move outward close to the cylinder 100. The two second curved rubber sheets 705 move outward close to the cylinder 100, which will drive the rubber rings 706 at the ends of the two second curved rubber sheets 705 to fit against the cylinder 100. The two rubber rings 706 and the rubber balls 502 in the middle of the two rubber rings 706 fit against the cylinder 100 at the same time, which can improve the sealing effect. The three-point sealing of the two rubber rings 706 and the rubber balls 502 in the middle of the two rubber rings 706 can achieve a better sealing effect on the cylinder 100. ;

[0027] It should be noted that one end of the pressing plate 500 is fixedly connected to the first arc-shaped rubber plate 501, one pressing plate 500 at the upper end of the two pressing plates 500 is fixedly connected to the column head pressure ring 405, and one pressing plate 500 at the lower end of the two pressing plates 500 is fixedly connected to the distributor 306, and one end of the two first arc-shaped rubber plates 501 is fixedly connected to the rubber ball 502; one third of water is filled in the airbag 601, and the water level in the airbag 601 is lower than the rubber ball 502. When the column head pressure ring 405 moves downward, the airbag 601 will be compressed downward. The downward compression of the airbag 601 will cause the water inside to flow into the rubber ball 502 through the hose 602 under the action of pressure, and the rubber ball 502 is filled with a certain amount of water. The water will expand and become larger, and the rubber ball 502 will expand and become larger to fit the inner side wall of the cylinder 100. The rubber ball 502 fitting the inner side wall of the cylinder 100 can play a role in sealing the cylinder 100. At the same time, the interior of the rubber ball 502 is filled with water, and water is difficult to be compressed. Therefore, when the rubber ball 502 moves outward, it will fit more tightly to the inner side wall of the cylinder 100 under the action of the water inside it. When the column head pressure ring 405 moves upward, it will drive the upper one of the two pressure plates 500 to move upward. The upward movement of the upper one of the two pressure plates 500 will drive the airbag 601 to move upward and expand. The upward movement of the airbag 601 will generate negative pressure inside it, and the negative pressure generated inside the airbag 601 will pass The water in the rubber ball 502 is pumped back into the airbag 601 through the hose 602. After the water in the rubber ball 502 is pumped back into the airbag 601, the rubber ball 502 will shrink and become smaller, thereby moving away from the inner side wall of the cylinder 100. Among the two pressing plates 500, the upper pressing plate 500 moves upward while the lower pressing plate 500 does not move, and at the same time, the bending curvature of the curved first arc-shaped rubber plate 501 becomes larger. At the same time, the first arc-shaped rubber plate 501 and the rubber ball 502 are driven to move toward one end of the airbag 601. The first arc-shaped rubber plate 501 and the rubber ball 502 move toward one end of the airbag 601 away from the cylinder 100. When the first arc-shaped rubber plate 501 and the rubber ball 502 move toward one end of the airbag 601, the squeezed second The arc-shaped rubber plate 705 is reset to a side away from the cylinder 100 under the action of elasticity. The second arc-shaped rubber plate 705 is reset to a side away from the cylinder 100 under the action of elasticity, which drives the rubber ring 706 away from the cylinder 100. When the rubber ring 706 moves away from the rear fixing block 701 of the cylinder 100, it drives the second arc-shaped rubber plate 705 at the upper end away from the first arc-shaped rubber plate 501. When the rubber ring 706 moves away from the front fixing block 701 of the cylinder 100 and moves upward, the second arc-shaped rubber plate 705 always wraps the first arc-shaped rubber plate 501 under the action of the spring 704. When the first arc-shaped rubber plate 501 and the rubber ball 502 move toward one end of the airbag 601, the second arc-shaped rubber plate 705 moves toward one end of the airbag 601 and resets.In this way, after the rubber ring 706 is away from the cylinder 100, the upward movement of the fixed block 701 will drive the second arc-shaped rubber plate 705 to move upward, so that the friction between the rubber ring 706 and the cylinder 100 can be avoided, thereby extending the service life of the chromatography column sealing assembly. By filling one-third of water in the airbag 601, the airbag 601 will be compressed downward when the column head pressure ring 405 moves downward. The airbag 601 is compressed downward to fill the water inside the rubber ball 502. The rubber ball 502 will expand and become larger when a certain amount of water is filled inside. The rubber ball 502 expands and becomes larger to fit the inner side wall of the cylinder 100. The rubber ball 502 fits the inner side wall of the cylinder 100 to seal the cylinder 100. At the same time, the inside of the rubber ball 502 is filled with water, which is difficult to be compressed. In this way, when the rubber ball 502 moves outward, it will fit more closely to the inner side wall of the cylinder 100 under the action of the water inside it.

[0028] It is worth mentioning that the water filling mechanism 600 includes an airbag 601, the upper end of the airbag 601 is fixedly connected to the bottom surface of a pressure plate 500 at the upper ends of the two pressure plates 500, the lower end of the airbag 601 is fixedly connected to the top surface of a pressure plate 500 at the lower ends of the two pressure plates 500, the upper end of the airbag 601 is connected to the pressure plate 500, and one end of a hose 602 is fixedly connected to the upper end of the airbag 601, and the other end of the hose 602 is fixedly connected to the rubber ball 502; one third of water is filled in the airbag 601, and the water level in the airbag 601 is lower than the rubber ball 502. When the column head pressure ring 405 moves downward, the airbag 601 will be compressed downward, and the downward compression of the airbag 601 will push the water inside Under the action of pressure, water flows through the hose 602 into the rubber ball 502. A certain amount of water is filled in the rubber ball 502, which will expand and become larger. The expanded rubber ball 502 will fit closely to the inner side wall of the cylinder 100. The rubber ball 502 fits closely to the inner side wall of the cylinder 100, which can seal the cylinder 100. At the same time, the inside of the rubber ball 502 is full of water, which is difficult to be compressed. Therefore, when the rubber ball 502 moves outward, it will fit more closely to the inner side wall of the cylinder 100 under the action of the water inside it. When the column head pressure ring 405 moves upward, it will drive the upper one of the two pressure plates 500 to move upward. The upward movement of the upper one of the two pressure plates 500 will drive The airbag 601 moves upward and expands. Negative pressure is generated inside the airbag 601. The negative pressure generated inside the airbag 601 draws the water in the rubber ball 502 back into the airbag 601 through the hose 602. After the water in the rubber ball 502 is drawn back into the airbag 601, the rubber ball 502 shrinks and becomes smaller, thereby moving away from the inner side wall of the cylinder 100. Among the two pressing plates 500, the upper pressing plate 500 moves upward while the lower pressing plate 500 does not move. The curvature of the curved first arc-shaped rubber plate 501 increases. At the same time, the first arc-shaped rubber plate 501 and the rubber ball 502 move toward one end of the airbag 601. When the first curved rubber sheet 501 and the rubber ball 502 move toward one end of the airbag 601, the squeezed second curved rubber sheet 705 is reset to a position away from the side of the cylinder 100 under the action of elasticity. When the second curved rubber sheet 705 is reset to a position away from the side of the cylinder 100 under the action of elasticity, the rubber ring 706 is driven to move away from the cylinder 100. When the rubber ring 706 moves away from the rear fixing block 701 of the cylinder 100, the second curved rubber sheet 705 at the upper end is driven to move away from the first curved rubber sheet 501. When the rubber ring 706 moves away from the front fixing block 701 of the cylinder 100 and moves upward, the second curved rubber sheet 705 always wraps the first curved rubber sheet 501 under the action of the spring 704.The first curved rubber plate 501 and the rubber ball 502 move toward one end of the airbag 601 to drive the second curved rubber plate 705 to move toward one end of the airbag 601 to reset. In this way, after the rubber ring 706 is away from the cylinder 100, the fixing block 701 moves upward to drive the second curved rubber plate 705 to move upward. This can avoid the friction between the rubber ring 706 and the cylinder 100, thereby extending the service life of the chromatography column sealing assembly. By filling one-third of water in the airbag 601, the airbag 601 is driven when the column head pressure ring 405 moves downward. The airbag 601 is compressed downward to fill the water inside the rubber ball 502. The rubber ball 502 will expand and become larger when a certain amount of water is filled inside the rubber ball 502. The rubber ball 502 expands and becomes larger to fit the inner side wall of the cylinder 100. The rubber ball 502 fits the inner side wall of the cylinder 100 to seal the cylinder 100. At the same time, the inside of the rubber ball 502 is filled with water, which is difficult to be compressed. In this way, when the rubber ball 502 moves outward, it will fit more closely to the inner side wall of the cylinder 100 under the action of the water inside.

[0029] It is worth mentioning that the wrapping mechanism 700 includes a fixed block 701, one end of the fixed block 701 is fixedly connected to the top surface of the column head pressure ring 405, the lower end of the fixed block 701 is fixedly connected to a sleeve 702, the sleeve 702 is slidably connected inside, the lower end of the telescopic rod 703 is fixedly connected to a second arc rubber plate 705, the lower end of the fixed block 701 is fixedly connected to a spring 704, the lower end of the spring 704 is fixedly connected to the second arc rubber plate 705, and the end of the second arc rubber plate 705 away from the spring 704 is fixedly connected to a rubber ring 706; when the column head pressure ring 405 moves downward, the fixed block 701 will also move downward, the downward movement of the fixed block 701 will drive the spring 704 to move downward, the downward movement of the fixed block 701 will drive the sleeve 702 to move downward, the downward movement of the sleeve 702 will drive the telescopic rod 703 to move downward, and the downward movement of the telescopic rod 703 will drive the second arc rubber plate 705 to move downward The second curved rubber plate 705 moves downward, and the downward movement of the second curved rubber plate 705 will drive the rubber ring 706 to move downward. The second curved rubber plate 705 is in an arc shape. When the second curved rubber plate 705 moves downward, it will fit the outer side wall of the first curved rubber plate. The second curved rubber plate 705 moves downward to wrap the first curved rubber plate. The second curved rubber plate 705 is made of hard rubber material. The second curved rubber plate 705 moves downward to wrap the first curved rubber plate, which can reduce the expansion degree of the first curved rubber plate to both sides of the rubber ball 502 under the action of pressure. The structure provided by the column head pressure ring 405 moves downward, and the second curved rubber plate 705 is driven to move downward to wrap the first curved rubber plate. The second curved rubber plate 705 is made of hard rubber material. The second curved rubber plate 705 moves downward to wrap the first curved rubber plate, which can reduce the expansion degree of the first curved rubber plate to both sides of the rubber ball 502 under the action of pressure.

[0030] Working principle: When the present invention is used, the first nut 303 is rotated to drive the screw rod 304 to move downward, and the downward movement of the screw rod 304 drives the distributor 306 to move downward.

[0031] At this time, rotating the second nut 401 downward, the downward movement of the second nut 401 will drive the second bearing 402 to move downward, the downward movement of the second bearing 402 will drive the sliding rod 403 to move downward, the downward movement of the sliding rod 403 will drive the connecting block 404 to move downward, the downward movement of the connecting block 404 will drive the column head pressing ring 405 to move downward, the downward movement of the column head pressing ring 405 will drive the pressing plate 500 to move downward, the downward movement of the pressing plate 500 will drive the first arc-shaped rubber plates 501 on both sides to bend outward, the outward bending of the first arc-shaped rubber plates 501 on both sides will drive the rubber balls 502 to move outward to fit the inner side walls of the cylinder 100, and at the same time, when the pressing plate 500 moves downward, the two pressing plates 500 and The air inside the cavity surrounded by the two first curved rubber plates 501 and the rubber ball 502 is compressed, and the compressed air inside the cavity will further drive the first curved rubber plate 501 to continue to fit against the inner side wall of the cylinder 100. When the first curved rubber plate 501 bends outward, it will also drive the two second curved rubber plates 705 wrapped outside thereof to move outward and close to the cylinder 100. The outward movement of the two second curved rubber plates 705 close to the cylinder 100 will drive the rubber rings 706 at the ends of the two second curved rubber plates 705 to fit against the cylinder 100. The rubber rings 706 at the ends of the two second curved rubber plates 705 fit against the cylinder 100, thereby further sealing the cylinder 100. The sealing effect can be improved by having the two rubber rings 706 and the rubber ball 502 in the middle of the two rubber rings 706 fit the cylinder 100 at the same time. The sealing effect of the cylinder 100 can be better achieved by the three-point sealing of the two rubber rings 706 and the rubber ball 502 in the middle of the two rubber rings 706. The structure is set so that when the column head pressure ring 405 moves downward, the first arc rubber plate 501 bends outward, which will drive the rubber ball 502 to move outward and fit the inner side wall of the cylinder 100. At the same time, when the pressing plate 500 moves downward, the air inside the cavity surrounded by the two pressing plates 500, the two first arc rubber plates 501 and the rubber ball 502 will be compressed. The air inside the cavity is compressed. The air will further drive the first curved rubber plate 501 to continue to fit against the inner side wall of the cylinder 100. When the first curved rubber plate 501 bends outward, it will also drive the two second curved rubber plates 705 wrapped thereon to move outward and close to the cylinder 100. The outward movement of the two second curved rubber plates 705 close to the cylinder 100 will drive the rubber rings 706 at the ends of the two second curved rubber plates 705 to fit against the cylinder 100. The sealing effect can be improved by the two rubber rings 706 and the rubber ball 502 in the middle of the two rubber rings 706 fitting against the cylinder 100 at the same time. The three-point sealing of the two rubber rings 706 and the rubber ball 502 in the middle of the two rubber rings 706 can achieve a better sealing effect on the cylinder 100.

[0032] One third of water is filled in the airbag 601, and the water level in the airbag 601 is lower than the rubber ball 502. When the column head pressure ring 405 moves downward, the airbag 601 will be compressed downward. The downward compression of the airbag 601 will cause the water inside to flow into the rubber ball 502 through the hose 602 under the action of pressure. The rubber ball 502 will expand and become larger when a certain amount of water is filled inside. The expanded rubber ball 502 will fit the inner side wall of the cylinder 100. The rubber ball 502 fits the inner side wall of the cylinder 100 to seal the cylinder 100. At the same time, the inside of the rubber ball 502 is filled with water, which is difficult to be compressed. In this way, when the rubber ball 502 moves outward, it will fit more tightly under the action of the water inside it. The inner side wall of the cylinder 100 will drive the upper one of the two pressure plates 500 to move upward when the column head pressure ring 405 moves upward. The upward movement of the upper one of the two pressure plates 500 will drive the airbag 601 to move upward and expand. The upward movement and expansion of the airbag 601 will generate negative pressure inside. The negative pressure generated inside the airbag 601 will draw the water in the rubber ball 502 back into the airbag 601 through the hose 602. After the water in the rubber ball 502 is drawn back into the airbag 601, the rubber ball 502 will shrink and become smaller, thereby moving away from the inner side wall of the cylinder 100. When the upper one of the two pressure plates 500 moves upward and the lower one does not move, it will also drive the curved first arc-shaped rubber plate 501 to bend. The rate increases, and at the same time, the first curved rubber plate 501 and the rubber ball 502 are driven to move toward one end of the airbag 601, and the first curved rubber plate 501 and the rubber ball 502 are driven to move toward one end of the airbag 601 away from the cylinder 100. When the first curved rubber plate 501 and the rubber ball 502 move toward one end of the airbag 601, the squeezed second curved rubber plate 705 is driven to reset away from the cylinder 100 side under the action of elasticity. The second curved rubber plate 705 is driven to reset away from the cylinder 100 side under the action of elasticity, and the rubber ring 706 is driven away from the cylinder 100. When the rubber ring 706 is away from the cylinder 100 and the fixing block 701, the second curved rubber plate 705 at the upper end is driven away from the first curved rubber plate 501. 06 is away from the cylinder 100 before the fixed block 701 moves upward, at this time, under the action of the spring 704, the second arc rubber plate 705 always wraps the first arc rubber plate 501, and the first arc rubber plate 501 and the rubber ball 502 move toward one end of the airbag 601 to drive the second arc rubber plate 705 to move toward one end of the airbag 601 to reset, so that after the rubber ring 706 is away from the cylinder 100, the fixed block 701 moves upward to drive the second arc rubber plate 705 to move upward, so that the friction between the rubber ring 706 and the cylinder 100 can be avoided, thereby extending the service life of the chromatography column sealing assembly, and by filling one third of water in the airbag 601, when the column head pressure ring 405 moves downward, it will drive the airbag 601 to compress downward,The airbag 601 is compressed downward to fill the water inside the rubber ball 502. The rubber ball 502 will expand and become larger when a certain amount of water is filled inside. The rubber ball 502 expands and becomes larger to fit the inner side wall of the cylinder 100. The rubber ball 502 fits the inner side wall of the cylinder 100 to seal the cylinder 100. At the same time, the inside of the rubber ball 502 is filled with water, which is difficult to be compressed. Therefore, when the rubber ball 502 moves outward, it will fit more closely to the inner side wall of the cylinder 100 under the action of the water inside.

[0033] When the column head pressure ring 405 moves downward, it will also drive the fixing block 701 to move downward, the fixing block 701 moving downward will drive the spring 704 to move downward, the fixing block 701 moving downward will drive the sleeve 702 to move downward, the sleeve 702 moving downward will drive the telescopic rod 703 to move downward, the telescopic rod 703 moving downward will drive the second arc-shaped rubber plate 705 to move downward, the second arc-shaped rubber plate 705 moving downward will drive the rubber ring 706 to move downward, the second arc-shaped rubber plate 705 is in an arc shape, and when the second arc-shaped rubber plate 705 moves downward, it will fit the outer side wall of the first arc-shaped rubber plate, and the second arc-shaped rubber plate 705 moving downward will have an impact on the first arc-shaped rubber plate The second curved rubber sheet 705 is made of hard rubber material, and the second curved rubber sheet 705 moves downward to wrap the first curved rubber sheet, which can reduce the expansion degree of the first curved rubber sheet to both sides of the rubber ball 502 under the action of pressure; the structure set up will also drive the second curved rubber sheet 705 to move downward to wrap the first curved rubber sheet when the column head pressure ring 405 moves downward, and the second curved rubber sheet 705 is made of hard rubber material, and the second curved rubber sheet 705 moves downward to wrap the first curved rubber sheet, which can reduce the expansion degree of the first curved rubber sheet to both sides of the rubber ball 502 under the action of pressure.

[0034] The above shows and describes the basic principles, main features and advantages of the present invention. Those skilled in the art should understand that the present invention is not limited to the above embodiments. The above embodiments and descriptions are only for explaining the principles of the present invention. Without departing from the spirit and scope of the present invention, the present invention may have various changes and improvements, which fall within the scope of the present invention. The scope of the present invention is defined by the attached claims and their equivalents.

Claims

1. A chromatography column sealing assembly, comprising a barrel (100), characterized in that: The cylinder (100) is sleeved with a fixing ring (200) on the outside and fixedly connected thereto; a lifting mechanism (300) is provided at the upper end of the cylinder (100); a pressing mechanism (400) is provided at one end of the upper end of the cylinder (100) close to the cylinder (100); two pressing plates (500) are provided inside the cylinder (100); a water filling mechanism (600) is provided between the two pressing plates (500); and a wrapping mechanism (700) is provided at one side of the pressing plate (500) close to the inner wall of the cylinder (100); The pressing mechanism (400) comprises a second nut (401), the internal thread of the second nut (401) is meshed with the screw rod (304), and the upper end of the second nut (401) is fixedly connected to the outer ring of the second bearing (402); The pressing mechanism (400) further comprises a sliding rod (403), the inner ring of the second bearing (402) is fixedly connected to the sliding rod (403), the surface of the sliding rod (403) is fixedly connected to a connecting block (404), and one end of the connecting block (404) is fixedly connected to a column head pressing ring (405); One end of the pressing plate (500) is fixedly connected to a first arc-shaped rubber plate (501); one pressing plate (500) at the upper end of the two pressing plates (500) is fixedly connected to the column head pressing ring (405); one pressing plate (500) at the lower end of the two pressing plates (500) is fixedly connected to the distributor (306); and one end of the two first arc-shaped rubber plates (501) is fixedly connected to a rubber ball (502).

2. A chromatography column sealing assembly according to claim 1, characterized in that: Brackets (201) are rotatably connected to both sides of the fixing ring (200).

3. A chromatography column sealing assembly according to claim 1, characterized in that: The lifting mechanism (300) comprises a cover (301), the lower end of the cover (301) is fixedly connected to the cylinder (100), a thread is provided inside the cover (301), the upper end of the cover (301) is rotatably connected to the outer ring of a first bearing (302), and the upper end of the inner ring of the first bearing (302) is fixedly connected to a first nut (303).

4. A chromatography column sealing assembly according to claim 3, characterized in that: The lifting mechanism (300) further comprises a screw (304), the first nut (303) has an internal thread meshing with the screw (304), a surface thread of the screw (304) meshing with an internal thread of the cover (301), a slide groove (305) is provided inside the screw (304), and a distributor (306) is fixedly connected to the lower end of the screw (304).

5. A chromatography column sealing assembly according to claim 1, characterized in that: The water filling mechanism (600) comprises an airbag (601), the upper end of the airbag (601) being fixedly connected to the bottom surface of a pressing plate (500) at the upper ends of the two pressing plates (500), the lower end of the airbag (601) being fixedly connected to the top surface of a pressing plate (500) at the lower ends of the two pressing plates (500), the upper end of the airbag (601) being fixedly connected to the pressing plate (500), and one end of a hose (602) being fixedly connected to the upper end of the airbag (601), and the other end of the hose (602) being fixedly connected to the rubber ball (502).

6. A chromatography column sealing assembly according to claim 1, characterized in that: The wrapping mechanism (700) comprises a fixed block (701), one end of the fixed block (701) is fixedly connected to the top surface of the column head pressure ring (405), the lower end of the fixed block (701) is fixedly connected to a sleeve (702), the sleeve (702) is slidably connected to a telescopic rod (703) inside, the lower end of the telescopic rod (703) is fixedly connected to a second arc-shaped rubber plate (705), and the lower end of the fixed block (701) is fixedly connected to a spring (704).

7. A chromatography column sealing assembly according to claim 6, characterized in that: The wrapping mechanism (700) further comprises a second arc-shaped rubber plate (705), the lower end of the spring (704) being fixedly connected to the second arc-shaped rubber plate (705), and one end of the second arc-shaped rubber plate (705) away from the spring (704) being fixedly connected to a rubber ring (706).

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