Reaction kettle structure for polypeptide synthesis and preparation

Abstract

The invention belongs to the technical field of polypeptide synthesis and preparation, and discloses a reaction kettle structure for polypeptide synthesis and preparation, which comprises a moving frame, a mounting frame is fixedly mounted above the moving frame, a reaction kettle is fixedly mounted on the inner side of the mounting frame, and a feeding pipe is fixedly mounted above the reaction kettle. And a discharge pipe is fixedly mounted below the reaction kettle. According to the reaction kettle structure for polypeptide synthesis and preparation, an inclined surface block is pressed inwards, after the inclined surface block is completely stored in a movable groove, a reset spring releases elastic potential energy to push a top plate to move upwards, and a pull ring is pulled, so that a filter plate is taken out for cleaning; according to the reaction kettle structure for polypeptide synthesis and preparation, the filter plate is taken out from the interior of the filter box by pressing the inclined surface block, so that impurities blocked in the filter holes can be conveniently cleaned, and the reaction kettle structure is convenient to use.

Description

Technical Field

[0001] The invention belongs to the technical field of polypeptide synthesis and preparation, and specifically relates to a reaction kettle structure for polypeptide synthesis and preparation. Background Art

[0002] Polypeptide is a biologically active substance related to various cellular functions in organisms. Its molecular structure is between amino acids and proteins. It is a compound composed of multiple amino acids linked by peptide bonds in a certain order. In the preparation of polypeptide synthesis, reactors are usually used for condensation reactions to form peptide bonds and connect amino acid residues.

[0003] The traditional reactor structure for peptide synthesis preparation has the following shortcomings: The traditional reactor structure for peptide synthesis preparation can realize continuous operation of peptide synthesis by installing a filtering mechanism. After the reactants react in the reactor, they are directly separated and purified by the filtering mechanism without interrupting the synthesis process, which improves the synthesis efficiency. However, the size of the peptide particles is not easy to control. If the particle size is too small, it is easy to clog the pores of the filter plate during the filtration process. Especially when fine particles and colloids are used as filtering materials, it is more likely to cause clogging of the filter plate, so it needs to be improved. Summary of the invention

[0004] The object of the present invention is to provide a reactor structure for polypeptide synthesis preparation to solve the problems raised in the above background technology.

[0005] In order to achieve the above-mentioned purpose, the present invention provides the following technical scheme: a reactor structure for polypeptide synthesis preparation, comprising a movable frame, a mounting frame is fixedly installed above the movable frame, a reactor is fixedly installed on the inner side of the mounting frame, a feed pipe is fixedly installed above the reactor, a discharge pipe is fixedly installed below the reactor, a filter box is fixedly installed below the discharge pipe, a connecting pipe is fixedly installed below the filter box, a top cover is movably installed on the outer side of the filter box, a filter plate located inside the filter box is evenly fixedly installed on the inner side of the top cover, filter holes are evenly opened on the surface of the filter plate, slots are opened on both sides of the top of the filter box, through holes are opened on the outer side of the slot, plug plates located inside the slot are fixedly installed on both sides of the bottom of the top cover, a movable groove is opened inside the plug plate, and a slope block extending to the inside of the through hole is movably installed inside the movable groove.

[0006] Preferably, an outer ring block located on the outside of the connecting pipe is fixedly installed at the bottom of the filter box, an inner ring block is fixedly installed on the inner side of the outer ring block, a mounting tube is movably installed on the inner side of the inner ring block, the inner diameter of the mounting tube corresponds to the outer diameter of the connecting pipe, sockets are provided on both sides of the inner ring block, and clamping blocks are fixedly installed on both sides of the inside of the mounting tube, and the clamping blocks correspond to the sockets.

[0007] Preferably, a sleeve is fixedly installed on the outer side of the reactor, a spiral plate is fixedly installed on the inner side of the sleeve, a liquid inlet pipe is fixedly installed above the sleeve, a liquid outlet pipe is fixedly installed below the sleeve, a servo motor is fixedly installed above the reactor, a rotating shaft extending to the interior of the reactor is fixedly installed below the servo motor, and a stirring rod is fixedly installed on the outer side of the rotating shaft.

[0008] Preferably, a pull ring is fixedly mounted on the outer side of the top cover, a telescopic spring 1 is elastically mounted on the bottom of the movable groove, and the telescopic spring 1 is located on the inner side of the inclined block.

[0009] Preferably, limiting grooves are provided on both sides of the movable groove, and limiting blocks located inside the limiting grooves are fixedly installed on both sides of the bottom of the inclined surface block.

[0010] Preferably, a top plate is movably installed inside the slot, and a return spring is elastically installed between the bottom of the slot and the inner side of the top plate.

[0011] Preferably, both sides of the bottom of the inner ring block are fixedly provided with clamping grooves, and the clamping grooves correspond to the clamping blocks.

[0012] Preferably, a second telescopic spring located between the outer side of the connecting pipe and the inner side of the inner ring block is elastically mounted at the bottom of the filter box, and the second telescopic spring is located on the inner side of the mounting pipe.

[0013] The beneficial effects of the present invention are as follows:

[0014] 1. The present invention presses the inclined surface block inward. When the inclined surface block is completely stored in the movable groove, the return spring releases the elastic potential energy to push the top plate upward, and pulls the pull ring to take out the filter plate for cleaning. Compared with the traditional reactor structure for peptide synthesis and preparation, the reactor structure for peptide synthesis and preparation takes out the filter plate from the inside of the filter box by pressing the inclined surface block, which is convenient for cleaning the debris blocked in the filter hole, thereby facilitating use.

[0015] 2. The present invention presses the mounting tube inward and then rotates the mounting tube to rotate the block to the bottom of the socket. At this time, the second telescopic spring releases elastic potential energy to push the block out of the inside of the socket, thereby separating the mounting tube from the connecting tube. Compared with the traditional reactor structure for peptide synthesis preparation, the reactor structure for peptide synthesis preparation is convenient to move through the easy-to-connect mounting tube.

[0016] 3. The present invention uses a spiral plate arranged inside the sleeve to evenly conduct heat to the outer wall of the reactor, and stirs the inside of the reactor through a stirring rod. Compared with the traditional reactor structure for peptide synthesis and preparation, the reactor structure for peptide synthesis and preparation installs a spiral plate inside the sleeve, so that cooling water or hot solution can evenly conduct heat to the reactor, thereby improving the reaction efficiency in the reactor. BRIEF DESCRIPTION OF THE DRAWINGS

[0017] Figure 1 It is a schematic diagram of the overall structure of the present invention;

[0018] Figure 2 It is a schematic diagram of the reaction kettle of the present invention;

[0019] Figure 3 It is a schematic cross-sectional view of the present invention;

[0020] Figure 4 for Figure 3 A schematic diagram of the local enlarged structure at point A in the middle;

[0021] Figure 5 This is a schematic diagram of the explosion structure of the filter box and top cover of the present invention;

[0022] Figure 6 It is a schematic cross-sectional view of the filter box of the present invention;

[0023] Figure 7 for Figure 6 Schematic diagram of the local enlarged structure at point B in the middle.

[0024] In the figure: 1. movable frame; 2. mounting frame; 3. reactor; 4. feed pipe; 5. discharge pipe; 6. filter box; 7. connecting pipe; 8. top cover; 9. filter plate; 10. pull ring; 11. filter hole; 12. slot; 13. through hole; 14. plug plate; 15. movable slot; 16. telescopic spring 1; 17. inclined block; 18. limit slot; 19. limit block; 20. reset spring; 21. top plate; 22. outer ring block; 23. inner ring block; 24. plug hole; 25. card slot; 26. telescopic spring 2; 27. mounting pipe; 28. card block; 29. ​​sleeve; 30. liquid inlet pipe; 31. liquid outlet pipe; 32. spiral plate; 33. servo motor; 34. rotating shaft; 35. stirring rod. DETAILED DESCRIPTION

[0025] The following will be combined with the drawings in the embodiments of the present invention to clearly and completely describe the technical solutions in the embodiments of the present invention. Obviously, the described embodiments are only part of the embodiments of the present invention, not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the present invention.

[0026] like Figures 1 to 7 As shown, an embodiment of the present invention provides a reactor structure for polypeptide synthesis preparation, comprising a mobile frame 1, a mounting frame 2 is fixedly installed above the mobile frame 1, a reactor 3 is fixedly installed on the inner side of the mounting frame 2, a feed pipe 4 is fixedly installed above the reactor 3, a discharge pipe 5 is fixedly installed below the reactor 3, a filter box 6 is fixedly installed below the discharge pipe 5, a connecting pipe 7 is fixedly installed below the filter box 6, a top cover 8 is movably installed on the outer side of the filter box 6, a filter plate 9 located inside the filter box 6 is evenly fixedly installed on the inner side of the top cover 8, filter holes 11 are evenly opened on the surface of the filter plate 9, slots 12 are opened on both sides of the top of the filter box 6, through holes 13 are opened on the outer side of the slot 12, plug plates 14 located inside the slot 12 are fixedly installed on both sides of the bottom of the top cover 8, a movable groove 15 is opened inside the plug plate 14, and a slope block 17 extending to the inside of the through hole 13 is movably installed inside the movable groove 15.

[0027] Impurities are filtered through the filter plate 9. When the filter hole 11 is blocked, the reactor 3 is stopped, and then the inclined surface block 17 is pressed inwardly, so that the inclined surface block 17 moves inwardly inside the movable groove 15 to squeeze the telescopic spring 16, so that the telescopic spring 16 is deformed. When the inclined surface block 17 is completely received in the movable groove 15, the return spring 20 releases the elastic potential energy to push the top plate 21 to move upward, so that the top plate 21 pushes the plug plate 14 out of the slot 12, and pulls the pull ring 10, so that the filter plate 9 is taken out for cleaning.

[0028] By pressing the inclined plane block 17 inward, when the inclined plane block 17 is completely stored in the movable groove 15, the return spring 20 releases the elastic potential energy to push the top plate 21 to move upward, pulling the pull ring 10, so that the filter plate 9 is taken out for cleaning. Compared with the traditional reactor structure for peptide synthesis and preparation, the reactor structure for peptide synthesis and preparation removes the filter plate 9 from the inside of the filter box 6 by pressing the inclined plane block 17, which is convenient for cleaning the debris blocked in the filter hole 11, thereby facilitating use.

[0029] like Figures 1 to 5 As shown, an outer ring block 22 located on the outside of the connecting pipe 7 is fixedly installed at the bottom of the filter box 6, an inner ring block 23 is fixedly installed on the inner side of the outer ring block 22, a mounting tube 27 is movably installed on the inner side of the inner ring block 23, and the inner diameter of the mounting tube 27 corresponds to the outer diameter of the connecting pipe 7, and holes 24 are provided on both sides of the inner ring block 23, and clamping blocks 28 are fixedly installed on both sides of the inside of the mounting tube 27, and the clamping blocks 28 correspond to the holes 24.

[0030] The mounting tube 27 is pressed inwardly to disengage the block 28 from the slot 25 to squeeze the telescopic spring 26, causing the telescopic spring 26 to deform. The mounting tube 27 is then rotated to rotate the block 28 to the bottom of the insertion hole 24. At this time, the telescopic spring 26 releases its elastic potential energy to push the block 28 out of the insertion hole 24, thereby separating the mounting tube 27 from the connecting tube 7, making it easier to transfer the reactor 3.

[0031] By pressing the mounting tube 27 inward and then rotating the mounting tube 27, the block 28 is rotated to the bottom of the socket 24. At this time, the telescopic spring 26 releases elastic potential energy to push the block 28 out of the inside of the socket 24, thereby separating the mounting tube 27 from the connecting tube 7. Compared with the traditional reactor structure for peptide synthesis preparation, the reactor structure for peptide synthesis preparation is convenient to move the reactor 3 through the easy-to-connect mounting tube 27.

[0032] like Figures 1 to 3 As shown, according to a reactor structure for peptide synthesis preparation according to claim 1, a sleeve 29 is fixedly installed on the outer side of the reactor 3, a spiral plate 32 is fixedly installed on the inner side of the sleeve 29, a liquid inlet pipe 30 is fixedly installed above the sleeve 29, a liquid outlet pipe 31 is fixedly installed below the sleeve 29, a servo motor 33 is fixedly installed above the reactor 3, a rotating shaft 34 extending to the interior of the reactor 3 is fixedly installed below the servo motor 33, and a stirring rod 35 is fixedly installed on the outer side of the rotating shaft 34.

[0033] Cooling water or hot solution is discharged from the liquid inlet pipe 30, and the spiral plate 32 arranged in the sleeve 29 makes it evenly conduct heat to the outer wall of the reactor 3, thereby effectively improving the reaction efficiency in the reactor 3, and starting the servo motor 33, so that the servo motor 33 drives the rotating shaft 34 to rotate, and the rotating shaft 34 drives the stirring rod 35 to rotate, so that the rotating shaft 34 drives the stirring rod 35 to rotate, thereby stirring the interior of the reactor 3 through the stirring rod 35.

[0034] The spiral plate 32 arranged in the sleeve 29 is used to uniformly conduct heat to the outer wall of the reactor 3, and the interior of the reactor 3 is stirred by the stirring rod 35. Compared with the traditional reactor structure for peptide synthesis and preparation, the reactor structure for peptide synthesis and preparation installs the spiral plate 32 inside the sleeve 29, so that the cooling water or hot solution can uniformly conduct heat to the reactor 3, thereby improving the reaction efficiency in the reactor 3.

[0035] like Figure 5 As shown, a pull ring 10 is fixedly installed on the outer side of the top cover 8, and a telescopic spring 16 is elastically installed on the bottom of the movable groove 15, and the telescopic spring 16 is located on the inner side of the inclined block 17.

[0036] The inclined surface block 17 is pressed inwards, and the pull ring 10 is pulled, so that the top cover 8 drives the filter plate 9 to move upwards, and the filter plate 9 is taken out for cleaning.

[0037] like Figure 7 As shown, limiting grooves 18 are provided on both sides of the movable groove 15 , and limiting blocks 19 located inside the limiting grooves 18 are fixedly installed on both sides of the bottom of the inclined block 17 .

[0038] The inward movement of the inclined surface block 17 drives the limiting block 19 to move inward inside the limiting groove 18 , thereby limiting the inclined surface block 17 .

[0039] like Figure 7 As shown, a top plate 21 is movably installed inside the slot 12 , and a return spring 20 is elastically installed between the bottom of the slot 12 and the inner side of the top plate 21 .

[0040] When the inclined block 17 is completely received in the movable groove 15 , the return spring 20 releases its elastic potential energy to push the top plate 21 upward, so that the top plate 21 pushes the inserting plate 14 out of the slot 12 .

[0041] like Figure 5 As shown, both sides of the bottom of the inner ring block 23 are fixedly provided with clamping grooves 25 , and the clamping grooves 25 correspond to the clamping blocks 28 .

[0042] The mounting tube 27 is pressed inwardly to disengage the block 28 from the slot 25 to squeeze the telescopic spring 26 , and then the mounting tube 27 is rotated to rotate the block 28 to the bottom of the socket 24 to separate the mounting tube 27 from the connecting tube 7 , making it easier to transfer the reactor 3 .

[0043] like Figure 5 As shown, a telescopic spring 26 located between the outer side of the connecting pipe 7 and the inner side of the inner ring block 23 is elastically installed at the bottom of the filter box 6 , and the telescopic spring 26 is located on the inner side of the mounting pipe 27 .

[0044] The block 28 is separated from the slot 25 to squeeze the telescopic spring 26, causing the telescopic spring 26 to deform. The telescopic spring 26 releases elastic potential energy to push the block 28 out of the socket 24, thereby separating the mounting tube 27 from the connecting tube 7.

[0045] Working principle and usage process:

[0046] Impurities are filtered through the filter plate 9. When the filter hole 11 is blocked, the reactor 3 is stopped, and then the inclined surface block 17 is pressed inwardly, so that the inclined surface block 17 moves inwardly inside the movable groove 15 to squeeze the telescopic spring 16, so that the telescopic spring 16 is deformed. When the inclined surface block 17 is completely received in the movable groove 15, the return spring 20 releases the elastic potential energy to push the top plate 21 to move upward, so that the top plate 21 pushes the plug plate 14 out of the slot 12, and pulls the pull ring 10, so that the filter plate 9 is taken out for cleaning.

[0047] The mounting tube 27 is pressed inwardly to disengage the block 28 from the slot 25 to squeeze the telescopic spring 26, causing the telescopic spring 26 to deform. The mounting tube 27 is then rotated to rotate the block 28 to the bottom of the insertion hole 24. At this time, the telescopic spring 26 releases its elastic potential energy to push the block 28 out of the insertion hole 24, thereby separating the mounting tube 27 from the connecting tube 7, making it easier to transfer the reactor 3.

[0048] Cooling water or hot solution is discharged from the liquid inlet pipe 30, and the spiral plate 32 arranged in the sleeve 29 makes it evenly conduct heat to the outer wall of the reactor 3, thereby effectively improving the reaction efficiency in the reactor 3, and starting the servo motor 33, so that the servo motor 33 drives the rotating shaft 34 to rotate, and the rotating shaft 34 drives the stirring rod 35 to rotate, so that the rotating shaft 34 drives the stirring rod 35 to rotate, thereby stirring the interior of the reactor 3 through the stirring rod 35.

[0049] It should be noted that, in this article, relational terms such as first and second, etc. are only used to distinguish one entity or operation from another entity or operation, and do not necessarily require or imply any such actual relationship or order between these entities or operations. Moreover, the terms "include", "comprise" or any other variants thereof are intended to cover non-exclusive inclusion, so that a process, method, article or device including a series of elements includes not only those elements, but also other elements not explicitly listed, or also includes elements inherent to such process, method, article or device.

[0050] Although embodiments of the present invention have been shown and described, it will be appreciated by those skilled in the art that various changes, modifications, substitutions and variations may be made to the embodiments without departing from the principles and spirit of the present invention, and that the scope of the present invention is defined by the appended claims and their equivalents.

Claims

1. A reaction kettle structure for peptide synthesis preparation, comprising a mobile frame (1), characterized in that: A mounting frame (2) is fixedly mounted above the movable frame (1), a reaction kettle (3) is fixedly mounted on the inner side of the mounting frame (2), a feed pipe (4) is fixedly mounted above the reaction kettle (3), a discharge pipe (5) is fixedly mounted below the reaction kettle (3), a filter box (6) is fixedly mounted below the discharge pipe (5), a connecting pipe (7) is fixedly mounted below the filter box (6), a top cover (8) is movably mounted on the outer side of the filter box (6), and a positioning device (7) is evenly fixedly mounted on the inner side of the top cover (8). A filter plate (9) is disposed inside the filter box (6), the surface of the filter plate (9) being evenly provided with filter holes (11), slots (12) being disposed on both sides of the top of the filter box (6), the outer sides of the slots (12) being provided with through holes (13), plug plates (14) located inside the slots (12) being fixedly mounted on both sides of the bottom of the top cover (8), a movable groove (15) being disposed inside the plug plate (14), and a slope block (17) extending to the inside of the through hole (13) being movably mounted inside the movable groove (15).

2. The reaction vessel structure for peptide synthesis and preparation according to claim 1, characterized in that: An outer ring block (22) located outside the connecting pipe (7) is fixedly mounted on the bottom of the filter box (6); an inner ring block (23) is fixedly mounted on the inner side of the outer ring block (22); a mounting tube (27) is movably mounted on the inner side of the inner ring block (23); the inner diameter of the mounting tube (27) corresponds to the outer diameter of the connecting pipe (7); insertion holes (24) are provided on both sides of the inner ring block (23); clamping blocks (28) are fixedly mounted on both sides of the inside of the mounting tube (27); the clamping blocks (28) correspond to the insertion holes (24).

3. The reaction vessel structure for peptide synthesis and preparation according to claim 1, characterized in that: A sleeve (29) is fixedly mounted on the outside of the reaction kettle (3), a spiral plate (32) is fixedly mounted on the inside of the sleeve (29), a liquid inlet pipe (30) is fixedly mounted above the sleeve (29), a liquid outlet pipe (31) is fixedly mounted below the sleeve (29), a servo motor (33) is fixedly mounted above the reaction kettle (3), a rotating shaft (34) extending into the interior of the reaction kettle (3) is fixedly mounted below the servo motor (33), and a stirring rod (35) is fixedly mounted on the outside of the rotating shaft (34).

4. The reaction vessel structure for polypeptide synthesis and preparation according to claim 1, characterized in that: A pull ring (10) is fixedly mounted on the outer side of the top cover (8), and a telescopic spring (16) is elastically mounted on the bottom of the movable groove (15), and the telescopic spring (16) is located on the inner side of the inclined surface block (17).

5. The reaction vessel structure for peptide synthesis and preparation according to claim 1, characterized in that: Limiting grooves (18) are provided on both sides of the movable groove (15), and limiting blocks (19) located inside the limiting grooves (18) are fixedly installed on both sides of the bottom of the inclined surface block (17).

6. The reaction vessel structure for peptide synthesis and preparation according to claim 1, characterized in that: A top plate (21) is movably mounted inside the slot (12), and a return spring (20) is elastically mounted between the bottom of the slot (12) and the inner side of the top plate (21).

7. The reaction vessel structure for polypeptide synthesis and preparation according to claim 2, characterized in that: The inner ring block (23) has fixedly provided clamping grooves (25) on both sides of the bottom, and the clamping grooves (25) correspond to the clamping blocks (28).

8. The reaction vessel structure for peptide synthesis and preparation according to claim 1, characterized in that: The bottom of the filter box (6) is elastically mounted with a second telescopic spring (26) located between the outer side of the connecting pipe (7) and the inner side of the inner ring block (23), and the second telescopic spring (26) is located on the inner side of the mounting pipe (27).

Images