Traditional Chinese medicine cold compress patch for acute stage of gouty arthritis as well as preparation method and application of traditional Chinese medicine cold compress patch

Abstract

The invention relates to a gouty arthritis acute-stage traditional Chinese medicine cold compress patch as well as a preparation method and application thereof, and relates to the technical field of traditional Chinese medicines. The traditional Chinese medicine cold compress patch for the acute stage of gouty arthritis is prepared from the following raw materials in parts by mass: 25 to 35 parts of radix et rhizoma rhei, 45 to 55 parts of mirabilite, 15 to 25 parts of herba speranskiae tuberculatae, 15 to 25 parts of rhizoma arisaematis preparata, 15 to 25 parts of rhizoma curcumae longae, 15 to 25 parts of herba violae, 25 to 35 parts of herba taraxaci, 25 to 35 parts of rhizoma smilacis glabrae, 25 to 35 parts of fructus gardeniae, 15 to 25 parts of cortex phellodendri and 15 to 25 parts of radix gentianae macrophyllae. The traditional Chinese medicine cold compress patch for the acute stage of the gouty arthritis can effectively relieve red, swollen and heat pain of the acute stage of the gouty arthritis, and is convenient to prepare, easy to store and less in anaphylactic reaction.

Description

Technical Field

[0001] The invention relates to the technical field of traditional Chinese medicines, and in particular to a traditional Chinese medicine cold compress patch for acute stage gouty arthritis and a preparation method and application thereof. Background Art

[0002] Gouty arthritis is caused by decreased uric acid excretion and purine metabolism disorders due to hereditary or (and) acquired factors. Urinary hydrochloric acid is deposited in the synovium or cartilage of the joints, causing inflammatory reactions in the synovium and soft tissues around the joints. The main clinical manifestations are recurrent joint pain, heat, swelling, and redness. At the same time, tophi are formed. In severe cases, joint deformities are caused, causing great pain to patients. In recent years, epidemiological surveys have found that due to dietary structure, a large amount of high-purine substances such as seafood, meat, and beer have greatly increased the chance of gout attacks. The primary purpose of the treatment of acute gout is to relieve pain. At present, clinical treatment mainly uses colchicine, non-steroidal anti-inflammatory drugs, etc. These drugs have adverse reactions such as liver and kidney damage and gastrointestinal reactions. Some patients cannot tolerate them, which affects the patient's compliance with medication. Patients with gouty arthritis combined with gastrointestinal bleeding, gastrointestinal ulcers, and renal insufficiency cannot use them. The condition cannot be relieved in time.

[0003] A large number of clinical studies have confirmed that Chinese medicine has relatively obvious advantages in these aspects. However, for the rapid disappearance of joint redness, swelling, heat and pain in the acute phase, oral decoction alone is not effective, and some patients cannot tolerate oral Chinese medicine decoction treatment.

[0004] At present, there is an urgent need to develop drugs with more obvious efficacy, which are more convenient, easier to store and carry, for use in the acute stage of gouty arthritis. Summary of the invention

[0005] In order to solve the above technical problems, the purpose of the present invention is to provide a Chinese medicine cold compress patch for acute stage of gouty arthritis and a preparation method and application thereof. The Chinese medicine cold compress patch for acute stage of gouty arthritis prepared by the method of the present invention has more obvious therapeutic effect and is convenient, easy to store and carry.

[0006] The technical solution of the present invention to solve the above technical problems is as follows:

[0007] The invention aims to provide a Chinese medicine cold compress for acute stage of gouty arthritis. The Chinese medicine cold compress for acute stage of gouty arthritis comprises the following raw materials in parts by weight: 25 to 35 parts of rhubarb, 45 to 55 parts of sodium sulfate, 15 to 25 parts of radix speranskiae radix, 15 to 25 parts of processed arisaema, 15 to 25 parts of turmeric, 15 to 25 parts of viola yedoensis, 25 to 35 parts of dandelion, 25 to 35 parts of smilax glabra, 25 to 35 parts of gardenia, 15 to 25 parts of phellodendron, and 15 to 25 parts of gentiana macrophylla.

[0008] Rhubarb: cold in nature, bitter in taste. Enters the spleen meridian, stomach meridian, large intestine meridian, liver meridian, and pericardium meridian. It has the functions of purging heat and relieving constipation, cooling blood and detoxifying, removing blood stasis and dredges the menstrual cycle. It is a laxative drug, which belongs to the category of laxative drugs.

[0009] Glauber's salt: It is salty, bitter and cold in nature, and belongs to the stomach meridian and large intestine meridian. It has the functions of purging bowels, moistening dryness and softening hard masses, clearing away heat and reducing swelling. It can be used to treat damp-heat stagnation, abdominal distension and pain, dry and hard stools, and swollen and painful intestinal abscesses. It can also be used externally to treat breast abscesses, swollen and painful hemorrhoids, etc.

[0010] Herba Tougucao: Spicy and warm in nature, it enters the liver and spleen meridians, can dispel rheumatism, relax muscles and tendons, and treat arthritis, tendon spasm, joint flexion and extension problems, and skin numbness caused by wind, cold and dampness.

[0011] Processed Arisaema: bitter, pungent, warm, and poisonous, it can be used in the lung, liver, and spleen meridians. It has the effects of drying dampness and resolving phlegm, dispelling wind and stopping spasms, and reducing swelling and dispersing nodules.

[0012] Turmeric: It tastes spicy, bitter, and warm in nature. It enters the spleen and liver meridians. It has the effects of breaking blood, promoting the flow of qi, and relieving menstruation and pain.

[0013] Viola yedoensis: It tastes bitter and spicy, is cold in nature, and enters the heart and liver meridians. It has the effects of clearing away heat and detoxifying, cooling blood and reducing swelling, and eliminating carbuncles and dispersing nodules.

[0014] Dandelion: It tastes bitter and sweet, and is cold in nature. It is a traditional Chinese medicine for clearing heat and detoxifying. It enters the liver and stomach meridians. It tastes bitter and sweet, and is cold in nature. It has the effects of clearing heat and detoxifying, eliminating carbuncles and dispersing nodules, promoting diuresis and relieving stranguria, and clearing the liver and improving eyesight.

[0015] Smilax glabra: neutral in nature; sweet and light in taste; enters the liver, stomach and spleen meridians. Detoxifies, removes dampness and benefits joints. Indications: Treats syphilis, stranguria, muscle and bone spasm, beriberi, furuncle, carbuncle, scrofula, limb spasm and muscle and bone pain caused by syphilis and mercury poisoning.

[0016] Gardenia: bitter in taste, cold in nature, enters the heart, lung, and triple burner meridians. It has the effects of purging fire and relieving restlessness, clearing heat and removing dampness, cooling blood and detoxifying.

[0017] Huangbai: bitter and cold in nature, belonging to the kidney, bladder, and large intestine meridians. Its main effects and functions are clearing away heat and dampness, purging fire and removing steam, and detoxifying and curing sores.

[0018] Gentiana macrophylla: pungent, bitter, slightly cold, belonging to the stomach, liver, and gallbladder meridians. It has the effects of removing rheumatism, relieving pain, relieving deficiency heat, and clearing damp heat.

[0019] The beneficial effects of the present invention are as follows: the Chinese medicine patch can effectively relieve the redness, swelling, heat and pain in the acute stage of gouty arthritis, is convenient to prepare, easy to store, and has few allergic reactions.

[0020] Based on the above technical solution, the present invention can also be improved as follows.

[0021] Furthermore, the Chinese medicine cold compress patch for acute stage of gouty arthritis also includes auxiliary materials and medical dressing materials.

[0022] Furthermore, the auxiliary material includes the following raw materials in parts by mass: 5 to 6 parts of NP-700 (sodium polyacrylate), 0.4 to 0.9 parts of Carbomer 940 (polyacrylic acid), 4 to 9 parts of micro powder silica gel, 20 to 32 parts of glycerol, and 9 to 12 parts of triethanolamine.

[0023] The beneficial effect of adopting the above further scheme is that the cold compress prepared by using the auxiliary materials of the present invention, such as thickener NP700, micropowder silica gel, emulsion stabilizer and penetration enhancer carbomer 940, has good bioadhesion, can act on the skin for a long time, is conducive to the release and absorption of the active ingredients of the drug, and is not difficult to clean like some very viscous ointments, and is very convenient for patients to use. In addition, glycerol is added to the Chinese medicine cold compress for acute stage of gouty arthritis of the present invention, so that the Chinese medicine cold compress for acute stage of gouty arthritis has the advantages of good moisturizing performance, good compatibility with the skin, breathability and repeated application.

[0024] Furthermore, the thickness of the Chinese medicine cold compress patch for acute stage of gouty arthritis is 1.5 mm to 3 mm.

[0025] Furthermore, the medical dressing material includes at least one of a medical sterile patch and a medical PU film blank patch.

[0026] Furthermore, the specifications of the medical sterile patch include at least one of 9cm×10cm, 9cm×15cm, and 9cm×20cm.

[0027] The beneficial effect of adopting the above further solution is: according to the size of the area to be applied and according to clinical needs, the above three specifications are set.

[0028] The second object of the present invention is to provide a method for preparing a Chinese medicine cold compress patch for acute stage gouty arthritis, characterized in that the preparation method comprises the following steps:

[0029] (1) dispersing NP-700 in glycerol, and then adding water to swell to obtain a swollen product; adding carbomer 940 to the swollen product, and adjusting the pH value with triethanolamine to prepare a gel matrix;

[0030] (2) mixing rhubarb, sodium sulfate, radix polygoni lobatae, processed arisaema, turmeric, Viola yedoensis, dandelion, smilax glabra, gardenia, phellodendron amurense, and gentiana macrophylla into fine powder, adding water and stirring to obtain a Chinese medicine mixture;

[0031] (3) adding the Chinese medicine mixture to the gel matrix under stirring, then adding micro-powder silica gel and continuing to stir until a gel is formed after stirring evenly, and coating the gel on a medical dressing material to prepare a Chinese medicine cold compress for acute stage gouty arthritis.

[0032] The beneficial effects of the present invention are as follows: the preparation method of the present invention is simple, the prepared Chinese medicine cold compress patch for acute stage gouty arthritis is convenient, easy to store and carry, and has the advantages of good moisturizing performance, good compatibility with the skin, breathability and repeated application.

[0033] Furthermore, the stirring speed in step (2) is 400 r / min to 600 r / min, the temperature is 40° C. to 50° C., and the time is 10 min to 20 min.

[0034] The third purpose of the present invention is to provide an application of a Chinese medicine cold compress patch for acute stage of gouty arthritis, wherein the Chinese medicine cold compress patch for acute stage of gouty arthritis is used in preparing medicine for acute stage of gouty arthritis.

[0035] The beneficial effects of the present invention are as follows: the Chinese medicine cold compress patch for acute stage gouty arthritis prepared by the present invention can effectively relieve the swelling and pain symptoms of acute stage gouty arthritis while avoiding inducing gastrointestinal bleeding, increasing the risk of infection, etc.

[0036] Furthermore, the Chinese medicine cold compress patch for acute stage of gouty arthritis is directly applied to the unbroken affected area when in use.

[0037] Furthermore, the use time of the Chinese medicine cold compress patch in the acute stage of gouty arthritis is 6 to 8 hours. BRIEF DESCRIPTION OF THE DRAWINGS

[0038] Figure 1 The Chinese medicine mixture obtained in step (2) of Example 1;

[0039] Figure 2 Three specifications of Chinese medicinal cold compresses for acute stage gouty arthritis prepared in Example 1. DETAILED DESCRIPTION

[0040] The principles and features of the present invention are described below, and the examples are only used to explain the present invention and are not used to limit the scope of the present invention. If no specific technology or conditions are specified in the embodiments, the technology or conditions described in the literature in this field or the product instructions are used. If the manufacturer of the reagents or instruments used is not specified, they are all conventional products that can be purchased through regular channels.

[0041] Example 1: Preparation of Chinese medicine cold compress for acute stage of gouty arthritis

[0042] (1) Disperse 75 g of NP-700 in 225 g of glycerol and swell in 450 g of water; add 9 g of Carbomer 940 solution and adjust the pH value to 7.0 with 110 g of triethanolamine to prepare a gel matrix;

[0043] (2) 30 g of rhubarb, 50 g of sodium sulfate, 20 g of radix scutellariae, 20 g of processed arisaema, 20 g of turmeric, 20 g of violet yedoensis, 30 g of dandelion, 30 g of smilax glabra, 30 g of gardenia, 20 g of phellodendron amurense, and 20 g of gentiana macrophylla were mixed and ground into fine powder, and then 700 g of purified water at 60° C. was added and stirred to obtain a Chinese medicine mixture, such as Figure 1 As shown;

[0044] (3) Add 232 g of the Chinese medicine mixture to the above gel matrix and stir for 10 min at 400 r / min to 600 r / min and 40° C. to 50° C., then add 84 g of micro-powder silica gel and continue stirring for 10 min. After stirring evenly, a gel is formed. The gel is applied on medical dressing materials of 9 cm×10 cm, 9 cm×15 cm, and 9 cm×20 cm to prepare a Chinese medicine cold compress for acute gouty arthritis with a thickness of 2 mm. Figure 2 shown.

[0045] Embodiments 2 to 9:

[0046] Compared with Example 1, Examples 2 to 9 differ only in the change of the drug ingredients, and the remaining steps and raw materials are the same. The specific composition of the drugs is shown in Table 1:

[0047] Table 1 (unit: g)

[0048]

[0049] Comparative Example 1:

[0050] This comparative example adopts commercially available diclofenac diethylamine emulsion.

[0051] Comparative Example 2:

[0052] This comparative example adopts a commercially available medical antipyretic patch.

[0053] Comparative Examples 3 to 10:

[0054] Comparative Examples 3 to 10 are compared with Example 1, the only difference being the change in the drug ingredients, and the remaining steps and raw materials are the same. The specific composition of the drugs is shown in Table 2:

[0055]

[0056] Test example:

[0057] 1. From January 2022 to January 2024, a total of 475 patients with acute gouty arthritis within 48 hours of onset were collected. The patients were randomly divided into 19 groups according to gender, age, and condition, specifically experimental groups 1 to 9 and comparison groups 1 to 10. 25 patients were randomly assigned to each group. There was no significant difference in the general information such as gender, age, course of disease, and condition of the patients in each group, and they were comparable. The cold compress for acute gouty arthritis of Examples 1 to 9 was used to treat the patients in experimental groups 1 to 9 respectively, and the drugs of Comparative Examples 1 to 10 were used to treat the patients in comparison groups 1 to 10, once a day, each time for 6 to 8 hours. The clinical efficacy was referred to the "Guiding Principles for Clinical Research of New Chinese Medicines", the evaluation criteria are shown in Table 3, and the results are shown in Table 4:

[0058] Table 3

[0059]

[0060] Table 4

[0061]

[0062]

[0063] As shown in Table 4, since the diclofenac diethylamine emulsion of the comparative group 1 has a short duration of action, its effectiveness is poor, and the medical antipyretic patch can only play a role in physical cooling. It can be seen from the comparative groups 3 to 10 that the main roles of the Chinese medicine cold compress patch are rhubarb and mirabilite, which work synergistically with radix scutellariae, processed arisaema, turmeric, Viola yedoensis, dandelion, smilax glabra, gardenia, phellodendron, and gentiana macrophylla, and the Chinese medicine cold compress patches of the present embodiments 1 to 9 are better than the Chinese medicine cold compress patches of comparative examples 3 to 10. It can be seen that the Chinese medicine cold compress patch for acute gouty arthritis prepared by the present embodiment has obvious therapeutic effect and high efficiency.

[0064] 2. Clinical case records

[0065] The grading criteria for joint swelling are shown in Table 5:

[0066] Table 5

[0067]

[0068] (1) Jiang Moumou, male, 31 years old, was admitted to the hospital on July 17, 2024 due to "recurrent swelling and pain in the left foot joint for more than a month, and then for another 5 days"; physical examination: swelling of the left talar joint and left dorsum of the foot, grade 3 tenderness, dark red skin color, increased skin temperature, and limited movement.

[0069] The Chinese medicine cold compress patch prepared in the above embodiment 1 of the present invention is used for treatment. When in use, the above Chinese medicine cold compress patch is evenly applied to the affected part of the patient every day so that the medicinal effect can be absorbed by the human body through the skin, once a day, each time for 6-8 hours.

[0070] Treatment effect: After 3 days of treatment, there was grade 1 swelling and grade 1 tenderness in the left talar joint and left dorsum of the foot, the skin color was slightly red, and the skin temperature was slightly high.

[0071] (2) Li Moumou, male, 51 years old, was admitted to the hospital on June 24, 2024 due to "recurrent swelling and pain in multiple joints for 14 years and skin ulceration for more than 20 days"; physical examination: the skin color of the right wrist, back of the right hand, and the right metacarpophalangeal joints was dark red, the skin temperature was slightly high, and the movement was limited.

[0072] The Chinese medicine cold compress patch prepared in Example 1 of the present invention is used for treatment. When in use, the Chinese medicine cold compress patch is evenly applied to the unbroken affected area of ​​the patient once a day for 6-8 hours each time.

[0073] Treatment effect: After 5 days of treatment, the right wrist, right hand back, and right metacarpophalangeal joints were swollen to level 1, tenderness to level 1, and the skin color and temperature were normal.

[0074] (3) Chen Moumou, male, 72 years old, was admitted to the hospital on June 24, 2024 due to "recurrent joint swelling and pain for 19 years, which recurred 2 days ago"; physical examination: swelling of the first metatarsophalangeal joint of the right foot and the left knee joint, grade 2 tenderness, dark red skin color, increased skin temperature, and limited movement.

[0075] The Chinese medicine cold compress patch prepared in Example 1 of the present invention is used for treatment. When in use, the Chinese medicine cold compress patch is evenly applied to the affected area of ​​the patient once a day for 6-8 hours each time, avoiding damaged skin.

[0076] Treatment effect: After 3 days of treatment, the swelling of the first metatarsophalangeal joint of the right foot and the left knee joint was reduced to level 1, and the tenderness was reduced to level 1, while the skin color and temperature were normal.

[0077] (4) Sun Moumou, female, 68 years old, was admitted to the hospital on May 30, 2024 due to "recurrent joint swelling and pain for more than 3 months, and swelling and pain in the right ankle for 1 day"; physical examination: right ankle joint swelling grade 3, tenderness grade 3, dark red skin color, increased skin temperature, limited movement, right dorsum of the foot swelling grade 2, tenderness grade 2, and slightly dark red skin color.

[0078] The Chinese medicine cold compress patch prepared in Example 1 of the present invention is used for treatment. When in use, the Chinese medicine cold compress patch is evenly applied to the affected area of ​​the patient once a day for 6-8 hours each time, avoiding damaged skin.

[0079] Treatment effect: After 3 days of treatment, the right ankle joint was swollen to level 1 and tenderness to level 1, the skin color was slightly dark red, the skin temperature was slightly high, and the skin temperature was normal. There was no swelling or tenderness on the right dorsum of the foot, and the skin color was normal.

[0080] (5) Yang Moumou, male, 74 years old, was admitted to the hospital on May 30, 2024 due to "recurrent joint swelling and pain for more than 20 years, aggravated for half a year"; physical examination: "tophelical tophi" deposits were seen around the 2nd and 3rd proximal interphalangeal joints of both hands, and both wrists, knees, and ankles were swollen at level 2 and tenderness at level 2, with slightly limited movement.

[0081] The Chinese medicine cold compress patch prepared in Example 1 of the present invention is used for treatment. When in use, the Chinese medicine cold compress patch is evenly applied to the affected area of ​​the patient once a day for 6-8 hours each time, avoiding damaged skin.

[0082] Treatment effect: After 3 days of treatment, the swelling and tenderness of both wrists, knees and ankles were reduced to level 1 and level 1 respectively.

[0083] (6) Yang Moumou, male, 47 years old, was admitted to the hospital on May 10, 2024 due to "recurrent joint swelling and pain for more than 20 years, which recurred for 5 days"; physical examination: lumpy tophi deposits with ulceration in the joints of both knees, ankles, wrists, metacarpophalangeal joints, and proximal interphalangeal joints; the skin temperature of the above joints was slightly high and the movement was limited.

[0084] The Chinese medicine cold compress patch prepared in Example 1 of the present invention is used for treatment. When in use, the Chinese medicine cold compress patch is evenly applied to the affected area of ​​the patient once a day for 6-8 hours each time, avoiding damaged skin.

[0085] Therapeutic effect: After 3 days of treatment, the skin temperature of both knees, ankles, wrists, metacarpophalangeal joints and proximal interphalangeal joints returned to normal.

[0086] (7) Liao, male, 20 years old, was admitted to the hospital on April 30, 2024 due to "recurrent swelling and pain in multiple joints for more than 5 years, which recurred 4 days ago"; physical examination: swelling of the 4th proximal interphalangeal joint of the right hand was grade 3, tenderness was grade 3, skin color was dark red, skin temperature was increased, movement was limited, tophi deposits were seen wrapping the joints, and the joints were flexed and deformed.

[0087] The Chinese medicine cold compress patch prepared in Example 1 of the present invention is used for treatment. When in use, the Chinese medicine cold compress patch is evenly applied to the patient's affected area every day so that the medicinal effect is absorbed by the human body through the skin, once a day, each time for 6-8 hours, avoiding skin damage.

[0088] Treatment effect: After 3 days of treatment, the swelling and tenderness of the 4th proximal interphalangeal joint of the right hand were level 1, the skin color was slightly dark red, and the skin temperature was normal.

[0089] (8) Wang, male, 54 years old, was admitted to the hospital on September 15, 2023 due to "recurrent swelling and pain in multiple joints for more than 10 years, which worsened for more than a month." Physical examination: tenderness and swelling of both ankles at level 2, tenderness and swelling of both knees at level 2, dark red skin color, elevated skin temperature, and slightly limited movement of the above joints;

[0090] The Chinese medicine cold compress patch prepared in Example 1 of the present invention is used for treatment. When in use, the Chinese medicine cold compress patch is evenly applied to the patient's affected area every day so that the medicinal effect is absorbed by the human body through the skin, once a day, each time for 6-8 hours, avoiding skin damage.

[0091] Treatment effect: After 3 days of treatment, the tenderness of both ankle joints was level 1, with no swelling; the tenderness of both knee joints was level 1, with no swelling; the skin color and temperature were normal.

[0092] (9) Xiao, male, 50 years old, was admitted to the hospital on September 9, 2023 due to "recurrent joint swelling and pain for 12 years, which recurred for 5 days"; physical examination: left knee swelling grade 2, tenderness grade 2, slightly dark red skin color, limited flexion and extension, no edema in both lower limbs;

[0093] The Chinese medicine cold compress patch prepared in Example 1 of the present invention is used for treatment. When in use, the Chinese medicine cold compress patch is evenly applied to the patient's affected area every day so that the medicinal effect is absorbed by the human body through the skin, once a day, each time for 6-8 hours, avoiding skin damage.

[0094] Treatment effect: After 3 days of treatment, the left knee was swollen to level 1 and tenderness to level 1, and the skin color and temperature were normal.

[0095] (10) Wu Moumou, male, 62 years old, was admitted to the hospital on August 1, 2023 due to "recurrent joint swelling and pain for more than 7 years, which recurred 2 days ago"; physical examination: left knee joint swelling grade 1, tenderness grade 1, slightly limited mobility, left first metatarsal toe swelling grade 1, tenderness grade 1, dark red skin color, slightly high skin temperature, limited mobility.

[0096] The Chinese medicine cold compress patch prepared in Example 1 of the present invention is used for treatment. When in use, the Chinese medicine cold compress patch is evenly applied to the patient's affected area every day so that the medicinal effect is absorbed by the human body through the skin, once a day, each time for 6-8 hours, avoiding skin damage.

[0097] Treatment effect: After 3 days of treatment, the left knee joint was swollen to level 1 and tenderness to level 1, the left first metatarsal toe was swollen to level 1 and tenderness to level 1, and the skin color and temperature were normal.

[0098] Although the embodiments of the present invention have been shown and described above, it is to be understood that the above embodiments are exemplary and are not to be construed as limitations of the present invention. A person skilled in the art may change, modify, replace and vary the above embodiments within the scope of the present invention.

Claims

1. A Chinese medicine cold compress for acute stage gouty arthritis, characterized in that: The Chinese medicine cold compress for acute stage of gouty arthritis comprises the following raw materials in parts by weight: 25 to 35 parts of rhubarb, 45 to 55 parts of sodium sulfate, 15 to 25 parts of radix speranskiae, 15 to 25 parts of processed arisaema, 15 to 25 parts of turmeric, 15 to 25 parts of viola yedoensis, 25 to 35 parts of dandelion, 25 to 35 parts of smilax glabra, 25 to 35 parts of gardenia, 15 to 25 parts of phellodendron, and 15 to 25 parts of gentiana macrophylla.

2. A Chinese medicine cold compress for acute stage gouty arthritis according to claim 1, characterized in that: The Chinese medicine cold compress patch for acute stage of gouty arthritis also includes auxiliary materials and medical dressing materials.

3. A Chinese medicine cold compress for acute stage gouty arthritis according to claim 2, characterized in that: The auxiliary materials include the following raw materials in parts by weight: 5 to 6 parts of NP-700, 0.4 to 0.9 parts of Carbomer 940, 4 to 9 parts of micro powder silica gel, 20 to 32 parts of glycerol, and 9 to 12 parts of triethanolamine.

4. A Chinese medicine cold compress for acute stage gouty arthritis according to claim 1, characterized in that: The thickness of the Chinese medicine cold compress for acute stage of gouty arthritis is 1.5 mm to 3 mm.

5. A Chinese medicine cold compress for acute stage gouty arthritis according to claim 3, characterized in that: The medical dressing material includes at least one of a medical sterile patch and a medical PU film blank patch.

6. A Chinese medicine cold compress for acute stage gouty arthritis according to claim 5, characterized in that: The specifications of the medical sterile patch include at least one of 9cm×10cm, 9cm×15cm, and 9cm×20cm.

7. The method for preparing a Chinese medicine cold compress for acute stage gouty arthritis according to any one of claims 1 to 6, characterized in that: The preparation method comprises the following steps: (1) dispersing NP-700 in glycerol, and then adding water to swell to obtain a swollen product; adding carbomer 940 to the swollen product, and adjusting the pH value with triethanolamine to prepare a gel matrix; (2) mixing rhubarb, sodium sulfate, radix polygoni lobatae, processed arisaema, turmeric, Viola yedoensis, dandelion, smilax glabra, gardenia, phellodendron amurense, and gentiana macrophyllae into fine powder, adding water and stirring to obtain a Chinese medicine mixture; (3) adding the Chinese medicine mixture to the gel matrix under stirring, then adding micro-powder silica gel and continuing to stir until a gel is formed after stirring evenly, and coating the gel on a medical dressing material to prepare a Chinese medicine cold compress for acute stage gouty arthritis.

8. The method for preparing a Chinese medicine cold compress for acute stage gouty arthritis according to claim 7, characterized in that: The stirring speed in step (3) is 400 r / min to 600 r / min, the temperature is 40° C. to 50° C., and the time is 10 min to 20 min.

9. An application of a Chinese medicine cold compress for acute stage gouty arthritis, characterized in that: The Chinese medicine cold compress patch for acute stage of gouty arthritis according to any one of claims 1 to 6 is used for preparing medicine for acute stage of gouty arthritis.

10. The use of a Chinese medicine cold compress for acute stage gouty arthritis according to claim 9, characterized in that: The use time of the Chinese medicine cold compress patch for acute stage of gouty arthritis is 6 to 8 hours.

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