Nesting coupling type autolysis needle and preparation method thereof

Abstract

The invention discloses a nested coupling type autolysis needle and a preparation method thereof, and relates to the technical field of medical instrument preparation. Comprising the following components in parts by weight: 92.5 parts of hyaluronic acid raw material, 1 part of methacrylic anhydride, 2.5 parts of chondroitin sulfate, 0.5 part of toluene diisocynate, 1.5 parts of hydroxyalkyl acrylate, 1.5 parts of benzophenone and 0.5 part of nano silicon dioxide; the preparation method comprises the following steps: constructing a 3D mold of the autolysis needle tip, weighing the components of the autolysis needle tip in parts by weight, injecting the components into the 3D mold of the autolysis needle tip, heating and curing in a static air environment, introducing ultraviolet rays, and curing to obtain the autolysis needle tip. According to the embodiment of the invention, blood vessel puncture caused by limb movement of a patient is avoided, and blood vessel injury is avoided.

Description

Technical Field

[0001] The present application belongs to the technical field of medical device preparation, and in particular, relates to an overlapping coupling autolytic needle and a preparation method thereof. Background Art

[0002] Intravenous drug administration has become an indispensable routine means of medical treatment. However, after venipuncture, intravenous access is usually maintained for 10 minutes to several hours, and in severe cases, intravenous access may even be maintained for several days.

[0003] In this case, because of the sharp needle tip, it is easy for patients to puncture blood vessels when moving their limbs, causing blood vessel damage and fluid overflow. In addition, drugs such as norepinephrine can penetrate into tissues and cause tissue necrosis. Pediatric patients are an important area for such problems. After establishing intravenous access, experienced nurses often use cotton swabs to form an angle of 15 to 45 degrees between the injection needle and the skin to prevent the bevel of the injection needle from adhering to the blood vessel wall. Even so, it is necessary to frequently observe the infusion speed and make appropriate adjustments.

[0004] The improvements to the injection needle in the prior art do not involve its working principle and cannot avoid the danger caused by limb movements. Summary of the invention

[0005] The purpose of the present application is to provide an overlapping coupling autolytic needle and a preparation method thereof, so as to prevent the needle tip from piercing the blood vessel and causing vascular damage when the patient moves his limbs.

[0006] In order to achieve the above objectives, the solution of this application is:

[0007] In the first aspect, an embodiment of the present application provides a stacked coupled autolytic needle, comprising an outer sleeve, a stacked needle head sleeved in the outer sleeve, and an autolytic needle tip stacked and coupled to the stacked needle head, wherein, by weight, the components of the autolytic needle tip include 92.5 parts of hyaluronic acid raw material, 1 part of methacrylic anhydride, 2.5 parts of chondroitin sulfate, 0.5 parts of toluene diisocyanate, 1.5 parts of hydroxyalkyl acrylate, 1.5 parts of benzophenone and 0.5 parts of nano-silica.

[0008] Furthermore, the diameter of nano-silica is ≤6nm.

[0009] Furthermore, the molecular weight of the hyaluronic acid raw material is 1000-200000 g / mol.

[0010] Furthermore, the molecular weight of the hyaluronic acid raw material is 3000-5000 g / mol.

[0011] Furthermore, the linear molecular formula of methacrylic anhydride is [H2C=C(CH3)CO]2O.

[0012] In the second aspect, an embodiment of the present application provides a method for preparing a stacked coupled autolytic needle, comprising: constructing a 3D mold of the autolytic needle tip, weighing the components of the autolytic needle tip by weight, injecting the components into the 3D mold of the autolytic needle tip, heating and curing in a static air environment, and introducing ultraviolet rays to solidify the autolytic needle tip; the size of the autolytic needle tip satisfies the stacked coupling with the stacked needle head; the size of the outer sleeve satisfies the stacked needle head to be sleeved in the outer sleeve; the autolytic needle tip is stacked and coupled with the stacked needle head, and the stacked needle head is sleeved in the outer sleeve to obtain a stacked coupled autolytic needle.

[0013] Furthermore, the preparation method includes: constructing a 3D mold of the autolytic needle tip, weighing the components of the autolytic needle tip by weight, injecting the 3D mold of the autolytic needle tip, heating to 105 to 110°C in a static air environment for 5 to 8 minutes, aging at 80°C for 30 to 45 minutes, introducing ultraviolet rays with a wavelength of 200nm to 400nm, and curing to obtain the autolytic needle tip.

[0014] Furthermore, the inner diameter and outer diameter of the outer sleeve satisfy the following formula:

[0015] R3=R2+(R2-R1)×n

[0016] Among them, R3 represents the outer diameter of the outer sleeve, R2 represents the standard setting outer diameter, R1 represents the standard setting inner diameter, n represents the adjustment parameter, and the value range of n is 0.125 to 0.2.

[0017] Furthermore, the value of the adjustment parameter n is 0.17.

[0018] Furthermore, the standard sets the inner diameter to be equal to the outer sleeve inner diameter.

[0019] Compared with the prior art, the telescoping coupling autolytic needle and the preparation method thereof provided in the embodiments of the present application have the following beneficial technical effects:

[0020] In the embodiment of the present application, after intravenous puncture, the self-dissolving needle tip can dissolve by itself, thereby preventing the patient from puncturing a blood vessel and causing vascular damage when moving his limbs; and preventing liquid overflow after puncturing a blood vessel, such as drugs such as norepinephrine, from infiltrating into tissues and causing dangerous adverse medical events such as tissue necrosis.

[0021] After the self-dissolving needle tip of the embodiment of the present application dissolves, the invaginated needle retained in the vein has a straight tube structure without a needle tip, and the original needle tip bevel will not adhere to the blood vessel wall, resulting in poor infusion. The components of the self-dissolving needle tip of the embodiment of the present application are carefully proportioned, including hyaluronic acid, methacrylic anhydride, chondroitin sulfate and other materials with good biocompatibility, and corrosive full-layer dissolution is achieved, rather than fracture dissolution, thereby ensuring the safety of dissolution.

[0022] The overlapping coupling design of the embodiment of the present application enables a close fit between the autolytic needle tip, the overlapping needle and the outer sleeve, thereby improving the accuracy during the injection process and reducing the risk of damage to surrounding tissues. At the same time, this design also enhances the stability of the structure, reduces the possibility of the overlapping needle breaking or bending during the injection process, and further improves safety.

[0023] The overlapping coupling design of the embodiment of the present application allows the autolytic needle to be positioned and operated more easily during use, reduces the complexity and risk of the injection process, and makes the operation simpler and safer. BRIEF DESCRIPTION OF THE DRAWINGS

[0024] Figure 1 A schematic diagram of the structure of a telescoping coupling autolytic needle according to an embodiment of the present application is shown;

[0025] Figure 2 A schematic diagram showing the structure of a telescoped needle according to an embodiment of the present application is shown;

[0026] Figure 3 A schematic structural diagram of a telescoping coupling autolytic needle according to another embodiment of the present application is shown;

[0027] Figure 4 A schematic structural diagram of a telescoped needle according to another embodiment of the present application is shown.

[0028] Explanation of the accompanying drawings: 1. outer sleeve; 2. self-dissolving needle tip; 3. overlapping needle. DETAILED DESCRIPTION

[0029] In order to make the above-mentioned purposes, features and advantages of the present application more obvious and easy to understand, the specific implementation methods of the present application are described in detail below in conjunction with the accompanying drawings. It is to be understood that the specific embodiments described herein are only used to explain the present application, rather than to limit the present application. It should also be noted that, for ease of description, only some structures related to the present application are shown in the accompanying drawings, rather than all structures. Based on the embodiments in the present application, all other embodiments obtained by ordinary technicians in this field without making creative work are within the scope of protection of this application.

[0030] The terms "including" and "having" and any variations thereof in this application are intended to cover non-exclusive inclusions. For example, a process, method, system, product or device comprising a series of steps or units is not limited to the listed steps or units, but may optionally include steps or units not listed, or may optionally include other steps or units inherent to these processes, methods, products or devices.

[0031] Reference to "embodiments" in this application means that a particular feature, structure, or characteristic described in conjunction with the embodiments may be included in at least one embodiment of the present application. The appearance of the phrase in various locations in the specification does not necessarily refer to the same embodiment, nor is it an independent or alternative embodiment that is mutually exclusive with other embodiments. It is explicitly and implicitly understood by those skilled in the art that the embodiments described in this application may be combined with other embodiments.

[0032] like Figure 1 and Figure 2 As shown, the embodiment of the present application provides a telescoping coupling autolytic needle, comprising an outer sleeve 1, a telescoping needle head 3, and an autolytic needle tip 2 telescopingly coupled to the telescoping needle head 3. This design not only makes the entire needle head structure more compact, but also improves the convenience and accuracy of use.

[0033] The components of the autolytic needle tip 2 include:

[0034] Hyaluronic acid raw material: Hyaluronic acid is a natural moisturizing ingredient widely present in human skin and other tissues. In the overlapping coupling autolytic needle, hyaluronic acid, as the main component of the autolytic needle tip 2, has excellent moisturizing, lubricating and filling effects. The molecular weight of the hyaluronic acid raw material is between 1000-200000g / mol, preferably 3000-5000g / mol. Hyaluronic acid of different molecular weights has different effects. For example, small molecule hyaluronic acid is easier to be absorbed by the skin, while large molecule hyaluronic acid has better filling and shaping effects.

[0035] Methacrylic anhydride: Methacrylic anhydride is an organic compound with a specific chemical structure and properties. In the overlapping coupling autolytic needle, it can be used as a crosslinking agent or modifier to enhance the physical and chemical stability of the autolytic needle tip 2. Its linear molecular formula is [H2C=C(CH3)CO]2O. This structural feature enables methacrylic anhydride to chemically react with other components such as hyaluronic acid to form a more stable structure. Specifically, the parameters of methacrylic anhydride in the embodiment of the present application are as follows:

[0036] Molecular weight: 154.16 g / mol;

[0037] Density: 1.035 g / mL at 25℃(lit.);

[0038] Refractive index: 1.418, n20 / D 1.453 (lit.).

[0039] Methacrylic anhydride is derived from methacrylic acid and belongs to the acrylic acid family. It is mainly used as a monomer for polymers, has excellent chemical and thermal stability, and is used in a wide range of industries, including pH-sensitive hydrogels and thermosetting materials. In the polymerization process of methacrylic anhydride, 2,4-dimethyl-6-tert-butylphenol (Topanol A) is used as an inhibitor. The addition amount is 2000ppm to prevent undesirable side reactions during the polymerization process and ensure controlled and high-quality polymer formation. Its functions include capturing reactive free radicals. 2,4-dimethyl-6-tert-butylphenol has high reactivity and can react with free radicals, thereby capturing free radicals and making them lose the ability to initiate polymerization; terminating the polymerization chain: when the free radical is captured by 2,4-dimethyl-6-tert-butylphenol, the reactive growth of the polymerization chain is terminated, thereby inhibiting the polymerization process; forming a relatively stable complex: 2,4-dimethyl-6-tert-butylphenol can form a stable complex with metal ions, and the complex inhibits the catalytic effect of metal ions on free radicals, thereby inhibiting the polymerization process. Methacrylic anhydride is used as a precursor in hyaluronic acid composites. It has high thermal sensitivity and good mechanical properties, making it a suitable matrix for the next step of the pultrusion process to shape the injection needle tip.

[0040] Chondroitin sulfate: Chondroitin sulfate is a naturally occurring component in cartilage and connective tissue that promotes cartilage repair and regeneration. In the invaginated autolytic needle, it can be used as an auxiliary component to enhance the biocompatibility of the autolytic needle tip 2.

[0041] Toluene diisocyanate: Toluene diisocyanate is an organic compound with excellent reactivity and chemical stability. In the telescoping coupling autolytic needle, it can be used as a crosslinking agent or curing agent to enhance the mechanical strength and durability of the autolytic needle tip 2.

[0042] Hydroxyalkyl acrylate: Hydroxyalkyl acrylate is a compound with balanced hydrophilicity and lipophilicity. In the telescoping coupling autolytic needle, it can be used as an emulsifier or dispersant to improve the dispersibility and stability of the autolytic needle tip 2.

[0043] The main chain formed by toluene diisocyanate polyol and the chain end formed by hydroxyalkyl acrylate, among which the composition and structure of the main chain have the greatest impact on the performance. Its curing characteristics depend on the acrylate at the chain end. According to the hyaluronic acid raw material added, the smaller the molecular weight of hyaluronic acid, the higher the molecular rigidity and the cross-linking density of the material. The increase of reactive functional groups will increase the cross-linking density and curing rate of the material, and the brittleness of the cured film will increase. Reach the puncture hardness of the injection needle tip.

[0044] Benzophenone: Benzophenone is an organic compound with excellent ultraviolet absorption properties. In the stacked coupled autolytic needle, it can be used as an ultraviolet absorber to protect the autolytic needle tip 2 from damage by ultraviolet rays. Specifically, the embodiment of the present application uses benzophenone as a photoinitiator, which has the following advantages: cheap and simple synthesis; benzophenone and its photolysis products are non-toxic and odorless; good stability and can be stored for a long time; the absorption spectrum of benzophenone matches the emission band, and the molar extinction coefficient is high; after absorbing light energy, the benzophenone molecule transitions to the excited singlet state, and can jump to the excited triplet state through intersystem crossing, so the intersystem crossing efficiency of benzophenone is high; benzophenone has a high initiation efficiency.

[0045] Nanosilica: Nanosilica is an inorganic nanomaterial with a high specific surface area and excellent chemical stability. In the stacked coupled autolytic needle, it can be used as a filler or reinforcing agent to improve the hardness and wear resistance of the autolytic needle tip 2. At the same time, the diameter of nanosilica is ≤ 6nm, which allows it to be more evenly dispersed in the autolytic needle tip 2, further improving its performance.

[0046] Specifically, the nano-silica and benzophenone in the embodiment of the present application are used as a photocurable combination material to increase the hardness of the puncture needle. In recent years, the interaction mechanism in the kidney and its interface effect have been widely experimented and studied. The filtration threshold of the glomerulus is 6nm, and nanomaterials less than or equal to 6nm can be effectively cleared by the kidney through urine. Glomerular filtration membrane structure: The glomerular filtration membrane has a total of three layers, namely the endothelial cell layer, the glomerular basement membrane layer and the podocyte layer. The endothelial cell layer has pores of 70 to 90nm. The pore size of the glomerular basement membrane layer is 2 to 8nm, and the podocyte layer is located on the other side of the glomerular basement membrane, facing the Bowman space, and the intercellular space is 4 to 11nm. Under the vortex effect of blood flow pressure, 6nm silica nanomaterials can be effectively passed and filtered.

[0047] Specifically, the components of the self-dissolving needle tip 2 of the embodiment of the present application include 92.5 parts of hyaluronic acid raw material, 1 part of methacrylic anhydride, 2.5 parts of chondroitin sulfate, 0.5 parts of toluene diisocyanate, 1.5 parts of hydroxyalkyl acrylate, 1.5 parts of benzophenone and 0.5 parts of nano-silica.

[0048] The present application also provides a method for preparing a telescoping coupled autolytic needle, which involves multiple key steps, including building a 3D mold, weighing components, injecting into the mold, heating and curing, UV curing, and assembly, etc. These steps together ensure the high quality and performance of the autolytic needle.

[0049] Specifically, the embodiment of the present application first constructs a corresponding 3D mold according to the design requirements of the autolytic needle tip 2. This step is the basis of the preparation process, which determines the shape and size of the autolytic needle tip 2. Next, various raw materials are accurately weighed by weight according to the components of the autolytic needle tip 2. This step ensures that the composition ratio of the autolytic needle tip 2 is accurate, thereby ensuring the stability and reliability of its performance. The weighed raw materials are injected into the constructed 3D mold. This step needs to ensure that the raw materials are evenly distributed to avoid defects in subsequent steps. In a static air environment, the mold is heated to a certain temperature (such as 105 to 110°C) and maintained for a certain time (such as 5 to 8 minutes). The purpose of this step is to melt and mix the raw materials evenly, while removing the volatile matter and moisture therein. Subsequently, the aging treatment is carried out at a lower temperature (such as 80°C) for 30 to 45 minutes. The aging process contributes to the chemical reaction between the raw materials and the stabilization of the structure.

[0050] After the aging is completed, ultraviolet rays with a wavelength of 200nm to 400nm are introduced for curing. The irradiation of ultraviolet rays can promote the cross-linking reaction between the raw materials, thereby forming a solid autolytic needle tip 2 structure. Finally, the cured autolytic needle tip 2 is coupled to the stacked needle head 3, and the stacked needle head 3 is sleeved in the outer sleeve 1. This step requires ensuring the close fit and stability between the various components to ensure that the autolytic needle can function normally during use.

[0051] Specifically, as an improved needle, in a conventional injection needle production device, since the focus of the embodiment of the present application is not the conventional production of needles, the above process is not described in detail. In the setting procedure of the grinding set, the standards are usually set according to WHO (World Health Organization), for example:

[0052] 1. Color: white; Specification: 1.6×38mm; Needle tip length: 1.6×44;

[0053] 2. Color: pink; Specification: 1.2×38mm; Needle tip length: 12.8×44;

[0054] 3. Color: milky white; Specification: 1.05×38mm; Needle tip length: 10.5×44;

[0055] 4. Color: yellow; Specification: 0.9×38mm; Needle tip length: 0.9×44;

[0056] 5. Color: green; Specification: 0.8×38mm; Needle tip length: 0.8×44;

[0057] 6. Color: black; Specification: 0.7×32mm; Needle tip length: 0.7×38;

[0058] 7. Color: dark blue; Specification: 0.60×25mm; Needle tip length: 0.63×32;

[0059] 8. Color: medium purple; Specification: 0.55×25mm; Needle tip length: 0.55×32;

[0060] 9. Color: orange; Specification: 0.5×16mm; Needle tip length: 0.5×22;

[0061] 10. Color: brown; Specification: 0.45×13mm; Needle tip length: 0.45×19;

[0062] 11. Color: gray; Specification: 0.4×13mm; Needle tip length: 0.4×19;

[0063] The length of the needle tip is uniformly set in the program, and the edge is polished smooth. In order to save costs, you can also directly customize the sleeve to remove the needle tip length when ordering, and directly set it to polish smooth when setting the polishing and cutting program.

[0064] The entire preparation process of the embodiment of the present application ensures the quality and performance of the autolytic needles by precisely controlling parameters such as temperature, time and ultraviolet wavelength. By adopting 3D molds and automated production equipment, efficient production of autolytic needles can be achieved, thereby improving production efficiency.

[0065] The components of the autolytic needle tip 2 have good biocompatibility, which can reduce stimulation and damage to surrounding tissues. The overlapping coupling design makes it easier to position and operate the autolytic needle during use, thereby improving the convenience of use.

[0066] The inner diameter and outer diameter of the outer sleeve 1 in the embodiment of the present application satisfy the following formula:

[0067] R3=R2+(R2-R1)×n

[0068] Among them, R3 represents the outer diameter of the outer sleeve, R2 represents the standard setting outer diameter, R1 represents the standard setting inner diameter, n represents the adjustment parameter, and the value range of n is 0.125 to 0.2.

[0069] Specifically, in this embodiment, the value of the adjustment parameter n is 0.17, the standard inner diameter is set to be equal to the inner diameter of the outer sleeve, and the modeling is prepared to execute the process according to the standards set by WHO (World Health Organization). Among them, the needle tip part and the XYZ axis dimensions of each model are completely in accordance with the set standards, and the length of the sleeve part behind the needle tip is completely in accordance with the set standards.

[0070] By introducing the adjustment parameter n, the embodiment of the present application can flexibly adjust the outer diameter R3 of the outer sleeve 1 to adapt to different usage requirements and scenarios. At the same time, by setting the value range of n, it is ensured that the size of the outer sleeve 1 changes within a reasonable range, which not only ensures its structural strength, but also meets the coupling requirements with other components.

[0071] The embodiment of the present application establishes a three-dimensional model of the autolytic needle tip 2 and the outer sleeve 1, imports the three-dimensional model into a two-photon three-dimensional printer, and places a sufficient amount of mold material printing powder in the printing area. Perform the printing process, set the 3D printing power to 5-10mw, the scanning rate to 0.01mm / s-0.02mm / s, and start two-photon three-dimensional printing. According to the production volume, the autolytic needle tip 2 and the outer sleeve 1 modeling array can be set, and after cooling, the uncured material is rinsed with water to dissolve, and the finished autolytic needle tip 2 and the outer sleeve 1 modeling mold or the autolytic needle tip 2 and the outer sleeve 1 modeling mold array is obtained.

[0072] Another example Figure 3 and Figure 4 As shown, it is a structural schematic diagram of a stacked coupled autolytic needle and a stacked needle head 3 of another embodiment of the present application. It should be noted that the figure is only used to illustrate another form of the stacked coupled autolytic needle of the present application, and is not used to limit the specific structure of the stacked coupled autolytic needle. All forms that use the autolytic needle head 2 of the present application and are connected to the stacked needle head 3 in a stacked coupling manner and are sleeved in the outer sleeve 1 are within the protection scope of the embodiments of the present application.

[0073] Furthermore, in the embodiment of the present application, the autolytic needle tip 2 and the outer sleeve 1 mold or mold array are aligned on a CNC machine tool to form a needle tip-free injection needle set, and the push of the pressure rod is stabilized to form a safety injection needle with the characteristics of the autolytic needle tip 2 after the injection of the overlapping coupling type. Each single needle is individually packaged through a collector, subjected to UV secondary disinfection, and packaged for storage.

[0074] The comparison table of thermosensitive dissolution temperatures of the self-dissolving needle tip 2 in the embodiment of the present application is as follows:

[0075] Table 1

[0076] Dissolving temperature Dissolution time(s) Solubility 0℃ -- Insoluble 30℃ 45 Completely dissolved 35℃ 28 Completely dissolved 37℃ 22 Completely dissolved 42℃ 18 Completely dissolved

[0077] In summary, the embodiment of the present application provides a stacked coupled autolytic needle and a preparation method thereof, comprising an outer sleeve 1, an stacked needle head 3 sleeved in the outer sleeve 1, and an autolytic needle tip 2 stacked and coupled to the stacked needle head 3, wherein, by weight, the components of the autolytic needle tip 2 include 92.5 parts of hyaluronic acid raw material, 1 part of methacrylic anhydride, 2.5 parts of chondroitin sulfate, 0.5 parts of toluene diisocyanate, 1.5 parts of hydroxyalkyl acrylate, 1.5 parts of benzophenone and 0.5 parts of nano-silica; construct a 3D mold of the autolytic needle tip 2, weigh the components of the autolytic needle tip 2 by weight, inject the 3D mold of the autolytic needle tip 2, heat and mature in a static air environment, and introduce ultraviolet rays to solidify to obtain the autolytic needle tip 2; the size of the autolytic needle tip 2 meets the requirements of the sleeve The stacked coupling is on the stacked needle 3; the size of the outer sleeve 1 is sufficient to allow the stacked needle 3 to be sleeved in the outer sleeve 1; the autolytic needle tip 2 is stacked and coupled to the stacked needle 3, and the stacked needle 3 is sleeved in the outer sleeve 1 to obtain a stacked coupled autolytic needle; the autolytic needle tip 2 of the embodiment of the present application avoids puncturing blood vessels and causing vascular damage when the patient moves his limbs, avoids dangerous medical adverse events caused by liquid overflow after puncturing blood vessels, ensures dissolution safety, improves the accuracy of the injection process, reduces the risk of damage to surrounding tissues, enhances the stability of the structure, reduces the possibility of breakage or bending of the stacked needle 3 during the injection process, further improves safety, reduces the complexity and risk of the injection process, and makes the operation simpler and safer.

[0078] The embodiments of the present application are described above in conjunction with the accompanying drawings, but the present application is not limited to the above-mentioned specific implementation methods. The above-mentioned specific implementation methods are merely illustrative and not restrictive. Under the guidance of the present application, ordinary technicians in this field can also make many forms without departing from the purpose of the present application and the scope of protection of the claims, all of which are within the protection of the present application.

Claims

1. A telescoping coupling autolytic needle, characterized in that: The autolytic needle comprises an outer sleeve (1), a telescoped needle head (3) telescoped inside the outer sleeve (1), and an autolytic needle tip (2) telescoped and coupled to the telescoped needle head (3), wherein, by weight, the components of the autolytic needle tip (2) include 92.5 parts of hyaluronic acid raw material, 1 part of methacrylic anhydride, 2.5 parts of chondroitin sulfate, 0.5 parts of toluene diisocyanate, 1.5 parts of hydroxyalkyl acrylate, 1.5 parts of benzophenone and 0.5 parts of nano-silica.

2. The telescoping coupling autolytic needle according to claim 1, characterized in that: The diameter of the nano silicon dioxide is ≤6nm.

3. The telescoping coupling autolytic needle according to claim 1, characterized in that: The molecular weight of the hyaluronic acid raw material is 1000-200000 g / mol.

4. The telescoping coupling autolytic needle according to claim 3, characterized in that: The molecular weight of the hyaluronic acid raw material is 3000-5000 g / mol.

5. The telescoping coupling autolytic needle according to claim 1, characterized in that: The linear molecular formula of the methacrylic anhydride is [H2C=C(CH3)CO]2O.

6. A method for preparing the telescoping coupling autolytic needle according to any one of claims 1 to 5, characterized in that: The preparation method comprises: Constructing a 3D mold of the autolytic needle tip (2), weighing the components of the autolytic needle tip (2) by weight, injecting them into the 3D mold of the autolytic needle tip (2), heating and curing them in a static air environment, and introducing ultraviolet rays to solidify the autolytic needle tip (2); The size of the self-dissolving needle tip (2) is sufficient to be coupled to the overlapping needle head (3); The outer sleeve (1) has a size sufficient to allow the invaginated needle (3) to be sleeved inside the outer sleeve (1); The autolytic needle tip (2) is telescoped and coupled to the telescoped needle head (3), and the telescoped needle head (3) is telescoped into the outer sleeve (1) to obtain the telescoped coupled autolytic needle.

7. The method for preparing the telescoping coupling autolytic needle according to claim 6, characterized in that: The preparation method comprises: A 3D mold of the autolytic needle tip (2) is constructed, the components of the autolytic needle tip (2) are weighed by weight, injected into the 3D mold of the autolytic needle tip (2), heated to 105 to 110° C. in a static air environment for 5 to 8 minutes, aged at 80° C. for 30 to 45 minutes, and ultraviolet rays are introduced with a wavelength of 200 nm to 400 nm to solidify to obtain the autolytic needle tip (2).

8. The method for preparing the telescoping coupling autolytic needle according to claim 6, characterized in that: The inner diameter and outer diameter of the outer sleeve (1) satisfy the following formula: R3=R2+(R2-R1)×n Among them, R3 represents the outer diameter of the outer sleeve, R2 represents the standard setting outer diameter, R1 represents the standard setting inner diameter, n represents the adjustment parameter, and the value range of n is 0.125 to 0.

2.

9. The method for preparing the telescoping coupling autolytic needle according to claim 8, characterized in that: The value of the adjustment parameter n is 0.

17.

10. The method for preparing the telescoping coupling autolytic needle according to claim 8, characterized in that: The standard sets the inner diameter equal to the outer sleeve inner diameter.

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