Automatic cleaning and separating device

Abstract

The invention relates to an automatic cleaning and separating device, which is used for removing uncombined components in reactants in a reaction container, and the automatic cleaning and separating device comprises a liquid injection and uniform mixing mechanism, a removal assembly and a liquid suction mechanism. A liquid injection driver is installed on the liquid injection and mixing mechanism, a liquid suction driver is installed on the liquid suction mechanism, the liquid injection driver drives the liquid injection and mixing mechanism to move up and down to complete liquid injection, and the liquid suction driver drives the liquid suction mechanism to move up and down to complete liquid suction. And the removal assembly removes the reaction container on the injected liquid uniform mixing mechanism under the relative movement of the liquid suction mechanism and the injected liquid uniform mixing mechanism. The automatic cleaning and separating device is simple in overall structure, convenient to produce and manufacture, short in movement stroke and time of the mechanism, good in cleaning and separating effect, high in efficiency and very practical.

Description

Technical Field

[0001] The invention relates to the technical field of in vitro diagnostic automated immunoassay equipment, in particular to an automatic cleaning and separation device. Background Art

[0002] Fully automatic chemiluminescence immunoassay is an important technology for automated analysis of in vitro diagnostics, which is mainly accomplished by fully automatic chemiluminescence immunoassay. In a fully automatic chemiluminescence immunoassay, in order to achieve the separation of free markers and immune complex markers, it is usually necessary to go through a cleaning and separation process in a cleaning and separation device to remove unbound components in the reactants, and then complete the luminescence reaction based on the immune complex markers.

[0003] In order to achieve the cleaning and separation functions, the existing cleaning and separation devices usually need to be equipped with independently driven cleaning and separation discs, liquid suction mechanisms, liquid injection mechanisms, mixing and grabbing mechanisms, and removal mechanisms. As a result, the overall structure of the cleaning and separation device and the analyzer is complex, large in size, and difficult to manufacture. In addition, there are also problems such as poor cleaning and separation effects and low efficiency, which affect the accuracy of analysis and detection. Summary of the invention

[0004] Based on this, it is necessary to provide an automatic cleaning and separation device with a simple structure, easy production and manufacturing, good cleaning and separation effect and high efficiency to address the problems existing in the cleaning and separation device.

[0005] An automatic cleaning and separation device is used to remove unbound components in reactants in a reaction container, characterized in that the automatic cleaning and separation device comprises: a liquid injection and mixing mechanism, a removal component, and a liquid suction mechanism; a liquid injection driver is installed on the liquid injection and mixing mechanism, and a liquid suction driver is installed on the liquid suction mechanism, the liquid injection driver drives the liquid injection and mixing mechanism to move up and down to complete liquid injection, the liquid suction driver drives the liquid suction mechanism to move up and down to complete liquid suction, and the removal component removes the reaction container on the liquid injection and mixing mechanism under the relative movement of the liquid suction mechanism and the liquid injection and mixing mechanism.

[0006] In one of the embodiments, it further includes a rotating drive mechanism and a turntable mechanism, wherein the turntable mechanism is installed on the rotating mechanism, and the liquid injection and mixing mechanism is installed on the turntable mechanism.

[0007] In one embodiment, the rotary drive mechanism includes a base plate, a rotary motor mounted on the base plate, and a rotary synchronous belt mounted on the rotary motor, and the rotary synchronous belt is connected to the turntable mechanism.

[0008] In one embodiment, the turntable mechanism includes a heat preservation pot and a turntable installed on the rotary drive mechanism, and the turntable is provided with a plurality of incubation tanks and cleaning and separation tanks. The incubation tanks are arranged in an inner circle on the turntable, and the cleaning and separation tanks are arranged in an outer circle on the turntable.

[0009] In one of the embodiments, a disc cover is installed on the heat preservation pot, and the disc cover is located above the incubation tank and the cleaning and separation tank and is connected to the liquid injection and mixing mechanism.

[0010] In one embodiment, the disk cover is provided with a plurality of first access holes, second access holes, third access holes and fourth access holes, the first access holes are arranged opposite to a plurality of incubation slots, the second access holes are arranged opposite to the cleaning and separation slots, the third access holes are used for aspirating liquid, and the fourth access holes are used for injecting liquid.

[0011] In one embodiment, the liquid suction driver of the liquid suction mechanism is connected to the liquid injection and mixing mechanism. In one embodiment, it is characterized in that the liquid injection and mixing mechanism includes a support guide column, a liquid injection plate installed on the support guide column, a mixing driver installed on the liquid injection plate, and at least two mixing components and a liquid injection needle tube, the mixing driver is connected to the mixing component, and the liquid injection needle tube passes through the liquid injection plate from above the liquid injection plate.

[0012] In one embodiment, the mixing component includes a synchronous pulley and a mixing chuck; the removing component includes a removing rod and a spring, and the injection needle passes through the middle of the mixing component and the removing component.

[0013] In one of the embodiments, the liquid aspiration mechanism includes a liquid aspiration plate installed on the support guide column and at least two liquid aspiration needles installed on the liquid aspiration plate, and the liquid aspiration plate is located above the liquid injection plate.

[0014] The automatic cleaning and separation device comprises a rotary drive mechanism, a turntable mechanism installed on the rotary drive mechanism, a liquid injection and mixing mechanism installed on the turntable mechanism, and a removal component and a liquid suction mechanism installed on the liquid injection and mixing mechanism. When in use, the entire automatic cleaning and separation device is installed on a fully automatic chemiluminescence immunoassay analyzer. The automatic cleaning and separation device integrates incubation, transfer and transportation, magnetic adsorption, liquid injection, liquid suction, mixing, and tube removal operations through the rotary drive mechanism, the turntable mechanism, the liquid injection and mixing mechanism removal component and the liquid suction mechanism. The structure is simple and compact, and it is easy to produce and manufacture. Through the three power sources of the liquid injection drive, the mixing drive and the liquid suction drive, multiple reaction containers can simultaneously perform different levels of separation, liquid injection, mixing and liquid suction operations. The operation method is simple and reliable, the separation and cleaning effect is good, and the efficiency is high, which ensures the accuracy of subsequent analysis and detection. BRIEF DESCRIPTION OF THE DRAWINGS

[0015] Figure 1 A schematic diagram of an automatic cleaning and separation device according to a preferred embodiment of the present invention;

[0016] Figure 2 for Figure 1 A schematic diagram of the automatic cleaning and separation device from another perspective;

[0017] Figure 3 for Figure 1 A partial schematic diagram of a turntable mechanism in the automatic cleaning and separation device shown;

[0018] Figure 4 for Figure 1 A partial schematic diagram of the liquid injection and mixing mechanism, the removal component, and the liquid suction mechanism in the automatic cleaning and separation device shown;

[0019] Notes on the attached drawings:

[0020] 100-automatic cleaning and separation device, 20-rotation drive mechanism, 21-bottom plate, 22-rotation motor, 23-rotation synchronous belt, 30-turntable mechanism, 31-magnetic part, 32-insulation pot, 33-turntable, 34-incubation tank, 35-cleaning and separation tank, 36-plate cover, 38-initial liquid injection assembly, 361-first access hole, 362-second access hole, 363-third access hole, 364-fourth access hole, 40-liquid injection and mixing mechanism, 41-liquid injection driver, 42-support Support guide column, 43-liquid injection plate, 44-mixing driver, 45-mixing assembly, 46-liquid injection needle, 47-guide idler, 48-mixing synchronous belt, 411-liquid injection drive rod, 431-first guide sleeve, 432-support arm, 451-synchronous pulley, 452-mixing chuck, 50-removal assembly, 51-removal rod, 52-spring, 60-liquid aspiration mechanism, 61-liquid aspiration plate, 62-liquid aspiration driver, 63-liquid aspiration needle, 64-second guide sleeve, 70-reaction container. DETAILED DESCRIPTION

[0021] In order to facilitate the understanding of the present invention, the present invention will be described more fully below with reference to the relevant drawings. The preferred embodiments of the present invention are given in the drawings. However, the present invention can be implemented in many different forms and is not limited to the embodiments described herein. On the contrary, the purpose of providing these embodiments is to make the understanding of the disclosure of the present invention more thorough and comprehensive.

[0022] It should be noted that when an element is referred to as being "fixed to" another element, it may be directly on the other element or there may be an intermediate element. When an element is considered to be "connected to" another element, it may be directly connected to the other element or there may be an intermediate element at the same time.

[0023] Unless otherwise defined, all technical and scientific terms used herein have the same meaning as those commonly understood by those skilled in the art of the present invention. The terms used in the specification of the present invention herein are only for the purpose of describing specific embodiments and are not intended to limit the present invention.

[0024] The automatic cleaning and separation device 100 of the present invention is used to clean and separate the reactants in the reaction container 70, and remove the unbound components in the reactants in the reaction container 70. The automatic cleaning and separation device 100 includes: a liquid injection and mixing mechanism 40, a removal component 50, and a liquid suction mechanism 60. A liquid injection driver 41 is installed on the liquid injection and mixing mechanism 40, and a liquid suction driver 62 is installed on the liquid suction mechanism 60. The liquid injection driver 41 drives the liquid injection and mixing mechanism 40 to move up and down to complete the liquid injection, and the liquid suction driver 62 drives the liquid suction mechanism 60 to move up and down to complete the liquid suction. The removal component 50 removes the reaction container 70 on the liquid injection and mixing mechanism 40 under the relative movement of the liquid suction mechanism 60 and the liquid injection and mixing mechanism 40.

[0025] Please refer to Figures 1 to 4 , which is an automatic cleaning and separation device 10 of a preferred embodiment of the present invention, further includes a rotary drive mechanism 20 and a turntable mechanism 30, wherein the turntable mechanism 30 is mounted on the rotary mechanism 20, and a liquid injection and mixing mechanism 40 is mounted on the turntable mechanism 30. The liquid suction driver 62 of the liquid suction mechanism 60 is connected to the liquid injection and mixing mechanism 40. It should be noted that, in other embodiments, the liquid suction driver 62 can be connected to the rotary drive mechanism 20 or other components of the fully automatic chemiluminescence immunoassay. When in use, the entire automatic cleaning and separation device 100 is installed on the fully automatic chemiluminescence immunoassay. It should be noted that, in other embodiments, the liquid injection and mixing mechanism 40 can be installed on the rotary drive mechanism 20 or other components of the fully automatic chemiluminescence immunoassay. The turntable mechanism 30 is used to place and transport the reaction container 70. The rotary drive mechanism 20 drives the turntable mechanism 30 to rotate so that the reaction container 70 passes through the liquid injection and mixing mechanism 40 and the liquid aspiration mechanism 60. The liquid aspiration mechanism 60 and the liquid injection and mixing mechanism 50 complete multiple liquid aspiration, liquid injection and mixing operations in the reaction container 70, and finally realize the cleaning and separation functions in immunoassay.

[0026] Reference Figure 1 and Figure 2 The rotary drive mechanism 20 includes a bottom plate 21, a rotary motor 22 mounted on the bottom plate 21, a rotary synchronous belt 23 mounted on the rotary motor 22, and the rotary synchronous belt 23 is connected to the turntable mechanism 30. The rotary motor 22 is located at the corner of the bottom plate 21, so that the spatial position arrangement of the rotary motor 22 and the turntable mechanism 30 can be ensured, and the space occupation can be reduced.

[0027] Refer to Figure 3 , a magnetic member 31 is installed on the side of the turntable mechanism 30 close to the injection and mixing mechanism 40, and the magnetic member 31 provides a magnetic field environment, so that the paramagnetic particles in the reaction container 70 are adsorbed to the inner wall of the reaction container 70 for a certain time, usually ranging from a few seconds to tens of seconds, so as to ensure that the reaction container 70 needs to pass through the magnetic field for a period of time before each aspiration. In other embodiments, the magnetic member 31 can be installed on the turntable mechanism 30 according to actual needs, and the magnetic member 31 can be installed through an external support mechanism to provide a magnetic field environment. The turntable mechanism 30 includes a heat preservation pot 32 installed on the bottom plate 21, a turntable 33 installed on the rotary drive mechanism 20, and a plurality of incubation tanks 34 and cleaning and separation tanks 35 are arranged on the turntable 33. The magnetic member 31 is installed on the side of the heat preservation pot 32 close to the rotating motor 22, the turntable 33 is connected to the rotating synchronous belt 23, the incubation tank 34 is arranged in an inner circle on the turntable 33, and specifically arranged in three circles in this embodiment, and the cleaning and separation tank 35 is arranged in an outer circle on the turntable 33. When in use, the incubation tank 34 and the cleaning and separation tank 35 are used to place the reaction container 70. The reaction container 70 rotates with the turntable 33 under the drive of the rotating motor 22, and the root area actually needs to advance one position or multiple positions each time it rotates. Furthermore, a disk cover 36 is installed on the insulation pot 32. The disk cover 36 is located above the incubation tank 34 and the cleaning and separation tank 35 and is connected to the liquid injection and mixing mechanism 40. The disk cover 36 is installed with an initial liquid injection component 38. A relatively closed insulation space is formed between the insulation pot 32 and the disk cover 36. The initial liquid injection component 38 performs the initial liquid injection before the reaction container 70 enters the liquid injection and mixing mechanism 40 and the liquid aspiration mechanism 50.

[0028] Furthermore, the disk cover 36 is provided with a plurality of first access holes 361 and second access holes 362. The first access holes 361 are arranged opposite to a plurality of incubation tanks 34, and the second access holes 362 are arranged opposite to the cleaning and separation tanks 35. In this embodiment, there are three first access holes 361. The incubation time of the reaction container 70 in the incubation tank 34 can be determined by which first access hole 361 the reaction container 70 is put in and taken out from as the turntable 33 rotates. The second access holes 362 are arranged opposite to a plurality of cleaning and separation tanks 34. In this embodiment, there are three second access holes 362. The second access holes 362 are used for the reaction container to enter and exit the cleaning and separation tanks 34. The disk cover 36 is also provided with a plurality of third access holes 363 and fourth access holes 364. The third access holes 363 are used for liquid suction processing, and the fourth access holes 364 are used for liquid injection processing. Usually, the third access holes 363 and the fourth access holes 364 are arranged one by one, so that the third access holes 363 are convenient for passing through to suck liquid, and the fourth access holes 364 are convenient for passing through to inject liquid. It can be understood by those skilled in the art that it is not necessary to arrange the third access holes 363 and the fourth access holes 364 one by one. In some embodiments, the third access holes 363 and the fourth access holes 364 can be combined to facilitate passing through the same position for sucking liquid and injecting liquid.

[0029] Refer to Figure 4 , the injection mechanism 40 is equipped with an injection driver 41, the injection driver 41 is in contact with the disk cover 36, and the injection driver 41 drives the injection mixing mechanism 40 to move up and down to complete the injection. It can be understood by those skilled in the art that it is not necessary for the injection mixing mechanism 40 to abut against the disk cover 36. In other embodiments, the injection mixing mechanism 40 can also be installed on the bottom plate of the rotating drive mechanism 20, etc. In this embodiment, the injection mixing mechanism 40 includes a support guide column 42 connected to the disk cover 36, an injection plate 43 installed on the support guide column 42, a mixing driver 44 installed on the injection plate 43, and at least two mixing components 45 and an injection needle tube 46. The injection needle tube 46 passes through the mixing component 45 and the removal component 50 and is adapted to the fourth access hole 364. Further, in this embodiment, there are three groups of injection needle tubes 46, and under the drive of the injection driver 41 and the injection plate 43, three groups of injections at different positions of the cleaning separation tank 35 can be carried out simultaneously. The mixing driver 44 is connected to the mixing assembly 45, and the injection needle 46 passes through the injection plate 43 from above the injection plate 43 and is arranged opposite to the disk cover 36. The injection plate 43 is equipped with a support arm 432 and a guide idler wheel 47, and the support arm 432 is located at the outer edge of the injection plate 43 for supporting the injection needle 46. The mixing assembly 45 includes a synchronous pulley 451 and a mixing chuck 452, the synchronous pulley 451 is installed on the injection plate 43, and the mixing chuck 452 is connected to the synchronous pulley 451, and the mixing chuck 452 can clamp the reaction container 70 by the resilience of the chuck.

[0030] The mixing driver 44 is provided with a mixing synchronous belt 48, which is wound around and abutted against the guide idler wheel 47 and the synchronous pulley 451. The mixing driver 44 can drive the reaction container 70 clamped in the mixing chuck 455 to rotate through the mixing synchronous belt 48, thereby achieving mixing of the reaction container 70. The support guide column 42 is provided with a first guide sleeve 431 connected to the liquid injection plate 43, and the liquid injection driver 41 is provided with a liquid injection driving rod 411 abutting against the disk cover 36. The first guide sleeve 431 ensures that the liquid injection plate 43 slides up and down smoothly under the action of the liquid injection driver 41 and the liquid injection driving rod 411. The liquid injection driver 41 can be a driving motor or a driving cylinder. In this embodiment, a driving motor is selected, and the mixing driver 44 is a driving motor.

[0031] Further, the removal assembly 50 includes a removal rod 51 and a spring 52, wherein the injection needle 46 passes through the middle of the synchronous pulley removal rod 51, the spring 52, the synchronous pulley 451 and the mixing chuck 452. Specifically, the upper part of the removal rod 51 is overlapped on the synchronous pulley 451 through the spring 52, and the lower part passes through the synchronous pulley 452. In other embodiments, the removal assembly 50 can also be directly connected to the liquid aspiration mechanism 60, and rise and fall with the liquid aspiration mechanism 60. The removal assembly 50 may also not include the spring 52. The removal assembly 50 can also be any other suitable component, one end of which can pass through the mixing assembly 45 to push the upper port of the reaction container 70 to remove the reaction container 70 from the mixing assembly 45. The injection needle 46 is used to inject a cleaning buffer or a signal reagent into the reaction container 70 after the liquid aspiration is completed, and the mixing chuck 452 can clamp the reaction container 70 by the resilience of the chuck. The stripping rod 51 passes through the synchronous pulley 451, the spring 52 is located at one end of the synchronous pulley 451 close to the liquid suction mechanism 60, the mixing chuck 452 is located at one end of the synchronous pulley 451 close to the turntable mechanism 30, and the stripping rod 51 can move up and down in the through hole of the synchronous pulley 451. In this embodiment, the stripping rod 51 is arranged opposite to the liquid suction mechanism 50 but is not connected. In other embodiments, the stripping rod 51 is connected to the liquid suction mechanism 60 and can also move up and down in the through hole of the synchronous pulley 452.

[0032] In reference Figure 4, the liquid suction mechanism 60 is equipped with a liquid suction driver 62 connected to the liquid injection and mixing mechanism 40, and the liquid suction driver 62 drives the liquid suction mechanism 40 to move up and down to complete the liquid suction, and the liquid suction mechanism 40 can move with the liquid injection and mixing mechanism 40 or make relative motion with the liquid injection and mixing mechanism 40. It can be understood by those skilled in the art that it is not necessary for the liquid suction mechanism 60 to be connected to the liquid injection and mixing mechanism 40. In other embodiments, the liquid suction mechanism 60 can also be abutted on the disk cover 36, installed on the bottom plate 21 of the rotating drive mechanism 20, etc. Further, the liquid suction mechanism 60 includes a liquid suction plate 61 installed on the support guide column 42, at least two liquid suction needles 63 installed on the liquid suction plate 61, the liquid suction plate 61 is located above the liquid injection plate 43, the liquid suction driver 62 is connected to the liquid injection plate 43, the liquid suction needle 36 passes through the liquid injection plate 43 from the liquid suction plate 61 downward, and the liquid suction needle 63 and the liquid injection needle 46 are arranged one by one and are located above the third inlet and outlet hole 363. Among them, the second guide sleeve 64 that is sleeved and adapted with the support guide column 42 is installed on the liquid absorption plate 61, and the second guide sleeve 64 can ensure that the liquid absorption plate 61 moves up and down smoothly and stably. In this embodiment, there are three groups of liquid absorption needles 63, which are located above the plate cover 36 and adapted for use with the third access hole 363. Driven by the liquid absorption driver 62 and the liquid absorption plate 61, three groups of liquid absorption at different cleaning and separation tank positions can be performed simultaneously. Among them, the liquid absorption driver 52 can be a driving motor or a driving cylinder, and the driving motor is selected in this embodiment.

[0033] The automatic cleaning and separation device 100 mainly includes the following processes:

[0034] Liquid aspiration process: the liquid injection driver 41 drives the liquid injection plate 43 to descend to the bottom position and then remains stationary. At this time, the liquid aspiration needle 63 descends into the reaction container 70, but does not descend to the bottom of the reaction container 70. Then the liquid aspiration driver 62 drives the liquid aspiration plate 61 to continue to descend until it drives the liquid aspiration needle 63 to descend to the bottom position of the reaction container 70. The liquid aspiration needle 63 completes the liquid aspiration at the bottom of the reaction container 70.

[0035] Injection and mixing process: the injection driver 41 drives the injection plate 43 down to the bottom tube gripping height, and the mixing chuck 452 clamps the top of the reaction container 70 by the chuck elastic force, and then the injection driver 41 drives the injection plate 43 up to the injection and mixing height. The injection needle 46 injects liquid into the reaction container 70, and at the same time, the mixing driver 44 drives the synchronous belt 48 to drive the synchronous belt wheel 451 and the mixing chuck 452 to rotate, thereby driving the reaction container 70 to rotate, so that the paramagnetic particles are resuspended and evenly dispersed in the washing buffer.

[0036] Removal process: while the injection driver 41 drives the injection plate 43 to rise, the suction driver 62 drives the suction plate 61 to move downward relative to the injection plate 43. When the suction plate 61 pushes the removal rod 51, the other end of the removal rod 51 pushes the reaction container 70 out of the mixing chuck 452. Then the injection driver 41 continues to drive the injection plate 43 to rise to the initial position, the suction driver 62 drives the suction plate 61 back to the initial position, and the removal rod 51 returns to the initial position under the restoring force of the spring 52.

[0037] In this embodiment, the liquid injection and liquid absorption can be completed through the overall movement and relative movement of the liquid absorption plate 61 and the liquid injection plate 43, and the removal component can also complete the removal of the reaction container 70 on the mixing chuck 452 under the relative movement of the liquid absorption plate 61 and the liquid injection plate 43. Not only the operation time of the liquid absorption mechanism 60 is saved and the speed of the whole machine is improved, but also the independent driving mechanism specially used for removal is omitted, the structure of the whole machine is simplified, the space occupied is small, the cost is saved, the whole automatic cleaning and separation device 100 is more compact, and the reliability is improved.

[0038] When the automatic cleaning and separation device 100 is used, the reaction container 70 that has been incubated for a period of time or completed in the incubation tank 34 of the turntable 33 is transferred to the cleaning and separation tank 35 through the first access hole 361 and the second access hole 362 by the manipulator. The rotary motor 22 drives the turntable 33 to rotate, and the reaction container 70 on the cleaning and separation tank 35 is transported to the bottom of the injection and mixing mechanism 40 and the liquid aspiration mechanism 60, and at the same time enters the magnetic field area generated by the magnetic part 31 on the heat preservation pot 32, and the magnetic particles in the reaction container 70 gradually approach the inner wall of the reaction container on the side of the magnetic part 31 under the magnetic field environment. When the reaction container 70 arrives below the first-stage liquid aspiration needle tube 63, the first-stage liquid aspiration process begins. After the first-stage liquid aspiration is completed, the turntable 33 rotates forward one position driven by the rotary motor 22, and the reaction container 70 that has completed the first-stage liquid aspiration is transported to the bottom of the first-stage liquid injection needle tube 46, and the first-stage liquid injection process of the reaction container 70 begins. Similarly, the reaction container 70 sequentially reaches the second-stage aspiration needle tube 63, the second-stage injection needle tube 46, the third-stage aspiration needle tube 63, and the third-stage injection needle tube 46 to complete the aspiration and injection process, wherein the last-stage injection needle tube 46 performs signal reagent injection, and the subsequent reaction container 70 also undergoes the first-stage, second-stage, and third-stage processes at once. It can be understood by those skilled in the art that in other embodiments, different stages of test needle tubes can be designed according to actual test needs. For example, when a four-stage test is to be performed, four groups of aspiration needle tubes 63 and injection needle tubes 46 can be correspondingly set.

[0039] The automatic cleaning and separation device 100 comprises a rotary drive mechanism 20, a turntable mechanism 30 mounted on the rotary drive mechanism 20, a liquid injection and mixing mechanism 40 mounted on the turntable mechanism 30, a removal component 50 and a liquid suction mechanism 60 mounted on the liquid injection and mixing mechanism 40. When in use, the entire automatic cleaning and separation device 100 is mounted on a fully automatic chemiluminescence immunoassay analyzer. The automatic cleaning and separation device 100 integrates incubation, transfer and transportation, magnetic adsorption, liquid injection, liquid suction, mixing and tube removal operations through the rotary drive mechanism 20, the turntable mechanism 30, the liquid injection and mixing mechanism 40, the removal component 50 and the liquid suction mechanism 60, and has a simple and compact structure and is easy to manufacture. Through the three power sources of the liquid injection driver 41, the mixing driver 44 and the liquid suction driver 62, multiple reaction containers 70 can simultaneously perform different levels of separation, liquid injection, mixing and liquid suction operations, and the operation mode is simple and reliable, the separation and cleaning separation effect is good, and the efficiency is high, which ensures the accuracy of subsequent analysis and detection.

[0040] Those skilled in the art will appreciate that, in order to complete liquid injection and liquid aspiration, the device of the present invention also involves fluid devices such as syringes (pumps), liquid aspiration peristaltic pumps (or vacuum pumps), fluid pipelines, and related circuits and software control units, which are common technologies in the field and are not introduced in detail in the present invention.

[0041] The technical features of the above-described embodiments may be arbitrarily combined. To make the description concise, not all possible combinations of the technical features in the above-described embodiments are described. However, as long as there is no contradiction in the combination of these technical features, they should be considered to be within the scope of this specification.

[0042] The above-mentioned embodiments only express several implementation methods of the present invention, and the descriptions thereof are relatively specific and detailed, but they cannot be understood as limiting the scope of the invention patent. It should be pointed out that, for ordinary technicians in this field, several variations and improvements can be made without departing from the concept of the present invention, and these all belong to the protection scope of the present invention. Therefore, the protection scope of the patent of the present invention shall be subject to the attached claims.

Claims

1. An automatic cleaning and separation device for removing unbound components from reactants in a reaction container, characterized in that: The automatic cleaning and separation device comprises: a liquid injection plate, on which a liquid suction needle is installed; a liquid suction plate, on which a liquid suction needle tube is installed, and the liquid suction plate is located above the liquid injection plate; the liquid suction needle tube and the liquid injection needle tube are arranged one by one opposite to each other, and the liquid suction needle tube and the liquid injection needle tube have at least two groups.

2. The automatic cleaning and separation device according to claim 1, characterized in that: The aspiration needle tubes and injection needle tubes are in groups of three or four.

3. The automatic cleaning and separation device according to any one of claims 1 to 2, characterized in that: The liquid aspiration needle tube passes through the liquid injection plate downward from the liquid aspiration plate.

4. The automatic cleaning and separation device according to any one of claims 1 to 3, characterized in that: It also includes a supporting guide column, and the liquid injection plate and / or the liquid absorption plate are installed on the supporting guide column.

5. The automatic cleaning and separation device according to claim 4, characterized in that: The supporting guide column is sleeved with a first guide sleeve connected with the liquid injection plate.

6. The automatic cleaning and separation device according to claim 1, characterized in that: The automatic cleaning and separation device also includes a mixing driver and a mixing component. The mixing driver is connected to the mixing component. The mixing driver is equipped with a mixing timing belt. The mixing component includes a timing belt wheel and a mixing chuck. The mixing driver drives the reaction container clamped in the mixing chuck to rotate through the mixing timing belt.

7. The automatic cleaning and separation device according to claim 7, characterized in that: The mixing driver and the synchronous pulley are mounted on the liquid injection plate.

8. The automatic cleaning and separation device according to claim 8, characterized in that: A guide idler wheel is installed on the liquid injection plate, and the mixing synchronous belt is passed through and abutted against the guide idler wheel and the synchronous belt wheel.

9. The automatic cleaning and separation device according to any one of claims 1 to 8, characterized in that: The automatic cleaning and separation device also includes a liquid suction driver, which is connected to the liquid injection plate. The liquid suction driver can drive the liquid suction plate to move up and down to complete liquid suction.

10. The automatic cleaning and separation device according to any one of claims 1 to 8, characterized in that: The automatic cleaning and separation device also includes a liquid injection driver, and the liquid suction driver can drive the liquid suction plate to move up and down to complete liquid suction.

11. The automatic cleaning and separation device according to claim 6, characterized in that: The automatic cleaning and separation device also includes a removal component, which removes the reaction container under the relative movement of the liquid absorption plate and the liquid injection plate. One end of the removal component can pass through the mixing component to push the upper port of the reaction container to remove the reaction container from the mixing component.

12. The automatic cleaning and separation device according to claim 11, characterized in that: The stripping assembly includes a stripping rod and a spring. The upper part of the stripping rod is overlapped above the synchronous pulley through the spring, and the lower part passes through the synchronous pulley. When the liquid absorption plate pushes the stripping rod, one end of the stripping rod pushes the reaction container out of the mixing chuck.

13. The automatic cleaning and separation device according to claim 12, characterized in that: The injection needle tube passes through the middle of the stripping rod, the spring, the synchronous pulley and the mixing chuck.

14. The automatic cleaning and separation device according to claim 1, characterized in that: A support arm is installed on the injection plate, and the injection needle is installed on the support arm.

15. The automatic cleaning and separation device according to claim 1, characterized in that: It also includes a rotating drive mechanism and a turntable mechanism, wherein the turntable mechanism is installed on the rotating drive mechanism, and the turntable mechanism has a disk cover, on which a plurality of third inlet and outlet holes and a fourth inlet and outlet holes are provided, wherein the third inlet and outlet holes are used for liquid suction processing, and the fourth inlet and outlet holes are used for liquid injection processing.

16. The automatic cleaning and separation device according to claim 15, characterized in that: The third access hole 3 and the fourth access hole are arranged one by one opposite to each other; or the third access hole and the fourth access hole are combined to form a single hole.

17. The automatic cleaning and separation device according to claim 15, characterized in that: The turntable mechanism includes an incubation tank and a cleaning and separation tank. The disk cover is provided with a plurality of first access holes and a second access holes. The plurality of first access holes are arranged opposite to the plurality of incubation tanks, and the second access holes are arranged opposite to the cleaning and separation tanks.

18. The automatic cleaning and separation device according to claim 15, characterized in that: It also includes a support guide column, which is connected to the disk cover, and the liquid injection plate and / or the liquid absorption plate are installed on the support guide column.

19. The automatic cleaning and separation device according to claim 15, characterized in that: The automatic cleaning and separation device further comprises a liquid injection driver, which is mounted on the liquid injection plate and has a liquid injection drive rod mounted on the liquid injection driver and abutting against the disk cover.

20. The automatic cleaning and separation device according to claim 15, characterized in that: The disc cover is equipped with an initial liquid injection component, which is used for initial liquid injection into the reaction container.

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