An exosome preparation for treating thin endometrium and its preparation method

By combining collagen gel with sheep placenta powder extract and exosome preparations, the problem of poor vascular development in thin endometrium was solved, endometrial regeneration was promoted, treatment side effects were reduced, and effective endometrial repair was achieved.

CN121081509BActive Publication Date: 2026-05-26ANHUI KEMEN BIOTECHNOLOGY CO LTD
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Patent Information

Application Number
CN202511297281.6
Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
Filing Date
2025-09-11
Publication Date
2026-05-26
Estimated Expiration
2045-09-11

AI Technical Summary

Technical Problem

The formation of thin endometrium is related to poor endometrial vascular development leading to reduced blood supply, which affects endometrial regeneration. Existing treatment methods have side effects and adverse reactions.

Method used

Collagen gel was used as a sustained-release matrix, combined with growth factors and exosomes from sheep placenta powder extract to promote angiogenesis. Soy isoflavones were used to balance estrogen receptor expression, and exosome preparations were prepared to promote endometrial regeneration.

Benefits of technology

It effectively promotes endometrial regeneration, reduces adverse reactions, improves blood supply, avoids the side effects of single hormone therapy, provides three-dimensional structural support, and enhances bioavailability.

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Abstract

This invention relates to the field of biomedical technology and discloses an exosome preparation for treating thin endometrium and its preparation method. The preparation method includes the following steps: Step 1, culturing mesenchymal stem cells; Step 2, extracting exosomes; Step 3, preparing a collagen solution; Step 4, preparing traditional Chinese medicine components; Step 5, stirring the collagen solution and sheep placenta powder extract evenly at 4°C, then adding the exosome solution and mixing, then adding soy isoflavone solution and excipients, and after sufficient reaction, obtaining an exosome gel, which is then stored at 4°C. This invention utilizes the above-mentioned exosome preparation for treating thin endometrium and its preparation method, using collagen gel as a sustained-release matrix to provide three-dimensional structural support for the active substances, slowing down their degradation. Simultaneously, the growth factors in the sheep placenta powder extract work synergistically with the exosomes to activate angiogenesis, improve blood supply, and promote endometrial regeneration.
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