A recombinant collagen wound dressing and a preparation method thereof

By modifying recombinant humanized type III collagen with chitosan and cross-linking it with polyvinyl alcohol, and combining it with nano-silver, a stable dressing network is formed, which solves the problem of insufficient mechanical properties of natural collagen in the wound healing process, and achieves effective protection and rapid healing of the wound.

CN121081708BActive Publication Date: 2026-06-26XINJIANG AIYOUHE BIOPHARMACEUTICAL CO LTD
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Patent Information

Application Number
CN202511260341.7
Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
Filing Date
2025-09-04
Publication Date
2026-06-26
Estimated Expiration
2045-09-04

AI Technical Summary

Technical Problem

Natural collagen loses its mechanical properties significantly after absorbing water, becomes easily broken, and cannot form a sustainable physical barrier. Furthermore, it lacks sufficient support in deep wounds, affecting wound healing.

Method used

Recombinant humanized type III collagen was used to modify chitosan and form a cross-linked network with polyvinyl alcohol and genipin. Nano-silver was dispersed in the gel and compounded on the surface of PEG-6000 modified nonwoven fabric to enhance the mechanical stability and anti-enzymatic ability of the dressing.

Benefits of technology

It significantly improves the mechanical stability and enzymatic resistance of the dressing, provides a suitable microenvironment to promote wound healing, reduces the risk of infection, and improves wound repair efficiency.

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Abstract

The present application relates to the technical field of dressings, and discloses a recombinant collagen wound dressing and a preparation method thereof.The recombinant collagen dressing takes recombinant humanized type III collagen as a matrix, is modified by chitosan, is closely adsorbed with a wound, takes polyvinyl alcohol as a mechanical reinforcing agent, takes genipin as a natural crosslinking agent, and is compounded with silver nanoparticles to construct a multifunctional composite wound dressing, and is compounded on the surface of PEG-6000 modified non-woven fabric to make the non-woven fabric easy to be peeled off from the recombinant collagen gel.The recombinant collagen dressing is crosslinked by genipin, is reinforced by polyvinyl alcohol, and is compounded with the antibacterial function of nano-silver, so that the mechanical stability, the anti-enzymatic ability and the repair efficiency of the recombinant collagen dressing can be significantly improved, a new type of dressing candidate with excellent performance is provided for clinical wound repair, the preparation process is repeatable and easy to be scaled up, and has clinical transformation potential.
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