A drug release capsule device based on external rotating magnetic field

Abstract

The application relates to the field of medical devices, and particularly discloses a drug releasing capsule device based on an external rotating magnetic field, which comprises a capsule shell, a medicine liquid is stored in the capsule shell, a drug releasing hole is arranged in the lateral wall of the capsule shell, and a spiral strip is arranged on the outer lateral wall of the capsule shell; a medicine pushing rod is slidably arranged in the capsule shell, a stop block is fixedly connected to the medicine pushing rod, the stop block slides along the inner lateral wall of the capsule shell and is used for shielding or opening the drug releasing hole; a first magnet is rotatably arranged in the capsule shell and is driven to rotate by the external rotating magnetic field; a cylindrical cam is coaxially fixed to the first magnet and is used for converting the rotating torque of the first magnet into an axial pushing force to push the medicine pushing rod; a spring is arranged in the capsule shell and is used for applying an elastic force opposite to the axial pushing force to the medicine pushing rod; and a second magnet is fixedly arranged in the capsule shell and is used for keeping the capsule shell fixed under the action of an external static magnetic field. The application adopts a non-contact magnetic driving mode and can realize fixed-point drug releasing and multiple quantitative drug releasing.

Description

Technical Field

[0001] This application relates to the field of medical devices, and in particular to a drug delivery capsule device based on an external rotating magnetic field. Background Technology

[0002] Capsule-type medical devices are widely used in the fields of gastrointestinal examination and targeted drug delivery. For example, capsule endoscopy systems, which are swallowed and inserted into body cavities, enable non-invasive diagnosis and treatment. In existing technologies, capsule devices mostly rely on internal batteries or wireless power to drive movement and drug release. For instance, patent CN102090876A discloses a wirelessly powered, externally magnetically controlled drug release capsule system that releases drugs through an external magnetic field combined with wireless energy transmission; patent CN113576374B discloses a leaf spring-driven, magnetically controlled drug delivery capsule robot that uses a leaf spring mechanism combined with an external magnetic field to control drug delivery; and patent CN115569298A discloses a magnetically controlled micro-soft drug-carrying capsule robot that uses soft compression of magnetic blocks to release drugs.

[0003] Although these magnetically controlled capsule systems introduce external magnetic field drive, drug release control relies on wireless power supply or auxiliary mechanisms such as leaf springs, resulting in complex structures. Furthermore, the drug release mechanism is singular, often resulting in a single release, making it difficult to achieve multiple cycles of quantitative control. The drug release accuracy is low, making it difficult to achieve targeted drug delivery in complex body cavity environments, thus affecting drug utilization and efficacy. Summary of the Invention

[0004] To achieve non-contact magnetic actuation and multiple quantitative drug release from drug-releasing capsules, this application provides a drug-releasing capsule device based on an external rotating magnetic field.

[0005] The drug delivery capsule device based on an external rotating magnetic field provided in this application adopts the following technical solution:

[0006] A drug delivery capsule device based on an external rotating magnetic field, comprising:

[0007] A capsule shell containing a liquid medicine, wherein the side wall of the capsule shell has a drug release hole;

[0008] A walking structure is used to drive the capsule shell to move as the capsule shell rotates;

[0009] The push rod is slidably disposed in the capsule shell along the axial direction of the capsule shell;

[0010] A shielding member is fixed to the periphery of the push rod. The shielding member slides along the inner wall of the capsule shell to shield or open the drug release hole.

[0011] A first magnet is rotatably disposed inside the capsule shell, and the first magnet rotates around the axis of the capsule shell under the drive of an external rotating magnetic field;

[0012] A torque converter is coaxially fixed to the first magnet. The torque converter is used to convert the rotational torque of the first magnet into an axial thrust to drive the push rod to translate along its own axis. The magnitude of the rotational torque of the first magnet is adjusted by the strength of an external rotating magnetic field.

[0013] An elastic element is used to apply a spring force to the push rod, the spring force being opposite in direction to the axial thrust;

[0014] A second magnet is fixedly disposed inside the capsule shell, and the capsule shell is kept fixed under the action of an external static magnetic field.

[0015] Furthermore, the walking structure includes a spiral strip fixed to the outer wall of the capsule shell.

[0016] Furthermore, the torque converter is a cylindrical cam, the cylindrical cam is provided with an inclined surface, and one end of the push rod is eccentrically connected to an abutment, the abutment abutting against the inclined surface.

[0017] Furthermore, the side of the abutment that contacts the inclined surface is a spherical surface.

[0018] Furthermore, the elastic element is a spring, and a sleeve for accommodating the spring is coaxially fixed inside the capsule shell.

[0019] Furthermore, a ball head is fixedly connected to the end of the push rod away from the torque converter, the ball head is slidably disposed in the sleeve, and the ball head abuts against one end of the spring.

[0020] Furthermore, a guide structure is provided inside the capsule shell to guide the sliding of the push rod along the axial direction of the capsule shell.

[0021] Furthermore, a push plate is fixedly connected to the periphery of the push rod, and the push plate corresponds to the position of the blocking member and a gap is provided between the two.

[0022] Furthermore, the first magnet and the second magnet are located at both ends of the capsule shell, respectively; the magnetization direction of the first magnet is radial, and the magnetization direction of the second magnet is axial.

[0023] Furthermore, multiple drug release holes are provided, and the multiple drug release holes are arranged spirally on the capsule shell. Multiple shielding members are also provided, and each one corresponds to a drug release hole.

[0024] In summary, this application includes at least one of the following beneficial technical effects:

[0025] 1. This application drives the first magnet inside the capsule shell to rotate through an external rotating magnetic field, without the need for an internal power supply or wireless power supply, thus achieving a completely non-contact magnetic drive, which is beneficial for reducing the size of the capsule device and improving safety;

[0026] 2. This application achieves the switching between walking mode and drug release mode by adjusting the intensity of the external rotating magnetic field, which is simple in structure and easy to operate;

[0027] 3. In walking mode, the capsule shell uses the spiral strips on its outer wall to achieve peristaltic walking in the gastrointestinal tract. The walking direction and posture can be adjusted by controlling the direction of the external rotating magnetic field.

[0028] 4. In drug release mode, the capsule shell is kept fixed by the interaction of the second magnet with the external static magnetic field, so as to achieve targeted drug release and improve drug release accuracy;

[0029] 5. By coordinating the rotation of the first magnet and the cylindrical cam with the extension and retraction of the spring, not only can the precise control of the drug release amount and release rate be achieved, reducing drug waste; at the same time, through the multiple compression-reset cycles of the spring, the limitation of the existing technology of single drug release can be overcome, supporting multiple quantitative drug releases and improving drug utilization. Attached Figure Description

[0030] Figure 1 This is a schematic diagram of the overall structure of a drug-releasing capsule device based on an external rotating magnetic field according to an embodiment of this application;

[0031] Figure 2 This is a partial cross-sectional schematic diagram illustrating the internal structure of a drug delivery capsule device based on an external rotating magnetic field, as described in this application embodiment.

[0032] Reference numerals in the attached drawings: 1. Capsule shell; 2. End cap; 3. Drug release hole; 4. Spiral strip; 5. Drug pusher; 6. Stop block; 7. Push plate; 8. First magnet; 9. Cylindrical cam; 10. Abutment joint; 11. Sleeve; 12. Spring; 13. Ball head; 14. Guide plate; 15. Mounting base; 16. Limiting ring; 17. Second magnet. Detailed Implementation

[0033] The following is in conjunction with the appendix Figure 1-2 This application will be described in further detail.

[0034] This application discloses a drug delivery capsule device based on an external rotating magnetic field. (Refer to...) Figure 1 and Figure 2The drug-releasing capsule device based on an external rotating magnetic field includes a capsule shell 1, which is a hollow cylinder with end caps 2 fixed at both ends. Both the end caps 2 and the capsule shell 1 are made of non-magnetic material, such as plastic. The end caps 2 and the capsule shell 1 can be connected by adhesive, snap-fit, or other methods. The capsule shell 1 stores liquid medicine. A drug release hole 3 is provided on the side wall of the capsule shell 1. The shape of the drug release hole 3 is not limited, but it is usually a circular hole or an oblong hole. The size of the drug release hole 3 can be reasonably set according to the required drug release amount and release rate.

[0035] Reference Figure 2 A push rod 5 is slidably disposed in the capsule shell 1 along its own axial direction. A blocking member is fixed to the periphery of the push rod 5. In this embodiment, the blocking member is a block 6. The cross-section of the block 6 is fan-shaped, and one side of it is an arc-shaped surface, which is adapted to the contour of the inner wall of the capsule shell 1. When the push rod 5 slides, the block 6 slides along the inner wall of the capsule shell 1, and the drug release hole 3 is located on the sliding path of the block 6, so that the drug release hole 3 can be blocked or opened as the block 6 moves.

[0036] When the baffle 6 blocks the drug release hole 3, it prevents the liquid medicine in the capsule shell 1 from flowing out of the drug release hole 3. The thickness of the baffle 6 should be greater than the diameter of the drug release hole 3 so that the baffle 6 can effectively block the drug release hole 3 and prevent the liquid medicine from leaking out in the drug storage state. When the baffle 6 moves to partially block or fully open the drug release hole 3, the liquid medicine flows out from the drug release hole 3 and is released into the target area. By controlling the moving distance of the baffle 6, the opening area of ​​the drug release hole 3 can be adjusted, thereby adjusting the rate of liquid medicine release.

[0037] Furthermore, refer to Figure 2 A push plate 7 is fixedly connected to the periphery of the push rod 5. The push plate 7 corresponds to the position of the stop block 6 and there is a gap between them. The push plate 7 is a fan-shaped plate, and its arc-shaped side is adapted to the contour of the inner wall of the capsule shell 1. When the push rod 5 moves axially along the capsule shell 1, the stop block 6 and the corresponding push plate 7 move synchronously. At the same time as the stop block 6 opens the drug release hole 3, the push plate 7 moves towards the drug release hole 3, thereby pushing the drug liquid out of the drug release hole 3, which helps to improve the drug release efficiency.

[0038] Reference Figure 1 and Figure 2 In this embodiment, three drug release holes 3 are provided, which are arranged spirally on the capsule shell 1. There are three baffles 6 and three push plates 7, each corresponding to one of the positions of the three drug release holes 3. The spiral arrangement of multiple drug release holes 3 allows the drug solution to be evenly released from multiple points to the target area, which is beneficial to improving the targeting coverage and efficacy of the drug solution.

[0039] To guide the sliding of the push rod 5 along the axial direction of the capsule shell 1, a guide structure is provided inside the capsule shell 1. Specifically, refer to... Figure 2The guiding structure includes a guide plate 14 fixed to the inner wall of the capsule shell 1, with the length direction of the guide plate 14 parallel to the axial direction of the capsule shell 1. Two guide plates 14 can be provided, with each guide plate 14 abutting against both sides of a stop block 6. The guide plates 14 help prevent the push rod 5 from rotating or shifting during translation, thus ensuring the reliability of the drug release process.

[0040] In this embodiment, the axial translation of the push rod 5 is achieved through a non-contact drive using an external rotating magnetic field. (Refer to...) Figure 2 A first magnet 8 is rotatably disposed inside the capsule shell 1. Specifically, a mounting base 15 for mounting the first magnet 8 is fixedly connected to the inner side of the end cap 2 at one end of the capsule shell 1. The mounting base 15 is rotatably connected to the first magnet 8 via a bearing. The first magnet 8 is a disc-shaped or ring-shaped permanent magnet with a radial magnetization direction. The first magnet 8 can rotate around the axis of the capsule shell 1 under the drive of an external rotating magnetic field. The rotational torque of the first magnet 8 is adjusted by the intensity of the external rotating magnetic field. To improve the stability of the rotation of the first magnet 8, a limit ring 16 is also fixedly disposed inside the capsule shell 1. One side of the first magnet 8 abuts against the limit ring 16 to prevent the first magnet 8 from moving axially.

[0041] Reference Figure 2 A torque converter is coaxially fixed to the first magnet 8. The torque converter converts the rotational torque of the first magnet 8 into an axial thrust to drive the push rod 5 to translate along its own axis. In this embodiment, the torque converter is a cylindrical cam 9, which is a truncated cylinder and coaxial with the push rod 5. The cylindrical cam 9 has an inclined surface. One end of the push rod 5 is eccentrically connected to an abutment 10, that is, the abutment 10 is not on the axis of the push rod 5. In this embodiment, the abutment 10 is fixed to one of the push plates 7. The abutment 10 abuts against the inclined surface of the cylindrical cam 9, and the side of the abutment 10 that contacts the inclined surface is a spherical surface.

[0042] When the external rotating magnetic field drives the first magnet 8 to rotate around the axis of the capsule shell 1, the cylindrical cam 9 rotates with the first magnet 8. The inclined surface of the cylindrical cam 9 abuts against the abutment 10 and applies an axial thrust to the push rod 5, thereby pushing the push rod 5 to translate along its own axis, thus opening or closing the drug release hole 3. During this process, relative sliding occurs between the abutment 10 and the inclined surface of the cylindrical cam 9. The spherical surface of the abutment 10 helps to reduce the resistance of relative sliding.

[0043] Furthermore, refer to Figure 2The capsule shell 1 also contains an elastic element for applying elastic force to the push rod 5, the elastic force being opposite in direction to the axial thrust. Specifically, a sleeve 11 is coaxially fixed to the inner side of the end cap 2 at the other end of the capsule shell 1, and the elastic element is a spring 12 coaxially disposed in the sleeve 11; the sleeve 11 guides the axial extension and retraction of the spring 12, helping to prevent the spring 12 from bending laterally during extension and retraction. A ball head 13 is fixedly connected to the end of the push rod 5 away from the cylindrical cam 9, the ball head 13 is slidably disposed in the sleeve 11, and the ball head 13 abuts against or is fixed to one end of the spring 12, enabling the elastic force of the spring 12 to be stably transmitted to the push rod 5.

[0044] Through the rotation of the first magnet 8 and the cylindrical cam 9, and the extension and retraction of the spring 12, the spring 12 can perform multiple compression-reset cycles, thereby achieving multiple drug administrations. Specifically, during drug administration, the first magnet 8 is driven to rotate by an external rotating magnetic field. The cylindrical cam 9 converts the rotational torque of the first magnet 8 into an axial thrust. The axial thrust overcomes the elastic force of the spring 12, causing the push rod 5 to translate along its own axis and compressing the spring 12, thereby moving the stop block 6 and opening the drug release hole 3 to release the drug.

[0045] After drug release is completed, to close the drug release hole 3, one implementation method is as follows: the external rotating magnetic field is removed, making the rotational torque of the first magnet 8 zero. The spring 12 returns to its original position under its own deformation force, pushing the drug pusher 5 to move in the opposite direction and pushing the cylindrical cam 9 to return to its original position. The stop block 6 moves in the opposite direction to block the drug release hole 3. Another implementation method is as follows: the direction of the external rotating magnetic field is changed, causing the cylindrical cam 9 to rotate in the opposite direction. The spring 12 returns to its original position under its own deformation force, pushing the drug pusher 5 to move in the opposite direction. The stop block 6 moves in the opposite direction to block the drug release hole 3.

[0046] In this way, spring 12 completes one compression-reset cycle, realizing a single drug delivery; repeating the above process allows for multiple drug deliveries.

[0047] To achieve targeted drug release, the position and orientation of the capsule shell 1 need to be kept fixed during drug release, referring to... Figure 2 A second magnet 17 is fixedly installed inside the capsule shell 1. The second magnet 17 is a disk-shaped or ring-shaped permanent magnet with its magnetization direction being axial. The second magnet 17 is fixed inside the end cap 2 where the sleeve 11 is located.

[0048] The capsule shell 1 is fixed in place by the attraction of the second magnet 17 by an external static magnetic field, causing the capsule shell 1 to adhere tightly to the inner wall of the gastrointestinal tract. The strength of the external static magnetic field can be controlled to adjust the firmness of the capsule shell 1 against the inner wall of the gastrointestinal tract.

[0049] In this embodiment, the second magnet 17 and the first magnet 8 are located at the two ends of the capsule shell 1, and the second magnet 17 and the first magnet 8 are axially magnetized and radially magnetized, respectively. This can reduce the interference of the external rotating magnetic field on the second magnet 17, so that after the capsule shell 1 is fixed under the action of the external static magnetic field, the external rotating magnetic field can independently drive the first magnet 8 to rotate, thereby completing the drug release.

[0050] Reference Figure 1 The capsule shell 1 is provided with a walking structure. In this embodiment, the walking structure is a spiral strip 4 fixed to the outer wall of the capsule shell 1. The spiral strip 4 can move as follows: Figure 1 The arrangement shown can be continuous or segmented. When the outer wall of the capsule shell 1 is in contact with the inner wall of the gastrointestinal tract, the spiral strip 4 converts the rotational motion of the capsule shell 1 around its axis into its own axial propulsive force, causing the capsule shell 1 to roll circumferentially along the inner wall of the gastrointestinal tract while also moving axially along the gastrointestinal tract. To prevent the spiral strip 4 from scratching the inner wall of the gastrointestinal tract, the surface of the spiral strip 4 is designed with rounding.

[0051] In addition, the spiral strip 4 can also serve as an anchoring structure to anchor the capsule shell 1 to the inner wall of the gastrointestinal tract. Specifically, the soft and deformable inner wall of the gastrointestinal tract can be embedded in the gaps between the spiral strips 4. The friction generated by this embedding helps to prevent the capsule shell 1 from undergoing unintended displacement during targeted drug release.

[0052] This embodiment employs an external rotating magnetic field (generated by the rotation of an external magnet located outside the capsule shell 1) interacting with a first magnet 8 inside the capsule shell 1 to achieve non-contact magnetic drive. Furthermore, the drug-releasing capsule device provided in this application has a walking mode and a drug-releasing mode, which are switched by adjusting the intensity of the external rotating magnetic field, as detailed below:

[0053] Walking mode:

[0054] An external rotating magnetic field is applied to the capsule shell 1, and the strength of the external rotating magnetic field is not greater than the critical value. At this time, the rotational torque of the first magnet 8 is small. The rotational torque of the first magnet 8 is converted into a small axial thrust through the cylindrical cam 9. This axial thrust is insufficient to overcome the elastic force of the spring 12, so that the cylindrical cam 9 and the push rod 5 remain stationary. The stop block 6 blocks the drug release hole 3, preventing the liquid medicine in the capsule shell 1 from flowing out of the drug release hole 3.

[0055] Maintaining a relatively small external rotating magnetic field strength, under the influence of this field, the first magnet 8 inside the capsule shell 1 rotates synchronously with the capsule shell 1 around its own axis. The outer wall of the capsule shell 1 adheres to the inner wall of the gastrointestinal tract. The spiral strip 4 converts the rotational motion of the capsule shell 1 into its own axial propulsion force, causing the capsule shell 1 to roll circumferentially along the inner wall of the gastrointestinal tract while simultaneously moving axially, thus achieving peristaltic movement within the gastrointestinal tract. In walking mode, the position of the external magnet moves synchronously with the capsule shell 1 (including circumferential and axial movement along the inner wall of the gastrointestinal tract) to propel the capsule shell 1 continuously.

[0056] By adjusting the rotation direction of the external rotating magnetic field, the rotation direction of the capsule shell 1 can be changed, thereby controlling the capsule shell 1 to move forward or backward; by adjusting the rotation speed of the external rotating magnetic field, the rotation speed of the capsule shell 1 can be adjusted, thereby controlling the movement speed of the capsule shell 1, so as to improve the controllability of the movement of the capsule shell 1 and adapt to the complex cavity morphology of the gastrointestinal tract.

[0057] Drug delivery mode:

[0058] First, an external static magnetic field is used to attract the second magnet 17, so that the capsule shell 1 is tightly attached to the inner wall of the gastrointestinal tract, thereby fixing the position and orientation of the capsule shell 1. At the same time, the spiral strip 4 can act as an anchoring structure to anchor the capsule shell 1 to the inner wall of the gastrointestinal tract, preventing the capsule shell 1 from moving or changing its orientation during drug release.

[0059] Maintain the application of an external static magnetic field, and then apply an external rotating magnetic field. The positions of the external static magnetic field and the external rotating magnetic field correspond to the positions of the second magnet 17 and the first magnet 8 in the capsule shell 1, respectively.

[0060] When the applied external rotating magnetic field strength is greater than the critical value, the rotational torque of the first magnet 8 is large. The rotational torque of the first magnet 8 is converted into a large axial thrust through the cylindrical cam 9. This axial thrust is sufficient to overcome the elastic force of the spring 12, causing the push rod 5 to translate along its own axis and compress the spring 12. The stop block 6 slides along the inner wall of the capsule shell 1 to open the drug release hole 3, thereby releasing the drug liquid.

[0061] By adjusting the intensity of the external rotating magnetic field, the rotational torque of the first magnet 8 can be adjusted, thereby adjusting the magnitude of the axial thrust, which in turn adjusts the distance the push rod 5 moves and the area of ​​the drug release hole 3 opening. In this way, the speed of drug release can be adjusted. By controlling the duration of the external rotating magnetic field, the duration of the drug release hole 3 opening can be controlled, that is, the duration of drug release can be controlled, thereby achieving quantitative drug administration.

[0062] After the drug release is completed, the external rotating magnetic field is removed, or the direction of the external rotating magnetic field is changed so that the cylindrical cam 9 rotates in the opposite direction. The deformation force of the spring 12 drives the push rod 5 to return to its original position, and the stop block 6 slides along the inner wall of the capsule shell 1 and blocks the drug release hole 3, thus completing one drug administration.

[0063] By repeating the above drug delivery process, multiple quantitative drug releases can be achieved through the multiple compression-reset cycles of spring 12, thereby improving drug utilization.

[0064] The above are all preferred embodiments of this application, and are not intended to limit the scope of protection of this application. Therefore, all equivalent changes made in accordance with the structure, shape and principle of this application should be covered within the scope of protection of this application.

Claims

1. A drug-release capsule device based on an external rotating magnetic field, characterized in that: include: A capsule shell containing a liquid medicine, wherein the side wall of the capsule shell has a drug release hole; A walking structure is used to drive the capsule shell to move as the capsule shell rotates; The push rod is slidably disposed in the capsule shell along the axial direction of the capsule shell; A shielding member is fixed to the periphery of the push rod. The shielding member slides along the inner wall of the capsule shell to shield or open the drug release hole. A first magnet is rotatably disposed inside the capsule shell, and the first magnet rotates around the axis of the capsule shell under the drive of an external rotating magnetic field; A torque converter is coaxially fixed to the first magnet. The torque converter is used to convert the rotational torque of the first magnet into an axial thrust to drive the push rod to translate along its own axis. The magnitude of the rotational torque of the first magnet is adjusted by the strength of an external rotating magnetic field. An elastic element is used to apply a spring force to the push rod, the spring force being opposite in direction to the axial thrust; A second magnet is fixedly disposed inside the capsule shell, and the capsule shell is kept fixed under the action of an external static magnetic field. The drug-releasing capsule device has a walking mode and a drug-releasing mode, which can be switched by adjusting the intensity of the external rotating magnetic field: In the walking mode, the intensity of the external rotating magnetic field is not greater than the critical value, the rotational torque of the first magnet is insufficient to overcome the elastic force of the elastic element, the push rod remains stationary, and the blocking element blocks the drug-releasing hole. Under the action of the external rotating magnetic field, the first magnet and the capsule shell rotate synchronously around their own axis, realizing the walking of the capsule shell; In the drug-releasing mode, the intensity of the external rotating magnetic field is greater than the critical value, the rotational torque of the first magnet overcomes the elastic force of the elastic element, drives the push rod to translate, and the blocking element opens the drug-releasing hole.

2. The drug-releasing capsule device based on an external rotating magnetic field according to claim 1, characterized in that: The walking structure includes a spiral strip fixed to the outer wall of the capsule shell.

3. The drug-releasing capsule device based on an external rotating magnetic field according to claim 1, characterized in that: The torque converter is a cylindrical cam, which has an inclined surface. One end of the push rod is eccentrically connected to an abutment, which abuts against the inclined surface.

4. The drug-releasing capsule device based on an external rotating magnetic field according to claim 3, characterized in that: The side of the abutment that contacts the inclined surface is a spherical surface.

5. The drug-releasing capsule device based on an external rotating magnetic field according to claim 1, characterized in that: The elastic element is a spring, and a sleeve for accommodating the spring is coaxially fixed inside the capsule shell.

6. The drug-releasing capsule device based on an external rotating magnetic field according to claim 5, characterized in that: A ball head is fixedly connected to one end of the push rod away from the torque converter. The ball head is slidably disposed in the sleeve and abuts against one end of the spring.

7. The drug-releasing capsule device based on an external rotating magnetic field according to claim 1, characterized in that: The capsule shell is provided with a guide structure to guide the sliding of the push rod along the axial direction of the capsule shell.

8. The drug-releasing capsule device based on an external rotating magnetic field according to claim 1, characterized in that: A push plate is also fixed to the periphery of the push rod, and the push plate corresponds to the position of the shielding member and there is a gap between them.

9. A drug-releasing capsule device based on an external rotating magnetic field according to claim 1, characterized in that: The first magnet and the second magnet are located at the two ends of the capsule shell, respectively; the magnetization direction of the first magnet is radial, and the magnetization direction of the second magnet is axial.

10. A drug-release capsule device based on an external rotating magnetic field according to any one of claims 1-9, characterized in that: The capsule shell is provided with multiple drug release holes, which are arranged in a spiral on the capsule shell. Multiple shielding members are also provided and correspond one-to-one with the drug release holes.

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