Liquid preparation and method for inhibiting degradation of penteic acid

By using a non-oxidizing gas to create a low-oxygen environment in the drug container, the problem of oxidative degradation of vitamin C or its salts when coexisting with pentiacin is solved, thereby improving the stability of the drug formulation and making it suitable for various liquid formulation systems.

CN122075404APending Publication Date: 2026-05-26YUNNUO PHARMACEUTICAL (TIANJIN) CO LTD +1
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Patent Information

Application Number
CN202610398864.6
Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
Filing Date
2026-03-27
Publication Date
2026-05-26

AI Technical Summary

Technical Problem

When vitamin C or its salts coexist with penteacin in a drug solution, the penteacin is easily degraded by oxidation, affecting the stability of the drug formulation. The degradation is exacerbated, especially under high temperature or radiation conditions.

Method used

By filling the drug container with a non-oxidizing gas, such as nitrogen, a low-oxygen environment is created, inhibiting the oxidative degradation of penteacin and maintaining the stability of the formulation.

Benefits of technology

It effectively inhibits the degradation of pentiacin, improves the physicochemical stability of drug formulations, and is suitable for various liquid formulation systems containing metal chelating agents and antioxidant excipients, especially for maintaining formulation quality under high temperature or radiation conditions.

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Abstract

The invention belongs to the technical field of medicines, and particularly relates to a liquid preparation and a method for inhibiting degradation of penteic acid. The liquid preparation comprises a medicine solution sealed in a medicine container and environment gas located above the medicine solution, and the medicine solution comprises one or more of medicine active ingredients, penteic acid and vitamin C and salts thereof; the environment gas is mainly composed of non-oxidizing gas. By establishing a non-oxidizing gas environment in a liquid preparation system containing vitamin C or a salt thereof and DTPA, the oxidation and degradation rate of DTPA in the storage process can be remarkably reduced, and generation of newly-added impurities derived from DTPA can be effectively inhibited, so that the physical and chemical stability of the preparation is improved, the storage period is prolonged, and the quality of the preparation is improved. And the use safety and the quality reliability of the product are enhanced.
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