Method for monitoring micro circulation blood flow time-space response characteristic on mesentery by using laser speckle imaging instrument

A technology of response characteristics and laser speckle, which is applied to devices using optical methods, blood flow measurement, instruments used for radiological diagnosis, etc. simple structure

CN1391869AInactive Publication Date: 2003-01-22HUAZHONG UNIV OF SCI & TECH
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
Publication Date
2003-01-22
Estimated Expiration
Not applicable · inactive patent

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Abstract

The equipment for monitoring micro circulation body flow time-space response characteristic on mesentery includes an optical path and an imaging system. In the optial path, the laser bean from helium neon laser is coupled to fiber bundle to form homogeneous diffused beam; and the imaging system consists of stereo microscope with CCD camera, image collecting card with image collecting and controlling software. The CCD signal is output to the image collecting card connected to PC, the collection parameters are set via the image collecting and controlling software and local blood flow information are obtained with the image signal and via the signal analysis software. The equipment provides one new way to the research of influence of medicine and other stimulation to the micro circulation blood flow on mesentery.
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Description

technical field

[0001] The invention relates to a method for monitoring the temporal-spatial response characteristics of mesenteric microcirculation blood flow using a laser speckle imager, and is particularly suitable for using reflection imaging methods to study the regional blood flow velocity of supra mesenteric microcirculation under the action of drugs and other stimuli , pipe diameter, and flow change. Background technique

[0002] At present, a large number of studies exploring the effects of drugs on the microcirculation in vivo use the transparency of the mesentery as an observation sample of the microcirculation. In these studies, the parameters of microcirculation in the mesentery were monitored by means of optical microscope, microvideo video system and laser Doppler microscope. Since these methods use the transmission method for measurement, the measurement object can only be the capillary with better transparency, but cannot measure the blood vessel with poor...

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Embodiment Construction

[0007] specific implementation plan

[0008] The invention relates to a method for monitoring the space-time response characteristics of mesenteric microcirculation blood flow by using a laser speckle imager, including an optical path and an imaging system. The optical path is composed of He-Ne laser, fiber bundle and three-dimensional adjustable frame; the imaging system is composed of a stereo microscope with a CCD camera, an image acquisition card, image acquisition control software, and signal analysis software. The method is that the beam emitted by the He-Ne laser is coupled to one end of the fiber bundle, and the other end of the fiber bundle is fixed by a three-dimensional adjustable frame, and the beam from the fiber bundle forms a uniformly diffused beam to illuminate the area to be monitored. CCD camera imaging, output to the image acquisition card, the image acquisition card is connected to the computer, and the acquisition parameters (image pixel size, image frame...