Oral cavity spraying agent for anticarious and preparation method

Abstract

An oral spray for preventing and treating the decayed tooth is prepared from vitelline antibody IgY, alcohol, wetting agent, surfactant, essence, antiseptic, pigment and deionized water through extracting IgY by water diluting method, PEG deposition method, membrane filtering method, or ammonium sulfate depositing method, and preparing oral spray.

Description

technical field

[0001] The invention relates to an anti-caries oral spray and a preparation method thereof. Background technique

[0002] At present, with the general improvement of people's living standards and the increase of sugar content and intake in the diet, dental caries is prevalent, especially in children's deciduous teeth. With the extension of population life, the root surface of the elderly Dental caries is also increasing, which seriously affects people's oral cavity and health, thereby seriously affecting people's quality of life. At present, the World Health Organization (WHO) has listed dental caries as the third largest non-communicable disease after cardiovascular disease and cancer, and as one of the 10 indicators of physical health.

[0003] Dental caries is a kind of common disease, frequently-occurring disease, and its sickness rate is high, and distribution is wide, and it is very harmful to human body. After the unremitting ...

Examples

Embodiment 1

[0053] The technical mechanism adopted in the present invention is as follows: first, an anti-caries yolk antibody is prepared, which is detected by non-denaturing polypropylene gel electrophoresis. After staining with Coomassie Brilliant Blue R250, the detection spectrum can present a single Bands, Western Bloting detection can find a single specific band at the molecular weight of 170 ~ 190KD; or according to denatured polypropylene gel electrophoresis for detection, after Coomassie brilliant blue R250 staining, the map shows two bands, Western Bloting Two specific bands can be found at the molecular weight of about 65KD and 25KD. The protein concentration is 0.1-20mg / ml measured by UV spectrophotometry; the titer is 1:50-1:100000 by enzyme-linked immunosorbent assay .

[0054] The anti-caries oral spray of the present invention is a medicament made of the following raw materials in weight ratio:

[0055] Xylitol 0.1%

[0056] Glycerin 1.0%

[0057] Aspa...

Embodiment 2

[0101] The anti-caries oral spray of the present invention is a medicament made of the following raw materials in weight ratio:

[0102] Xylitol 5.0%

[0103] Glycerin 15.0%

[0104] Aspartame 0.2%

[0105] Acesulfame K 0.2%

[0106] Potassium sorbate 0.05%

[0107] Anti-Caries Yolk Antibody 1.0%

[0108] Deionized water 59.05%

[0109] Propylene Glycol 15.0%

[0110] Fragrance 1.5%

[0111] Polysorbate 2.0%

[0112] Pigment 1.0%

[0113] The above components add up to 100%.

[0114] Solution preparation:

[0115] A solution

[0116] Xylitol 5.0%

[0117] Glycerin 15.0%

[0118] Aspartame 0.2%

[0119] Acesulfame K 0.2%

[0120] Potassium sorbate 0.05%

[0121] Anti-Caries Yolk Antibody 1.0%

[0122] Deionized water 30.0%

[0123] Solution B

[0124] Propylene Glycol 15.0%

[0125] Fragrance 1.5%

[0126] Polysorbate 2.0%

[0127] C solution

[0128] Pigment 1.0%

[0129] D solut...

Embodiment 3

[0133] The anti-caries oral spray of the present invention is a medicament made of the following raw materials in weight ratio:

[0134] Xylitol 3.0%

[0135] Glycerin 8.0%

[0136] Aspartame 0.1%

[0137] Acesulfame K 0.1%

[0138] Potassium sorbate 0.03%

[0139] Anti-Caries Yolk Antibody 0.5%

[0140] Deionized water 78.77%

[0141] Propylene Glycol 8.0%

[0142] Fragrance 1.0%

[0143] Polysorbate 1.0%

[0144] Pigment 0.5%

[0145] The above components add up to 100%.

[0146] Solution preparation:

[0147] A solution

[0148] Xylitol 3.0%

[0149] Glycerin 8.0%

[0150] Aspartame 0.1%

[0151] Acesulfame K 0.1%

[0152] Potassium sorbate 0.03%

[0153] Anti-Caries Yolk Antibody 0.5%

[0154] Deionized water 50.0%

[0155] Solution B

[0156] Propylene Glycol 8.0%

[0157] Fragrance 1.0%

[0158] Polysorbate 1.0%

[0159] C solution

[0160] Pigment 0....

technical field

[0001] The invention relates to an anti-caries oral spray and a preparation method thereof. Background technique

[0002] At present, with the general improvement of people's living standards and the increase of sugar content and intake in the diet, dental caries is prevalent, especially in children's deciduous teeth. With the extension of population life, the root surface of the elderly Dental caries is also increasing, which seriously affects people's oral cavity and health, thereby seriously affecting people's quality of life. At present, the World Health Organization (WHO) has listed dental caries as the third largest non-communicable disease after cardiovascular disease and cancer, and as one of the 10 indicators of physical health.

[0003] Dental caries is a kind of common disease, frequently-occurring disease, and its sickness rate is high, and distribution is wide, and it is very harmful to human body. After the unremitting ...

Examples

Embodiment 1

[0053] The technical mechanism adopted in the present invention is as follows: first, an anti-caries yolk antibody is prepared, which is detected by non-denaturing polypropylene gel electrophoresis. After staining with Coomassie Brilliant Blue R250, the detection spectrum can present a single Bands, Western Bloting detection can find a single specific band at the molecular weight of 170 ~ 190KD; or according to denatured polypropylene gel electrophoresis for detection, after Coomassie brilliant blue R250 staining, the map shows two bands, Western Bloting Two specific bands can be found at the molecular weight of about 65KD and 25KD. The protein concentration is 0.1-20mg / ml measured by UV spectrophotometry; the titer is 1:50-1:100000 by enzyme-linked immunosorbent assay .

[0054] The anti-caries oral spray of the present invention is a medicament made of the following raw materials in weight ratio:

[0055] Xylitol 0.1%

[0056] Glycerin 1.0%

[0057] Aspa...

Embodiment 2

[0101] The anti-caries oral spray of the present invention is a medicament made of the following raw materials in weight ratio:

[0102] Xylitol 5.0%

[0103] Glycerin 15.0%

[0104] Aspartame 0.2%

[0105] Acesulfame K 0.2%

[0106] Potassium sorbate 0.05%

[0107] Anti-Caries Yolk Antibody 1.0%

[0108] Deionized water 59.05%

[0109] Propylene Glycol 15.0%

[0110] Fragrance 1.5%

[0111] Polysorbate 2.0%

[0112] Pigment 1.0%

[0113] The above components add up to 100%.

[0114] Solution preparation:

[0115] A solution

[0116] Xylitol 5.0%

[0117] Glycerin 15.0%

[0118] Aspartame 0.2%

[0119] Acesulfame K 0.2%

[0120] Potassium sorbate 0.05%

[0121] Anti-Caries Yolk Antibody 1.0%

[0122] Deionized water 30.0%

[0123] Solution B

[0124] Propylene Glycol 15.0%

[0125] Fragrance 1.5%

[0126] Polysorbate 2.0%

[0127] C solution

[0128] Pigment 1.0%

[0129] D solut...

Embodiment 3

[0133] The anti-caries oral spray of the present invention is a medicament made of the following raw materials in weight ratio:

[0134] Xylitol 3.0%

[0135] Glycerin 8.0%

[0136] Aspartame 0.1%

[0137] Acesulfame K 0.1%

[0138] Potassium sorbate 0.03%

[0139] Anti-Caries Yolk Antibody 0.5%

[0140] Deionized water 78.77%

[0141] Propylene Glycol 8.0%

[0142] Fragrance 1.0%

[0143] Polysorbate 1.0%

[0144] Pigment 0.5%

[0145] The above components add up to 100%.

[0146] Solution preparation:

[0147] A solution

[0148] Xylitol 3.0%

[0149] Glycerin 8.0%

[0150] Aspartame 0.1%

[0151] Acesulfame K 0.1%

[0152] Potassium sorbate 0.03%

[0153] Anti-Caries Yolk Antibody 0.5%

[0154] Deionized water 50.0%

[0155] Solution B

[0156] Propylene Glycol 8.0%

[0157] Fragrance 1.0%

[0158] Polysorbate 1.0%

[0159] C solution

[0160] Pigment 0....