Ticagrelor bulk drug rotary evaporator

Abstract

The utility model discloses a ticagrelor bulk drug rotary evaporator which comprises a support, a condensation recovery assembly and an evaporation rotary assembly are arranged on the support, the evaporation rotary assembly comprises a rotary drum and an evaporation bottle, one end of the rotary drum is provided with a buffer tube, the buffer tube comprises a first connecting part and a second connecting part, and the first connecting part is connected with the second connecting part. One end of the first connecting part is communicated with the rotary drum and is fixed through a locking piece, a ball body is arranged at the other end of the first connecting part, one end of the second connecting part is connected with the ball body and is provided with an inner pipe located in the ball body, a through hole is formed in the side wall of the inner pipe, and the other end of the second connecting part is connected with a grinding opening of an evaporating flask. According to the utility model, the solvent can be subjected to rotary evaporation in the preparation process of ticagrelor, the solvent in the recovery bottle is prevented from being polluted by bumping during evaporation, and compared with the additional arrangement of a buffer ball, the assembly steps are reduced, and the installation efficiency is improved.

Description

Technical Field

[0001] The utility model relates to the technical field of raw material medicine production, and in particular to a rotary evaporator for ticagrelor raw material medicine. Background Art

[0002] Ticagrelor is a cyclopentyltriazole pyrimidine drug, a new type of direct-acting, reversibly binding, potent oral P2Y12 receptor antagonist. It has the function of inhibiting platelet activity, effectively inhibiting the activity of reticulocytes, and indirectly inhibiting the P2Y12 receptor on human cells. Its drug activity is not affected by the CYP2C19 genotype. Since 2011, it has been recommended by many European and American guidelines as the first-line or preferred antiplatelet drug for ACS patients.

[0003] In the preparation process of Ticagrelor, the solvent removal stage usually uses rotary evaporation technology to achieve efficient refining. The existing rotary evaporator uses a motor to drive its drum to rotate, and the connecting tube at one end of the drum drives the evaporation bottle to rotate in the water bath. Before starting evaporation, the distillation bottle needs to be vacuumed to reduce the internal pressure, but the boiling point of the solvent in the vacuum state is significantly reduced, which will cause the solvent to roll violently or even boil violently. The solvent liquid may rush out of the bottleneck of the evaporation bottle and overflow into the recovery bottle of the condensation recovery component, which will contaminate the solvent in the recovery bottle.

[0004] In order to prevent the occurrence of violent boiling, a buffer ball is added between the connecting tube and the evaporation flask to stabilize the evaporation process. Adding a separate buffer ball takes up experimental time, requires more time for correct installation and fixation, and the assembly is cumbersome. Utility Model Content

[0005] The purpose of the utility model is to provide a rotary evaporator for Ticagrelor raw materials, which can rotary evaporate the solvent in the preparation process of Ticagrelor to prevent violent boiling during evaporation and contamination of the solvent in the recovery bottle. Compared with adding a buffer ball, it reduces the number of assembly steps and improves the installation efficiency.

[0006] To achieve the above-mentioned purpose, the technical solution adopted by the utility model is: a rotary evaporator for ticagrelor raw material, comprising a bracket, on which a condensation recovery component and an evaporation rotary component are provided, the evaporation rotary component comprises a rotating drum and an evaporation flask, a buffer tube is provided at one end of the rotating drum, the buffer tube comprises a first connecting part and a second connecting part, one end of the first connecting part is communicated with the rotating drum and fixed by a locking piece, and the other end is provided with a sphere, one end of the second connecting part is connected to the sphere and is provided with an inner tube located in the sphere, the side wall of the inner tube is provided with a through hole, and the other end of the second connecting part is connected to the ground mouth of the evaporation flask.

[0007] A further improvement of the utility model is that the locking piece is a spiral coil, the diameter of the first connecting part is smaller than the diameter of the rotating drum, one end of the first connecting part is provided with a circular ring with a diameter matching the rotating drum, one end of the spiral coil is provided with a retaining ring, the inner diameter of the retaining ring is smaller than the outer diameter of the circular ring, the outer wall of the rotating drum is provided with an external thread and is locked and connected to the first connecting part through the spiral coil.

[0008] A further improvement of the present invention is that a sealing ring is provided between the end surface of the drum and the circular ring.

[0009] A further improvement of the utility model is that a ring groove is provided on the end surface of the rotating drum, and the outer diameter of the circular ring is matched with the diameter of the ring groove.

[0010] A further improvement of the present invention is that the sphere and the inner tube are an integrated structure, one end of the inner tube is connected to the second connecting portion, and the other end is provided with a curved surface head.

[0011] The beneficial effects of the utility model are:

[0012] The utility model can rotary evaporate the solvent in the preparation process of ticagrelor to prevent violent boiling during evaporation from contaminating the solvent in the recovery bottle. The buffer tube of the utility model can be directly connected to the rotating drum and the evaporation bottle, which reduces the assembly steps and improves the installation efficiency compared to adding a buffer ball.

[0013] The utility model directly connects the rotating drum and the evaporating flask through the buffer tube, which reduces the number of connection nodes compared to adding a buffer ball, thereby reducing the possibility of loosening and leakage, and improving the safety of production.

[0014] The utility model locks the rotating drum and the circular ring through the spiral ring and the retaining ring, and the retaining ring squeezes the circular ring by tightening the spiral ring, so that the connection between the rotating drum and the first connecting part is firm, and the disassembly is simple and fast.

[0015] The utility model provides an annular groove on the end surface of the rotating drum, the outer diameter of the circular ring is matched with the diameter of the annular groove, and the wall of the annular groove can be in contact with the outer wall of the circular ring, thereby further improving the sealing effect. BRIEF DESCRIPTION OF THE DRAWINGS

[0016] Figure 1 It is a structural schematic diagram of the utility model.

[0017] Figure 2 It is a partially enlarged schematic diagram of the structure of the utility model.

[0018] In the figure, 1- bracket, 2- rotating drum, 3- evaporating flask, 4- buffer tube, 5- first connecting part, 6- second connecting part, 7- sphere, 8- inner tube, 9- through hole, 10- spiral coil, 11- circular ring, 12- retaining ring, 13- ring groove, 14- arc surface head, 15- sealing ring. DETAILED DESCRIPTION

[0019] The present invention will be further described below in conjunction with the accompanying drawings and specific embodiments.

[0020] Example 1: Combination Figure 1~2 It can be known that a rotary evaporator for Ticagrelor API comprises a bracket 1, on which a condensation recovery component and an evaporation rotary component are provided, the evaporation rotary component comprises a drum 2 and an evaporation bottle 3, one end of the drum 2 is provided with a buffer tube 4, the buffer tube 4 comprises a first connection part 5 and a second connection part 6, one end of the first connection part 5 is communicated with the drum 2 and fixed by a locking member, the other end is provided with a sphere 7, one end of the second connection part 6 is connected to the sphere 7 and is provided with an inner tube 8 located inside the sphere 7, a through hole 9 is provided on the side wall of the inner tube 8, and the other end of the second connection part 6 is ground-connected with the evaporation bottle 3. The condensation recovery component and the evaporation rotary component of the utility model are both conventional components in conventional rotary evaporators in the prior art, and the solvent is vaporized in the evaporation rotary component and then reliquefied by the condensation recovery component and collected in the recovery bottle, and the utility model makes improvements to the anti-violation structure of the drum and the evaporation bottle.

[0021] The locking piece is a spiral coil 10, the diameter of the first connecting part 5 is smaller than the diameter of the drum 2, one end of the first connecting part 5 is provided with a circular ring 11 whose diameter matches the drum 2, one end of the spiral coil 10 is provided with a retaining ring 12, the inner diameter of the retaining ring 12 is smaller than the outer diameter of the circular ring 11, the outer wall of the drum 2 is provided with an external thread and is locked and connected to the first connecting part 5 through the spiral coil 10.

[0022] A sealing ring 15 is provided between the end surface of the drum 2 and the circular ring 11. An annular groove 13 is provided on the end surface of the drum 2, and the outer diameter of the circular ring 11 is matched with the diameter of the annular groove 13.

[0023] The sphere 7 and the inner tube 8 are an integrated structure, one end of the inner tube 8 is connected to the second connecting portion 6, and the other end is provided with a curved surface end cap 14. Preferably, two through holes 9 are provided.

[0024] The buffer tube 4 is made of glass. The bottle mouth of the evaporating flask 3 and one end of the second connecting part 5 are ground mouths that match each other.

[0025] The working principle of the rotary evaporator of Ticagrelor raw materials provided by the utility model is as follows: during installation, the sealing ring 15 is placed in the annular groove 13 at one end of the rotating drum 2, the first connecting part 5 of the buffer tube 4 is connected to the rotating drum 2, the ring 11 on the first connecting part 5 is located in the annular groove 13, and then the screw ring 10 is tightened so that the retaining ring 12 squeezes the ring 11 to fix the rotating drum 2 and the buffer tube 4, and the buffer tube 4 is sealed and connected to the ground mouth of the evaporation bottle 3 through the ground mouth at one end of its second connecting part 6.

[0026] In the description of the present utility model, it should be understood that the terms "upper", "lower", "front", "back", "left", "right", "top", "bottom", "inside", "outside", etc. indicate directions or positional relationships based on the directions or positional relationships shown in the accompanying drawings, and are only for the convenience of describing the present utility model and simplifying the description, rather than indicating or implying that the device or element referred to must have a specific direction, be constructed and operated in a specific direction, and therefore cannot be understood as a limitation on the present utility model. Any equivalent structure or equivalent process transformation made using the contents of the utility model specification and the accompanying drawings, or directly or indirectly used in other related technical fields, are similarly included in the patent protection scope of the present utility model.

Claims

1. A rotary evaporator for Ticagrelor API, comprising a support (1), on which a condensation recovery component and an evaporation rotary component are provided, wherein the evaporation rotary component comprises a rotating drum (2) and an evaporation flask (3), characterized in that: A buffer tube (4) is provided at one end of the rotating drum (2), and the buffer tube (4) comprises a first connecting portion (5) and a second connecting portion (6), one end of the first connecting portion (5) is in communication with the rotating drum (2) and is fixed by a locking member, and the other end of the first connecting portion (5) is provided with a sphere (7), one end of the second connecting portion (6) is connected to the sphere (7) and is provided with an inner tube (8) located inside the sphere (7), a through hole (9) is provided on a side wall of the inner tube (8), and the other end of the second connecting portion (6) is connected to a ground joint of the evaporating flask (3).

2. A rotary evaporator for Ticagrelor API according to claim 1, characterized in that: The locking member is a spiral coil (10); the diameter of the first connecting portion (5) is smaller than the diameter of the rotating drum (2); a circular ring (11) having a diameter matching that of the rotating drum (2) is provided at one end of the first connecting portion (5); a retaining ring (12) is provided at one end of the spiral coil (10); the inner diameter of the retaining ring (12) is smaller than the outer diameter of the circular ring (11); an outer wall of the rotating drum (2) is provided with an external thread and is locked and connected to the first connecting portion (5) via the spiral coil (10).

3. A rotary evaporator for Ticagrelor API according to claim 2, characterized in that: A sealing ring (15) is provided between the end surface of the rotating drum (2) and the circular ring (11).

4. A rotary evaporator for Ticagrelor API according to claim 2, characterized in that: An annular groove (13) is provided on the end surface of the rotating drum (2), and the outer diameter of the circular ring (11) is matched to the diameter of the annular groove (13).

5. A rotary evaporator for Ticagrelor API according to claim 1, characterized in that: The sphere (7) and the inner tube (8) are an integrated structure; one end of the inner tube (8) is connected to the second connecting portion (6), and the other end is provided with a curved surface sealing head (14).

Images