Dry column chromatography device

Abstract

The utility model relates to a dry column chromatography device. The dry column chromatography device comprises a dry column filling and separating system and a filler detecting and cutting system, the dry column chromatography device has the beneficial effects that the dry column chromatography device has practicability and reliability; the dry column filling and separating system is used for filling a chromatographic column in the column tube part, and the filler detecting and cutting system is used for qualitatively identifying components in a chromatographic column filler in the column tube part and cutting the pushed chromatographic column filler; the balance and stability of the dry column chromatography device can be ensured, and the device can be conveniently moved through universal wheels; when the push-out component moves abnormally, the control component is used for enabling the push-out component to stop working so as to protect the whole device; and the device can also be used for classifying and collecting the column chromatography silica gel subjected to detection analysis, pushing-out and cutting, so that convenience is provided for obtaining monomer components in the next step and reusing filler.

Description

Technical Field

[0001] The utility model belongs to the technical field of chromatographic separation, and particularly relates to a dry column chromatography device. Background Art

[0002] With the increasing requirements for energy conservation and environmental protection, the concept of green chemistry has been deeply rooted in people's minds; however, the traditional laboratory wet column chromatography technology, if it wants to achieve better separation efficiency, will use a large amount of developing agent, which will cause waste of resources and environmental pollution; new chromatographic separation and preparation instruments, although they can quickly achieve efficient separation of components, are generally expensive, costing hundreds of thousands, which is not conducive to multi-level and large-scale separation and preparation in the laboratory;

[0003] Therefore, it is necessary to design a new type of efficient and cost-effective dry column chromatography device. Utility Model Content

[0004] The utility model aims to overcome the deficiencies in the prior art and provide a dry column chromatography device.

[0005] The dry column chromatography device is provided with a matching column tube component, which can be detachably mounted on the dry column chromatography device; it includes: a dry column filling and separation system and a filler detection and cutting system;

[0006] The dry column packing and separation system comprises a vibration component, a decompression component, a sealing and fixing component and an injection component; the dry column packing and separation system is used to pack the chromatographic column in the column tube component;

[0007] The filler detection and cutting system includes a detection and analysis component, a push-out component, a cutting component, a collection component, a control component and a safety component; the control component is electrically connected to the detection and analysis component, the push-out component, the cutting component, the collection component and the safety component; the filler detection and cutting system is used to qualitatively identify the components in the chromatographic column filler in the column tube component and cut the pushed-out chromatographic column filler.

[0008] Preferably, the dry column is packed in the separation system:

[0009] The vibration component includes a spring, a vibration motor, an adjustable tension wire rope and a frequency converter; the frequency converter is electrically connected to the vibration motor, and the frequency converter is used to control the rotation speed of the vibration motor, which serves as the vibration source of the dry column filling and separation system; a plurality of columns are fixedly provided on the bottom plate A of the dry column filling and separation system, and a flat plate is arranged on the top of the plurality of columns, and the flat plate and the columns together serve as the support structure of the injection component; one end of the spring is fixedly connected to the bottom plate A, the vibration motor is fixedly arranged at the bottom of the support plate, and the other end of the spring is fixedly connected to the support plate, and the spring plays the role of supporting the vibration motor, buffering and converting the vibration effect of the motor; a plurality of column tubes are also fixed on the support plate, and a flat plate is arranged on the top of the column tube, and the column tube and the flat plate together serve as the support structure of the column tube component; the column tube on the support plate and the column on the bottom plate A are clamped by an adjustable tension wire rope to adjust the vibration frequency and intensity of each part of the column and the column to be consistent; the vibration motor provides a stable vibration frequency and intensity for the column tube component, so that the filler is tightly and evenly distributed, thereby improving the column efficiency;

[0010] The decompression component includes a circulating water multi-purpose vacuum pump, a vacuum decompression connecting component and a safety bottle; the vacuum decompression connecting component is connected to the safety bottle, and the safety bottle is also connected to the vacuum pump; the vacuum pump is used to provide power for the dry column filling and separation of the column tube component, the vacuum decompression connecting component is used to ensure the air tightness of the decompression component, and the safety bottle is used to prevent water back-inhalation caused by improper closing of the vacuum pump;

[0011] The column tube component includes a chromatographic column, a column cap and a dovetail piston; the sealing and fixing component includes two E-type plates, two column caps, two compression locks and a locker; grooves are provided on the upper and lower sides of the chromatographic column, and sealing rings are installed in the grooves, and column caps are also provided next to the sealing rings; the two E-type plates and two compression locks respectively press the column cap on the lower side of the chromatographic column and the column support platform on both sides to ensure the overall sealing of the decompression component and the column tube component; the locker fixes and locks the column cap on the upper side of the chromatographic column in the column tube component to the flat plate supporting the column tube component to ensure that the column tube component as a whole is perpendicular to the support platform and maintains vertical stability during vibration; the column cap on the lower side is fixedly connected to one end of the dovetail piston; the chromatographic column is filled with a developing agent; the dovetail piston is composed of a piston, a fluororubber sealing ring, a dense stainless steel mesh and a fluororubber cap with holes from bottom to top;

[0012] The sampling component comprises an expansion valve, an air release valve, a uniform liquid adder and a funnel; the lower part of the funnel is connected to the uniform liquid adder, and the expansion valve is arranged on the connecting pipeline between the funnel and the uniform liquid adder; the uniform liquid adder is also provided with an air release valve.

[0013] Preferably, the filler detection cutting system includes:

[0014] The filler detection and cutting system is provided with a bottom plate B, and a plurality of universal wheels are symmetrically provided at the bottom of the bottom plate B; the power supply, control components and safety components are all provided on the bottom plate B; a plurality of support columns are provided on the bottom plate B, and a column support platform is provided on the top of the support column; a push-out component is provided at the center of the bottom plate B; a support column is provided on the outer side of the column support platform, and a support plate is provided on the top of the support column;

[0015] The detection and analysis components are arranged above the supporting cutting platform;

[0016] The cutting component is arranged on the upper part of the support plate; the bottom of both sides of the support plate is provided with slides and slide rails in the vertical direction, which are used to adjust the height of the supporting plate according to the degree to which the column tube component is pushed out; the cutting component includes a stepper motor A, a power supply, a stepper motor driver with a housing, a rectifier bridge, a transformer A and a single-chip microcomputer; the output end of the power supply is electrically connected to the input end of the transformer A, the output end of the transformer A is electrically connected to the input end of the rectifier bridge, and the output end of the rectifier bridge is electrically connected to the stepper motor A and the stepper motor driver with a housing; the rotating shaft of the stepper motor A is connected to the scraper arranged on the cutting platform; the single-chip microcomputer The stepper motor driver with housing is electrically connected, and the stepper motor driver with housing is electrically connected to the stepper motor A; the transformer A and the rectifier bridge are used to convert 220V AC power into 12V DC power to supply power to the stepper motor A and the stepper motor driver with housing; the single chip computer sends commands to the stepper motor A and the stepper motor driver with housing to control the speed and direction of the stepper motor A and cut the dry column section after being pushed out; the model of the stepper motor A is SK4234-51, the model of the stepper motor driver with housing is TB6600, and the model of the transformer A is YD-400VA;

[0017] The ejection components include a power supply, a transformer B, a single-chip microcomputer, a stepper motor driver, a stepper motor B, a plum blossom coupling, a ball screw, a ball support seat, a column push rod connector and a dovetail column push rod; the output end of the power supply is electrically connected to the input end of the transformer B, and the output end of the transformer B is electrically connected to the stepper motor driver and the stepper motor B; the stepper motor B is connected to the plum blossom coupling and the column push rod connector; the lower side of the dovetail piston is connected to the dovetail column push rod by a seam, which ensures the stability of the hardware connection during the process of ejecting the filler and the disassembly of the components after the experiment is completed; the model of the transformer B is YD-400VA, the model of the stepper motor driver is HB-556H, and the model of the stepper motor B is 86BY GH250D; transformer B converts 220V AC power into 46V AC voltage to power the stepper motor driver and the stepper motor; the single chip microcomputer is used to control the stepper motor driver to drive the stepper motor B, and the stepper motor B controls the rotation step and direction of the ball screw, thereby controlling the rise or fall of the dovetail column push rod, and controls the push-out distance of the push-out component by changing the rotation step of the ball screw; the dovetail column push rod is also fixedly connected to the ball support seat, and the ball support seat is also fixedly connected to the column push rod connector; the column push rod connector is fixedly connected to the ball screw, and the ball screw is fixedly connected to the plum blossom coupling; a plurality of screw guide rails are symmetrically arranged on the bottom plate A, and the outer edge of the column support platform is fixedly arranged on the screw guide rail;

[0018] The collecting component is used to classify and collect the column chromatography silica gel that has been detected, analyzed, pushed out and cut, so as to facilitate the reuse of monomer components and fillers in the next step.

[0019] As a preferred embodiment, the bottom plate B is a carbon steel base; and a foot brake is provided on the universal wheel.

[0020] As a preferred embodiment, the control component uses the STC-12C5A60S2 single-chip microcomputer.

[0021] Preferably, the safety component is a touch switch; and the detection and analysis component is an ultraviolet detection component or an optical fiber spectrometer detection component.

[0022] Preferably: the ultraviolet detection component consists of an ultraviolet light source, two convex lenses, an ultraviolet detector, an AD conversion module, a digital display screen, a circuit board, a switch and a plurality of wire arrangements; the digital display screen is electrically connected to the AD conversion module, and the AD conversion module is electrically connected to the ultraviolet detector; the ultraviolet light source is located on the optical path of one of the convex lenses, and the ultraviolet detector is placed on the exit optical path of the second convex lens; the column chromatography silica gel surface is placed on the exit optical path of the first convex lens and the incident optical path of the second convex lens.

[0023] As a preference, the support platform is a lifting support platform.

[0024] Preferably, the chromatographic column comprises a glass column and a stainless steel column.

[0025] The beneficial effects of the utility model are as follows: the dry column chromatography device designed by the utility model is practical and reliable; the dry column filling and separation system is used to fill the chromatographic column in the column tube component, and the filler detection and cutting system is used to qualitatively identify the components in the chromatographic column filler in the column tube component, and cut the pushed out chromatographic column filler; the balance and stability of the dry column chromatography device can be ensured, and the convenient movement of the device can be achieved by the universal wheel; when the pushing component moves abnormally, the control component is used to stop the pushing component from working to protect the entire device; it can also be used to classify and collect the column chromatography silica gel that has been detected, analyzed, pushed out and cut, so as to provide convenience for the next step of obtaining the monomer components and the reuse of the filler. BRIEF DESCRIPTION OF THE DRAWINGS

[0026] Figure 1 A schematic diagram of the filling and separation system structure;

[0027] Figure 2 It is a structural schematic diagram of a dovetail piston;

[0028] Figure 3 It is a structural schematic diagram of the injection component;

[0029] Figure 4 It is a structural schematic diagram of the filler detection and cutting system;

[0030] Figure 5 It is a schematic diagram of the composition of the ultraviolet detection component;

[0031] Figure 6 It is a structural schematic diagram of the detection components of the optical fiber spectrometer;

[0032] Figure 7 This is a schematic diagram of the structure of the launch system.

[0033] Description of reference numerals: spring 1, vibration motor 2, adjustable tension wire rope 3, vacuum decompression connecting component 4, vacuum pump 5, safety bottle 6, column tube component 7, injection component 8, E-type plate 9, pressure lock 10, lock 11, bottom plate A12, stainless steel mesh 13, perforated fluororubber cap 14, dovetail piston 15, column tube 16, expansion valve 17, deflation valve 18, uniform liquid adder 19, funnel 20, sealing ring 21, universal wheel 22, power supply 23, control component 24, safety component 25, ejection component 26, cutting component 27, detection and analysis component 28, Base plate B29, column supporting platform 30, supporting column 31, slide and slide rail 32, cutting platform 33, ultraviolet light source 34, convex lens 35, column chromatography silica gel surface 36, ultraviolet detector 37, AD conversion module 38, digital display screen 39, light source 40, optical fiber bundle 41, sampling probe 42, silica gel surface to be tested 43, optical fiber spectrometer 44, control equipment 45, stepper motor B46, plum blossom coupling 47, ball screw 48, ball support seat 49, column push rod connector 50, dovetail column push rod 51, column cap 52, screw guide rail 53, chromatographic column 54. DETAILED DESCRIPTION

[0034] The utility model is further described below in conjunction with the embodiments. The description of the following embodiments is only used to help understand the utility model. It should be pointed out that for ordinary people in this technical field, the utility model can also be modified in some ways without departing from the principle of the utility model, and these improvements and modifications also fall within the scope of protection of the claims of the utility model.

[0035] As an example, Figures 1 to 7 As shown, a dry column chromatography device is provided with a column tube component 7 matched therewith, and the column tube component 7 can be detachably mounted on the dry column chromatography device; it is characterized in that it comprises: a dry column filling and separation system and a filler detection and cutting system;

[0036] The dry column packing and separation system comprises a vibration component, a decompression component, a sealing and fixing component and a sampling component 8; the dry column packing and separation system is used to pack the chromatographic column in the column tube component 7; in the dry column packing and separation system:

[0037] The vibration component includes a spring 1, a vibration motor 2, an adjustable tension wire rope 3 and a frequency converter; the frequency converter is electrically connected to the vibration motor 2, and the frequency converter is used to control the rotation speed of the vibration motor 2, which serves as the vibration source of the dry column filling and separation system; a plurality of columns are fixedly provided on the bottom plate A12 of the dry column filling and separation system, and a flat plate is arranged on the top of the plurality of columns, and the flat plate and the columns together serve as the support structure of the injection component 8; one end of the spring 1 is fixedly connected to the bottom plate A12, the vibration motor 2 is fixedly arranged at the bottom of the support plate, and the other end of the spring 1 is fixedly connected to the support The plate and the spring play the role of supporting the vibration motor, buffering and converting the vibration effect of the motor; a plurality of column tubes 16 are also fixed on the support plate, and a flat plate is set on the top of the column tube 16, and the column tube 16 and the flat plate together serve as the support structure of the column tube component 7; the column tube 16 on the support plate and the column on the bottom plate A12 are clamped by an adjustable tension wire rope 3, so that the vibration frequency and intensity of each part of the column and the column are adjusted to be consistent; the vibration motor provides a stable vibration frequency and intensity for the column tube component, so that the filler is tightly and evenly distributed, thereby improving the column efficiency;

[0038] The decompression component includes a circulating water multi-purpose vacuum pump 5, a vacuum decompression connecting component 4 and a safety bottle 6; the vacuum decompression connecting component 4 is connected to the safety bottle 6, and the safety bottle 6 is also connected to the vacuum pump 5; the vacuum pump is used to provide power for the dry column filling and separation of the column tube component, the vacuum decompression connecting component is used to ensure the airtightness of the decompression component, and the safety bottle is used to prevent water back-sucking caused by improper closing of the vacuum pump;

[0039] The column tube component 7 includes a chromatographic column 54 glass column and a stainless steel column, a column cap 52 and a dovetail piston 15; the sealing and fixing components include two E-shaped plates 9, two column caps 52, two pressure locks 10 and a locker 11; the chromatographic column 54 is provided with grooves on both sides, and a sealing ring 21 is installed in the groove, and a column cap 52 is also provided next to the sealing ring 21; the two E-shaped plates 9 and the two pressure locks 10 respectively press the column cap 52 on the lower side of the chromatographic column 54 and the column support platform 30 lifting support platform on both sides to ensure the reduction The locking device 11 fixes and locks the column cap 52 on the upper side of the chromatographic column 54 in the column tube component 7 on the flat plate supporting the column tube component 7, ensuring that the column tube component as a whole is perpendicular to the supporting platform and maintains vertical stability during vibration; the column cap 52 on the lower side is fixedly connected to one end of the dovetail piston 15; the chromatographic column 54 is filled with a developing agent; the dovetail piston 15 is composed of a piston, a fluororubber sealing ring, a dense stainless steel mesh 13 and a perforated fluororubber cap 14 from bottom to top;

[0040] The sample injection component 8 includes an expansion valve 17, an air release valve 18, a uniform liquid feeder 19 and a funnel 20; the lower part of the funnel 20 is connected to the uniform liquid feeder 19, and the expansion valve 17 is provided on the connecting pipe between the funnel 20 and the uniform liquid feeder 19; the uniform liquid feeder 19 is also provided with an air release valve 18;

[0041] The packing detection and cutting system includes a detection and analysis component 28, a push component 26, a cutting component 27, a collecting component, a control component 24 STC-12C5A60S2 single chip computer and a safety component 25 touch switch; the control component 24 is electrically connected to the detection and analysis component 28, the push component 26, the cutting component 27, the collecting component and the safety component 25; the packing detection and cutting system is used to qualitatively identify the components in the chromatographic column packing in the column tube component 7 and cut the pushed chromatographic column packing; in the packing detection and cutting system:

[0042] The filler detection and cutting system is provided with a bottom plate B29 carbon steel base, a plurality of universal wheels 22 are symmetrically provided at the bottom of the bottom plate B29, and a foot brake is provided on the universal wheel 22; a power supply 23, a control component 24 and a safety component 25 are all provided on the bottom plate B29; a plurality of support columns 31 are provided on the bottom plate B29, and a column support platform 30 lifting support platform is provided on the top of the support column 31; a push-out component 26 is provided at the center of the bottom plate B29; a support column is provided on the outer side of the column support platform 30, and a support plate is provided on the top of the support column;

[0043] The detection and analysis component 28 is arranged above the cutting platform 33; the detection and analysis component 28 is an ultraviolet detection component or an optical fiber spectrometer detection component; the ultraviolet detection component is composed of an ultraviolet light source 34, two convex lenses 35, an ultraviolet detector 37, an AD conversion module 38, a digital display screen 39, a circuit board, a switch and a plurality of wires; the digital display screen 39 is electrically connected to the AD conversion module 38, and the AD conversion module 38 is electrically connected to the ultraviolet detector 37; the ultraviolet light source 34 is located on the optical path of one of the convex lenses 35, and the ultraviolet detector 37 is placed The optical fiber spectrometer detection component is composed of a light source 40, an optical fiber bundle 41, a sampling probe 42, an optical fiber spectrometer 44 and a control device 45; the light source 40 is connected to the sampling probe 42 through the optical fiber bundle 41, the sampling probe 42 is connected to the optical fiber spectrometer 44 through the optical fiber bundle 41, and the optical fiber spectrometer 44 is electrically connected to the control device 45; the sampling probe 42 is placed perpendicular to the silica gel surface 43 to be tested;

[0044] The cutting component 27 is arranged on the upper part of the support plate; the bottom of both sides of the support plate is provided with slides and slide rails 32 in the vertical direction, which are used to adjust the height of the supporting plate according to the degree to which the column tube component is pushed out; the cutting component 27 includes a stepper motor A, a power supply 23, a stepper motor driver with a housing, a rectifier bridge, a transformer A and a single-chip microcomputer; the output end of the power supply 23 is electrically connected to the input end of the transformer A, the output end of the transformer A is electrically connected to the input end of the rectifier bridge, and the output end of the rectifier bridge is electrically connected to the stepper motor A and the stepper motor driver with a housing; the rotating shaft of the stepper motor A is connected to the stepper motor driver provided on the cutting platform 33 Scraper; the single chip microcomputer is electrically connected to the stepper motor driver with housing, and the stepper motor driver with housing is electrically connected to the stepper motor A; the transformer A and the rectifier bridge are used to convert 220V AC power into 12V DC power to supply power to the stepper motor A and the stepper motor driver with housing; the single chip microcomputer sends commands to the stepper motor A and the stepper motor driver with housing to control the speed and direction of the stepper motor A to cut the pushed-out dry column segment; the model of the stepper motor A is SK4234-51, the model of the stepper motor driver with housing is TB6600, and the model of the transformer A is YD-400VA;

[0045] The ejection component 26 includes a power supply 23, a transformer B, a single-chip microcomputer, a stepper motor driver, a stepper motor B46, a plum blossom coupling 47, a ball screw 48, a ball support seat 49, a column push rod connector 50 and a dovetail column push rod 51; the output end of the power supply 23 is electrically connected to the input end of the transformer B, and the output end of the transformer B is electrically connected to the stepper motor driver and the stepper motor B46; the stepper motor B46 is connected to the plum blossom coupling 47 and the column push rod connector 50; the lower side of the dovetail piston 15 is connected to the dovetail column push rod 51 by a seam, which ensures the stability of the hardware connection during the process of ejecting the filler and the disassembly of the components after the experiment is completed; the model of the transformer B is YD-400VA, the model of the stepper motor driver is HB-556H, and the model of the stepper motor B is 8 6BYGH250D; transformer B converts 220V AC into 46V AC voltage to power the stepper motor driver and the stepper motor; the single chip microcomputer is used to control the stepper motor driver to drive the stepper motor B, and the stepper motor B controls the rotation step and direction of the ball screw, thereby controlling the rise or fall of the dovetail column push rod, and controls the push distance of the push component by changing the rotation step of the ball screw; the dovetail column push rod 51 is also fixedly connected to the ball support seat 49, and the ball support seat 49 is also fixedly connected to the column push rod connector 50; the column push rod connector 50 is fixedly connected to the ball screw 48, and the ball screw 48 is fixedly connected to the plum blossom coupling 47; a plurality of screw guide rails 53 are symmetrically arranged on the bottom plate A12, and the outer edge of the column support platform 30 is fixedly arranged on the screw guide rail 53;

[0046] The collecting component is used to classify and collect the column chromatography silica gel that has been detected, analyzed, pushed out and cut, so as to facilitate the reuse of monomer components and fillers in the next step.

Claims

1. A dry column chromatography device, provided with a column tube component (7) matching therewith, wherein the column tube component (7) can be detachably mounted on the dry column chromatography device; characterized in that: include: Dry column filling and separation system and filler detection and cutting system; The dry column filling and separation system comprises a vibration component, a decompression component, a sealing and fixing component and a sampling component (8); the dry column filling and separation system is used to fill the chromatographic column in the column tube component (7); The filler detection and cutting system comprises a detection and analysis component (28), a pushing component (26), a cutting component (27), a collecting component, a control component (24) and a safety component (25); the control component (24) is electrically connected to the detection and analysis component (28), the pushing component (26), the cutting component (27), the collecting component and the safety component (25); the filler detection and cutting system is used to qualitatively identify the components in the chromatographic column filler in the column tube component (7) and cut the pushed chromatographic column filler.

2. The dry column chromatography device according to claim 1, characterized in that: Dry column packing separation system: The vibration component comprises a spring (1), a vibration motor (2), an adjustable tension steel wire rope (3) and a frequency converter; the frequency converter is electrically connected to the vibration motor (2), and the frequency converter is used to control the rotation speed of the vibration motor (2); a plurality of columns are fixedly provided on the bottom plate A (12) of the dry column filling separation system, a flat plate is mounted on the top of the plurality of columns, and the flat plate and the columns together serve as a support structure for the sample injection component (8); one end of the spring (1) is fixedly connected to the bottom plate A (12), the vibration motor (2) is fixedly arranged at the bottom of the support plate, and the other end of the spring (1) is fixedly connected to the support plate; a plurality of column tubes (16) are also fixed on the support plate, a flat plate is mounted on the top of the column tubes (16), and the column tubes (16) and the flat plate together serve as a support structure for the column tube component (7); the column tubes (16) on the support plate and the columns on the bottom plate A (12) are clamped by the adjustable tension steel wire rope (3); The decompression component comprises a vacuum pump (5), a vacuum decompression connecting component (4) and a safety bottle (6); the vacuum decompression connecting component (4) is connected to the safety bottle (6), and the safety bottle (6) is also connected to the vacuum pump (5); The column tube component (7) comprises a chromatographic column (54), a column cap (52) and a dovetail piston (15); the sealing and fixing component comprises two E-shaped plates (9), two column caps (52), two press locks (10) and a locker (11); the chromatographic column (54) is provided with grooves on both upper and lower sides, a sealing ring (21) is installed in the groove, and a column cap (52) is also provided adjacent to the sealing ring (21); the two E-shaped plates (9) and the two press locks (10) respectively lock the chromatographic column (54) at both sides. The column cap (52) on the side is pressed against the column support platform (30); the locking device (11) fixes and locks the column cap (52) on the upper side of the chromatographic column (54) in the column tube component (7) on the flat plate supporting the column tube component (7); the column cap (52) on the lower side is fixedly connected to one end of the dovetail piston (15); the chromatographic column (54) is filled with a developing agent; the dovetail piston (15) is composed of a piston, a fluororubber sealing ring, a stainless steel mesh (13) and a fluororubber cap (14) with holes from bottom to top; The sample injection component (8) comprises an expansion valve (17), an air release valve (18), a uniform liquid adder (19) and a funnel (20); the lower part of the funnel (20) is connected to the uniform liquid adder (19); the expansion valve (17) is arranged on the connecting pipe between the funnel (20) and the uniform liquid adder (19); and the uniform liquid adder (19) is also provided with an air release valve (18).

3. The dry column chromatography device according to claim 1, characterized in that: Filler detection and cutting system: The filler detection and cutting system is provided with a bottom plate B (29), and a plurality of universal wheels (22) are symmetrically provided at the bottom of the bottom plate B (29); a power supply (23), a control component (24) and a safety component (25) are all provided on the bottom plate B (29); a plurality of support columns (31) are provided on the bottom plate B (29), and a column support platform (30) is provided on the top of the support column (31); a push-out component (26) is provided at the center of the bottom plate B (29); a support column is provided on the outer side of the column support platform (30), and a support plate is provided on the top of the support column; The detection and analysis component (28) is arranged above the cutting support platform (33); The cutting component (27) is arranged on the upper part of the support plate; slides and slide rails (32) are arranged on the bottom of both sides of the support plate in the vertical direction; the cutting component (27) comprises a stepper motor A, a power supply (23), a stepper motor driver with a housing, a rectifier bridge, a transformer A and a single-chip microcomputer; the output end of the power supply (23) is electrically connected to the input end of the transformer A, the output end of the transformer A is electrically connected to the input end of the rectifier bridge, and the output end of the rectifier bridge is electrically connected to the stepper motor A and the stepper motor driver with a housing; the rotating shaft of the stepper motor A is connected to a scraper arranged on the cutting platform (33); the single-chip microcomputer is electrically connected to the stepper motor driver with a housing, and the stepper motor driver with a housing is electrically connected to the stepper motor A; The push-out component (26) comprises a power supply (23), a transformer B, a single-chip microcomputer, a stepper motor driver, a stepper motor B (46), a plum blossom coupling (47), a ball screw (48), a ball support seat (49), a column push rod connector (50) and a dovetail column push rod (51); the output end of the power supply (23) is electrically connected to the input end of the transformer B, and the output end of the transformer B is electrically connected to the stepper motor driver and the stepper motor B (46); the stepper motor B (46) is connected to the plum blossom coupling (47) and the column push rod connector (50); the lower side of the dovetail piston (15) is connected to the dovetail column push rod (51); the dovetail column push rod (51) is also fixedly connected to the ball support seat (49), and the ball support seat (49) is also fixedly connected to the column push rod connector (50); the column push rod connector (50) is fixedly connected to the ball screw (48), and the ball screw (48) is fixedly connected to the plum blossom coupling (47); a plurality of screw guide rails (53) are symmetrically arranged on the bottom plate A (12), and the outer edge of the column support platform (30) is fixedly arranged on the screw guide rail (53).

4. The dry column chromatography device according to claim 3, characterized in that: The bottom plate B (29) is a carbon steel base; the universal wheel (22) is provided with a foot brake.

5. The dry column chromatography device according to claim 3, characterized in that: The control component (24) is a STC-12C5A60S2 single chip microcomputer.

6. The dry column chromatography device according to claim 3, characterized in that: The safety component (25) is a touch switch; and the detection and analysis component (28) is an ultraviolet detection component or an optical fiber spectrometer detection component.

7. The dry column chromatography device according to claim 6, characterized in that: The ultraviolet detection component is composed of an ultraviolet light source (34), two convex lenses (35), an ultraviolet detector (37), an AD conversion module (38), a digital display screen (39), a circuit board, a switch, and a plurality of wires and cables; the digital display screen (39) is electrically connected to the AD conversion module (38), and the AD conversion module (38) is electrically connected to the ultraviolet detector (37); the ultraviolet light source (34) is located on the optical path of one of the convex lenses (35), and the ultraviolet detector (37) is placed on the exit optical path of the second convex lens (35); and the column chromatography silica gel surface (36) is placed on the exit optical path of the first convex lens (35) and the incident optical path of the second convex lens (35).

8. The dry column chromatography device according to claim 3, characterized in that: The supporting platform (30) is a lifting supporting platform.

9. The dry column chromatography device according to claim 2, characterized in that: The chromatographic column (54) includes a glass column and a stainless steel column.

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