Mannitol injection production line

Abstract

The mannitol injection production line comprises a water preparation system, a liquid preparation system, a bag making system, a filling and sealing system, a sterilization system and a detection system, the liquid preparation system comprises a thick preparation tank, a thin preparation tank, a fifth filtering device, a sixth filtering device, a seventh filtering device and a second static electricity removing device, the second static electricity removing device is arranged in the space where the thick preparation tank is located, the thick preparation tank is communicated with the thin preparation tank, the input end of the fifth filtering device is communicated with the output end of the liquid preparation system, and the output end of the sixth filtering device is communicated with the output end of the liquid preparation system. The input end of the sixth filtering device is communicated with the thick mixing tank and the thin mixing tank, the output end of the sixth filtering device is communicated with the thin mixing tank, the output end of the sixth filtering device is communicated with the input end of the seventh filtering device, and the output end of the seventh filtering device is communicated with the filling and sealing system. The production line changes a traditional structure and does not need to use activated carbon.

Description

Technical Field

[0001] The utility model relates to the technical field of pharmaceuticals, in particular to a mannitol injection production line. Background Art

[0002] 20% mannitol injection is widely used in the clinic of neurosurgery as a free radical scavenger to reduce intracranial pressure. At present, mannitol is the first choice for treating cerebral edema and reducing intracranial pressure. It has a significant effect in reducing intracranial pressure without obvious "rebound phenomenon". Since 20% mannitol solution is a supersaturated solution, the crystallization of mannitol injection has brought great inconvenience to clinical use. When the room temperature is lower than 15°C, mannitol will precipitate crystals and cannot be used immediately. The crystals need to be dissolved before intravenous injection, which is time-consuming and laborious. In addition, some crystals are tiny particles that are invisible to the naked eye. In this case, using it will lead to adverse consequences such as infusion reactions.

[0003] As shown in the Chinese invention patent application with application number 96120548.2 and the Chinese invention patent application with application number 201711416420.8, the preparation method of mannitol injection and the corresponding production line are disclosed. It can be seen that the prior art mainly improves the formula of mannitol injection by adding substances such as mannitol, glucose or glycerol to the mannitol injection or adding auxiliary materials such as cosolvents to solve the problem of easy crystallization of mannitol. However, there are few additives with good efficacy, no crystallization at low temperature and high safety, and there are many restrictions in terms of selection; and the production line of the prior art needs to add activated carbon to remove pyrogens when preparing the liquid, but this not only requires the addition of an activated carbon removal device, making the production line complicated, but also introduces some impurities and insoluble particles, which will bring risks to the application safety of the liquid. Utility Model Content

[0004] The utility model aims to provide a mannitol injection production line, which can at least solve one of the above problems.

[0005] To achieve the above object, according to one aspect of the utility model, a mannitol injection production line is provided, comprising a water preparation system, a liquid preparation system, a bag making system, a filling system, a sterilization system and a detection system;

[0006] The water preparation system is used to prepare drinking water into water for injection;

[0007] The liquid preparation system is configured to prepare mannitol injection using water for injection;

[0008] The bag making system is configured to prepare empty flexible bags;

[0009] The filling and sealing system is configured to fill the mannitol injection prepared by the liquid preparation system into an empty soft bag and seal it to obtain a semi-finished product;

[0010] The sterilization system is configured to sterilize semi-finished products;

[0011] The inspection system is configured to perform light inspection on semi-finished products after sterilization;

[0012] The liquid preparation system includes a concentrated preparation tank, a dilute preparation tank, a fifth filter device, a sixth filter device, a seventh filter device and a second static electricity removal device. The second static electricity removal device is arranged in the space where the concentrated preparation tank is located. The concentrated preparation tank is connected to the dilute preparation tank. The input end of the fifth filter device is connected to the output end of the liquid preparation system, and the output end is connected to the concentrated preparation tank and the dilute preparation tank respectively. The input end of the sixth filter device is connected to the dilute preparation tank, and the output end is connected to the input end of the seventh filter device. The output end of the seventh filter device is connected to the filling system.

[0013] Therefore, the utility model provides a mannitol injection production line with a brand-new structure. The production line changes the traditional production line structure. By adopting a static electricity removal device before liquid preparation, the introduction of particles in raw materials or air is reduced or even avoided. At the same time, a filtering device is set before and after liquid preparation to filter the liquid before and after liquid preparation, which can effectively remove endotoxins in raw materials and introduced during the preparation process. Through this design, the purity and safety of the final output liquid can be guaranteed. Most importantly, no activated carbon is required in the entire liquid preparation process.

[0014] In some embodiments, the fifth filtration device is a microporous filter equipped with a 0.22 μm filter element.

[0015] In some embodiments, the sixth filter device is a microporous filter equipped with a 0.1 μm filter element, and the seventh filter device is a microporous filter equipped with a 0.22 μm filter element.

[0016] In some embodiments, the liquid preparation system further includes a weighing device and a first static electricity removal device. The weighing device is used to weigh the raw materials added to the concentrated preparation tank, and the first static electricity removal device is arranged in the space where the weighing device is located; the first static electricity removal device and the second static electricity removal device are ion blowers. Therefore, the weighing device is convenient for accurately weighing the raw materials, and the arrangement of the first static electricity removal device can effectively reduce or even prevent particles in the air or other equipment and facilities from being brought into the raw materials during weighing.

[0017] In some embodiments, the water preparation system includes a first filter device, a second filter device, a third filter device, a primary reverse osmosis device, an ion exchange device, a fourth filter device and a distillation device, wherein the input end of the first filter device is connected to the drinking water supply end, and the output end is connected to the input end of the second filter device, the output end of the second filter device is connected to the input end of the third filter device, the output end of the third filter device is connected to the input end of the primary reverse osmosis device, the output end of the primary reverse osmosis device is connected to the input end of the ion exchange device, the output end of the ion exchange device is connected to the input end of the fourth filter device, the output end of the fourth filter device is connected to the input end of the distillation device, and the output end of the distillation device is connected to the input end of the fifth filter device. Thus, pharmaceutical grade water for injection is easily prepared.

[0018] In some embodiments, the first filter device is a multi-media filter, the second filter device is an activated carbon filter, the third filter device is a security filter, and the fourth filter device is a microporous filter equipped with a 0.1 μm filter element.

[0019] In some embodiments, the bag making system includes a heat sealing bag making device and a printing device. The printing device is arranged in front of the heat sealing bag making device and is used to print on the film material entering the heat sealing bag making device. The heat sealing bag making device uses the film material and the interface to heat seal the bag to obtain an empty soft bag with an interface.

[0020] In some embodiments, the filling system includes a filling device and a sealing device. The filling device cooperates with the seventh filtering device and the heat-sealing bag-making device to fill the liquid medicine output from the seventh filtering device into an empty soft bag prepared by the heat-sealing bag-making device. The sealing device cooperates with the filling device to seal the soft bag filled with the liquid medicine using a combination cover to obtain a semi-finished product.

[0021] In some embodiments, the potting system further comprises a third static electricity removal device, and the third static electricity removal device is disposed between the sealing device and;

[0022] The third static electricity removal device includes a conveyor belt and an ion wind rod. The two ends of the conveyor belt are respectively connected to the output end of the filling device and the input end of the sterilization system. The conveyor belt is a mesh conveyor belt. The ion wind rods are at least a pair. The paired ion wind rods are arranged opposite to each other and are respectively located at the upper and lower ends of the conveying surface of the conveyor belt.

[0023] In some embodiments, the mannitol injection production line further includes a packaging system, which is disposed behind the detection system and is configured to package semi-finished products with packaging materials to obtain finished products.

[0024] Beneficial effects of the utility model:

[0025] The utility model provides a mannitol injection production line with a brand-new structure. The production line changes the traditional production line structure and does not need to use activated carbon in the liquid preparation process. By adopting a static electricity removal device before liquid preparation, the introduction of particles in raw materials or air can be reduced or even avoided, thereby controlling the source. At the same time, by arranging a filtering device before and after liquid preparation, the liquid medicine before and after liquid preparation is filtered, which can effectively remove the endotoxin introduced in the raw materials and the preparation process. Through this design, the purity and safety of the final output liquid medicine can be guaranteed. BRIEF DESCRIPTION OF THE DRAWINGS

[0026] Figure 1 This is a simplified system block diagram of a mannitol injection production line according to one embodiment of the utility model;

[0027] Figure 2 for Figure 1 The structural block diagram of the mannitol injection production line after further refinement is shown;

[0028] Figure 3 for Figure 2 A simplified structural schematic diagram of a third static electricity removal device in one embodiment of a mannitol injection production line is shown.

[0029] Figure numerals: 1-water preparation system; 2-liquid preparation system; 3-bag making system; 4-filling system; 5-sterilization system; 6-detection system; 7-packaging system; 11-first filtering device; 12-second filtering device; 13-third filtering device; 14-primary reverse osmosis device; 15-ion exchange device; 16-fourth filtering device; 17-distillation device; 21-concentrated preparation tank; 22-diluted preparation tank; 23-fifth filtering device; 24-sixth filtering device; 25- The seventh filtering device; 26- weighing device; 27- the first static electricity removal device; 28- the second static electricity removal device; 31- printing device; 32- heat sealing bag making device; 41- filling device; 42- sealing device; 43- the third static electricity removal device; 100- drinking water; 200- water for injection; 300- empty soft bag; 400- film material; 500- interface; 600- combination cover; 700- packaging material; 800- semi-finished product; 900- finished product; 1000- raw and auxiliary materials. DETAILED DESCRIPTION

[0030] The utility model is further described in detail below in conjunction with the accompanying drawings.

[0031] Figures 1 to 3 The figure schematically shows a mannitol injection production line according to one embodiment of the utility model.

[0032] like Figures 1 to 3As shown, the mannitol injection production line includes a water preparation system 1, a liquid preparation system 2, a bag making system 3, a filling system 4, a sterilization system 5 and a detection system 6;

[0033] The water preparation system 1 is used to prepare drinking water 100 into water for injection 200;

[0034] The liquid preparation system 2 is configured to prepare mannitol injection using water for injection 200;

[0035] The bag making system 3 is configured to prepare an empty flexible bag 300;

[0036] The filling system 4 is configured to fill the mannitol injection prepared by the liquid preparation system 2 into the empty soft bag 300 and seal it to obtain a semi-finished product 800;

[0037] The sterilization system 5 is configured to sterilize the semi-finished product 800;

[0038] The detection system 6 is configured to perform light inspection on the semi-finished product 800 after sterilization;

[0039] The liquid preparation system 2 includes a concentrated preparation tank 21, a dilute preparation tank 22, a fifth filter device 23, a sixth filter device 24, a seventh filter device 25 and a second static electricity removal device 28. The second static electricity removal device 28 is arranged in the space where the concentrated preparation tank 21 is located. The concentrated preparation tank 21 is connected to the dilute preparation tank 22. The input end of the fifth filter device 23 is connected to the output end of the liquid preparation system 2, and the output end is respectively connected to the concentrated preparation tank 21 and the dilute preparation tank 22. The input end of the sixth filter device 24 is connected to the dilute preparation tank 22, and the output end is connected to the input end of the seventh filter device 25. The output end of the seventh filter device 25 is connected to the potting system 4.

[0040] The fifth filter device 23 is a microporous filter equipped with a 0.22 μm filter element.

[0041] The sixth filter device 24 is a microporous filter equipped with a 0.1 μm filter element, and the seventh filter device 25 is a microporous filter equipped with a 0.22 μm filter element.

[0042] The liquid preparation system 2 also includes a weighing device 26 and a first static electricity removal device 27. The weighing device 26 is used to weigh the raw and auxiliary materials 1000 added to the concentrated preparation tank 21. The first static electricity removal device 27 is arranged in the space where the weighing device 26 is located; the first static electricity removal device 27 and the second static electricity removal device 28 are commercially available ion blowers. The main function of the ion blower is to remove static electricity. It has outstanding static electricity removal performance and prevents static electricity pollution and damage. It is an ideal device for electronic production lines to prevent electrostatic discharge (ESD) phenomena, maintenance stations and other personal electrostatic protection areas (EPA). It is designed for local areas. It has the characteristics of small size, light weight and easy installation. It can be installed in a building block style and is suitable for various places. Generally, ion blowers can be divided into desktop ion blowers, horizontal ion blowers, hanging ion blowers and micro ion blowers. As a result, it is convenient to accurately weigh the raw and auxiliary materials 1000. The setting of the first static electricity removal device 27 can effectively reduce or even prevent particles in the air or other equipment and facilities from being brought into the raw and auxiliary materials 1000 during weighing.

[0043] The water preparation system 1 comprises a first filter device 11, a second filter device 12, a primary reverse osmosis device 14, an ion exchange device 15, a fourth filter device 16 and a distillation device 17, wherein the input end of the first filter device 11 is connected to the supply end of drinking water 100, and the output end is connected to the input end of the second filter device 12, the output end of the second filter device 12 is connected to the input end of the primary reverse osmosis device 14, the output end of the primary reverse osmosis device 14 is connected to the input end of the ion exchange device 15, the output end of the ion exchange device 15 is connected to the input end of the fourth filter device 16, the output end of the fourth filter device 16 is connected to the input end of the distillation device 17, and the output end of the distillation device 17 is connected to the input end of the fifth filter device 23. Thus, it is convenient to prepare pharmaceutical grade water for injection 200.

[0044] The water preparation system 1 further comprises a third filtering device 13 , the input end of the third filtering device 13 is connected to the output end of the second filtering device 12 , and the output end of the third filtering device 13 is connected to the input end of the primary reverse osmosis device 14 .

[0045] The first filter device 11 is a multi-media filter, the second filter device 12 is an activated carbon filter, the third filter device 13 is a security filter, and the fourth filter device 16 is a microporous filter equipped with a 0.1 μm filter element. The ion exchange device 15 is an ion mixed bed device.

[0046] The bag making system 3 includes a heat-sealing bag making device 32 and a printing device 31. The printing device 31 is arranged in front of the heat-sealing bag making device 32 and is used to print the film material 400 entering the heat-sealing bag making device 32. The heat-sealing bag making device 32 uses the film material 400 and the interface 500 to heat-seal and make bags, and obtains an empty soft bag 300 with the interface 500. The filling system 4 includes a filling device 41 and a sealing device 42. The filling device 41 cooperates with the seventh filtering device 25 and the heat-sealing bag making device 32 and is used to fill the liquid medicine output from the seventh filtering device 25 into the empty soft bag 300 prepared by the heat-sealing bag making device 32. The sealing device 42 cooperates with the filling device 41 and is used to seal the soft bag filled with liquid medicine using a combination cover 600 to obtain a semi-finished product 800.

[0047] The filling system 4 further includes a third static electricity removal device 43, which is arranged between the sealing device 42 and the sterilization system 5;

[0048] The third static electricity removal device 43 includes a conveyor belt 431 and an ion wind rod 432. The two ends of the conveyor belt 431 are connected to the output end of the sealing device 42 and the input end of the sterilization system 5 respectively. The conveyor belt 431 is a mesh conveyor belt. The ion wind rod 432 is at least a pair. The ion wind rod 432 of this embodiment is a pair. The paired ion wind rods 432 are arranged opposite to each other and are respectively located at the upper and lower ends of the conveying surface of the conveyor belt 431. Therefore, the third static electricity removal device 43 can effectively remove static electricity on the surface of the semi-finished product 800 to avoid subsequent influence on manual operation or machine operation.

[0049] The mannitol injection production line also includes a packaging system 7 , which is disposed behind the detection system 6 and is configured to package the semi-finished product 800 with packaging materials 700 to obtain a finished product 900 .

[0050] Except for the liquid preparation system 2, the other structures of this embodiment are all prior art, specifically: the specific structure of the heat-sealing bag-making device 32 refers to the Chinese utility model patent with the announcement number CN213198994U and the patent name of the large-capacity infusion bag heat-sealing bag-making device. The specific structure of the printing device 31 refers to the Chinese utility model patent with the announcement number CN208827372U and the patent name of the infusion bag printing device. The specific structure of the sterilization system 5 refers to the Chinese utility model patent with the announcement number CN207810546U and the patent name of the multi-layer co-extrusion large-capacity infusion bag sterilization equipment. The specific structure of the packaging system 7 refers to the Chinese utility model patent with the announcement number CN210761415U and the patent name of the large-capacity infusion bag vacuum packaging machine. The specific structure of the finished product 900 refers to the Chinese utility model patent with the announcement number CN213251239U and the patent name of the infusion bag with outer packaging.

[0051] The specific process flow and parameters of the water preparation system 1 are as follows:

[0052] S11, pre-processing:

[0053] Drinking water 100 passes through a pipeline and a delivery pump, enters a multi-media filter, an activated carbon filter and a security filter, and when the water inlet pressure is greater than 0.1MPa, the high-pressure pump is started to enter the first-stage reverse osmosis.

[0054] S12, first-stage reverse osmosis:

[0055] When the conductivity of produced water is less than 20μs / cm, the produced water can enter the intermediate water tank.

[0056] S13, ion exchange:

[0057] The water produced by the primary reverse osmosis device 14 passes through the ion exchange device 15, and the conductivity and pH of the produced water meet the "Quality Standard for Pharmaceutical Water"; it is sent to the purified water storage tank through a filter with a 1um filter element.

[0058] S14. Preparation of water for injection 200:

[0059] Purified water passes through a multi-effect distilled water machine and a hot-pressed distilled water machine. When the produced water temperature is ≥75°C and the produced water conductivity and pH value meet the "Quality Standards for Pharmaceutical Water", the produced water is sent to the injection water 200 storage tank and circulated at a temperature above 70°C. The storage time shall not exceed 12 hours. If it exceeds 12 hours, it shall be emptied and treated in time and re-prepared.

[0060] Process control points for preparing purified water: ① Drinking water 100 should meet national standards. ② When the inlet and outlet pressure difference of the multi-media filter exceeds 0.05MPa, the multi-media filter should be backwashed. ③ When the inlet and outlet pressure difference of the activated carbon filter exceeds 0.05Mpa, the activated carbon filter should be backwashed. ④ When the inlet and outlet pressure difference of the reverse osmosis security filter is higher than 0.07Mpa, the security filter element should be replaced. ⑤ The conductivity of the reverse osmosis water should be <20μs / cm. ⑥ The resistivity of the ion exchange water should be greater than 1MΩ.cm. ⑦ The conductivity of the prepared purified water should be ≤1.0μs / cm (25℃) during storage, and the pH should comply with the provisions of Part II of the 2015 edition of the Chinese Pharmacopoeia. The storage adopts circulation storage, and the storage time does not exceed 24 hours.

[0061] Preparation of injection water 200 process control points: ① Conductivity ≤1.0μs / cm (25℃), distilled water temperature should be ≥75℃. ② pH 5.2~6.6③ Online TOC ≤250ppb. ④ Storage adopts heat preservation circulation above 70℃, and the storage time does not exceed 12 hours.

[0062] The specific process flow and parameters of the liquid preparation system 2 are as follows:

[0063] S21. Preparation before liquid preparation:

[0064] Check the cleaning records and cleaning water test results to confirm that all tools, filters, and containers have been sterilized and cleaned as required. Collect 1000 raw and auxiliary materials for production with the batch production instruction. All containers and pipelines are tested and leak-free, and the weighing equipment has been calibrated. Take the capacity of sterilization system 5 as the production batch, and refer to the following table for the raw and auxiliary materials 1000 used in one sterilization system 5 (4000 bags) and the usage table:

[0065]

[0066] S22. Weighing:

[0067] The weighing of 1000 raw and auxiliary materials should be carried out in the weighing room, and scales or measuring instruments that are within the validity period of calibration and have appropriate range and accuracy should be selected for weighing or measuring; according to the provisions of the requisition form, various raw and auxiliary materials should be weighed or measured in batches of 1000, and marked, and checked by two people to ensure their accuracy.

[0068] S23, Preparation:

[0069] Add an appropriate volume of injection water 200 into the concentrated preparation tank 21.

[0070] Start the agitator, add the configured amount of mannitol and stir until it dissolves to make a concentrated solution of 50%-60% (g / ml), boil (100°C) for 15-20 minutes, cool slightly, and transfer or pump it into the dilution tank 22 through a pipeline after internal circulation for 10 minutes; add 200 ml of injection water to the total volume through the dilution tank 22, stir and reflux for 15 minutes, take samples to measure the pH value and content of the drug solution, and after meeting the requirements, cool the drug solution to about 60°C, pre-filter it through the 0.1μm filter element of the sixth filter device 24, and fine filter it through the 0.22μm filter element of the seventh filter device 25 for filling.

[0071] The specific process flow and parameters of bag making system 3 are as follows:

[0072] (1) Bag specifications: The empty soft bag 300 has a capacity of 500 ml, a bag width of 135 mm / 130 mm, and a bag length of 220 mm.

[0073] (2) Compressed air pressure: 0.40Mpa~0.80Mpa.

[0074] (3) Bag making process and adjustment of setting parameters (actual operating parameters of the equipment):

[0075]

[0076] The time from preparation of the drug solution to the completion of filling should not exceed 12 hours.

[0077] Sterilization system 5 uses a sterilization tank for sterilization, and the parameters are: temperature 121°C, time 15 minutes (F0 value ≥ 12).

[0078] The detection system 6 adopts a light inspection method, which can be carried out manually with the help of lamps, or it can be automatically inspected by an automatic light inspection device, and light inspection is carried out bag by bag according to the specified visible foreign matter inspection standards.

[0079] The packaging system 7 uses a commercially available automatic packaging machine to form a finished product 900 by adding an outer packaging to the semi-finished product 800.

[0080] The utility model provides a mannitol injection production line with a brand-new structure. The production line changes the traditional production line structure and does not need to use activated carbon in the liquid preparation process. By adopting a static electricity removal device before liquid preparation, the introduction of particles in raw materials or air can be reduced or even avoided, thereby controlling the source. At the same time, by arranging a filtering device before and after liquid preparation, the liquid medicine before and after liquid preparation is filtered, which can effectively remove the endotoxin introduced in the raw materials and the preparation process. Through this design, the purity and safety of the final output liquid medicine can be guaranteed.

[0081] The above are only some embodiments of the present invention. For those skilled in the art, several modifications and improvements can be made without departing from the inventive concept of the present invention, which all belong to the protection scope of the present invention.

Claims

1. A mannitol injection production line, characterized in that: It comprises a water preparation system (1), a liquid preparation system (2), a bag making system (3), a filling system (4), a sterilization system (5) and a detection system (6); The water preparation system (1) is used to prepare water for injection (200) from drinking water (100); The liquid preparation system (2) is configured to prepare mannitol injection using the water for injection (200); The bag making system (3) is configured to prepare empty soft bags (300); The filling and sealing system (4) is configured to fill the mannitol injection solution prepared by the liquid preparation system (2) into the empty soft bag (300) and seal it to obtain a semi-finished product (800); The sterilization system (5) is configured to sterilize the semi-finished product (800); The detection system (6) is configured to perform light inspection on the semi-finished product (800) after sterilization; The liquid preparation system (2) comprises a concentrated preparation tank (21), a diluted preparation tank (22), a fifth filter device (23), a sixth filter device (24), a seventh filter device (25) and a second static electricity removal device (28); the second static electricity removal device (28) is arranged in a space where the concentrated preparation tank (21) is located; the concentrated preparation tank (21) is connected to the diluted preparation tank (22); the input end of the fifth filter device (23) is connected to the output end of the liquid preparation system (2); the output end is respectively connected to the concentrated preparation tank (21) and the diluted preparation tank (22); the input end of the sixth filter device (24) is connected to the diluted preparation tank (22); the output end is connected to the input end of the seventh filter device (25); the output end of the seventh filter device (25) is connected to the potting system (4); The liquid preparation system (2) further comprises a weighing device (26) and a first static electricity removal device (27), wherein the weighing device (26) is used to weigh the raw and auxiliary materials (1000) added to the concentrated preparation tank (21), and the first static electricity removal device (27) is arranged in a space where the weighing device (26) is located; The first static electricity removal device (27) and the second static electricity removal device (28) are ion blowing fans; The bag making system (3) comprises a heat-sealing bag making device (32) and a printing device (31). The printing device (31) is arranged in front of the heat-sealing bag making device (32) and is used to print words on the film material (400) entering the heat-sealing bag making device (32). The heat-sealing bag making device (32) uses the film material (400) and the interface (500) to heat-seal the bag to obtain an empty soft bag (300) with the interface (500). The filling and sealing system (4) comprises a filling device (41) and a sealing device (42); the filling device (41) cooperates with the seventh filtering device (25) and the heat-sealing bag-making device (32) to fill the liquid medicine output from the seventh filtering device (25) into an empty soft bag (300) prepared by the heat-sealing bag-making device (32); the sealing device (42) cooperates with the filling device (41) to seal the soft bag filled with liquid medicine using a combined cover (600) to obtain a semi-finished product (800); The potting system (4) further comprises a third static electricity removal device (43), wherein the third static electricity removal device (43) is arranged between the sealing device (42) and the sterilization system (5); The third static electricity removal device (43) includes a conveyor belt (431) and an ion wind rod (432), and the two ends of the conveyor belt (431) are respectively connected to the output end of the sealing device (42) and the input end of the sterilization system (5). The conveyor belt (431) is a mesh conveyor belt, and the ion wind rod (432) is at least a pair. The paired ion wind rods (432) are arranged opposite to each other and are respectively located at the upper and lower ends of the conveying surface of the conveyor belt (431).

2. The mannitol injection production line according to claim 1, characterized in that: The fifth filtering device (23) is a microporous filter equipped with a 0.22 μm filter element.

3. The mannitol injection production line according to claim 1, characterized in that: The sixth filter device (24) is a microporous filter equipped with a 0.1 μm filter element, and the seventh filter device (25) is a microporous filter equipped with a 0.22 μm filter element.

4. The mannitol injection production line according to claim 1, characterized in that: The water preparation system (1) comprises a first filter device (11), a second filter device (12), a third filter device (13), a primary reverse osmosis device (14), an ion exchange device (15), a fourth filter device (16) and a distillation device (17); the input end of the first filter device (11) is connected to a drinking water (100) supply end, and the output end is connected to the input end of the second filter device (12); the output end of the second filter device (12) is connected to the input end of the third filter device (13); the output end of the third filter device (13) is connected to the input end of the primary reverse osmosis device (14); the output end of the primary reverse osmosis device (14) is connected to the input end of the ion exchange device (15); the output end of the ion exchange device (15) is connected to the input end of the fourth filter device (16); the output end of the fourth filter device (16) is connected to the input end of the distillation device (17); and the output end of the distillation device (17) is connected to the input end of the fifth filter device (23).

5. The mannitol injection production line according to claim 4, characterized in that: The first filter device (11) is a multi-media filter, the second filter device (12) is an activated carbon filter, the third filter device (13) is a security filter, and the fourth filter device (16) is a microporous filter equipped with a 0.1 μm filter element.

6. The mannitol injection production line according to any one of claims 1 to 5, characterized in that: It also includes a packaging system (7), which is arranged behind the detection system (6) and is configured to use packaging materials (700) to package the semi-finished product (800) to obtain a finished product (900).

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