Concentration device for byproduct protein peptide of heparin sodium

Abstract

The utility model provides a heparin sodium byproduct protein peptide concentration device which comprises a support frame, a concentration tank and a condensation box, a bearing seat close to the bottom is transversely and slidably connected in the support frame, and a support plate is transversely and slidably connected to the top of the bearing seat. The concentration tank is horizontally arranged, the bottom of the middle of the peripheral wall of the concentration tank is fixedly connected with the top of the supporting plate, a heating cylinder and a cooling cylinder which are located at the two ends of the concentration tank are fixedly arranged in the supporting frame, the opposite sides of the heating cylinder and the cooling cylinder are open, and the condensation box is fixedly arranged at the top of the supporting frame. The heating cylinder and the cooling cylinder are arranged, the concentration tank capable of transversely moving is arranged between the heating cylinder and the cooling cylinder, and the concentration tank can respectively enter the heating cylinder and the cooling cylinder when moving left and right, so that the concentration tank can be quickly cooled after being heated and concentrated at high temperature, and a protein peptide concentrated solution after being concentrated can be conveniently and timely discharged; the overall concentration treatment efficiency is greatly improved.

Description

Technical Field

[0001] The utility model relates to the technical field of protein peptide concentration, in particular to a device for concentrating sodium heparin byproduct protein peptides. Background Art

[0002] At present, there are two processes for heparin extraction in China: salting out and enzymatic hydrolysis. The salting out method is to add salt and alkali to the intestinal mucosa to adjust the pH, heat it to about 50°C and keep it warm so that the heparin dissolves and transfers to water, then heat it to 95°C to coagulate the intestinal membrane protein, and then separate the byproduct intestinal membrane residue (or intestinal membrane protein). The separated clear liquid is then subjected to resin adsorption, analysis, alcohol precipitation, drying and other steps to obtain heparin. The enzymatic hydrolysis method is to add salt, alkali to adjust the pH, and protease to the intestinal mucosa, heat it to about 50°C and keep it warm so that the intestinal mucosa is enzymatically hydrolyzed to obtain an enzymatic solution, and the enzymatic solution is then subjected to enzyme inactivation, resin adsorption, analysis, alcohol precipitation, drying and other steps to obtain heparin. Compared with the salting out method, the enzymatic hydrolysis method has the advantages of high heparin yield, less wastewater, and low salt consumption, and is therefore widely used.

[0003] At present, the primary concentrated protein peptide solution obtained by enzymatic hydrolysis still needs to be vacuum concentrated. The common vacuum concentration treatment method is to use a vacuum pump, a condensation box and a concentration tank. During the concentration, the concentration tank needs to be heated to accelerate the volatilization of the gas in the concentration tank. The volatilized gas is condensed by the condensation box. The liquid left in the concentration tank is a pure protein peptide concentrate. Finally, the protein peptide concentrate is taken out and dried to obtain the protein peptide. However, the existing concentration equipment still has shortcomings: 1. After the concentration tank is heated and concentrated, it needs to be cooled and cooled before the protein peptide concentrate can be discharged. The existing heating equipment is usually steam heated, which causes the concentration tank to cool naturally, and then there is a defect of low concentration efficiency; 2. During concentration, the liquid in the concentration tank is in a static state, resulting in uneven heating of the liquid and poor concentration quality.

[0004] To this end, the utility model provides a heparin sodium by-product protein peptide concentration device. Utility Model Content

[0005] In view of the deficiencies in the prior art, the purpose of the utility model is to provide a heparin sodium by-product protein peptide concentration device to solve the problems raised in the above-mentioned background technology. The utility model has the advantages of quickly cooling the high-temperature concentration tank after concentration, and also has the advantage of improving the uniformity of concentration.

[0006] In order to achieve the above-mentioned purpose, the utility model is realized through the following technical scheme: a heparin sodium byproduct protein peptide concentration device, including a support frame, a concentration tank and a condensation box, a bearing seat near the bottom is connected to the support frame in a transverse sliding manner, and a support plate is connected to the top of the bearing seat in a transverse sliding manner, the concentration tank is horizontally arranged and the bottom of the middle part of its outer peripheral wall is fixedly connected to the top of the support plate, a heating cylinder and a cooling cylinder located at both ends of the concentration tank are fixedly arranged in the support frame, and the opposite sides of the heating cylinder and the cooling cylinder are opened, the condensation box is fixedly arranged on the top of the support frame, and a drive group 1 for controlling the reciprocating sliding of the support plate relative to the bearing seat and a drive group 2 for controlling the sliding of the bearing seat relative to the support frame are arranged in the support frame.

[0007] Furthermore, the support frame is a rectangular frame structure, in which a crossbeam close to the bottom is fixedly connected, the bearing seat is provided with a guide hole which is sleeved on the outside of the crossbeam, and the top of the bearing seat is provided with a sliding groove which is slidably connected to the bottom of the support plate.

[0008] Furthermore, the driving group 1 includes a reciprocating screw and a reciprocating wire sleeve mounted on the reciprocating screw, the reciprocating screw is rotatably connected in the slide groove, and the reciprocating wire sleeve is fixedly connected to the support plate.

[0009] Furthermore, the second driving group includes a transmission screw and a transmission wire sleeve mounted on the transmission screw, the transmission screw is rotatably connected below the crossbeam, and the outer peripheral wall of the transmission wire sleeve is fixedly connected to the bottom of the bearing seat through a connecting plate.

[0010] Furthermore, the heating cylinder comprises an outer cylinder 1 and an inner coil 1 fixedly sleeved in the outer cylinder 1, and the cooling cylinder comprises an outer cylinder 2 and an inner coil 2 fixedly sleeved in the outer cylinder 2.

[0011] Furthermore, the outer peripheral wall of the outer tube one is fixedly connected to a hanging tube one fixedly connected to the top of the support frame, and the outer peripheral wall of the outer tube two is fixedly connected to a hanging tube two fixedly connected to the top of the support frame.

[0012] Furthermore, the top of the middle portion of the outer peripheral wall of the concentration tank is fixedly connected with an exhaust pipe and a feeding pipe located on one side of the exhaust pipe, and the bottom of the middle portion of the outer peripheral wall of the concentration tank is fixedly connected with a feeding pipe.

[0013] The beneficial effects of the utility model are as follows:

[0014] 1. The utility model sets a heating cylinder and a cooling cylinder, and then sets a concentration tank that can move laterally between the heating cylinder and the cooling cylinder. When the concentration tank moves left and right, it enters the heating cylinder and the cooling cylinder respectively, so that the concentration tank can be quickly cooled down after high-temperature heating and concentration, which is convenient for timely removal of the concentrated protein peptide concentrate, and greatly improves the efficiency of the overall concentration process.

[0015] 2. The utility model arranges a bearing seat in the support frame, and a support plate capable of horizontal reciprocating sliding is arranged on the bearing seat. The support plate is fixedly connected to the bottom of the concentration tank. When one end of the concentration tank enters the heating cylinder or the cooling cylinder, the support plate is controlled to slide reciprocatingly, and the liquid in the concentration tank will perform axial turbulent motion, so that the liquid in the concentration tank is heated or cooled more evenly, thereby greatly improving the uniformity of concentration. BRIEF DESCRIPTION OF THE DRAWINGS

[0016] Figure 1 This is a schematic diagram of the structure of a heparin sodium byproduct protein peptide concentration device of the utility model;

[0017] Figure 2 for Figure 1 The main view;

[0018] Figure 3 It is a schematic diagram of a heating cylinder of a heparin sodium byproduct protein peptide concentration device of the utility model;

[0019] Figure 4 It is a schematic diagram of a cooling cylinder of a heparin sodium byproduct protein peptide concentration device of the utility model;

[0020] In the figure: 1. support frame; 11. crossbeam; 2. concentration tank; 21. exhaust pipe; 22. feeding pipe; 23. feeding pipe; 3. bearing seat; 31. slide groove; 4. support plate; 5. heating cylinder; 51. outer cylinder one; 511. hanging tube one; 52. inner coil one; 6. cooling cylinder; 61. outer cylinder two; 611. hanging tube two; 62. inner coil two; 7. condensing box; 8. driving group one; 81. reciprocating screw; 82. reciprocating wire sleeve; 9. driving group two; 91. transmission screw; 92. transmission wire sleeve; 921. connecting plate. DETAILED DESCRIPTION

[0021] In order to make the technical means, creative features, objectives and effects achieved by the present invention easy to understand, the present invention is further described below in conjunction with specific implementation methods.

[0022] See also Figures 1 to 4 The utility model provides a technical solution: a heparin sodium byproduct protein peptide concentration device, including a support frame 1, a concentration tank 2 and a condensation box 7. The support frame 1 plays a role in supporting other components on the device. The concentration tank 2 provides a concentration space. The external vacuum pump is connected to the concentration tank 2 through the condensation box 7, the purpose is to pass a vacuum environment to the concentration tank 2, and the condensation box 7 plays a role in condensing the volatile high-temperature gas.

[0023] In the technical solution, a bearing seat 3 near the bottom is slidably connected in the support frame 1, and a support plate 4 is slidably connected to the top of the bearing seat 3, and the sliding directions of the support plate 4 and the bearing seat 3 are in a parallel state. The concentration tank 2 is horizontally arranged and the bottom of the middle part of its outer peripheral wall is fixedly connected to the top of the support plate 4. When the bearing seat 3 slides, it can drive the support plate 4 to move, and then drive the concentration tank 2 to move horizontally, wherein the support plate 4 slides slightly relative to the bearing seat 3, and the bearing seat 3 slides greatly relative to the support frame 1.

[0024] A heating cylinder 5 and a cooling cylinder 6 are fixedly arranged at both ends of the concentration tank 2 in the support frame 1. The opposite sides of the heating cylinder 5 and the cooling cylinder 6 are opened. When the concentration tank 2 slides left and right, its two ends can enter the heating cylinder 5 and the cooling cylinder 6 respectively. The heating cylinder 5 and the cooling cylinder 6 are used to heat and cool the concentration tank 2 respectively. The condensation box 7 is fixedly arranged on the top of the support frame 1. The condensation box 7 is connected to the concentration tank 2 through a pipeline. Specifically, the top of the middle part of the outer peripheral wall of the concentration tank 2 is fixedly connected with an exhaust pipe 21, and the inlet of the condensation box 7 is connected to the exhaust pipe 21 through a hose.

[0025] The support frame 1 is provided with a driving group 1 8 for controlling the reciprocating sliding of the support plate 4 relative to the bearing seat 3 and a driving group 2 9 for controlling the sliding of the bearing seat 3 relative to the support frame 1 .

[0026] Specifically, the drive group 1 8 includes a reciprocating screw 81 and a reciprocating wire sleeve 82 sleeved on the reciprocating screw 81, the reciprocating screw 81 is rotatably connected in the slide slot 31, the reciprocating wire sleeve 82 is fixedly connected to the support plate 4, a driving motor can be fixedly connected to one end of the bearing seat 3, the output shaft of the driving motor is fixedly connected to one end of the reciprocating screw 81, and when the reciprocating screw 81 rotates, the reciprocating wire sleeve 82 will axially reciprocate. Further, the drive group 2 9 includes a transmission screw 91 and a transmission wire sleeve 92 sleeved on the transmission screw 91, the transmission screw 91 is rotatably connected to the bottom of the crossbeam 11, the outer peripheral wall of the transmission wire sleeve 92 is fixedly connected to the bottom of the bearing seat 3 through the connecting plate 921, a control motor can be fixedly connected to the outside of the support frame 1, the output shaft of the control motor is fixedly connected to one end of the transmission screw 91, and the rotation of the transmission screw 91 can drive the transmission wire sleeve 92 to move axially.

[0027] In this embodiment, the heating cylinder 5 includes an outer cylinder 1 51 fixedly sleeved in the outer cylinder 1 51 and an inner coil 1 52, steam flows in the inner coil 1 52, and the outer wall of the concentration tank 2 is heated by the steam. The cooling cylinder 6 includes an outer cylinder 2 61 and an inner coil 2 62 fixedly sleeved in the outer cylinder 2 61, cooling water flows in the inner coil 2 62, and the outer wall of the concentration tank 2 is heated by the cold water. Furthermore, the outer peripheral wall of the outer cylinder 1 51 is fixedly connected to a suspension pipe 1 511 fixedly connected to the top of the support frame 1, and the outer peripheral wall of the outer cylinder 2 61 is fixedly connected to a suspension pipe 2 611 fixedly connected to the top of the support frame 1.

[0028] In this embodiment, a feeding pipe 22 located on one side of the exhaust pipe 21 is fixedly connected to the top of the middle part of the outer peripheral wall of the concentration tank 2, and the feeding pipe 22 is a raw liquid injection channel. A feeding pipe 23 is fixedly connected to the bottom of the middle part of the outer peripheral wall of the concentration tank 2, and the feeding pipe 23 is a channel for discharging the concentrated liquid.

[0029] When using this concentrating device, during concentration, steam is introduced into the inner coil 1 52, and then the transmission screw 91 is controlled to rotate, and the transmission wire sleeve 92 drives the bearing seat 3 to slide along the crossbeam 11, and one end of the concentrating tank 2 enters the outer cylinder 1 51. At this time, the inner coil 1 52 heats the concentrating tank 2, and then the reciprocating screw 81 is controlled to rotate. At this time, the reciprocating wire sleeve 82 will drive the concentrating tank 2 to reciprocate axially through the support plate 4. At this time, the liquid in the concentrating tank 2 will move axially turbulently, so that the liquid is heated evenly, and the external vacuum pump is started. The concentrating tank 2 is in a negative pressure state, and the gas volatilized after the liquid is heated will enter the condensation box 7, thereby realizing the concentration of the protein peptide stock solution. After concentration, the other end of the concentrating tank 2 is controlled to enter the cooling cylinder 6, and then cooling water is introduced into the inner coil 2 62, and the concentrating tank 2 is controlled to reciprocate at the same time. At this time, the cooling of the concentrated liquid can be accelerated and the cooling speed can be increased.

[0030] In addition, it should be understood that although the present specification is described according to implementation modes, not every implementation mode contains only one independent technical solution. This description of the specification is only for the sake of clarity. Those skilled in the art should regard the specification as a whole. The technical solutions in each embodiment may also be appropriately combined to form other implementation modes that can be understood by those skilled in the art.

Claims

1. A heparin sodium byproduct protein peptide concentration device, comprising a support frame (1), a concentration tank (2) and a condensation tank (7), characterized in that: A bearing seat (3) near the bottom is slidably connected in the support frame (1), and a support plate (4) is slidably connected in the support frame (1). The top of the bearing seat (3) is slidably connected in the support frame (1). The concentration tank (2) is arranged horizontally and the bottom of the middle part of the outer peripheral wall is fixedly connected to the top of the support plate (4). A heating cylinder (5) and a cooling cylinder (6) located at both ends of the concentration tank (2) are fixedly arranged in the support frame (1). The opposite sides of the heating cylinder (5) and the cooling cylinder (6) are open. The condensation box (7) is fixedly arranged on the top of the support frame (1). A driving group 1 (8) for controlling the reciprocating sliding of the support plate (4) relative to the bearing seat (3) and a driving group 2 (9) for controlling the sliding of the bearing seat (3) relative to the support frame (1) are arranged in the support frame (1).

2. The device for concentrating heparin sodium byproduct protein peptides according to claim 1, characterized in that: The support frame (1) is a rectangular frame structure, a crossbeam (11) close to the bottom is fixedly connected inside the support frame (1), a guide hole is provided on the bearing seat (3) and is sleeved on the outside of the crossbeam (11), and a sliding groove (31) is provided on the top of the bearing seat (3) and is slidably connected to the bottom of the support plate (4).

3. A heparin sodium byproduct protein peptide concentration device according to claim 2, characterized in that: The driving group 1 (8) comprises a reciprocating screw (81) and a reciprocating wire sleeve (82) sleeved on the reciprocating screw (81); the reciprocating screw (81) is rotatably connected in the slide groove (31); and the reciprocating wire sleeve (82) is fixedly connected to the support plate (4).

4. A heparin sodium byproduct protein peptide concentration device according to claim 3, characterized in that: The second drive group (9) comprises a transmission screw (91) and a transmission thread sleeve (92) sleeved on the transmission screw (91); the transmission screw (91) is rotatably connected to the bottom of the crossbeam (11); and the outer peripheral wall of the transmission thread sleeve (92) is fixedly connected to the bottom of the bearing seat (3) via a connecting plate (921).

5. The device for concentrating heparin sodium byproduct protein peptides according to claim 1, characterized in that: The heating tube (5) comprises an outer tube one (51) and an inner coil one (52) fixedly mounted inside the outer tube one (51); the cooling tube (6) comprises an outer tube two (61) and an inner coil two (62) fixedly mounted inside the outer tube two (61).

6. The device for concentrating heparin sodium byproduct protein peptides according to claim 5, characterized in that: The outer peripheral wall of the outer tube one (51) is fixedly connected to a hanging tube one (511) fixedly connected to the top of the support frame (1), and the outer peripheral wall of the outer tube two (61) is fixedly connected to a hanging tube two (611) fixedly connected to the top of the support frame (1).

7. The device for concentrating heparin sodium byproduct protein peptides according to claim 1, characterized in that: The top of the middle portion of the outer peripheral wall of the concentration tank (2) is fixedly connected to an exhaust pipe (21) and a feeding pipe (22) located on one side of the exhaust pipe (21), and the bottom of the middle portion of the outer peripheral wall of the concentration tank (2) is fixedly connected to a discharge pipe (23).

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