High-throughput removal device for serum high-peak protein in proteomics

Abstract

The utility model discloses a high-flux removal device for serum high peak protein in proteomics, which comprises a base plate and a beaker body, and a high-flux removal component is coaxially suspended above the top of the beaker body. The high-flux removal device has the beneficial effects that the chemical precipitation operation of serum protein can be realized in a manner of dropping a reagent into a solution in the beaker body through the liquid injection pipe of the high-flux removal assembly, so that the removal efficiency of the serum protein can be improved; meanwhile, the air-blowing stirring operation on the solution can be realized in a manner of blowing air into the solution in the beaker body by virtue of an air-blowing pipe of the micro air pump body, so that the mixing rate of a reagent and the solution in the beaker body is conveniently accelerated, and the removal efficiency of serum protein is further improved; in addition, the condition that the solution is splashed out in the air-blowing stirring process can be avoided in the mode that the cover plate is used for blocking the opening in the top of the beaker body, and the serum protein removal operation can be smoothly completed.

Description

Technical Field

[0001] The utility model relates to the field of serum protein removal auxiliary components, in particular to a high-throughput removal device for serum high peak protein in proteomics. Background Art

[0002] Proteomics is a science that studies the protein composition and its changing patterns of cells, tissues or organisms, taking the proteome as the research object. The study of the proteome can not only provide a material basis for the laws of life activities, but also provide a theoretical basis and solutions for the elucidation and control of the mechanisms of many diseases. Specifically, through comparative analysis of the proteomes between normal individuals and pathological individuals, we can find certain "disease-specific protein molecules", which can become molecular targets for the design of new drugs, or provide molecular markers for the early diagnosis of diseases.

[0003] In the prior art, when studying the proteome, it is necessary to remove the serum high peak protein in proteomics, so a high-throughput removal device is needed. However, the existing high-throughput removal device mostly uses static adsorption to remove serum proteins in the proteome, which has a long waiting time for removal and low work efficiency, causing great inconvenience to the proteome research work. Utility Model Content

[0004] The purpose of the utility model is to provide a high-throughput removal device for serum high-peak protein in proteomics in order to solve the above-mentioned problems. A high-throughput removal component is coaxially arranged on the top of the beaker body, so that the chemical precipitation operation of serum protein can be realized by dripping the reagent into the solution in the beaker body through the injection tube of the high-throughput removal component, which is beneficial to improving the removal efficiency of serum protein. At the same time, the solution in the beaker body can be aerated and stirred by aerating the solution in the beaker body with the help of the air pipe of the micro air pump body, which is convenient for accelerating the mixing rate of the reagent and the solution in the beaker body, and then it is beneficial to further improve the removal efficiency of serum protein, as described below for details.

[0005] In order to achieve the above purpose, the utility model provides the following technical solutions:

[0006] The utility model provides a high-throughput removal device for serum high-peak protein in proteomics, comprising a substrate and a beaker body, wherein the substrate is arranged horizontally, the top of the beaker body is open and placed in the middle of the top surface of the substrate, and a lifting support component capable of vertical reciprocating lifting is installed on one side of the top surface of the substrate;

[0007] A high-throughput removal component for removing serum high-peak protein from the solution in the beaker body is coaxially suspended above the top of the beaker body;

[0008] A disassembly assembly component is installed between the high-flux removal component and the lifting support component, and the high-flux removal component and the lifting support component can be disassembled and assembled together through the disassembly assembly component.

[0009] Preferably, a storage cylinder is vertically fixed to the middle of the top surface of the base plate, and the lower part of the beaker body is coaxially placed on the storage cylinder by means of vertical sliding fit.

[0010] Preferably, the high-throughput removal component includes a cover plate, a pH detector body and a micro air pump body, the cover plate coaxially seals the top opening of the beaker body, the pH detector body and the micro air pump body are fixedly installed on both sides of the top surface of the cover plate, and the probe rod at the bottom of the pH detector body passes through the bottom surface of the cover plate in a vertical sliding fit and extends to the inner bottom of the beaker body, the air inflation tube at the bottom of the micro air pump body passes through the bottom surface of the cover plate in a vertical sliding fit and extends to the inner bottom of the beaker body, and injection tubes are vertically inserted and fixed at the front and rear positions of the top surface of the cover plate.

[0011] Preferably, the outer diameter of the cover plate is larger than the outer diameter of the beaker body, and a cover for controlling opening and closing is coaxially and detachably mounted on the top of the liquid injection tube.

[0012] Preferably, the power connections on the top of the pH detector body and the micro air pump body extend backward, the cover and the injection tube are coaxially detachably connected by threaded fitting, and a wing plate is fixed on the periphery of the cover plate to facilitate hand force application.

[0013] Preferably, the lifting support assembly includes a guide screw and a mounting arm, the guide screw is vertically fixed to one side of the top surface of the base plate through a fixing sleeve, the mounting arm is horizontally arranged, and the guide screw passes through one side end of the mounting arm in a vertical sliding fit, and the other side end of the mounting arm is detachably connected to the cover plate through the disassembly and assembly assembly.

[0014] Preferably, the guide screw is coaxially engaged with a limit nut at a position below the mounting arm, and an anti-drop cap is coaxially tensioned and mounted on the top end of the guide screw.

[0015] Preferably, the disassembly and assembly assembly includes an insertion plate and a slot, the insertion plate is horizontally extended and fixed on one side of the outer periphery of the cover plate, and a locking hole is vertically opened in the middle of the top surface of the insertion plate, the slot is horizontally opened along the side end surface of the mounting arm away from the guide screw, and the insertion plate is inserted into the slot in a transverse sliding fit manner, a matching hole is vertically opened on the top surface of the mounting arm, the matching hole is vertically connected with the slot, and the matching hole is vertically coaxial with the locking hole, the matching holes are all detachably inserted with locking rods in a vertically fitting manner, and the lower part of the locking rod is coaxially and detachably inserted into the locking hole.

[0016] Preferably, the locking rod is a stud, the matching hole and the locking hole are both threaded through holes, and the locking rod can be detachably combined with the matching hole and the locking hole by means of threaded matching.

[0017] Preferably, the plug plate is a rectangular plate, the slot is a rectangular blind slot, and the inner end of the plug plate is in close contact with the inner end of the slot, and a holding end is coaxially fixed to the top end of the locking rod for easy holding.

[0018] When the high-throughput removal device for serum high-peak protein in proteomics is used to remove serum high-peak protein from a biological sample solution, the high-throughput removal component is coaxially arranged on the top of the beaker body, so that the chemical precipitation operation of serum protein can be achieved by dripping reagent into the solution in the beaker body through the injection tube of the high-throughput removal component, which is beneficial to improving the removal efficiency of serum protein. At the same time, the solution in the beaker body can be aerated and stirred by aerating the solution with the help of the air blowing tube of the micro air pump body, which is convenient for accelerating the mixing of the reagent and the solution in the beaker body. The combination rate is increased, which is beneficial to further improve the removal efficiency of serum protein, and the method of blocking the top opening of the beaker body with the help of the cover plate can avoid the situation that the solution splashes out during the aeration and stirring process, which is beneficial to the smooth completion of the serum protein removal operation. Specifically, the lifting support assembly can be driven by the mounting arm of the lifting support assembly to slide vertically along the guide screw to drive the high-throughput removal assembly to perform a lifting operation, and then the cover plate can be smoothly dropped to block the top opening of the beaker body by driving the high-throughput removal assembly to descend, so that the high-throughput removal assembly can be smoothly removed. The high-throughput removal component is used to remove serum protein, and at the same time, the cover plate can be smoothly raised to leave the beaker body by driving the high-throughput removal component to descend, so that the high-throughput removal component and the beaker body can be separated from each other to allow the solution in the beaker body to be statically precipitated and removed and poured out. Specifically, in the combination and disassembly operation of the high-throughput removal component and the lifting support component, when the combination is performed, the cover plate of the high-throughput removal component can be disassembled and assembled by the horizontal sliding cooperation between the plug plate of the disassembly and assembly component and the vertical cooperation between the locking rod and the locking hole through the cooperation hole. The mounting arms of the lifting support assembly can be detachably assembled together. When disassembling, the locking rod only needs to be disengaged from the locking hole and the matching hole in sequence, so that the plug plate can be disengaged from the slot laterally to separate the cover plate of the high-throughput removal assembly and the mounting arms of the lifting support assembly from each other. The assembly and disassembly operations of the cover plate of the high-throughput removal assembly and the mounting arms of the lifting support assembly are simple and easy to implement, which is convenient for quickly combining the high-throughput removal assembly and the lifting support assembly for use, and is also convenient for subsequent cleaning and maintenance of the high-throughput removal assembly and the lifting support assembly after they are separated from each other.

[0019] The beneficial effects are as follows: 1. The utility model is coaxially provided with a high-throughput removal component on the top of the beaker body, so that the chemical precipitation operation of serum protein can be realized by dripping the reagent into the solution in the beaker body through the injection tube of the high-throughput removal component, which is beneficial to improving the removal efficiency of serum protein. At the same time, the aeration and stirring operation of the solution can be realized by aerating the solution in the beaker body with the aid of the aeration tube of the micro air pump body, which is convenient for accelerating the mixing rate of the reagent and the solution in the beaker body, and then is beneficial to further improve the removal efficiency of serum protein. Moreover, by blocking the top opening of the beaker body with the aid of a cover plate, the situation of solution splashing during the aeration and stirring process can be avoided, which is beneficial to smoothly complete the removal operation of serum protein.

[0020] 2. The installation arm of the lifting support assembly can be driven to lift the high-throughput removal assembly by vertically sliding along the guide screw, and then the high-throughput removal assembly can be driven down to make the cover plate smoothly fall to block the top opening of the beaker body, so that the serum protein removal operation can be smoothly performed with the help of the high-throughput removal assembly. At the same time, the cover plate can be smoothly raised to leave the beaker body by driving the high-throughput removal assembly down, so that the high-throughput removal assembly and the beaker body can be separated from each other, and the solution in the beaker body can be statically precipitated and removed and poured out;

[0021] 3. The cover plate of the high-throughput removal component and the mounting arm of the lifting support component can be detachably combined together by sliding the plug plate of the disassembly and assembly assembly with the slot horizontally and the locking rod vertically cooperating with the matching hole and the locking hole. The plug plate can be disengaged from the slot horizontally to separate the cover plate of the high-throughput removal component and the mounting arm of the lifting support component from each other only by disengaging the locking rod from the locking hole and the matching hole in turn. The combination and disassembly operation of the cover plate of the high-throughput removal component and the mounting arm of the lifting support component are simple and easy to implement, which is convenient for quickly combining the high-throughput removal component and the lifting support component for use, and is also convenient for subsequent cleaning and maintenance of the high-throughput removal component and the lifting support component after they are separated from each other. BRIEF DESCRIPTION OF THE DRAWINGS

[0022] In order to more clearly illustrate the embodiments of the utility model or the technical solutions in the prior art, the drawings required for use in the embodiments or the description of the prior art will be briefly introduced below. Obviously, the drawings described below are only some embodiments of the utility model. For ordinary technicians in this field, other drawings can be obtained based on these drawings without paying creative work.

[0023] Figure 1 This is the overall axonometric diagram of the utility model. Figure 1 ;

[0024] Figure 2 This is the overall axonometric diagram of the utility model. Figure 2 ;

[0025] Figure 3 This utility model Figure 1 Schematic cross-section diagram;

[0026] Figure 4 This utility model Figure 3 A local enlarged view of point A;

[0027] Figure 5 This utility model Figure 1 A front view schematic diagram of

[0028] Figure 6 This utility model Figure 1 Schematic diagram of the left side;

[0029] Figure 7 This utility model Figure 1 A right side schematic diagram of

[0030] Figure 8 This utility model Figure 1 Schematic top view of .

[0031] The following are the descriptions of the reference numerals:

[0032] 1. High-throughput removal component; 101. Power connection; 102. Micro air pump body; 103. Liquid injection tube; 104. Cover; 105. pH detector body; 106. Cover plate; 107. Wing plate; 108. Probe rod; 109. Air tube; 2. Beaker body; 3. Base plate; 301. Storage tube; 4. Lifting support component; 401. Anti-drop cap; 402. Mounting arm; 403. Limit nut; 404. Guide screw; 405. Fixing sleeve; 5. Disassembly and assembly assembly; 501. Insert plate; 502. Slot; 503. Holding end; 504. Matching hole; 505. Locking hole; 506. Locking rod. DETAILED DESCRIPTION

[0033] In order to make the purpose, technical solution and advantages of the utility model clearer, the technical solution of the utility model will be described in detail below. Obviously, the described embodiments are only part of the embodiments of the utility model, not all of the embodiments. Based on the embodiments of the utility model, all other implementation methods obtained by ordinary technicians in this field without creative work belong to the scope of protection of the utility model.

[0034] See also Figure 1-Figure 8As shown, the utility model provides a high-throughput removal device for serum high-peak protein in proteomics, including a substrate 3 and a beaker body 2. The substrate 3 is arranged horizontally, and the top of the beaker body 2 is open and placed in the middle of the top surface of the substrate 3. A lifting support assembly 4 capable of vertical reciprocating lifting is installed on one side of the top surface of the substrate 3. Specifically, the lifting support assembly 4 includes a guide screw 404 and a mounting arm 402. The guide screw 404 is vertically fixed to one side of the top surface of the substrate 3 through a fixing sleeve 405. The mounting arm 402 is arranged horizontally, and the guide screw 404 passes through the fixing sleeve 405 in a vertical sliding manner. One end of the mounting arm 402 and the other end of the mounting arm 402 are detachably connected to the cover plate 106 through the disassembly assembly assembly 5. The purpose of this arrangement is to enable the high-throughput removal component 1 to be lifted and lowered by vertically sliding the mounting arm 402 of the lifting support assembly 4 along the guide screw 404, so that the cover plate 106 can be smoothly dropped to block the top opening of the beaker body 2 by driving the high-throughput removal component 1 to descend, and at the same time, the cover plate 106 can be smoothly raised to leave the beaker body 2 by driving the high-throughput removal component 1 to descend.

[0035] See also Figure 1-Figure 4As shown, a high-throughput removal component 1 for removing serum high-peak protein from the solution in the beaker body 2 is coaxially suspended above the top of the beaker body 2. Specifically, the high-throughput removal component 1 includes a cover plate 106, a pH detector body 105 and a micro air pump body 102. The cover plate 106 is coaxially sealed at the top opening of the beaker body 2. The pH detector body 105 and the micro air pump body 102 are fixedly installed on both sides of the top surface of the cover plate 106, and the probe rod 108 at the bottom of the pH detector body 105 is vertically slidably matched. The bottom surface of the cover plate 106 is passed through in a vertical sliding manner and extends to the inner bottom of the beaker body 2. The air blowing tube 109 at the bottom of the micro air pump body 102 passes through the bottom surface of the cover plate 106 and extends to the inner bottom of the beaker body 2. The top surface of the cover plate 106 is vertically interspersed with injection tubes 103 at the front and rear positions. The purpose of this arrangement is to achieve a chemical precipitation operation of serum protein by dripping reagents into the solution in the beaker body 2 through the injection tube 103 of the high-throughput removal component 1. At the same time, by using the micro air pump body The method of blowing air into the solution in the beaker body 2 by the air blowing tube 109 of 102 can realize the blowing and stirring operation of the solution, which is convenient for accelerating the mixing rate of the reagent and the solution in the beaker body 2, and the method of blocking the top opening of the beaker body 2 with the help of the cover plate 106 can avoid the situation that the solution splashes out during the blowing and stirring process. Specifically, when removing the serum high peak protein in the solution, sulfosalicylic acid can be added to the solution in the beaker body 2 through the front injection tube 103, so that the serum protein in the solution combines with the salicylic acid radical to form an insoluble salt and precipitate, and then dilute hydrochloric acid can be added to the solution in the beaker body 2 through the rear injection tube 103, and the pH value of the solution is adjusted to below 4.7 by real-time detection of the pH value of the solution with the probe 108 of the pH detector body 105, so that the serum protein can be removed after precipitation. It should be noted that only during the process of adding sulfosalicylic acid and dilute hydrochloric acid, blowing and stirring are performed to accelerate the mixing of the solution. After the pH value of the solution is adjusted, the blowing and stirring function should be stopped to smoothly complete the static precipitation of the precipitate.

[0036] See also Figure 1-Figure 8As shown, a disassembly assembly component 5 is installed between the high-throughput removal component 1 and the lifting support component 4, and the high-throughput removal component 1 and the lifting support component 4 can be detachably assembled together through the disassembly assembly component 5. Specifically, the disassembly assembly component 5 includes a plug plate 501 and a slot 502. The plug plate 501 is horizontally extended and fixed on one side of the outer periphery of the cover plate 106, and a locking hole 505 is vertically opened in the middle of the top surface of the plug plate 501. The side end surface of the mounting arm 402 away from the guide screw 404 is horizontally opened with a slot 502, and the plug plate 501 is inserted into the slot 502 in a horizontal sliding fit manner. A matching hole 504 is vertically opened on the top surface of the mounting arm 402, and the matching hole 504 is vertically connected to the slot 502, and the matching hole 504 is vertically coaxial with the locking hole 505, and the matching holes 504 are vertically matched. The locking rod 506 is detachably inserted in the locking hole 505, and the lower part of the locking rod 506 is coaxially detachably inserted into the locking hole 505. The reason for this arrangement is that the cover plate 106 of the high-throughput removal component 1 and the mounting arm 402 of the lifting support component 4 can be detachably combined together by the horizontal sliding fit of the plug plate 501 of the disassembly and assembly assembly 5 and the vertical fit of the locking rod 506 with the locking hole 505 through the matching hole 504. The plug plate 501 can be horizontally removed from the slot 502 to separate the cover plate 106 of the high-throughput removal component 1 and the mounting arm 402 of the lifting support component 4 from each other only by making the locking rod 506 successively disengage from the locking hole 505 and the matching hole 504. The combination and disassembly operations of the cover plate 106 of the high-throughput removal component 1 and the mounting arm 402 of the lifting support component 4 are simple and easy to achieve.

[0037] See also Figure 1-Figure 8As shown, the following optimizations are respectively performed on the substrate 3, the high-throughput removal assembly 1, the lifting support assembly 4 and the disassembly assembly 5. Specifically for the substrate 3, a storage cylinder 301 is vertically fixed to the middle of the top surface of the substrate 3, and the lower part of the beaker body 2 is coaxially placed on the storage cylinder 301 by means of vertical sliding fit. With such a configuration, it is convenient to quickly position the beaker body 2 on the top of the substrate 3. Specifically for the high-throughput removal assembly 1, the outer diameter of the cover plate 106 is larger than the outer diameter of the beaker body 2, and the top of the injection tube 103 is coaxially and detachably installed with a cover 104 for controlling the opening and closing. With such a configuration, firstly, it is convenient for the cover plate 106 to completely block the top of the beaker body 2, and at the same time, it is convenient to control the opening and closing state of the injection tube 103 through the cover 104. At the same time, optionally, the power wiring 101 on the top of the pH detector body 105 and the micro air pump body 102 are extended backward, so that the pH detector body 105 and the micro air pump body 102 can be electrically connected to the external power supply cable through the corresponding power wiring 101 and then powered on. The cover 104 and the injection tube 103 are coaxially detachably connected by threaded cooperation, and the outer extension of the cover 106 is fixed with a wing plate 107 for facilitating hand force application. With this arrangement, firstly, it is convenient for the cover 104 to be quickly combined and disassembled with the injection tube 103 by twisting, and at the same time, it is convenient to drive the cover 106 to move vertically and horizontally by applying force by pinching the wing plate 107 by hand, ensuring that the cover 106 can be smoothly moved to completely block the top opening of the beaker body 2.

[0038] Specifically for the lifting support assembly 4, the guide screw 404 is coaxially engaged with the limit nut 403 at the position below the mounting arm 402, and the top of the guide screw 404 is coaxially tightened with an anti-drop cap 401. With this arrangement, first, after the mounting arm 402 drives the cover plate 106 to rise until the bottom ends of the probe rod 108 and the air inflation tube 109 are higher than the top of the beaker body 2, it is convenient to maintain the position height of the mounting arm 402 and the cover plate 106 by screwing the limit nut 403 to rise to the bottom surface of the mounting arm 402 to contact the bottom surface of the mounting arm 402. At the same time, it is convenient to prevent the mounting arm 402 and the guide screw 404 from accidentally separating from each other through the setting of the anti-drop cap 401. It should be noted that when the cover plate 106 is used to block the top of the beaker body 2, the cover plate 106 can be adjusted to completely block the top of the beaker body 2 by horizontally rotating the mounting arm 402 around the guide screw 404 at a certain angle. Specifically for the disassembly and assembly component 5, the locking rod 506 is a stud, the matching hole 504 and the locking hole 505 are both threaded through holes, and the locking rod 506 and the matching hole 504 and the locking hole 505 are all detachably assembled by threaded engagement, so that the locking rod 506 and the matching hole 504 and the locking hole 505 can be quickly assembled and disassembled by twisting the locking rod 506. At the same time, optionally, the plug plate 501 is a rectangular plate, the slot 502 is a rectangular blind slot, and the inner end of the plug plate 501 is in close contact with the inner end of the slot 502. In this way, firstly, it is convenient for the plug plate 501 and the slot 502 to have a good positioning guide design when they slide horizontally. At the same time, when the plug plate 501 slides horizontally along the slot 502, when the locking hole 505 moves horizontally with the plug plate 501 to be coaxial with the locking rod 506, an obvious prompt can be given by the inner end of the plug plate 501 being in close contact with the inner end of the slot 502. Further, optionally, a holding end 503 for easy holding is coaxially fixed to the top of the locking rod 506, so that the locking rod 506 can be twisted by applying force by holding the holding end 503 by hand.

[0039] With the above structure, when the biological sample solution is used for the removal of serum high-intensity protein, since the high-throughput removal component 1 is coaxially arranged on the top of the beaker body 2, the chemical precipitation operation of the serum protein can be realized by dripping the reagent into the solution in the beaker body 2 through the injection tube 103 of the high-throughput removal component 1, which is beneficial to improve the removal efficiency of the serum protein. At the same time, the solution in the beaker body 2 can be aerated by the air pipe 109 of the micro air pump body 102. The solution can be aerated and stirred, which is convenient for accelerating the mixing rate of the reagent and the solution in the beaker body 2, which is beneficial to further improve the removal efficiency of the serum protein. The removal efficiency of serum protein is improved, and the top opening of the beaker body 2 is blocked by the cover plate 106 to avoid the splashing of the solution during the aeration and stirring process, which is conducive to the smooth completion of the serum protein removal operation. Specifically, the lifting support assembly 4 can drive the high-throughput removal assembly 1 to perform a lifting operation by the vertical sliding of the mounting arm 402 of the lifting support assembly 4 along the guide screw 404, and then the cover plate 106 can be smoothly dropped to block the top opening of the beaker body 2 by driving the high-throughput removal assembly 1 to descend, so that the serum protein can be removed smoothly with the help of the high-throughput removal assembly 1. The high-throughput removal component 1 is operated, and the cover plate 106 can be smoothly raised to leave the beaker body 2 by driving the high-throughput removal component 1 to descend, so that the high-throughput removal component 1 and the beaker body 2 can be separated from each other to allow the solution in the beaker body 2 to be settled and removed and poured out. Specifically, in the combination and disassembly operation of the high-throughput removal component 1 and the lifting support component 4, when the combination is performed, the cover plate 106 of the high-throughput removal component 1 can be installed with the lifting support component 4 by the horizontal sliding fit of the plug plate 501 of the disassembly and assembly component 5 and the slot 502 and the vertical fit of the locking rod 506 through the matching hole 504 and the locking hole 505. The arm 402 can be detachably assembled together. When disassembling, it is only necessary to make the locking rod 506 disengage from the locking hole 505 and the matching hole 504 in turn, so that the plug plate 501 can be horizontally disengaged from the slot 502 to separate the cover plate 106 of the high-throughput removal component 1 and the mounting arm 402 of the lifting support component 4 from each other. The combination and disassembly operation of the cover plate 106 of the high-throughput removal component 1 and the mounting arm 402 of the lifting support component 4 are simple and easy to implement, which is convenient for quickly combining the high-throughput removal component 1 and the lifting support component 4 for use, and is also convenient for subsequent cleaning and maintenance of the high-throughput removal component 1 and the lifting support component 4 after they are separated from each other.

[0040] The above is only a specific implementation of the utility model, but the protection scope of the utility model is not limited thereto. Any technician familiar with the technical field can easily think of changes or substitutions within the technical scope disclosed by the utility model, which should be included in the protection scope of the utility model. Therefore, the protection scope of the utility model should be based on the protection scope of the claims.

Claims

1. A high-throughput removal device for serum high-peak protein in proteomics, comprising a substrate (3) and a beaker body (2), characterized in that: The base plate (3) is arranged horizontally, the top of the beaker body (2) is open and placed in the middle of the top surface of the base plate (3), and a lifting support component (4) capable of vertical reciprocating lifting is installed on one side of the top surface of the base plate (3); A high-throughput removal component (1) for removing serum high-peak protein from the solution in the beaker body (2) is coaxially suspended above the top of the beaker body (2); A disassembly assembly component (5) is installed between the high-throughput removal component (1) and the lifting support component (4), and the high-throughput removal component (1) and the lifting support component (4) can be disassembled and assembled together via the disassembly assembly component (5).

2. The high-throughput removal device for serum high-peak protein in proteomics according to claim 1, characterized in that: A storage cylinder (301) is vertically fixed to the middle of the top surface of the base plate (3), and the lower part of the beaker body (2) is coaxially placed on the storage cylinder (301) by means of vertical sliding fit.

3. The high-throughput removal device for serum high-peak protein in proteomics according to claim 1, characterized in that: The high-throughput removal component (1) comprises a cover plate (106), a pH detector body (105) and a micro air pump body (102); the cover plate (106) coaxially blocks the top opening of the beaker body (2); the pH detector body (105) and the micro air pump body (102) are respectively fixedly mounted on both sides of the top surface of the cover plate (106); the probe rod (108) at the bottom of the pH detector body (105) passes through the bottom surface of the cover plate (106) in a vertical sliding manner and extends to the inner bottom of the beaker body (2); the air blowing tube (109) at the bottom of the micro air pump body (102) passes through the bottom surface of the cover plate (106) in a vertical sliding manner and extends to the inner bottom of the beaker body (2); and injection tubes (103) are vertically inserted and fixed at the front and rear positions of the top surface of the cover plate (106).

4. The high-throughput removal device for serum high-peak protein in proteomics according to claim 3, characterized in that: The outer diameter of the cover plate (106) is greater than the outer diameter of the beaker body (2), and a sealing cover (104) for controlling opening and closing is coaxially and detachably mounted on the top of the liquid injection tube (103).

5. The high-throughput removal device for serum high-peak protein in proteomics according to claim 4, characterized in that: The power supply wires (101) on the top of the pH detector body (105) and the micro air pump body (102) are both extended backwards, the cover (104) and the injection tube (103) are both coaxially detachably connected by means of threaded engagement, and a wing plate (107) is fixedly extended on the periphery of the cover plate (106) for facilitating hand force application.

6. The high-throughput removal device for serum high-peak protein in proteomics according to any one of claims 3 to 5, characterized in that: The lifting support assembly (4) comprises a guide screw (404) and a mounting arm (402); the guide screw (404) is vertically fixed to one side of the top surface of the base plate (3) via a fixing sleeve (405); the mounting arm (402) is arranged horizontally, and the guide screw (404) passes through one end of the mounting arm (402) in a vertical sliding manner; the other end of the mounting arm (402) is detachably connected to the cover plate (106) via the disassembly assembly assembly (5).

7. The high-throughput removal device for serum high-peak protein in proteomics according to claim 6, characterized in that: The guide screw (404) is coaxially engaged with a limit nut (403) at a position below the mounting arm (402), and an anti-drop cap (401) is coaxially tensioned and mounted on the top end of the guide screw (404).

8. The high-throughput removal device for serum high-peak protein in proteomics according to claim 7, characterized in that: The disassembly assembly component (5) comprises an insert plate (501) and a slot (502); the insert plate (501) is horizontally extended and fixed on one side of the outer periphery of the cover plate (106); a locking hole (505) is vertically opened in the middle of the top surface of the insert plate (501); the slot (502) is horizontally opened in the side end surface of the mounting arm (402) away from the guide screw (404) along the horizontal direction; the insert plate (501) is inserted into the slot (502) in a horizontal sliding manner; a matching hole (504) is vertically opened on the top surface of the mounting arm (402); the matching hole (504) is vertically connected to the slot (502); the matching hole (504) and the locking hole (505) are vertically coaxially aligned; the matching holes (504) are detachably inserted with locking rods (506) in a vertically matching manner; and the lower part of the locking rod (506) is coaxially detachably inserted into the locking hole (505).

9. The high-throughput removal device for serum high-peak protein in proteomics according to claim 8, characterized in that: The locking rod (506) is a stud, the matching hole (504) and the locking hole (505) are both threaded through holes, and the locking rod (506) and the matching hole (504) and the locking hole (505) are detachably assembled in a threaded matching manner.

10. The high-throughput removal device for serum high-peak protein in proteomics according to claim 8 or 9, characterized in that: The plug plate (501) is a rectangular plate, the slot (502) is a rectangular blind slot, and the inner end of the plug plate (501) is in close contact with the inner end of the slot (502), and the top end of the locking rod (506) is coaxially fixed with a holding end (503) for easy holding.

Images