Novel feedback bag capable of filtering and flushing cells
By setting up a multi-layer filtration device and cleaning tube in the cell retract bag, the problem of cell mass formation and waste during cell filling and retracting is solved, and the operation safety and cell utilization are improved.
Patent Information
- Application Number
- CN202420465394.7
- Authority / Receiving Office
- CN · China
- Patent Type
- Utility models(China)
- Current Assignee / Owner
- Filing Date
- 2024-03-12
- Publication Date
- 2025-01-03
- Estimated Expiration
- 2034-03-12
AI Technical Summary
In the existing cell filling technology, cell clusters are easily formed during cell filtration and re-transfusion, which increases operational risks and cell waste. The existing re-transfusion bag design is not convenient for effective filtration and cleaning, resulting in easy cell preparations during transportation. Remaining.
Design a new type of re-entry bag that can filter and flush cells, including soft bag body, cleaning tube, input tube, infusion tube and output tube. Each pipe is equipped with filtering devices, including multi-layer medical infusion filters, through which filtering The device can be filtered multiple times during cell filling and re-infusion to reduce cell mass formation and set up cleaning tubes on the top of the re-infusion bag to facilitate the rinsing of residual cells in normal saline.
The formation of cell mass is reduced through multiple filtration, the risk of capillary blockage is reduced, the safety of return is improved, and cell waste is reduced through the use of cleaning tubes, improving cell utilization and accuracy of detection results.
Smart Images
Figure CN222285964U_ABST
Abstract
Description
Technical Field
[0001] The utility model relates to the technical field of cell filling in cell therapy, in particular to a novel reinfusion bag capable of filtering and flushing cells. Background Art
[0002] Cell therapy is a rising biological treatment technology, including immune cell therapy and stem cell therapy. Currently, cell therapy technology is becoming more and more mature and has been increasingly used in clinical practice. Cell therapy is to collect cells from the human body and culture them in vitro. After the cells are expanded to a certain number, they are filled into a re-infusion bag to make a cell preparation, which is then re-infused into the human body, thereby preventing certain diseases, improving the body's immunity, and improving the body's health and quality of life.
[0003] At present, the commonly used method of cell filling in clinical practice is to resuspend the prepared single cells with physiological saline and inject them into an infusion bag or blood bag. In this process, the cells are revived, washed, centrifuged, filtered, resuspended, etc. to make a cell suspension, which is injected into the reinfusion bag through a syringe. At present, the commonly used cell reinfusion bag has a single input tube and a single infusion tube, both of which are connected to a soft bag body with a liquid cavity. The input tube and the infusion tube are at the lower end of the soft bag body and are connected to the liquid cavity.
[0004] The prepared cell preparation enters the liquid-containing cavity through the input tube, and the needle tube is connected to the infusion tube for infusion. Before the cell filling operation, the collected cells must be filtered to remove possible impurities and cell clusters to obtain a single cell suspension (cell preparation) to prevent cell clusters from clogging the capillaries and causing capillary embolism. This increases the operation time and cell exposure time, which increases the risk. In addition, since the cell concentration of the cell preparation is generally very high, cell clusters are also easily formed during cell transportation, which brings certain risks to the reinfusion. During the cell reinfusion process, the cell preparation is a high-concentration cell suspension, which is easy to remain in the cell packaging, resulting in a lot of cell waste. Utility Model Content
[0005] The purpose of the utility model is to provide a novel reinfusion bag capable of filtering and flushing cells, so as to solve the problems encountered in the above-mentioned background technology.
[0006] To achieve the above purpose, the technical solution of the utility model is as follows:
[0007] A novel reinfusion bag capable of filtering and flushing cells comprises a soft bag body, wherein a liquid containing cavity is arranged in the soft bag body, and the characteristics are as follows: a cleaning tube is arranged on one side of the top of the soft bag body, and an input tube, an infusion tube and an output tube are arranged on the bottom of the soft bag body, the cleaning tube, the input tube, the infusion tube and the output tube are all connected with the liquid containing cavity, and filtering devices are arranged on the cleaning tube, the input tube, the infusion tube and the output tube.
[0008] In the above scheme, the filtering device is a medical infusion filter, which includes a first filter, a second filter, a third filter and a fourth filter. The first filter is installed on the cleaning tube, the second filter is installed on the input tube, the third filter is installed on the infusion tube, and the fourth filter is installed on the output tube.
[0009] In the above scheme, the outer side of the first filter, the outer side of the second filter, and the outer side of the fourth filter are all provided with protective sleeves. In addition, the lower end of the infusion tube is provided with a cap.
[0010] In the above solution, a hanging hole is provided on the top of the soft bag body. As a preferred solution, the hanging hole is a long groove structure.
[0011] Compared with the prior art, the beneficial effects of the utility model are:
[0012] 1. Adding a micro filter to the original input tube can save the time of the filtration step during the operation. If it is to ensure product quality, it can also play the role of multiple filtration, which may reduce the formation of cell clusters and prevent excessive precipitation of cell clusters in the liquid chamber; adding a micro filter to the original infusion set may reduce the formation of cell clusters during reinfusion, reduce the risk of capillary blockage, and improve reinfusion safety; adding a micro filter to the output tube can reduce the aggregation of cell clusters when extracting cell quality inspection samples, making the test results more accurate and reliable.
[0013] 2. During the cell reinfusion process, the cell preparation is a high-concentration cell suspension, which is easy to remain in the cell packaging, resulting in a lot of cell waste. A cleaning tube is set on the top of the reinfusion bag, and a filtering device is installed. Physiological saline can be injected into the reinfusion bag through the cleaning tube to clean the cells remaining in the liquid cavity for re-infusion. The filter membrane in the filtering device reduces the risk of impurities in the physiological saline and avoids contamination of the cells in the liquid cavity. By cleaning the cells, the waste of cells is reduced and the effect of full utilization is achieved. BRIEF DESCRIPTION OF THE DRAWINGS
[0014] The disclosure of the present invention is described with reference to the accompanying drawings. It should be understood that the drawings are only for illustrative purposes and are not intended to limit the scope of protection of the present invention. In the accompanying drawings, the same reference numerals are used to refer to the same components. Among them:
[0015] Figure 1 It is a schematic diagram of the overall structure of the utility model;
[0016] Numbers in the figure: 1-hanging hole; 2-first protective cover; 3-cleaning tube; 4-first filter; 5-soft bag body; 6-liquid chamber; 7-second protective cover; 8-input tube; 9-second filter; 10-infusion tube; 11-third filter; 12-cap; 13-output tube; 14-fourth filter; 15-third protective cover. DETAILED DESCRIPTION
[0017] In order to make the technical means, creative features, objectives and effects of the utility model easier to understand, the utility model is now further described in detail with reference to the accompanying drawings. These drawings are simplified schematic diagrams, which only illustrate the basic structure of the utility model in a schematic manner, and therefore only show the relevant components of the utility model.
[0018] According to the technical solution of the utility model, without changing the essential spirit of the utility model, a person skilled in the art can propose a variety of interchangeable structural modes and implementation modes. Therefore, the following specific implementation modes and drawings are only exemplary descriptions of the technical solution of the utility model, and should not be regarded as the entirety of the utility model or as a limitation or restriction to the technical solution of the utility model.
[0019] The technical solution of the utility model is further described in detail below in conjunction with the accompanying drawings and embodiments.
[0020] like Figure 1 As shown, a novel reinfusion bag capable of filtering and flushing cells comprises a soft bag body 5, in which a liquid containing cavity 6 is arranged, and the characteristics are as follows: a cleaning tube 3 is arranged on one side of the top of the soft bag body 5, an input tube 8, an infusion tube 10, and an output tube 13 are arranged on the bottom of the soft bag body 5, the cleaning tube 3, the input tube 8, the infusion tube 10, and the output tube 13 are all connected with the liquid containing cavity 6, and filtering devices are arranged on the cleaning tube 3, the input tube 8, the infusion tube 10, and the output tube 13, and the cell solution passing through is filtered by setting the filtering device.
[0021] Specifically, the filtering device is a medical infusion filter, that is, a common micro filter. The filtering device includes a first filter 4, a second filter 9, a third filter 11 and a fourth filter 14. The first filter 4 is installed on the cleaning tube 3, the second filter 9 is installed on the input tube 8, the third filter 11 is installed on the infusion tube 10, and the fourth filter 14 is installed on the output tube 13.
[0022] In addition, protective covers are provided on the outside of the first filter 4, the outside of the second filter 9, and the outside of the fourth filter 14, and a cap 12 is provided at the lower end of the infusion tube 10. For the sake of easy distinction, the protective cover on the outside of the first filter 4 is the first protective cover 2, the protective cover on the outside of the second filter 9 is the second protective cover 7, and the protective cover on the outside of the fourth filter 14 is the third protective cover 15.
[0023] Furthermore, one end of the cleaning tube 3 is connected to the top of the soft bag body 5 and communicates with the liquid containing cavity 6. A first filter 4 is provided in the middle of the cleaning tube 3, which is wrapped in the first protective cover 2 and formed as a whole with the first protective cover 2. The first protective cover 2 can act as a hemostatic clamp to prevent liquid from leaking out when closed. The cleaning tube 3 can be used to inject physiological saline to re-rinse the liquid containing cavity, which reduces the waste of cells in the original technology and fully improves the cell utilization rate. The first filter 4 filters the impurities in the physiological saline to reduce the health risks during the secondary flushing and re-infusion.
[0024] One end of the input tube 8 is connected to the bottom of the soft bag body 5 and communicates with the liquid containing cavity 6. A second filter 9 is arranged in the middle of the input tube 8, which is wrapped in the second protective cover 7 and forms an integral body with the second protective cover 7. The second protective cover 7 can act as a hemostatic clamp to prevent liquid from leaking out when closed. The prepared cells enter the liquid containing cavity through the input tube 8, and pass through the second filter 9 to achieve a filtering effect, thereby reducing the formation of cell clusters.
[0025] One end of the infusion tube 10 is connected to the bottom of the soft bag body 5 and communicates with the liquid containing cavity 6. A third filter 11 is provided in the middle of the infusion tube 10, and a cap 12 is provided at the lower end. When reinfusion is performed, the cap 12 is removed and connected to the reinfusion device. The solution passes through the third filter 11 to achieve a filtering effect, reducing the number of cell clusters entering the capillaries through the infusion tube 10 and reducing the risk.
[0026] One end of the output tube 13 is connected to the bottom of the soft bag body 5 and communicates with the liquid containing cavity 6. A fourth filter 14 is arranged in the middle of the output tube 13, which is wrapped in a third protective cover 15 and integrated with the third protective cover 15. The third protective cover 15 can act as a hemostatic clamp to prevent liquid from leaking out when closed. Liquid sampling can be performed through the output tube 13 for quality inspection. The solution passes through the fourth filter 14 to achieve a filtering effect, thereby preventing cell precipitation and cell clusters from affecting the test results.
[0027] In addition, a hanging hole 1 is provided on the top of the soft bag body 5, and the soft bag body 5 is hung through the hanging hole 1 during reinfusion. As a preferred solution, the hanging hole 1 is a long groove structure, because the soft bag body 5 is made of soft material, when hanging, the long groove-shaped hanging hole 1 passes through the hook, which is very convenient, and is affected by the gravity of the solution in the soft bag body 5, and automatically slides, so that the hook is in the middle of the hanging hole 1.
[0028] In this solution, a micro filter is added to the original input tube 8, which can save the time of the filtration step in the operation. If the purpose is to ensure product quality, the effect of multiple filtration can also be exerted, which may reduce the formation of cell clusters and prevent excessive precipitation of cell clusters in the liquid chamber; adding a micro filter to the original infusion set 10 may reduce the formation of cell clusters during reinfusion, reduce the risk of capillary blockage, and improve the safety of reinfusion; adding a micro filter to the output tube 13 can reduce the aggregation of cell clusters when it is necessary to extract cell quality inspection samples, so that the test results can be more accurate and reliable.
[0029] During the cell reinfusion process, the cell preparation is a high-concentration cell suspension, which is easy to remain in the cell packaging, resulting in a large amount of cell waste. A cleaning tube 3 is set on the top of the reinfusion bag, and a filtering device is installed. Physiological saline can be injected into the reinfusion bag through the cleaning tube 3 to clean the cells remaining in the liquid chamber for re-infusion. The filter membrane in the filtering device reduces the risk of impurities in the physiological saline and avoids contamination of the cells in the liquid chamber. By cleaning the cells, the waste of cells is reduced, and the effect of full utilization is achieved.
[0030] It should be noted that, in this article, relational terms such as first and second, etc. are only used to distinguish one entity or operation from another entity or operation, and do not necessarily require or imply any such actual relationship or order between these entities or operations. Moreover, the terms "include", "comprises" or any other variants thereof are intended to cover non-exclusive inclusion, so that a process, method, article or device including a series of elements includes not only those elements, but also other elements not explicitly listed, or also includes elements inherent to such process, method, article or device. These undisclosed elements are all prior art that can be known to those skilled in the art.
[0031] The specific implementation methods described above further illustrate the purpose, technical solutions and beneficial effects of the utility model in detail. It should be understood that the above description is only the specific implementation method of the utility model and is not used to limit the protection scope of the utility model. Any modifications, equivalent substitutions, improvements, etc. made within the spirit and principles of the utility model should be included in the protection scope of the utility model.
Claims
1. A novel reinfusion bag capable of filtering and flushing cells, comprising a soft bag body (5), wherein a liquid containing cavity (6) is provided in the soft bag body (5), and characterized in that: A cleaning tube (3) is provided on one side of the top of the soft bag body (5), and an input tube (8), an infusion tube (10), and an output tube (13) are provided on the bottom of the soft bag body (5); the cleaning tube (3), the input tube (8), the infusion tube (10), and the output tube (13) are all connected to the liquid containing cavity (6); and filtering devices are provided on the cleaning tube (3), the input tube (8), the infusion tube (10), and the output tube (13).
2. A novel cell-filtering and flushing reinfusion bag according to claim 1, characterized in that: The filtering device is a medical infusion filter, comprising a first filter (4), a second filter (9), a third filter (11) and a fourth filter (14), wherein the first filter (4) is mounted on a cleaning tube (3), the second filter (9) is mounted on an input tube (8), the third filter (11) is mounted on an infusion tube (10), and the fourth filter (14) is mounted on an output tube (13).
3. A novel cell-filtering and flushing reinfusion bag according to claim 2, characterized in that: The outer side of the first filter (4), the outer side of the second filter (9), and the outer side of the fourth filter (14) are all provided with protective covers.
4. A novel reinfusion bag capable of filtering and flushing cells according to claim 2, characterized in that: The lower end of the infusion tube (10) is provided with a cap (12).
5. A novel reinfusion bag capable of filtering and flushing cells according to claim 1, characterized in that: The top of the soft bag body (5) is provided with a hanging hole (1).
6. A novel reinfusion bag capable of filtering and flushing cells according to claim 5, characterized in that: The hanging hole (1) is a long groove structure.