Novel micron-sized particle size grading device

Abstract

The utility model belongs to the technical field of gel particle grading, and discloses a novel micron-sized particle size grading device. The device comprises a base, an outer column pipe is arranged on the surface of the base, an inner column pipe is arranged in the outer column pipe in a sleeved mode, the top of the inner column pipe penetrates through the top of the outer column pipe through a transmission shaft to be connected to the driving end of a driving motor, and a feeding hopper and an emptying valve are further arranged on the two sides of the top of the outer column pipe correspondingly. The bottom of the inner column pipe penetrates through the bottom of the outer column pipe through a hollow pipe and is connected to a first discharge valve, a liquid inlet pipeline is further arranged at the bottom of the outer column pipe, and a second discharge valve and a liquid inlet valve are arranged on the liquid inlet pipeline. The inner column pipe is driven by the driving motor to rotate, then the screen on the surface of the inner column pipe is driven to rotate, and it can be avoided that filter cakes are formed in the inner column pipe in the grading process, and through holes are blocked. And the screening efficiency is improved. When the device is used, the screening and filtering efficiency is high, large-scale production can be met, and the production cost of enterprises is reduced.

Description

Technical Field

[0001] The utility model relates to the technical field of gel particle classification, in particular to a novel micron-level particle size classification device. Background Art

[0002] The particle size of micron-sized gel particles is widely distributed during preparation, and classification has always been difficult, especially for large-scale production of more than dozens of liters. For example, for commercial agarose, dextran, cellulose, and acrylamide chromatography media used for chromatographic separation, most of the particle sizes are between 50 and 300 μm. It is necessary to remove smaller particles below 50 μm and larger particles above 300 μm before they can be used. This type of micron-sized gel particles are mostly stored or used in aqueous solutions, so wet classification is required. If classification is performed after drying, due to the strong hydrophilicity of the matrix material itself, the surface electrostatic properties are very strong after drying, and it is easy to agglomerate; second, it is easy to absorb moisture in the air, and the particle size changes to different degrees after absorbing water; third, after drying, many gel particles cannot swell to the original particle size when adding water, which changes the physical and chemical properties of the gel particles; fourth, the process cost will be greatly increased if the classification is performed after drying and then absorbing water and re-dissolving.

[0003] There are currently two processing methods for wet classification in production: one is free sedimentation classification, that is, based on the principle that large particles settle quickly and small particles settle slowly during free sedimentation, the particles at both ends are continuously sedimented to obtain the desired middle section; the second is to use a large-area filter screen in water with an agitator to grade while stirring. The first method is only suitable for initial separation of small or large separations, because the boundary line of the particle size of the sedimentation method cannot be determined, which also leads to a long period of mixed layers of large and small particles during the sedimentation process, which is difficult to separate; the second method is more practical, but requires a stirrer to continuously stir to prevent the formation of filter cakes. In summary, the existing device is complicated to operate when in use, the labor intensity of the staff is high, the filtration efficiency is low, and it is difficult to achieve large-scale production. Utility Model Content

[0004] The purpose of the utility model is to provide a novel micron-level particle size classification device to solve the problems raised in the above background technology.

[0005] In order to achieve the above purpose, the utility model provides the following technical solutions:

[0006] A novel micron-level particle size classification device comprises a base, an outer column tube is arranged on the surface of the base, an inner column tube is sleeved inside the outer column tube, the top of the inner column tube passes through the top of the outer column tube through a transmission shaft and is connected to the driving end of a driving motor, a feed funnel and an emptying valve are respectively arranged on both sides of the top of the outer column tube, the bottom of the inner column tube passes through the bottom of the outer column tube through a hollow tube and is connected to a first discharge valve, a liquid inlet pipeline is also arranged at the bottom of the outer column tube, and a second discharge valve and a liquid inlet valve are respectively arranged on the liquid inlet pipeline.

[0007] Further preferably, sealing plates are provided at both ends of the inner column tube, and a plurality of through holes are evenly provided on the circumferential surface of the inner column tube.

[0008] Further preferably, the circumferential surface of the inner column tube is also provided with a screen in a detachable manner. The screen is made of materials such as stainless steel, PP, nylon or nylon.

[0009] Further preferably, the pore size of the sieve is 1 μm to 1000 μm.

[0010] Further preferably, the outer column tube surface is also provided with an observation window. The outer column tube is made of ordinary glass, organic glass, other synthetic polymer transparent materials or metal materials. When the outer column tube is made of ordinary glass, organic glass or other synthetic polymer transparent materials, it is not necessary to set an observation window on its surface; when it is made of metal materials, it is necessary to set an observation window on the outer column tube surface. This is to facilitate observation of the liquid level and classification inside the outer column tube.

[0011] Further preferably, the liquid inlet valve is arranged between the outer column tube and the second discharge valve.

[0012] Compared with the prior art, the beneficial effects of the utility model are:

[0013] By driving the inner column tube to rotate through the driving motor, the screen on the surface of the inner column tube is driven to rotate, which can avoid the formation of filter cakes in the inner column tube during the classification process, thereby clogging the through hole, thereby improving the screening efficiency.

[0014] By adjusting the rotation speed of the driving motor, the entry speed of the liquid passing through the screen and the through hole into the inner column tube can be controlled, thereby controlling the outflow speed of the small particles screened out by the inner column tube.

[0015] The drain valve, the first discharge valve, the second discharge valve and the liquid inlet valve can be manually controlled valves, or they can be replaced by pneumatic valves or electromagnetic valves to achieve automatic control in conjunction with a control panel, thereby further improving the working efficiency of the device.

[0016] The device can also be used in series with multiple sets of devices according to different particle size classification requirements, thereby improving production efficiency and saving production costs.

[0017] In summary, the device is easy to operate, has low labor intensity for staff, has high screening and filtration efficiency, can meet large-scale production, and reduce the production cost of the enterprise. BRIEF DESCRIPTION OF THE DRAWINGS

[0018] Figure 1 It is a schematic diagram of the overall structure of the utility model;

[0019] In the figure: 1. Feed funnel; 2. Drive motor; 3. Emptying valve; 4. Outer column tube; 5. Inner column tube; 6. Base; 7. First discharge valve; 8. Second discharge valve; 9. Liquid inlet valve. DETAILED DESCRIPTION

[0020] The following will be combined with the drawings in the embodiments of the utility model to clearly and completely describe the technical solutions in the embodiments of the utility model. Obviously, the described embodiments are only part of the embodiments of the utility model, not all of the embodiments. Based on the embodiments in the utility model, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the utility model.

[0021] See also Figure 1 , the utility model provides a technical solution:

[0022] A novel micron-level particle size classification device comprises a base 6, an outer column tube 4 is arranged on the surface of the base 6, an inner column tube 5 is sleeved inside the outer column tube 4, the top of the inner column tube 5 penetrates the top of the outer column tube 4 through a transmission shaft and is connected to the driving end of a driving motor 2, a feeding funnel 1 and an emptying valve 3 are respectively arranged on both sides of the top of the outer column tube 4, the bottom of the inner column tube 5 penetrates the bottom of the outer column tube 4 through a hollow tube and is connected to a first discharge valve 7, and a liquid inlet pipeline is also arranged at the bottom of the outer column tube 4, and a second discharge valve 8 and a liquid inlet valve 9 are respectively arranged on the liquid inlet pipeline. A sealing structure is arranged at the connection between the transmission shaft at the top of the inner column tube 5 and the top of the outer column tube 4, and at the connection between the hollow tube at the bottom of the inner column tube 5 and the bottom of the outer column tube 4.

[0023] In the utility model, sealing plates are provided at both ends of the inner column tube 5, and a plurality of through holes are evenly provided on the circumferential surface of the inner column tube 5. A screen is also provided on the circumferential surface of the inner column tube 5 in a detachable manner. The aperture of the screen is 1 μm to 1000 μm. The screen is made of materials such as stainless steel, PP, nylon or nylon.

[0024] In the utility model, an observation window is also provided on the surface of the outer column tube 4. The outer column tube 4 is made of ordinary glass, organic glass, other synthetic high molecular polymer transparent materials or metal materials. When the outer column tube 4 is made of ordinary glass, organic glass or other synthetic high molecular polymer transparent materials, it is not necessary to set an observation window on its surface; when it is made of metal materials, it is necessary to set an observation window on the surface of the outer column tube 4. This is to facilitate observation of the liquid level and classification inside the outer column tube 4.

[0025] In the utility model, the liquid inlet valve 9 is arranged between the outer column tube 4 and the second discharge valve 8 .

[0026] Example 1: Taking the sieving of 0-280 μm agarose microsphere particles into 45-165 μm particles as an example, firstly, a 165 μm stainless steel screen is installed on the surface of the inner column tube 5, and then other components of the device such as Figure 1 Combine together. Then open the inlet valve 9 on the inlet pipeline, add deionized water or distilled water to the outer column tube 4 until it is added to one-half of the outer column tube 4, then add the agarose microsphere particles that need to be screened from the feed funnel 1 to the outer column tube 4, and then turn on the switch of the drive motor 2, and drive the inner column tube 5 to rotate through the drive motor 2. At the same time, open the first discharge valve 7, and discharge the agarose microsphere particles below 165μm through the hollow tube at the bottom of the inner column tube 5 and the first discharge valve 7. During the screening and discharge process, the inlet valve 9 is in a normally open state, and deionized water or distilled water is continuously added to the outer column tube 4. The water inlet amount through the inlet valve 9 and the water outlet amount through the first discharge valve 7 are guaranteed to be equal. Collect them through a collection bucket or other collection device for further classification. After a period of time, when the liquid discharged from the first discharge valve 7 does not contain agarose microsphere particles, close the first discharge valve 7 and the liquid inlet valve 9, open the second discharge valve 8 on the liquid inlet pipeline to discharge the agarose microsphere particles containing more than 165μm in the outer column tube 4, thereby achieving the preliminary screening of agarose microsphere particles of 0 to 280μm. Then, replace the 165μm stainless steel screen installed on the surface of the inner column tube 5 with a 45μm stainless steel screen, repeat the above steps, and perform secondary screening on the liquid containing agarose microsphere particles below 165μm discharged from the first discharge valve 7 collected by the collection bucket or other collection devices, thereby achieving the screening of 45 to 165μm particles from 0 to 280μm agarose microsphere particles.

[0027] Example 2: The difference between this example and Example 1 is that when the gel particles need to be screened and graded in multiple stages, it is only necessary to connect the first discharge valve 7 and the second discharge valve 8 of multiple new micron-level particle size grading devices in series with the feed funnel 1, thereby repeating the steps in Example 1 to complete the multi-stage screening and grading of the gel particles.

[0028] It is obvious to those skilled in the art that the present invention is not limited to the details of the exemplary embodiments described above, and that the present invention can be implemented in other specific forms without departing from the spirit or basic features of the present invention. Therefore, no matter from which point of view, the embodiments should be regarded as exemplary and non-restrictive, and the scope of the present invention is defined by the appended claims rather than the above description, and it is intended that all changes falling within the meaning and scope of the equivalent elements of the claims are included in the present invention, and any figure mark in the claims should not be regarded as limiting the claims involved.

[0029] The above description is only a preferred specific implementation manner of the present invention, but the protection scope of the present invention is not limited thereto. Any technician familiar with the technical field can make equivalent replacements or changes within the technical scope disclosed by the present invention according to the technical scheme and the utility model concept of the present invention, which should be covered by the protection scope of the present invention.

Claims

1. A novel micron-sized particle size classification device, comprising a base (6), characterized in that: An outer column tube (4) is arranged on the surface of the base (6), an inner column tube (5) is sleeved inside the outer column tube (4), the top of the inner column tube (5) passes through the top of the outer column tube (4) via a transmission shaft and is connected to the driving end of the driving motor (2), a feeding funnel (1) and an emptying valve (3) are also arranged on both sides of the top of the outer column tube (4), the bottom of the inner column tube (5) passes through the bottom of the outer column tube (4) via a hollow tube and is connected to the first discharge valve (7), and a liquid inlet pipeline is also arranged at the bottom of the outer column tube (4), and a second discharge valve (8) and a liquid inlet valve (9) are respectively arranged on the liquid inlet pipeline.

2. A novel micron-sized particle size classification device according to claim 1, characterized in that: Sealing plates are provided at both ends of the inner column tube (5), and a plurality of through holes are evenly provided on the circumferential surface of the inner column tube (5).

3. A novel micron-sized particle size classification device according to claim 2, characterized in that: The circumferential surface of the inner column tube (5) is also provided with a screen in a detachable manner.

4. A novel micron-sized particle size classification device according to claim 3, characterized in that: The pore size of the sieve is 1 μm to 1000 μm.

5. A novel micron-sized particle size classification device according to claim 1, characterized in that: An observation window is also provided on the surface of the outer column tube (4).

6. A novel micron-sized particle size classification device according to claim 1, characterized in that: The liquid inlet valve (9) is arranged between the outer column tube (4) and the second discharge valve (8).

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