Animal fixing device and ultrasonic focusing equipment

Abstract

The utility model provides an animal fixing device and ultrasonic focusing equipment, and relates to the technical field of ultrasonic equipment. The animal fixing device and the ultrasonic focusing equipment comprise a carrying table, a base, an up-down clamping assembly, a left-right clamping assembly and an occlusion piece. The base is arranged on the carrying table, the up-down clamping assembly and the left-right clamping assembly are movably connected to the base and matched with the carrying table to form a clamping space used for fixing the small animal, and the occlusion piece is connected to the base, located in the clamping space and used for occlusion of the small animal. According to the animal fixing device and the ultrasonic focusing equipment, small animals with different figures can be fixed, damage to the small animals is reduced, and the accuracy, stability and safety in the experiment or treatment process are improved.

Description

Technical Field

[0001] The utility model relates to the technical field of ultrasonic equipment, in particular to an animal fixing device and ultrasonic focusing equipment. Background Art

[0002] Ultrasonic focusing uses ultrasound as an energy source to focus multiple beams of ultrasound on one point. Through the conversion of sound waves and heat energy, a high-temperature treatment point of 70℃~100℃ is formed within 0.5 to 1 second. This high-temperature point is equivalent to a scalpel cutting a tumor, causing the tumor tissue to produce coagulative necrosis and lose the ability to proliferate, infiltrate and metastasize. Therefore, it is widely used in thermal ablation treatment of diseases such as uterine fibroids, adenomyosis, breast tumors, prostate tumors, Parkinson's disease, and essential tremor caused by Parkinson's disease.

[0003] In addition to thermal effects, focused ultrasound also has biological effects such as cavitation and mechanics. In order to accurately grasp these principles and apply them clinically, multiple experimental demonstrations are required. In the experimental stage, small animals are generally selected as experimental subjects. If the existing clinical focused ultrasound equipment is used directly, on the one hand, due to the small size of small animals and the large size of the equipment, it is not easy to locate the target area of ​​the small animal, resulting in changes in the position of the treatment area, resulting in low treatment accuracy, relatively complicated operation, and easy to cause unnecessary harm to the small animal, affecting safety and treatment stability; on the other hand, due to the differences in the body shape of small animals, the same equipment can only fix small animals of similar size, resulting in poor applicability of the device. Utility Model Content

[0004] The purpose of the utility model is to provide an animal fixing device and an ultrasonic focusing device, which can fix small animals of different shapes, reduce harm to the small animals, and improve the accuracy, stability and safety during experiments or treatments.

[0005] To achieve this purpose, the utility model adopts the following technical solutions:

[0006] Animal restraints, including;

[0007] Carrier;

[0008] A base is arranged on the carrier;

[0009] Upper and lower clamping components, movably connected to the base;

[0010] Left and right clamping assemblies are movably connected to the base and cooperate with the upper and lower clamping assemblies and the carrier to form a clamping space for fixing small animals;

[0011] A biting piece is connected to the base and is located in the clamping space for biting the small animal.

[0012] As a further technical solution, the base is arranged on the upper surface of the carrier, the engaging member is arranged as a rod, the first end of the engaging member is movably connected to the base through a first adjusting member, the second end of the engaging member is located in the clamping space and is arranged as an engaging portion, and the second end of the engaging member is inclined in a direction away from the carrier.

[0013] As a further technical solution, the upper and lower clamping assemblies include a pressing member, which is rotatably connected to the base to adjust the size of the clamping space in the Z direction.

[0014] As a further technical solution, the upper and lower clamping assemblies further include a second adjusting member and an elastic member, the base includes a first connecting rod extending along the Y direction, and the pressing member includes a pressing rod and a pressing portion and an adjusting portion respectively connected to both ends of the pressing rod;

[0015] The middle part of the pressure rod is rotatably connected to the first connecting rod, and the adjusting part is located below the first connecting rod, the elastic member is arranged between the adjusting part and the first connecting rod, the second adjusting member is used to adjust the relative position of the adjusting part and the first connecting rod, and the pressing part is used to press the small animal.

[0016] As a further technical solution, the base includes two second connecting rods extending along the Y direction, the two second connecting rods are arranged in parallel and spaced apart, and each of the second connecting rods is respectively provided with a set of left and right clamping components;

[0017] The left and right clamping assemblies include an auxiliary part and a clamping rod. The auxiliary part is connected to the corresponding second connecting rod. The clamping rod is movably connected to the auxiliary part for clamping the small animal and adjusting the size of the clamping space in the X direction.

[0018] As a further technical solution, the left and right clamping assemblies also include a clamping arm and a third adjusting member, the clamping arm is movably connected to the corresponding second connecting rod through the third adjusting member to adjust the size of the clamping space in the Y direction, and the auxiliary member is fixedly connected to the clamping arm.

[0019] As a further technical solution, the animal fixing device further comprises a positioning ring, which is located in the clamping space and is arranged on the small animal to confirm the position of the small animal.

[0020] As a further technical solution, the animal fixing device also includes a bottom plate and a connecting component, the carrier is arranged on the bottom plate, the connecting component is movably connected to the bottom plate, and the base is movably connected to the connecting component to adjust the relative position of the clamping space.

[0021] The ultrasonic focusing device comprises a coupling water tank, an ultrasonic focusing device and an animal fixing device, wherein the ultrasonic focusing device is movably arranged on a bottom plate in the animal fixing device, the coupling water tank is arranged above the carrier, and the clamping space is located between the carrier and the coupling water tank.

[0022] As a further technical solution, the ultrasonic focusing device includes a focused ultrasonic probe and a support frame mechanism, wherein the support frame mechanism supports the focused ultrasonic probe and can adjust the relative position of the focused ultrasonic probe and the animal fixing device along the X direction, the Y direction and the Z direction, and the focused ultrasonic probe is configured to be connected to the terminal.

[0023] Compared with the prior art, the animal fixation device and ultrasonic focusing device provided by the utility model have the following technical advantages:

[0024] The utility model forms a clamping space for fixing small animals through the cooperation of the upper and lower clamping components and the left and right clamping components in the animal fixing device with the carrier, and a bite piece is arranged in the clamping space. When it is necessary to fix the small animal, the head of the small animal is placed in the clamping space to limit the target small animal, and the small animal is allowed to bite the bite piece to further limit the relative position of the small animal, so as to avoid the change of the position of the target area due to the movement of the head of the small animal or the shaking and twitching of the small animal, and the occurrence of low treatment accuracy, while reducing the damage to the small animal and improving the safety and stability during the experiment or treatment. At the same time, since the upper and lower clamping components and the left and right clamping components are all movably connected to the base, when fixing the small animal, the size of the clamping space can be changed according to the actual body shape of the small animal by changing the relative position of the upper and lower clamping components and / or the left and right clamping components and the base, so as to further reduce the damage to the small animal and improve the application scope of the animal fixing device. BRIEF DESCRIPTION OF THE DRAWINGS

[0025] Figure 1 This is a schematic diagram of the structure of the animal fixing device provided by the embodiment of the utility model. Figure 1 ;

[0026] Figure 2 It is a structural schematic diagram of an animal fixing device provided in an embodiment of the utility model (excluding left and right clamping components);

[0027] Figure 3 is a side view of an animal fixing device provided by an embodiment of the utility model;

[0028] Figure 4 This is a schematic diagram of the structure of the animal fixing device provided by the embodiment of the utility model. Figure 2 ;

[0029] Figure 5It is a structural schematic diagram of a base in an animal fixing device provided in an embodiment of the utility model;

[0030] Figure 6 It is a structural schematic diagram of a pressing member in an animal fixing device provided by an embodiment of the utility model;

[0031] Figure 7 is an exploded diagram of an ultrasonic focusing device provided by an embodiment of the utility model;

[0032] Figure 8 It is a schematic diagram of the structure of the ultrasonic focusing device provided in an embodiment of the utility model.

[0033] In the figure: 10, clamping space; 20, small animals;

[0034] 100, base; 110, first connecting rod; 111, bearing seat; 112, first adjustment groove; 120, second connecting rod; 121, second adjustment groove;

[0035] 200, bite member; 210, bite portion; 220, first adjustment member;

[0036] 310, pressing member; 311, pressing rod; 3110, connecting through hole; 312, pressing portion; 313, adjusting portion; 3131, limiting groove; 3132, auxiliary portion; 320, second adjusting member; 330, elastic member;

[0037] 400, left and right clamping components; 410, auxiliary component; 420, clamping rod; 430, clamping arm; 440, third adjusting component;

[0038] 500, carrier;

[0039] 600, coupling water tank;

[0040] 700, bottom plate; 710, third adjustment slot;

[0041] 800, ultrasonic focusing device; 810, focused ultrasonic probe; 820, support frame mechanism; 821, vertical adjustment assembly; 8211, universal ball joint; 822, X-direction adjustment assembly; 823, Y-direction adjustment assembly; 830, installation assembly;

[0042] 900. Connecting components. DETAILED DESCRIPTION

[0043] The present invention is further described in detail below in conjunction with the accompanying drawings and embodiments. It is to be understood that the specific embodiments described herein are only used to explain the present invention, rather than to limit the present invention. It should also be noted that, for ease of description, only the parts related to the present invention, rather than all structures, are shown in the accompanying drawings.

[0044] In the description of the present invention, unless otherwise clearly specified and limited, the terms "connected", "connected", and "fixed" should be understood in a broad sense, for example, it can be a fixed connection, a detachable connection, or an integral connection; it can be a mechanical connection or an electrical connection; it can be a direct connection or an indirect connection through an intermediate medium, it can be the internal connection of two elements or the interaction relationship between two elements. For ordinary technicians in this field, the specific meanings of the above terms in the present invention can be understood according to specific circumstances.

[0045] In the present utility model, unless otherwise clearly specified and limited, a first feature being "above" or "below" a second feature may include that the first and second features are in direct contact, or may include that the first and second features are not in direct contact but are in contact through another feature between them. Moreover, a first feature being "above", "above" and "above" a second feature includes that the first feature is directly above and obliquely above the second feature, or simply indicates that the first feature is higher in level than the second feature. A first feature being "below", "below" and "below" a second feature includes that the first feature is directly below and obliquely below the second feature, or simply indicates that the first feature is lower in level than the second feature.

[0046] In the description of this embodiment, the terms "upper", "lower", "right", etc., are based on the directions or positions shown in the drawings, and are only for the convenience of description and simplified operation, rather than indicating or implying that the device or element referred to must have a specific direction, be constructed and operated in a specific direction, and therefore cannot be understood as a limitation of the present invention. In addition, the terms "first" and "second" are only used to distinguish in the description and have no special meaning.

[0047] Combination Figure 1-Figure 8 As shown, this embodiment provides an ultrasonic focusing device for conducting experiments or treatments on small animals 20. Specifically, the ultrasonic focusing device includes a coupling water tank 600, an ultrasonic focusing device 800, and an animal fixing device, wherein the ultrasonic focusing device 800 is disposed on a bottom plate 700 in the animal fixing device, the coupling water tank 600 is disposed above the stage 500, and the clamping space 10 is located between the stage 500 and the coupling water tank 600.

[0048] Since the ultrasonic focusing device is provided with an ultrasonic focusing device 800, and the ultrasonic focusing device 800 is provided on the bottom plate 700 and is located above the animal fixing device, during the experiment or treatment process, the ultrasonic focusing device 800 can meet the requirements of different target area depths, ensuring that the target position is treated while avoiding damage to other areas. And since the ultrasonic focusing device 800 is movably provided on the bottom plate 700, during the experiment or treatment process, the relative position of the ultrasonic focusing device 800 can be changed to avoid problems such as changes in the treatment target position caused by moving the small animal 20 and damage to the small animal 20. The coupling water tank 600 is provided above the animal fixing device and is located between the animal fixing device and the ultrasonic focusing device. The coupling water tank 600 is used to accommodate the medium, and a sound-permeable membrane is provided at the bottom of the coupling water tank 600. The sound-permeable membrane separates the small animal 20 and the medium placed in the clamping space 10, while ensuring that the ultrasonic focusing device 800 is fully coupled with the small animal 20. The medium in the coupling water tank 600 has a guiding function and can provide incident position information of the focus; and the depth of focused ultrasound treatment can be adjusted by controlling the amount of the medium in the coupling water tank 600.

[0049] Preferably, the ultrasonic focusing device 800 includes a focused ultrasonic probe 810 and a support frame mechanism 820, the support frame mechanism 820 supports the focused ultrasonic probe 810 and can adjust the relative position of the focused ultrasonic probe 810 and the animal fixing device along the X direction, Y direction and Z direction, and the focused ultrasonic probe 810 is connected to the terminal (not shown in the figure).

[0050] Specific combination Figure 7 and Figure 8As shown, the support frame mechanism 820 is fixedly arranged on the base plate 700, and the focused ultrasound probe 810 is installed on the support frame mechanism 820. The support frame mechanism 820 is adjusted to be composed of a plurality of groups of relatively movable support components. By adjusting the relative positions between the plurality of groups of support components, the relative position of the focused ultrasound probe 810 and the animal fixing device can be changed, thereby adjusting the position of the treatment focus. The support frame mechanism 820 adjusts the relative position of the focused ultrasound probe 810 along the X direction, the Y direction and the Z direction as follows: the support frame mechanism 820 includes a vertical adjustment component 821, an X direction adjustment component 822 and a Y direction adjustment component 823, and the Y direction adjustment component 823 is arranged on the bottom plate 700; the vertical adjustment component 821 is movably connected to the Y direction adjustment component 823, and the relative position of the vertical adjustment component 821 and the Y direction adjustment component 823 can be adjusted along the Y direction; the X direction adjustment component 822 is movably connected to the vertical adjustment component 821, and the X direction adjustment component 822 can be raised and lowered on the vertical adjustment component 821 along the Z direction to achieve adjustment of the X direction along the Z direction. The relative position of the X-direction adjustment component 822 and the vertical adjustment component 821 is determined, and the X-direction adjustment component 822 can also slide relative to the vertical adjustment component 821 along the X-direction to adjust the relative position of the X-direction adjustment component 822 and the vertical adjustment component 821 along the X-direction; in addition, a universal ball joint 8211 is also provided in the vertical adjustment component 821 to realize the multi-directional rotation adjustment of the vertical adjustment component 821 itself; the focused ultrasonic probe 810 is connected to the X-direction adjustment component 822 through the mounting component 830, and the relative position of the mounting component 830 and the X-direction adjustment component 822 can be adjusted according to actual needs, thereby changing the relative position of the focused ultrasonic probe 810 and the coupling water tank 600. In this embodiment, the relative position of the support frame mechanism 820 along the X-direction, Y-direction and Z-direction is adjusted by adjusting the lead screw, which ensures the adjustment effect and improves the accuracy of position adjustment. In addition, the coupling water tank 600 may also be connected to the support frame mechanism 820 to ensure the relative positions among the coupling water tank 600 , the stage 500 and the focused ultrasound probe 810 .

[0051] The focused ultrasound probe 810 is connected to the support frame mechanism 820, and includes a transmitting part and a receiving part. Specifically, the transmitting part is provided with a focused ultrasound transducer and a concave spherical surface. The focused ultrasound transducer is distributed on the concave spherical surface and can self-focus. The curvature radius of the concave spherical surface is smaller than that of the ultrasound transducer of clinical equipment such as uterine fibroids. The transmitting part converts the electrical signal provided by the terminal into the ultrasonic energy required for treatment. There is a hole in the center of the concave spherical surface for placing the receiving part. The receiving part converts the ultrasonic echo returned by the animal tissue into an electrical signal for cavitation detection at the terminal. The focused ultrasound probe 810 is coupled with the small animal 20 through the coupling water tank 600. In this embodiment, the focused ultrasound transducer adopts a circular phased array, so that the treatment depth and focus size can be adjusted according to actual needs, which can meet the needs of different target depths, and avoid damage to other areas while ensuring that the target position is treated.

[0052] The terminal in this embodiment includes a touch screen treatment parameter setting module, a cavitation signal detection module and a treatment energy supply module. The touch screen treatment parameter setting module can realize the overall control of the ultrasonic focusing device 800, and can select different ultrasonic output modes, such as continuous output mode, pulse output mode, etc.; multiple ultrasonic treatment parameters in the same mode can be set, such as pulse length, ultrasonic frequency, sound pressure, duty cycle, duration, etc., and different ultrasonic treatment parameters in the mode can also be selected to control the emission or stop of treatment energy. The terminal can perform cavitation signal detection based on the ultrasonic echo signal returned by the animal tissue after the ultrasonic emission, check whether cavitation is successfully generated in this treatment, decide whether to continue or end this treatment, and perform cavitation detection on the echo signal, and then transmit the data to the operator's PC device, and finally display it in the form of time domain and frequency domain spectrograms. The operator can review the cavitation detection data, export all cavitation detection data of the machine, and also import past cavitation detection data into the terminal.

[0053] In addition, the ultrasonic focusing device 800 provided in this embodiment can also replace the applicable medium or the components installed on the support frame mechanism 820 according to different diseases or treatment requirements to improve the comprehensiveness and flexibility of experiments or treatments.

[0054] Specific combination Figures 1 to 4As shown, the animal fixing device provided in this embodiment is applied to the above-mentioned ultrasonic focusing device 800, and is mainly used to fix the small animal 20 during the experiment or treatment process, so as to improve the accuracy, safety and stability during the experiment or treatment process. Specifically, the animal fixing device includes a platform 500, a base 100, an upper and lower clamping assembly, a left and right clamping assembly 400 and a bite piece 200; the base 100 is arranged on the platform 500, the upper and lower clamping assemblies and the left and right clamping assemblies 400 are all movably connected to the base 100, and cooperate with the platform 500 to form a clamping space 10 for fixing the small animal 20, and the bite piece 200 is connected to the base 100 and is located in the clamping space 10, and is used for the small animal 20 to bite.

[0055] Since the upper and lower clamping components and the left and right clamping components 400 in the animal fixing device cooperate with the carrier 500 to form a clamping space 10 for fixing the small animal 20, and a bite piece 200 is provided in the clamping space 10, when the small animal 20 needs to be fixed, the head of the small animal 20 is placed in the clamping space 10 to limit the target small animal 20, and at the same time, the small animal 20 bites the bite piece 200 to further limit the relative position of the small animal 20, thereby avoiding the change of the position of the target area due to the movement of the head of the small animal 20 or the shaking and twitching of the small animal 20, resulting in low treatment accuracy, and at the same time reducing damage to the small animal 20, thereby improving safety and stability during experiments or treatments.

[0056] In addition, since the upper and lower clamping components and the left and right clamping components 400 are movably connected to the base 100, when fixing the small animal 20, the size of the clamping space 10 can be changed according to the actual size of the small animal 20 by changing the relative positions of the upper and lower clamping components and / or the left and right clamping components 400 and the base 100, thereby further reducing damage to the small animal 20 and improving the scope of application of the animal fixing device.

[0057] In an optional technical solution of the present embodiment, the base 100 is arranged on the upper surface of the carrier 500, the bite member 200 is arranged as a rod, the first end of the bite member 200 is movably connected to the base 100 through the first adjustment member 220, the second end of the bite member 200 is arranged as the bite portion 210, and the second end of the bite member 200 is inclined in a direction away from the carrier 500.

[0058] Specific combination Figure 2As shown, the second end of the bite piece 200 is flattened and contracted to form a bite portion 210, which is convenient for the small animal 20 to bite; the second end of the bite piece 200 is tilted in the direction away from the carrier 500, so that a certain gap is formed between the bite portion 210 and the carrier 500 to accommodate the head of the small animal 20, which is convenient for the small animal 20 to bite and does not damage the small animal 20; the base 100 is provided with a first adjustment groove 112 extending along the Y direction, and the first adjustment member 220 is configured as a threaded connector. The first end of the bite piece 200 is connected to the first adjustment groove 112 through the threaded connector, and the relative position of the bite portion 210 and the base 100 is adjusted by loosening the threaded connector to facilitate the bite of small animals 20 of different sizes; the relative position of the bite portion 210 and the base 100 is limited by tightening the threaded connector to avoid displacement of the small animal 20 after biting. In addition, a first guide and limit device is provided between the engaging member 200 and the base 100 to guide and adjust the relative position between the engaging member 200 and the base 100 and prevent the engaging member 200 from being separated from the base 100. The first guide and limit device can be provided as a slide block or a slide rail.

[0059] In the optional technical solution of this embodiment, the upper and lower clamping components include a pressing member 310, which is rotatably connected to the base 100 to adjust the size of the clamping space 10 in the Z direction to achieve clamping of small animals 20 of different sizes while avoiding damage to the small animals 20. Figure 1 , Figure 2 and Figure 6As shown, the upper and lower clamping assemblies also include a second adjusting member 320 and an elastic member 330, the base 100 includes a first connecting rod 110 extending along the Y direction, the pressing member 310 includes a pressing rod 311 and a pressing portion 312 and an adjusting portion 313 respectively connected to both ends of the pressing rod 311; the middle part of the pressing rod 311 is rotatably connected to the first connecting rod 110, and the adjusting portion 313 is located below the first connecting rod 110, the elastic member 330 is arranged between the adjusting portion 313 and the first connecting rod 110, the second adjusting member 320 is used to adjust the relative position of the adjusting portion 313 and the first connecting rod 110, and the pressing portion 312 is used to press the small animal 20. Specifically, the first end of the bite member 200 is movably connected to the first connecting rod 110; the pressing member 310 is configured as a "mouth" shape, and two pressing rods 311 are provided, and the two pressing rods 311 are arranged in parallel and spaced apart, and the first ends of the two pressing rods 311 are connected to the pressing portion 312, and the second ends are connected to the adjusting portion 313, and in the direction from the adjusting portion 313 to the pressing portion 312, the two pressing rods 311 are inclined in the direction away from the carrier 500, and when the middle parts of the two pressing rods 311 are rotated and connected to the first connecting rod 110, the adjusting portion 313 is adjusted. The part 313 is located below the first connecting rod 110, and the pressing part 312 is located above the biting part 210; when the small animal 20 is located in the clamping space 10, the pressing part 312 presses the head of the small animal 20, and cooperates with the carrier 500 to prevent the small animal 20 from shifting along the Z direction in the clamping space 10; and because the pressing member 310 is configured as a "mouth" shape, when the pressing part 312 presses the head of the small animal 20, it can ensure that the pressing force of the pressing part 312 on the small animal 20 is equal, thereby reducing the damage to the small animal 20. In addition, in this embodiment, a bearing seat 111 is provided on the first connecting rod 110, and a connecting through hole 3110 is provided in the middle of the two pressing rods 311, and the connecting bearing passes through the connecting through hole 3110 to be connected to the bearing seat 111.

[0060] The elastic member 330 can be set as a tension spring or a compression spring according to actual needs, the second adjusting member 320 is set as a threaded connector, the end surface of the adjusting portion 313 close to the first connecting rod 110 is provided with a limiting groove 3131, and the bottom wall of the limiting groove 3131 is provided with an adjusting hole; one end of the spring abuts against the bottom wall of the limiting groove 3131, and the other end abuts against the first connecting rod 110, the threaded connector passes through the adjusting hole and is threadedly connected to the first connecting rod 110, and the spring is sleeved on the threaded connector. By twisting the threaded connector, the distance between the pressing portion 312 and the carrier 500 can be adjusted to facilitate clamping of small animals 20 of different sizes, and because a spring is provided between the adjusting portion 313 and the first connecting rod 110, when the small animal 20 struggles or shakes, the spring can be compressed or stretched accordingly, thereby changing the pressing force of the pressing portion 312 on the small animal 20 to a certain extent, reducing damage to the small animal 20. In addition, the end surface of the adjusting portion 313 away from the first connecting rod 110 is provided with an auxiliary portion 3132 , and the end surface of the auxiliary portion 3132 away from the first connecting rod 110 is provided as a curved surface to guide the pressing member 310 to rotate relative to the base 100 as a whole.

[0061] In the optional technical solution of this embodiment, combined with Figure 5 As shown, the base 100 includes two second connecting rods 120 extending along the Y direction, and the two second connecting rods 120 are arranged in parallel and spaced apart; Figure 1 and Figure 2 As shown, each second connecting rod 120 is provided with a group of left and right clamping assemblies 400, and the left and right clamping assemblies 400 include an auxiliary component 410 and a clamping rod 420. The auxiliary component 410 is connected to the corresponding second connecting rod 120, and the clamping rod 420 is movably connected to the auxiliary component 410, and is used to clamp the small animal 20 and adjust the size of the clamping space 10 in the X direction.

[0062] The clamping rods 420 in the two left and right clamping assemblies 400 are arranged opposite to each other, and by clamping the two sides of the head of the small animal 20 in the clamping space 10, the relative position of the small animal 20 in the clamping space 10 in the X direction is limited, so as to facilitate experiments or treatment; the two auxiliary parts 410 are arranged perpendicular to the platform 500, the first ends of the two auxiliary parts 410 are connected to the corresponding second connecting rods 120, and the second ends extend in the direction away from the platform 500, and the two clamping rods 420 are movably connected to the second ends of the corresponding auxiliary parts 410, so that a certain gap is formed between the clamping rods 420 and the platform 500 to accommodate the head of the small animal 20, and the size of the clamping space 10 can be adjusted in the X direction, so as to clamp small animals 20 of different sizes. In addition, in this embodiment, the two clamping rods 420 are both arranged as threaded rods, and the size of the clamping space 10 can be adjusted by their own structure. At the same time, after the adjustment is completed, no other limiting parts are required to assist, and the relative position with the auxiliary parts 410 can be limited by their own structure.

[0063] Preferably, the left and right clamping assemblies 400 also include a clamping arm 430 and a third adjusting member 440, the clamping arm 430 is movably connected to the corresponding second connecting rod 120 through the third adjusting member 440 to adjust the size of the clamping space 10 in the Y direction, and the auxiliary member 410 is fixedly connected to the clamping arm 430.

[0064] Taking one set of left and right clamping components 400 as an example, the specific combination Figure 1 , Figure 3 , Figure 4 and Figure 5 As shown, the auxiliary member 410 is fixedly connected to the second end of the clamping arm 430, the second connecting rod 120 is provided with a second adjustment groove 121 extending along the Y direction, the first end of the clamping arm 430 is correspondingly provided with a threaded adjustment hole, the second adjustment member 320 is provided as a threaded connector, the threaded connector passes through the second adjustment groove 121 and the threaded adjustment hole, the clamping arm 430 is connected to the second connecting rod 120, and the relative position of the clamping rod 420 and the base 100 is adjusted by loosening the threaded connector, so as to adjust the size of the clamping space 10 in the Y direction, so as to fix small animals 20 of different sizes, so as to improve the application range of the animal fixing device. In addition, a second guide limiter is also provided between the clamping arm 430 and the corresponding second connecting rod 120 to guide and adjust the relative position between the clamping arm 430 and the corresponding second connecting rod 120, and prevent the clamping arm 430 from disengaging. The second guide limiter can be provided as a slideway slider or a slideway rail.

[0065] Preferably, the animal fixing device further comprises a positioning ring (not shown in the figure), which is located in the clamping space 10 and is arranged on the small animal 20 to confirm the position of the small animal 20 .

[0066] Since a positioning ring is also provided in the clamping space 10, during the experiment or treatment process, after the small animal 20 bites the biting part 210, the positioning ring is scanned by the external device to guide the external device to quickly and accurately locate the position of the small animal 20, which can not only improve the image resolution and clarity, but also make the brain image of the small animal 20 clearer, so that the operator can accurately locate the lesion tissue or the treatment brain area, maximize the accuracy of treatment, avoid damage to healthy tissues, and is not limited by organ characteristics, and can image gas-rich organs and bones and other particularly dense tissues. In this embodiment, the external device is set as a treatment point calibration device or CT.

[0067] Preferably, the animal fixing device further comprises a base plate 700 and a connecting assembly 900 , the carrier 500 is disposed on the base plate 700 , the connecting assembly 900 is movably connected to the base plate 700 , and the animal fixing device is movably connected to the connecting assembly 900 to adjust the relative position of the animal fixing device and the carrier 500 .

[0068] Specific combination Figure 7 and Figure 8 As shown, in this embodiment, at least one third adjustment slot 710 extending along the X direction and / or at least one third adjustment slot 710 extending along the Y direction is provided on the bottom plate 700, and the connecting assembly 900 is movably connected to the corresponding third adjustment slot 710. The platform 500 is provided on the bottom plate 700. By adjusting the relative position of the connecting assembly 900 and the third adjustment slot 710, the relative position of the animal fixing device and the platform 500 in the X direction or the Y direction is changed, thereby changing the position of the clamping space 10. A sliding shaft extending along the Z direction is provided on the connecting assembly 900, and the animal fixing device is slidably connected to the sliding shaft. By adjusting the relative position of the animal fixing device connected to the sliding shaft, the relative position of the animal fixing device and the platform 500 in the Z direction is changed.

[0069] In summary, the workflow of the animal fixation device and the ultrasonic focusing device provided in this embodiment during experiment or treatment is as follows:

[0070] According to the experimental requirements and experimental purposes, a suitable focused ultrasound probe 810 is selected to connect with the terminal, and the focused ultrasound probe 810 is fixed on the support frame mechanism 820; after the small animal 20 is anesthetized and prepared before treatment, it is placed on the platform 500 and the head is fixed in the clamping space 10; the medium is poured into the coupling water tank 600, and the coupling water tank 600 is fixed above the small animal 20 on the platform 500; the position of the target area and the treatment focus is set by the image guidance method of the treatment point calibration device or the CT scanning positioning ring, and the focused ultrasound probe 810 is moved to the position by adjusting the support frame mechanism 820; a suitable ultrasound emission mode is selected, and ultrasound treatment parameters for different focuses are determined; then ultrasound irradiation is started, and during the irradiation process, the terminal will prompt whether the ultrasound irradiation is successful, and the treatment can be stopped and the parameters and treatment mode can be adjusted according to the actual situation; after the irradiation is completed, the terminal issues a prompt, and the operator records all irradiation information.

[0071] Obviously, the above embodiments of the present invention are merely examples for the purpose of clearly illustrating the present invention, and are not intended to limit the implementation methods of the present invention. For those skilled in the art, various obvious changes, readjustments and substitutions can be made without departing from the scope of protection of the present invention. It is not necessary and impossible to list all implementation methods here. Any modifications, equivalent substitutions and improvements made within the spirit and principles of the present invention shall be included in the scope of protection of the claims of the present invention.

Claims

1. An animal fixing device, characterized in that: include: Carrier (500); A base (100) is arranged on the carrier (500); Upper and lower clamping components, movably connected to the base (100); Left and right clamping assemblies (400) are movably connected to the base (100) and cooperate with the upper and lower clamping assemblies and the carrier (500) to form a clamping space (10) for fixing a small animal (20); A biting piece (200) is connected to the base (100) and is located in the clamping space (10) and is used for biting the small animal (20).

2. The animal fixing device according to claim 1, characterized in that: The base (100) is arranged on the upper surface of the carrier (500), the bite member (200) is arranged as a rod, the first end of the bite member (200) is movably connected to the base (100) through a first adjustment member (220), the second end of the bite member (200) is located in the clamping space (10) and is arranged as a bite portion (210), and the second end of the bite member (200) is inclined in a direction away from the carrier (500).

3. The animal fixing device according to claim 1, characterized in that: The upper and lower clamping assemblies include a pressing member (310), and the pressing member (310) is rotatably connected to the base (100) to adjust the size of the clamping space (10) in the Z direction.

4. The animal fixing device according to claim 3, characterized in that: The upper and lower clamping components further include a second adjusting member (320) and an elastic member (330); the base (100) includes a first connecting rod (110) extending along the Y direction; the pressing member (310) includes a pressing rod (311) and a pressing portion (312) and an adjusting portion (313) respectively connected to two ends of the pressing rod (311); The middle part of the pressing rod (311) is rotatably connected to the first connecting rod (110), and the adjusting portion (313) is located below the first connecting rod (110), the elastic member (330) is arranged between the adjusting portion (313) and the first connecting rod (110), the second adjusting member (320) is used to adjust the relative position of the adjusting portion (313) and the first connecting rod (110), and the pressing portion (312) is used to press the small animal (20).

5. The animal securing device according to claim 1, characterized in that: The base (100) comprises two second connecting rods (120) extending along the Y direction, the two second connecting rods (120) are arranged in parallel and spaced apart, and each of the second connecting rods (120) is respectively provided with a set of left and right clamping assemblies (400); The left and right clamping assemblies (400) include an auxiliary component (410) and a clamping rod (420), wherein the auxiliary component (410) is connected to the corresponding second connecting rod (120), and the clamping rod (420) is movably connected to the auxiliary component (410) and is used for clamping the small animal (20) and adjusting the size of the clamping space (10) in the X direction.

6. The animal securing device according to claim 5, characterized in that: The left and right clamping assemblies (400) further include a clamping arm (430) and a third adjusting member (440), wherein the clamping arm (430) is movably connected to the corresponding second connecting rod (120) via the third adjusting member (440) so as to adjust the size of the clamping space (10) in the Y direction, and the auxiliary member (410) is fixedly connected to the clamping arm (430).

7. The animal securing device according to claim 1, characterized in that: The animal fixing device also includes a positioning ring, which is located in the clamping space (10) and is arranged on the small animal (20) to confirm the position of the small animal (20).

8. The animal fixing device according to any one of claims 1 to 7, characterized in that: The animal fixing device also includes a bottom plate (700) and a connecting assembly (900), the carrier (500) is arranged on the bottom plate (700), the connecting assembly (900) is movably connected to the bottom plate (700), and the base (100) is movably connected to the connecting assembly (900) to adjust the relative position of the clamping space (10).

9. An ultrasonic focusing device, characterized in that The invention comprises a coupling water tank (600), an ultrasonic focusing device (800) and an animal fixing device according to any one of claims 1 to 8, wherein the ultrasonic focusing device (800) is movably arranged on a bottom plate (700) in the animal fixing device, the coupling water tank (600) is arranged above the carrier (500), and the clamping space (10) is located between the carrier (500) and the coupling water tank (600).

10. The ultrasonic focusing device according to claim 9, characterized in that: The ultrasonic focusing device (800) comprises a focused ultrasonic probe (810) and a support frame mechanism (820), wherein the support frame mechanism (820) supports the focused ultrasonic probe (810) and can adjust the relative position of the focused ultrasonic probe (810) and the animal fixing device along the X direction, the Y direction and the Z direction, and the focused ultrasonic probe (810) is configured to be connected to a terminal.

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