Liquid separation flow channel for micro-fluidic control and micro-fluidic chip
By designing a liquid separation channel structure with a gradient width in the microfluidic chip, the liquid is filled first and the flow is controlled smoothly, the problem of uncontrollable liquid inlet timing in the prior art is solved, and the effective use of the reaction unit is achieved Partition and size control.
Patent Information
- Application Number
- CN202421061967.6
- Authority / Receiving Office
- CN · China
- Patent Type
- Utility models(China)
- Current Assignee / Owner
- Filing Date
- 2024-05-15
- Publication Date
- 2025-01-14
- Estimated Expiration
- 2034-05-15
AI Technical Summary
The liquid separation chamber structure of the existing microfluidic chips is simple, which makes it difficult to control the liquid inlet timing of each bifurcated flow channel, and cannot meet the detection items that require the order of reactions.
A liquid separation flow channel structure is designed including a main flow channel, a liquid separation chamber and a bifurcation flow channel, wherein the width of the first bifurcation flow channel is smaller than the second bifurcation flow channel, the inlet is lower than its inlet, and the liquid separation is The cavity is in a stepped shape, forming a drainage space, the width of the liquid separation cavity gradually increases in the direction of the liquid flow, and the third bifurcation flow channel extends in an arc shape around the second bifurcation flow channel, forming an annular structure.
The preferential filling and secondary distribution of liquid samples are achieved, the formation of winding gas is avoided, the liquid flows smoothly, and the chip size is compactly controlled through the ring structure to distinguish the reaction unit.
Smart Images
Figure CN222342919U_ABST
Abstract
Description
Technical Field
[0001] The utility model relates to the field of containers or vessels for experiments, in particular to a liquid separation channel and a microfluidic chip for microfluidics. Background Art
[0002] Microfluidic chip technology is called a laboratory on a chip, which can integrate all aspects of the experiment on a chip. Microfluidic chips have the advantages of high integration, small size, small reagent usage, low cost, and easy operation.
[0003] In the existing microfluidic chip, the liquid separation chamber is connected to multiple bifurcated flow channels, and each bifurcated flow channel is connected to multiple reaction chambers. The existing liquid separation chamber has a simple structure and usually only serves to connect multiple bifurcated flow channels so that the liquid flow can flow into all bifurcated flow channels. As a result, the order of liquid inflow into each bifurcated flow channel is difficult to determine, making the timing of liquid inflow into the reaction chamber on each bifurcated flow channel uncontrollable, and thus unable to meet some detection projects that require a reaction order. Summary of the invention
[0004] The purpose of the utility model is to provide a liquid separation channel and a microfluidic chip for microfluidics, and the purpose is to overcome the above-mentioned problems existing in the prior art.
[0005] In order to achieve the above purpose, the utility model provides the following technical solutions:
[0006] A liquid separation channel for microfluidics, comprising a main channel, a liquid separation chamber and a plurality of bifurcated channels connected in sequence along a liquid flow direction; the plurality of bifurcated channels include a second bifurcated channel and at least one first bifurcated channel, the main channel and the second bifurcated channel are connected to the two ends of the liquid separation chamber opposite to each other, the liquid separation chamber is provided with the first bifurcated channel on at least one side of the second bifurcated channel, the inlet of the first bifurcated channel is lower than the inlet of the second bifurcated channel, and the width of the first bifurcated channel is smaller than the width of the second bifurcated channel.
[0007] Furthermore, one end of the liquid separation chamber connected to the second bifurcated flow channel is in a stepped shape between the first bifurcated flow channel and the second bifurcated flow channel.
[0008] Furthermore, the stepped shape is composed of a first table surface, a transition surface and a second table surface connected in sequence.
[0009] Furthermore, the width of the liquid separation chamber gradually increases along the liquid flow direction.
[0010] Furthermore, the width of one end of the liquid separation chamber connected to the main flow channel is equal to the width of the main flow channel.
[0011] Furthermore, the liquid separation chamber is provided with the first bifurcated flow channel on both sides of the second bifurcated flow channel.
[0012] Furthermore, the width ratio of the first bifurcated flow channel to the second bifurcated flow channel is 1:2.
[0013] Furthermore, two third branched flow channels are symmetrically arranged at one end of the second branched flow channel away from the liquid separation chamber, and the third branched flow channels and the first branched flow channels are both extended in an arc shape, so that the two third branched flow channels and the two first branched flow channels are annularly distributed around the second branched flow channel to form a ring.
[0014] Furthermore, one end of the third bifurcated flow channel connected to the second bifurcated flow channel is inclined so that the two third bifurcated flow channels and the second bifurcated flow channel form an inverted Y shape.
[0015] A microfluidic chip comprises a chip body, wherein the chip body is provided with a liquid separation channel having a structure as described above.
[0016] Compared with the prior art, the beneficial effects of the utility model are:
[0017] First, in the utility model, the liquid separation chamber is provided with a second bifurcated flow channel and a first bifurcated flow channel. Since the width of the first bifurcated flow channel is smaller than that of the second bifurcated flow channel, the capillary force of the first bifurcated flow channel is greater, and the entrance of the first bifurcated flow channel is lower than the entrance of the second bifurcated flow channel, so that the liquid sample in the liquid separation chamber can enter the first bifurcated flow channel more easily, and the first bifurcated flow channel is preferentially filled with liquid samples, and the liquid flow is preferentially distributed for a second time, thereby realizing the priority selection function.
[0018] Second, in the present invention, one end of the liquid separation chamber connected to the second bifurcated flow channel is stepped between the first bifurcated flow channel and the second bifurcated flow channel, and the stepped shape is specifically composed of a first table surface, a transition surface, and a second table surface connected in sequence. This allows the liquid separation chamber to form a drainage space above the entrance of the first bifurcated flow channel, making it easier for the liquid sample to enter the first bifurcated flow channel.
[0019] Third, compared with a straight rectangular cavity or other non-gradient shapes, the width of the liquid separation cavity of the utility model gradually increases along the liquid flow direction. When the liquid sample flows slowly, air will not be formed in the liquid separation cavity, avoiding the dead volume that cannot be filled with the sample liquid sample. In addition, the gradual change direction of the liquid separation cavity matches the direction of the first bifurcated flow channel, which can make the flow of the liquid sample smoother.
[0020] Fourth, in the utility model, two third bifurcated flow channels are symmetrically arranged at one end of the second bifurcated flow channel away from the liquid separation chamber, and the third bifurcated flow channel and the first bifurcated flow channel are both extended in an arc shape, so that the two third bifurcated flow channels and the two first bifurcated flow channels are annularly distributed around the second bifurcated flow channel to form a ring. The interior of the ring is used to open the reaction unit, and the structural design is compact, which can effectively control the size of the microfluidic chip. In addition, each bifurcated flow channel can be used to partition each reaction unit, which helps to distinguish the reaction units connected to each bifurcated flow channel. BRIEF DESCRIPTION OF THE DRAWINGS
[0021] Figure 1 This is the front view of the chip body in the present invention.
[0022] Figure 2 for Figure 1 A partial enlarged view of part A.
[0023] Figure 3 In the present invention, the three-dimensional chip body Figure 1 .
[0024] Figure 4 for Figure 3 A partial enlarged view of part A'.
[0025] Figure 5 In the present invention, the three-dimensional chip body Figure 2 . DETAILED DESCRIPTION
[0026] The specific implementation of the present invention is described below with reference to the accompanying drawings. In order to fully understand the present invention, many details are described below, but for those skilled in the art, the present invention can be implemented without these details.
[0027] For ease of understanding, the various parts of the utility model are described one by one mainly according to the direction of liquid flow.
[0028] like Figure 2 and Figure 4 As shown, a liquid separation channel for microfluidics includes a main channel 12, a liquid separation chamber 13 and a plurality of bifurcated channels connected in sequence along the liquid flow direction. The plurality of bifurcated channels specifically include a second bifurcated channel 142 and two first bifurcated channels 141. The main channel 12 and the second bifurcated channel 142 are connected to the two ends of the liquid separation chamber 13 opposite to each other, and the liquid separation chamber 13 is provided with a first bifurcated channel 141 on both sides of the second bifurcated channel 142, and the inlet of the first bifurcated channel 141 is lower than the inlet of the second bifurcated channel 142, and the width of the first bifurcated channel 141 is less than the width of the second bifurcated channel 142. Of course, the liquid separation chamber 13 can also be provided with a first bifurcated channel 141 only on one side of the second bifurcated channel 142.
[0029] like Figure 2 and Figure 4 As shown, one end of the liquid separation chamber 13 connected to the second bifurcated flow channel 142 is stepped between the first bifurcated flow channel 141 and the second bifurcated flow channel 142, so that the inlet of the first bifurcated flow channel 141 is lower than the inlet of the second bifurcated flow channel 142. Specifically, the stepped shape is composed of a first table 131, a transition surface 132, and a second table 133 connected in sequence.
[0030] like Figure 2 and Figure 4 As shown, the width of the liquid separation chamber 13 gradually increases along the direction of liquid flow. Specifically, the left and right side walls of the liquid separation chamber 13 are arranged in an eight-shaped shape. Preferably, the liquid separation chamber 13 is connected to one end of the main channel 12, and its width is equal to the width of the main channel 12. The transition surface 132 is an inclined surface, which is parallel to the side wall (specifically the left side wall or the right side wall) of the liquid separation chamber 13. A drainage chamber is formed outside the entrance of the first bifurcated flow channel 141 by the side wall of the liquid separation chamber 13 and the transition surface, so that the liquid sample can flow more easily to the top of the first bifurcated flow channel 141.
[0031] like Figure 2 and Figure 4 As shown, preferably, the width ratio of the first bifurcated flow channel 141 to the second bifurcated flow channel 142 is 1:2.
[0032] like Figures 1 to 4 As shown, two third branched flow channels 143 are symmetrically arranged at one end of the second branched flow channel 142 away from the liquid separation chamber 13, and the third branched flow channel 143 and the first branched flow channel 141 are both extended in an arc shape, so that the two third branched flow channels 143 and the two first branched flow channels 141 are annularly distributed around the second branched flow channel 142 to form a ring.
[0033] like Figures 1 to 4 As shown, the width of the third bifurcated flow channel 143 is smaller than the width of the second bifurcated flow channel 142. Preferably, the width ratio of the third bifurcated flow channel 143 to the second bifurcated flow channel 142 is 1:2.
[0034] like Figures 1 to 4 As shown, as a preference, in order to facilitate flow diversion and ensure smooth liquid flow, one end of the third bifurcated flow channel 143 connected to the second bifurcated flow channel 142 is tilted so that the two third bifurcated flow channels 143 and the second bifurcated flow channel 142 form an inverted Y shape.
[0035] like Figures 1 to 5 As shown, the utility model also discloses and protects a microfluidic chip, including a chip body 1, and the chip body 1 is provided with a liquid separation channel with the structure as described above. Further, a plurality of reaction units 15 are connected and arranged on the first bifurcated channel 141 and the third bifurcated channel 143, and these reaction units 15 are annularly distributed and arranged within the above-mentioned ring.
[0036] The above is only a specific implementation method of the utility model, but the design concept of the utility model is not limited to this. Any non-substantial changes to the utility model using this concept shall be deemed as an infringement of the protection scope of the utility model.
Claims
1. A liquid separation channel for microfluidics, comprising a main channel (12), a liquid separation cavity (13) and a plurality of branched channels which are sequentially connected along a liquid flow direction; characterized in that: The plurality of bifurcated flow channels include a second bifurcated flow channel (142) and at least one first bifurcated flow channel (141); the main flow channel (12) and the second bifurcated flow channel (142) are connected to two ends of a liquid separation chamber (13) in an opposite manner; the liquid separation chamber (13) is provided with the first bifurcated flow channel (141) on at least one side of the second bifurcated flow channel (142); the inlet of the first bifurcated flow channel (141) is lower than the inlet of the second bifurcated flow channel (142); and the width of the first bifurcated flow channel (141) is smaller than the width of the second bifurcated flow channel (142).
2. A liquid separation channel for microfluidics according to claim 1, characterized in that: One end of the liquid separation chamber (13) connected to the second bifurcated flow channel (142) is in a stepped shape between the first bifurcated flow channel (141) and the second bifurcated flow channel (142).
3. A liquid separation channel for microfluidics according to claim 2, characterized in that: The stepped shape is composed of a first table surface (131), a transition surface (132), and a second table surface (133) which are connected in sequence.
4. The liquid separation channel for microfluidics according to claim 1, characterized in that: The width of the liquid separation chamber (13) gradually increases along the liquid flow direction.
5. A liquid separation channel for microfluidics according to claim 4, characterized in that: One end of the liquid separation chamber (13) is connected to the main channel (12), and its width is equal to that of the main channel (12).
6. A liquid separation channel for microfluidics according to any one of claims 1 to 5, characterized in that: The liquid separation chamber (13) is provided with the first bifurcated flow channel (141) on both sides of the second bifurcated flow channel (142).
7. A liquid separation channel for microfluidics according to claim 6, characterized in that: The width ratio of the first bifurcated flow channel (141) to the second bifurcated flow channel (142) is 1:
2.
8. The liquid separation channel for microfluidics according to claim 1, characterized in that: Two third branched flow channels (143) are symmetrically arranged at one end of the second branched flow channel (142) away from the liquid separation chamber (13), and the third branched flow channels (143) and the first branched flow channel (141) are both extended in an arc shape, so that the two third branched flow channels (143) and the two first branched flow channels (141) are annularly distributed around the second branched flow channel (142) to form a ring.
9. A liquid separation channel for microfluidics according to claim 8, characterized in that: One end of the third bifurcated flow channel (143) connected to the second bifurcated flow channel (142) is arranged obliquely, so that the two third bifurcated flow channels (143) and the second bifurcated flow channel (142) form an inverted Y shape.
10. A microfluidic chip, comprising a chip body (1), characterized in that: The chip body (1) is provided with a liquid separation channel having a structure as described in any one of claims 1 to 9.