Mycoplasma analysis system

Abstract

The utility model discloses a mycoplasma analysis system which comprises a machine table, a liquid suction head, an oil suction head, a culture box feeding mechanism, a cover opening mechanism, a bottle opening mechanism, a sample adding mechanism, a transferring mechanism and a culture box collecting mechanism, and a culture box station is arranged on a discharging track of the culture box feeding mechanism; the uncovering mechanism is used for lifting away a cover of the culture box; the bottle opening mechanism is used for taking away bottle caps of the sample bottles; a liquid suction assembly and an oil suction assembly on the sample adding mechanism are in butt joint with a liquid suction head and an oil suction head respectively, the liquid suction head is used for sucking sample liquid in a sample bottle and injecting the sample liquid into a culture hole of a culture box, and the oil suction head is used for sucking paraffin oil in a paraffin oil bottle and injecting the paraffin oil into the culture hole; a first clamping jaw of the transferring mechanism can be used for transferring the culture box to the culture box, the visual inspection mechanism and the culture box collecting mechanism in sequence. The sample adding mechanism can effectively improve the efficiency of sample adding and mycoplasma analysis, the culture box does not need to be moved, the system structure can be more compact, and the occupied space and area are smaller.

Description

Technical Field

[0001] The utility model relates to the technical field of microbial analysis, in particular to a mycoplasma analysis system. Background Art

[0002] Mycoplasma is a prokaryotic microorganism similar to bacteria but without cell walls. It can be inoculated, grown and reproduced on inanimate artificial culture media. Drug sensitivity test refers to an in vitro test to determine the antibacterial or bactericidal ability of drugs. The samples of mycoplasma and other microorganisms, culture media and corresponding staining liquid are mixed to obtain sample liquid, and then the sample liquid is distributed and injected or dripped into each culture well of the culture box, and paraffin oil is injected to complete the sample addition. Then the culture box is placed in an environment with a suitable temperature for cultivation, and finally the drug sensitivity is judged by observing the color of the sample liquid (or mixture) in the culture box. At this stage, the mycoplasma analysis system needs to set up two sets of drive devices to assist in the addition of sample liquid and paraffin oil respectively, and the culture box needs to pass through each station in turn to complete the sample addition, which is inefficient, and the structure volume and floor space of the sample addition device are large. Utility Model Content

[0003] The utility model aims to solve at least one of the technical problems existing in the prior art. To this end, the utility model provides a mycoplasma analysis system with a compact structure and can improve the efficiency of sample addition and analysis.

[0004] According to a mycoplasma analysis system of an embodiment of the utility model, it includes a machine platform, a liquid suction head, an oil suction head, a culture box feeding mechanism, a cover opening mechanism, a bottle opening mechanism, a sample adding mechanism, a transport mechanism and a culture box collecting mechanism. A limit plate, a culture box, a visual inspection mechanism and a culture box collecting mechanism are arranged on the machine platform. The limit plate is provided with a paraffin oil bottle limit hole, a sample bottle clamp and a suction head carrier. The sample bottle clamp is used to clamp the sample bottle, the suction head carrier is used to set a plurality of liquid suction heads and a plurality of oil suction heads, and the paraffin oil bottle limit hole is used to set the paraffin oil bottle; the culture box feeding mechanism includes a discharge track arranged on the machine platform, and a culture box station is arranged at the front end of the discharge track; the cover opening mechanism is arranged on the machine platform, and is used to lift the cover of the culture box on the culture box station; the bottle opening mechanism is arranged on the machine platform, and is used to take away the bottle cap of the sample bottle on the sample bottle clamp; the sample adding mechanism includes a movable plate arranged on the machine platform The movable rack can be moved in the front-back and left-right directions, and the movable rack is provided with a liftable liquid suction component and an oil suction component, the lower end of the liquid suction component is used to dock with the liquid suction head on the tip carrier, the liquid suction head is used to suck the sample liquid in the sample bottle and inject the sample liquid into the culture hole of the culture box, the lower end of the oil suction component is used to dock with the oil suction head on the tip carrier, the oil suction head is used to suck the paraffin oil in the paraffin oil bottle and inject the paraffin oil into the culture hole of the culture box; the transfer mechanism includes a first clamping jaw which can be lifted and lowered on the machine platform, the first clamping jaw is arranged in the middle of the culture box station, the incubator, the visual inspection mechanism and the culture box collection mechanism, the first clamping jaw can rotate in a horizontal plane to transfer the culture box on the culture box station to the incubator, the visual inspection mechanism and the culture box collection mechanism, and the incubator in sequence.

[0005] At least the following beneficial effects are achieved: since the liquid suction component and the oil suction component are arranged on the same mobile frame, the mobile frame can simultaneously drive the liquid suction head and the oil suction head to move. Initially, the liquid suction head sucks a certain amount of sample liquid, the mobile frame moves to the top of the culture box station, and the liquid suction head injects the sample liquid into the first empty culture well. Then the mobile frame is reset, and the liquid suction head and the oil suction head suck a certain amount of sample liquid and paraffin oil respectively. The mobile frame moves to the top of the culture box station, and the liquid suction head injects the sample liquid into the second empty culture well. The oil suction head injects the paraffin oil into the first culture well that has been injected with the sample liquid but not with the paraffin oil, and so on. In the continuous operation of the mobile frame, the mobile frame moves back and forth once to complete the injection of sample liquid and paraffin oil into a culture well until the sample addition work is completed, which can effectively improve the efficiency of sample addition, and thus improve the efficiency of mycoplasma analysis. During the sample loading process, the culture box is always on the culture box station, and there is no need to move the culture box, that is, there is no need to set a driving mechanism for moving the culture box to complete the sample loading, and the liquid suction component, oil suction component, liquid suction head and oil suction head are arranged on the same mobile rack, which can make the structure of the mycoplasma analysis system more compact and occupy less space and area. After the sample loading of the culture box is completed, the first clamping claw transfers the culture box on the culture box station to the incubator, the visual inspection mechanism and the culture box collection mechanism in sequence, the sample liquid is cultured in the incubator, and then the sample liquid is inspected by the visual inspection mechanism, and finally the sample liquid after the inspection and the culture box containing the sample liquid are uniformly collected by the culture box collection mechanism.

[0006] According to some embodiments of the utility model, the transfer mechanism also includes a first rotation drive mechanism, a support rod and a first lifting drive mechanism, the first rotation drive mechanism is arranged on the machine platform, the support rod is rotatably arranged on the machine platform and is transmission-connected to the first rotation drive mechanism, the first lifting drive mechanism is arranged on the support rod, and the output end of the first lifting drive mechanism is connected to the first clamp to drive the first clamp to rise and fall.

[0007] According to some embodiments of the utility model, the first clamping jaw includes a first clamping arm, a second clamping arm and a second lifting drive mechanism, the output end of the first lifting drive mechanism is connected to the first clamping arm, the second clamping arm and the second lifting drive mechanism are both arranged on the first clamping arm, the second clamping arm is above the first clamping arm, and the output end of the second lifting drive mechanism is connected to the second clamping arm to drive the second clamping arm close to or away from the first clamping arm.

[0008] According to some embodiments of the utility model, the culture box collection mechanism includes a first lower plate, a first upper plate and a plurality of first surrounding rods, the first lower plate and the first upper plate are connected together by a plurality of first surrounding rods, the plurality of first surrounding rods enclose a first limiting space for limiting the culture box, the first lower plate and the first upper plate are both provided with a channel connected to the first limiting space, and the rear ends of the first lower plate and the first upper plate are both provided with a first avoidance opening for the first clamp to pass through.

[0009] According to some embodiments of the utility model, the visual inspection mechanism includes a first horizontal plate, a second horizontal plate and a camera, the first horizontal plate and the second horizontal plate are both connected to the machine, the first horizontal plate is above the second horizontal plate, the camera is arranged on the second horizontal plate, and the first horizontal plate is provided with a stepped hole in the area corresponding to the camera, and the stepped hole is used to support the culture box.

[0010] According to some embodiments of the utility model, a first supporting frame is provided on the machine platform, a first front-rear driving mechanism is provided on the first supporting frame, an output end of the first front-rear driving mechanism is connected to a first left-right driving mechanism, an output end of the first left-right driving mechanism is connected to the movable frame, a third lifting driving mechanism and a fourth lifting driving mechanism are provided on the movable frame, and the output ends of the third lifting driving mechanism and the fourth lifting driving mechanism are respectively connected to the liquid suction assembly and the oil suction assembly to respectively drive the liquid suction assembly and the oil suction assembly to lift and lower.

[0011] According to some embodiments of the utility model, the liquid pipetting assembly includes a first liquid pipetting syringe and a fifth lifting drive mechanism, the first liquid pipetting syringe and the fifth lifting drive mechanism are both connected to the output end of the third lifting drive mechanism through a first connecting plate, the lower end of the first liquid pipetting syringe faces downward and can be docked with the liquid pipetting head, and the output end of the fifth lifting drive mechanism is connected to the first piston rod of the first liquid pipetting syringe.

[0012] According to some embodiments of the utility model, the cover opening mechanism includes a second rotary drive mechanism arranged on the machine platform, a first swing arm arranged on the output end of the second rotary drive mechanism, and a suction nozzle arranged on the swing end of the first swing arm. The output end of the second rotary drive mechanism is horizontally arranged so that the first swing arm swings in a vertical plane, and the suction nozzle is used to adsorb the lid of the culture box on the culture box station.

[0013] According to some embodiments of the utility model, a third rotary drive mechanism is provided on the machine platform, a second swing arm is provided on the output end of the third rotary drive mechanism, a cover plate is provided on the swing end of the second swing arm, the second swing arm swings in a horizontal plane, and the cover plate is used to cover the bottle mouth of the paraffin oil bottle on the limiting hole of the paraffin oil bottle.

[0014] According to some embodiments of the utility model, a semi-enclosure is provided at the lower end of the cover plate, and the semi-enclosure is used to surround the bottle mouth of the paraffin oil bottle.

[0015] Additional aspects and advantages of the present invention will be given in part in the following description, and in part will become apparent from the following description, or will be learned through the practice of the present invention. BRIEF DESCRIPTION OF THE DRAWINGS

[0016] The present invention is further described below with reference to the accompanying drawings and embodiments, wherein:

[0017] Figure 1 This is one of the structural schematic diagrams of a mycoplasma analysis system according to an embodiment of the utility model;

[0018] Figure 2 This is a second structural schematic diagram of a mycoplasma analysis system according to an embodiment of the utility model;

[0019] Figure 3 This is one of the structural schematic diagrams of a sample adding mechanism, a liquid aspirating head and an oil aspirating head of a mycoplasma analysis system according to an embodiment of the utility model;

[0020] Figure 4 This is a second structural schematic diagram of a sample adding mechanism, a liquid aspirating head and an oil aspirating head of a mycoplasma analysis system according to an embodiment of the utility model;

[0021] Figure 5 This is a schematic structural diagram of a second support frame, a second front-rear drive mechanism, a second left-right drive mechanism, a seventh lifting drive mechanism and a bottle opening mechanism of a mycoplasma analysis system according to an embodiment of the utility model;

[0022] Figure 6 This is a schematic structural diagram of a limit plate, a cover opening mechanism and a discharge track of a mycoplasma analysis system according to an embodiment of the utility model;

[0023] Figure 7 This is a schematic diagram of the structure of a transport mechanism of a mycoplasma analysis system according to an embodiment of the utility model;

[0024] Figure 8 This is a structural schematic diagram of a culture box collection mechanism of a mycoplasma analysis system according to an embodiment of the utility model;

[0025] Fig. 9This is a schematic structural diagram of a third rotary drive mechanism, a second swing arm, a cover plate and a paraffin oil bottle of a mycoplasma analysis system according to an embodiment of the utility model;

[0026] Fig.10 This is a structural schematic diagram of a culture box loading mechanism of a mycoplasma analysis system according to an embodiment of the utility model;

[0027] Figure Number:

[0028] Machine 100; limit plate 110; sample bottle clamp 111; pipette tip carrier 112; sample bottle positioning hole 113; incubator 120; visual inspection mechanism 130; first horizontal plate 131; second horizontal plate 132; camera 133; first support frame 140; first front and rear drive mechanism 150; first left and right drive mechanism 160; third rotation drive mechanism 170; second swing arm 171; cover plate 172; semi-enclosure 173; second support frame 180; second front and rear drive mechanism 181; second left and right drive mechanism 182; seventh lifting drive mechanism 183;

[0029] Liquid suction head 200;

[0030] Oil suction head 300;

[0031] Cultivation box feeding mechanism 400; discharging track 410; feeding mechanism 420; second lower plate 421; second upper plate 422; second surrounding rod 423; second avoidance opening 424; third front and rear driving mechanism 430; hook plate 431;

[0032] Cover opening mechanism 500; second rotation driving mechanism 510; first swing arm 520; suction nozzle 530;

[0033] Bottle opening mechanism 600; mounting plate 610; fourth rotary drive mechanism 620; second clamping jaw 630;

[0034] Sample loading mechanism 700; moving frame 710; third lifting drive mechanism 711; fourth lifting drive mechanism 712; liquid suction assembly 720; first liquid suction syringe 721; fifth lifting drive mechanism 722; oil suction assembly 730; second liquid suction syringe 731; sixth lifting drive mechanism 732;

[0035] The transport mechanism 800; the first clamping claw 810; the first clamping arm 811; the second clamping arm 812; the second lifting drive mechanism 813; the first rotation drive mechanism 820; the support rod 830; the first lifting drive mechanism 840;

[0036] The culture box collecting mechanism 900 ; the first lower plate 910 ; the first upper plate 920 ; the first surrounding rod 930 ; the first avoidance opening 940 ; the fourth front-rear driving mechanism 950 ; the eighth lifting driving mechanism 960 ; and the supporting plate 961 . DETAILED DESCRIPTION

[0037] The embodiments of the present invention are described in detail below, and examples of the embodiments are shown in the accompanying drawings, wherein the same or similar reference numerals throughout represent the same or similar elements or elements having the same or similar functions. The embodiments described below with reference to the accompanying drawings are exemplary and are only used to explain the present invention, and cannot be understood as limiting the present invention.

[0038] In the description of the present invention, it should be understood that descriptions involving orientation, such as up, down, front, back, left, right, etc., indicating orientations or positional relationships, are based on the orientations or positional relationships shown in the accompanying drawings, and are only for the convenience of describing the present invention and simplifying the description, and do not indicate or imply that the device or element referred to must have a specific orientation, be constructed and operated in a specific orientation, and therefore cannot be understood as a limitation on the present invention.

[0039] In the description of the present utility model, "a plurality" means more than two. If there is a description of "first" or "second", it is only for the purpose of distinguishing the technical features, and cannot be understood as indicating or implying the relative importance or implicitly indicating the number of the indicated technical features or implicitly indicating the order of the indicated technical features.

[0040] In the description of the present invention, unless otherwise clearly defined, terms such as setting, installing, connecting, etc. should be understood in a broad sense, and technicians in the relevant technical field can reasonably determine the specific meanings of the above terms in the present invention based on the specific content of the technical solution.

[0041] Reference Figures 1 to 5 The utility model discloses a mycoplasma analysis system, including a machine 100, a liquid suction head 200, an oil suction head 300, a culture box feeding mechanism 400, a cover opening mechanism 500, a bottle opening mechanism 600, a sample adding mechanism 700, a transport mechanism 800 and a culture box collecting mechanism 900. The machine 100 is provided with a limit plate 110, a culture box 120, a visual inspection mechanism 130 and a culture box collecting mechanism 900. See Figure 1 and Figure 6 The limiting plate 110 is provided with a paraffin oil bottle limiting hole, a sample bottle clamp 111 and a suction head carrier 112. The sample bottle clamp 111 is used to clamp the sample bottle, the suction head carrier 112 is used to set a plurality of suction heads 200 and a plurality of oil suction heads 300, and the paraffin oil bottle limiting hole is used to set the paraffin oil bottle; the culture box loading mechanism 400 includes a discharge track 410 arranged on the machine 100, and a culture box station is arranged at the front end of the discharge track 410; the cover opening mechanism 500 is arranged on the machine 100, and is used to lift the cover of the culture box on the culture box station; the bottle opening mechanism 600 is arranged on the machine 100, and is used to take away the bottle cap of the sample bottle on the sample bottle clamp 111; see Figure 1 , 3 and Figure 4 The sample loading mechanism 700 includes a movable frame 710 disposed on the machine platform 100. The movable frame 710 can move in the front-back and left-right directions. The movable frame 710 is provided with a liquid suction component 720 and an oil suction component 730 that can be raised and lowered. The lower end of the liquid suction component 720 is used to dock with the liquid suction head 200 on the suction head carrier 112. The liquid suction head 200 is used to suck the sample liquid in the sample bottle and inject the sample liquid into the culture well of the culture box. The lower end of the oil suction component 730 is used to dock with the oil suction head 300 on the suction head carrier 112. The oil suction head 300 is used to suck the paraffin oil in the paraffin oil bottle and inject the paraffin oil into the culture well of the culture box; see Figure 7 The transfer mechanism 800 includes a first clamp 810 which is liftably disposed on the machine platform 100. The first clamp 810 is disposed between the culture box station, the incubator 120, the visual inspection mechanism 130 and the culture box collection mechanism 900. The first clamp 810 can rotate in a horizontal plane to transfer the culture box on the culture box station to the incubator 120, the visual inspection mechanism 130 and the culture box collection mechanism 900 in sequence.

[0042] Paraffin oil is placed in a paraffin oil bottle, a paraffin oil bottle without a cover or with an open cover is placed in a paraffin oil bottle limiting hole, a sample bottle is clamped on a sample bottle fixture 111, a plurality of liquid suction heads 200 and a plurality of oil suction heads 300 are arranged on a suction head carrier 112, and a plurality of culture boxes are placed on a culture box loading mechanism 400; the culture box loading mechanism 400 transports the culture boxes to the culture box station one by one, the cover opening mechanism 500 lifts off the cover of the culture box on the culture box station, and the bottle opening mechanism 600 removes the bottle cap of the sample bottle on the sample bottle fixture 111; the liquid suction component 720 takes the sample in the opened sample bottle through the liquid suction head 200 The sample liquid is injected into the culture hole of the culture box on the culture box station, and the oil suction component 730 injects the paraffin oil in the paraffin oil bottle into the culture hole with the sample liquid through the oil suction head 300; the first clamp 810 transfers the culture box filled with the sample liquid and paraffin oil to the incubator 120, the visual inspection mechanism 130 and the culture box collecting mechanism 900 in sequence, the sample liquid in the culture box is cultivated in the incubator 120, the visual inspection mechanism 130 inspects the color change of the sample liquid, and makes a drug sensitivity judgment based on the color change, thereby completing the mycoplasma analysis, and the culture box is uniformly collected by the culture box collecting mechanism 900 after the culture box is inspected.

[0043] See also Figure 3 and Figure 4, the mobile frame 710 can carry the liquid suction component 720 and the oil suction component 730 to move in the front-back and left-right directions, that is, the liquid suction component 720 and the oil suction component 730 can be moved in the front-back and left-right directions (horizontal movement), and then the liquid suction component 720 and the oil suction component 730 can be raised and lowered, so the liquid suction component 720 can drive the liquid suction head 200 to extend into the sample bottle and move to the top of the culture hole of the culture box, thereby completing the suction of the sample liquid in the sample bottle and injecting the sample liquid into the culture hole of the culture box. Similarly, the oil suction component 730 can drive the oil suction head 300 to extend into the paraffin oil bottle and move to the top of the culture hole of the culture box, thereby completing the suction of the paraffin oil in the paraffin oil bottle and injecting the paraffin oil into the culture hole of the culture box.

[0044] The first clamp 810 can be raised and lowered and rotated in the horizontal plane. The first clamp 810 is arranged in the middle of the culture box station, the incubator 120, the visual inspection mechanism 130 and the culture box collection mechanism 900, so the first clamp 810 can be moved to the culture box station, the incubator 120, the visual inspection mechanism 130 and the culture box collection mechanism 900.

[0045] Since the liquid suction component 720 and the oil suction component 730 are arranged on the same mobile frame 710, the mobile frame 710 can simultaneously drive the liquid suction head 200 and the oil suction head 300 to move. Initially, the liquid suction head 200 sucks a certain amount of sample liquid, and the mobile frame 710 moves to the top of the culture box station. The liquid suction head 200 injects the sample liquid into the first empty culture well. Then the mobile frame 710 is reset, and the liquid suction head 200 and the oil suction head 300 respectively suck a certain amount of sample liquid and paraffin oil. The mobile frame 710 moves to the top of the culture box station, and the liquid suction head 200 injects the sample liquid into the second empty culture well, and the oil suction head 300 injects the paraffin oil into the first culture well that has been injected with the sample liquid but not injected with the paraffin oil, and so on. In the continuous operation of the mobile frame 710, the mobile frame 710 moves back and forth once, and the injection of sample liquid and paraffin oil into a culture well can be completed until the sample addition work is completed, which can effectively improve the efficiency of sample addition, and thus improve the efficiency of mycoplasma analysis. During the sample loading process, the culture box is always in the culture box station, and there is no need to move the culture box, that is, there is no need to set up a driving mechanism for moving the culture box to complete the sample loading, and the liquid suction component 720, the oil suction component 730, the liquid suction head 200 and the oil suction head 300 are arranged on the same mobile frame 710, which can make the structure of the mycoplasma analysis system more compact and occupy less space and area.

[0046] A liquid suction head 200 and an oil suction head 300 may be pre-connected to the liquid suction component 720 and the oil suction component 730, respectively. If a liquid suction head 200 and an oil suction head 300 are not pre-connected to the liquid suction component 720 and the oil suction component 730, respectively, during operation, the liquid suction component 720 and the oil suction component 730 are respectively connected to a liquid suction head 200 and an oil suction head 300.

[0047] It is understandable that the spacing between the liquid suction component 720 and the oil suction component 730 is equal to the spacing between two adjacent culture wells on the same culture box. When the liquid suction head 200 and the oil suction head 300 are connected to the liquid suction component 720 and the oil suction head 730 respectively, the spacing between the liquid suction head 200 and the oil suction head 300 is also equal to the spacing between two adjacent culture wells on the same culture box. At this time, the liquid suction head 200 and the oil suction head 300 can respectively inject sample liquid and paraffin oil into two adjacent culture wells, further improving the efficiency of sample addition. Of course, the spacing between the liquid suction component 720 and the oil suction component 730 can also be set at will.

[0048] It is understandable that the liquid suction head 200 and the oil suction head 300 can be the same component. The liquid suction head 200 is a pipe with a tapered lower end. Due to the difference in samples, to avoid contamination between samples, the liquid suction head 200 used for each sample or between each sample is different, that is, the liquid suction head 200 needs to be replaced frequently, while paraffin oil does not need to be replaced frequently. Setting an oil suction head 300 can also continuously perform the work of sucking paraffin oil from the paraffin oil bottle and injecting paraffin oil into the culture hole of the culture box.

[0049] See also Figure 2 and Figure 7 In some embodiments, the transfer mechanism 800 further includes a first rotation drive mechanism 820, a support rod 830 and a first lifting drive mechanism 840. The first rotation drive mechanism 820 is disposed on the platform 100. The support rod 830 is rotatably disposed on the platform 100 and is in transmission connection with the first rotation drive mechanism 820. The first rotation drive mechanism 820 drives the support rod 830 to rotate on the platform 100. The first lifting drive mechanism 840 is disposed on the support rod 830. The output end of the first lifting drive mechanism 840 is connected to the first clamping claw 810. The first lifting drive mechanism 840 is used to drive the first clamping claw 810 to rise and fall.

[0050] In some of the embodiments, the first clamping jaw 810 includes a first clamping arm 811, a second clamping arm 812, and a second lifting drive mechanism 813. The output end of the first lifting drive mechanism 840 is connected to the first clamping arm 811. The second clamping arm 812 and the second lifting drive mechanism 813 are both arranged on the first clamping arm 811. The second clamping arm 812 is above the first clamping arm 811. The output end of the second lifting drive mechanism 813 is connected to the second clamping arm 812. The second lifting drive mechanism 813 drives the second clamping arm 811. 2 is lifted or lowered so that the second clamp arm 812 approaches or moves away from the first clamp arm 811. When the second clamp arm 812 descends and approaches the first clamp arm 811, the second clamp arm 812 and the first clamp arm 811 can clamp the culture box. When the second clamp arm 812 is on and away from the first clamp arm 811, the second clamp arm 812 and the first clamp arm 811 are opened to release the culture box. Or when the second clamp arm 812 and the first clamp arm 811 are opened, the culture box can be placed on the first clamp arm 811 and between the second clamp arm 812 and the first clamp arm 811.

[0051] The second clamp arm 812 and the first clamp arm 811 are both plate-shaped, and there are gaps in the three horizontal directions between the second clamp arm 812 and the first clamp arm 811. Therefore, when the second clamp arm 812 and the first clamp arm 811 swing horizontally, the culture box can be placed between the second clamp arm 812 and the first clamp arm 811, so that the second clamp arm 812 and the first clamp arm 811 can clamp and release the culture box.

[0052] It is understandable that the first lifting drive mechanism 840 and the second lifting drive mechanism 813 can both be cylinders or lead screw pairs. The first rotation drive mechanism 820 is a second motor.

[0053] See also Figure 1 and Figure 8 In some embodiments, the culture box collection mechanism 900 includes a first lower plate 910, a first upper plate 920, and a plurality of first surrounding rods 930. The first lower plate 910 and the first upper plate 920 are connected together by the plurality of first surrounding rods 930. The plurality of first surrounding rods 930 enclose a first limited space for limiting the culture box. The first lower plate 910 and the first upper plate 920 are both provided with a channel connected to the first limited space. The culture boxes can be placed into the first limited space one by one through the channel on the first upper plate 920, and a plurality of culture boxes are stacked together. The first avoidance opening 940 through which the first clamping claw 810 passes is provided at the rear ends of the first lower plate 910 and the first upper plate 920. The first avoidance opening 940 allows the hand and other components such as the clamping assembly to pass through, so as to facilitate the placement of the culture box in the first limited space.

[0054] The culture box collection mechanism 900 also includes a fourth front-to-back drive mechanism 950, an eighth lifting drive mechanism 960 and a support plate 961. The fourth front-to-back drive mechanism 950 is connected to the machine platform 100. The output end of the fourth front-to-back drive mechanism 950 is connected to the eighth lifting drive mechanism 960. The fourth front-to-back drive mechanism 950 can drive the eighth lifting drive mechanism 960 to move along the front-to-back direction. The output end of the eighth lifting drive mechanism 960 is connected to the support plate 961. The support plate 961 can pass through the channel of the first lower plate 910, the first limiting space and the channel of the first upper plate 920. The eighth lifting drive mechanism 960 can drive the support plate 961 to rise and fall below the channel of the first lower plate 910, the channel of the first lower plate 910, the first limiting space and the channel of the first upper plate 920, so as to push the culture box collected in the first limiting space out of the channel of the first upper plate 920, and then the personnel can take away the culture box collected in the culture box collection mechanism 900.

[0055] It can be understood that a protrusion is provided on the support plate 961, and the protrusion can be inserted into the first avoidance opening 940 and connected to the output end of the eighth lifting drive mechanism 960. The first lower plate 910, the first upper plate 920 and the plurality of first enclosure rods 930 form a collection mechanism. In this embodiment, there are two collection mechanisms, and the two collection mechanisms are arranged one in front of the other. When the fourth front-to-back drive mechanism 950 drives the eighth lifting drive mechanism 960 to move in the front-to-back direction, the support plate 961 can sequentially enter the first limited space formed by the two collection mechanisms. Both the fourth front-to-back drive mechanism 950 and the eighth lifting drive mechanism 960 can be cylinders or screw pairs.

[0056] See also Figure 2 In some embodiments, the visual inspection mechanism 130 includes a first horizontal plate 131, a second horizontal plate 132 and a camera 133. The first horizontal plate 131 and the second horizontal plate 132 are both connected to the machine 100. The first horizontal plate 131 is located above the second horizontal plate 132. The camera 133 is disposed on the second horizontal plate 132. The first horizontal plate 131 is provided with a stepped hole in the area corresponding to the camera 133. The stepped hole is used to support a culture box. The culture box taken out from the incubator 120 is placed in the stepped hole. At this time, the camera 133 is facing the culture box on the stepped hole. The camera 133 can take a picture of the sample liquid in the culture box to obtain the color change of the sample liquid, so as to analyze the mycoplasma.

[0057] It can be imagined that the first horizontal plate 131 and the second horizontal plate 132 are both connected to the inner wall of the machine 100 through the side plate, and the side plate is connected to a cover plate located above the first horizontal plate 131, and a light source can be set on the cover plate.

[0058] Reference Figure 1 and Figure 2In some of the embodiments, a first support frame 140 is provided on the machine 100, and a first front-to-back driving mechanism 150 is provided on the first support frame 140. The output end of the first front-to-back driving mechanism 150 is connected to the first left-to-right driving mechanism 160, and the output end of the first left-to-right driving mechanism 160 is connected to the moving frame 710. The first support frame 140 supports the first front-to-back driving mechanism 150, the first left-to-right driving mechanism 160 and the moving frame 710. The first front-to-back driving mechanism 150 drives the first left-to-right driving mechanism 160 and the moving frame 710 to move in the front-to-back direction, and the first left-to-right driving mechanism 160 drives the moving frame 710 to move in the left-to-right direction, thereby realizing the front-to-back and left-to-right movement of the moving frame 710.

[0059] The movable frame 710 is provided with a third lifting drive mechanism 711 and a fourth lifting drive mechanism 712. The output ends of the third lifting drive mechanism 711 and the fourth lifting drive mechanism 712 are respectively connected to the liquid suction component 720 and the oil suction component 730. The third lifting drive mechanism 711 and the fourth lifting drive mechanism 712 respectively drive the liquid suction component 720 and the oil suction component 730 to rise and fall, thereby realizing the docking of the liquid suction component 720 with the liquid suction head 200 and driving the liquid suction head 200 to perform lifting and falling movements, thereby realizing the docking of the oil suction component 730 with the oil suction head 300 and driving the oil suction head 300 to perform lifting and falling movements.

[0060] Reference Figure 3 and Figure 4 In some embodiments, the liquid suction component 720 includes a first liquid suction syringe 721 and a fifth lifting drive mechanism 722. The first liquid suction syringe 721 and the fifth lifting drive mechanism 722 are both connected to the output end of the third lifting drive mechanism 711 through a first connecting plate. The third lifting drive mechanism 711 drives the first liquid suction syringe 721 and the fifth lifting drive mechanism 722 to rise and fall synchronously.

[0061] The lower end of the first pipette syringe 721 faces downward and can be connected to the pipette head 200. The output end of the fifth lifting drive mechanism 722 is connected to the first piston rod of the first pipette syringe 721. When the third lifting drive mechanism 711 drives the first pipette syringe 721 and the fifth lifting drive mechanism 722 to descend, the pipette head 200 on the lower end of the first pipette syringe 721 can be extended into the sample bottle. The fifth lifting drive mechanism 722 drives the first piston rod to rise, and the first pipette syringe 721 can complete the suction of the sample liquid. When the fifth lifting drive mechanism 722 drives the first piston rod to descend, the sample liquid in the first pipette syringe 721 will be discharged through the pipette head 200 or injected into the culture hole.

[0062] Similarly, the oil suction assembly 730 includes a second suction syringe 731 and a sixth lifting drive mechanism 732. The second suction syringe 731 and the sixth lifting drive mechanism 732 are both connected to the output end of the fourth lifting drive mechanism 712 through a second connecting plate. The lower end of the second suction syringe 731 faces downward and can be connected to the oil suction head 300. The output end of the sixth lifting drive mechanism 732 is connected to the second piston rod of the second suction syringe 731.

[0063] It can be understood that the first front-rear driving mechanism 150, the first left-right driving mechanism 160, the third lifting driving mechanism 711, the fourth lifting driving mechanism 712, the fifth lifting driving mechanism 722 and the sixth lifting driving mechanism 732 can all be cylinders or screw pairs.

[0064] Reference Figure 1 and Figure 2 In this embodiment, the first front-to-back driving mechanism 150 is a belt driving mechanism, which includes a first belt, a second belt, a third belt and a fourth belt, and a first motor, a first pulley, a second pulley, a third pulley and a fourth pulley, all of which are arranged on the first support frame 140. The first pulley, the second pulley and the third pulley each have two pulley surfaces, and the central axes of the first pulley, the second pulley, the third pulley and the fourth pulley are all vertically arranged. The first pulley, the second pulley, the third pulley and the fourth pulley are distributed in four corners, and the first pulley, the second pulley, The third pulley and the fourth pulley are connected in sequence to form a rectangle, the line connecting the first pulley and the fourth pulley is in the left and right direction, the first pulley is directly in front of the second pulley, the fourth pulley is directly in front of the third pulley, the first belt is wound around the output end of the first belt and the first pulley, the second belt is wound around the first pulley and the second pulley, the third belt is wound around the second pulley and the third pulley, the fourth belt is wound around the third pulley and the fourth pulley, the first motor can drive the first belt, the second belt, the third belt and the fourth belt to rotate at the same time, and the two ends of the cross plate are respectively connected to the second belt and the fourth belt.

[0065] The first support frame 140 is provided with a first sliding mechanism and a second sliding mechanism, which are distributed left and right and both run forward and backward, and the first sliding mechanism and the second sliding mechanism are straddled with a cross plate, the first left and right driving mechanism 160 is provided on the cross plate, and the third sliding mechanism is provided on the cross plate, the movable frame 710 is connected to the cross plate through the third sliding mechanism, and the output end of the first left and right driving mechanism 160 is connected to the movable frame 710.

[0066] Reference Figure 1 and Figure 6In some embodiments, the cover opening mechanism 500 includes a second rotary drive mechanism 510 disposed on the machine 100, a first swing arm 520 disposed on the output end of the second rotary drive mechanism 510, and a suction nozzle 530 disposed on the swing end of the first swing arm 520. The output end of the second rotary drive mechanism 510 is horizontally arranged, and the suction nozzle 530 is used to absorb the lid of the culture box on the culture box station. The second rotary drive mechanism 510 drives the first swing arm 520 to swing in a vertical plane, so that the suction nozzle 530 can move along an arc track on the vertical plane. When the suction nozzle 530 is in a low position, the suction nozzle 530 is against the lid of the culture box on the culture box station and can absorb the lid. Then, when the first swing arm 520 swings upward, the suction nozzle 530 carries the lid and moves to the upper side of the box body of the culture box, so as to avoid the first swing arm 520 and the suction nozzle 530 from interfering with the liquid suction head 200 and the oil suction head 300.

[0067] It is conceivable that the second rotation driving mechanism 510 may be a third motor, and the suction nozzle 530 is connected to a negative pressure device.

[0068] See also Figure 1 and Figure 6 In some embodiments, the limiting plate 110 is provided with a plurality of sample bottle positioning holes 113 for positioning the sample bottles. The plurality of sample bottles can be placed in the sample bottle positioning holes 113 respectively, and the sample liquids in each sample bottle can be different.

[0069] Reference Figure 6 and Fig. 9 In some embodiments, a third rotary drive mechanism 170 is provided on the machine 100, a second swing arm 171 is provided on the output end of the third rotary drive mechanism 170, a cover plate 172 is provided on the swing end of the second swing arm 171, the output end of the third rotary drive mechanism 170 is vertically arranged, the third rotary drive mechanism 170 drives the second swing arm 171 to swing in a horizontal plane, and the cover plate 172 moves with the second swing arm 171, so that the cover plate 172 blocks the bottle mouth of the paraffin oil bottle on the limiting hole of the paraffin oil bottle or avoids the bottle mouth of the paraffin oil bottle. When the cover plate 172 blocks the bottle mouth of the paraffin oil bottle, foreign matter can be prevented from entering the paraffin oil bottle to contaminate the paraffin oil. When the cover plate 172 avoids the bottle mouth of the paraffin oil bottle, the oil suction head 300 can extend into the paraffin oil bottle through the bottle mouth of the paraffin oil bottle.

[0070] In some embodiments, a semi-enclosed block 173 is provided at the lower end of the cover plate 172, and the semi-enclosed block 173 forms a gap. When the cover plate 172 swings with the semi-enclosed block 173, the bottle mouth of the paraffin oil bottle can pass through the gap, so that the semi-enclosed block 173 can be against the bottle mouth of the paraffin oil bottle, thereby preventing the cover plate 172 from being unable to completely cover the bottle mouth of the paraffin oil bottle due to excessive swinging. It is conceivable that the third rotation drive mechanism 170 can be a fourth motor.

[0071] See also Fig.10 In some embodiments, the culture box loading mechanism 400 includes a feeding mechanism 420 and a third front-rear driving mechanism 430. There are two discharge tracks 410. The feeding mechanism 420 is arranged at the rear ends of the two discharge tracks 410. The feeding mechanism 420 is used to stack the culture boxes. The gap between the feeding mechanism 420 and the discharge track 410 is adapted to the height of the culture boxes. The feeding mechanism 420 serves to temporarily store multiple culture boxes. The lowest culture box on the feeding mechanism 420 falls on the two discharge tracks 410 and can slide on the two discharge tracks 410.

[0072] The third front-to-back driving mechanism 430 is disposed between the two discharge tracks 410. A hook plate 431 is connected to the output end of the third front-to-back driving mechanism 430. The hook plate 431 is used to hook the bottom of the culture box. When the third front-to-back driving mechanism 430 drives the hook plate 431 to move from the back to the front, the rear end of the culture box on the discharge track 410 can be driven to move to the front end on the discharge track 410, that is, the culture box is transported to the culture box station. The first clamping jaw 810 can pass between the two discharge tracks 410 so that the second clamping arm 812 and the first clamping arm 811 are respectively against the upper and lower surfaces of the culture box, thereby clamping or releasing the culture box.

[0073] It is conceivable that the third front-to-back driving mechanism 430 is a belt driving mechanism. The output end of the third front-to-back driving mechanism 430 is connected to a support plate, a storage slot is provided on the support plate, an elastic member is provided in the storage slot, the lower end of the hook plate 431 extends into the storage slot and abuts against the elastic member, the upper end of the hook plate 431 is wedge-shaped, the inclined surface of the hook plate 431 faces backward and upward, the hook plate 431 moves from front to back, and when the inclined surface of the hook plate 431 hits the front edge of the culture box, the culture box can drive the hook plate 431 to move downward and compress the elastic member, so that the hook plate 431 passes over the front edge of the culture box and extends into the slot at the bottom of the culture box.

[0074] In another embodiment, the output end of the third front-rear driving mechanism 430 is connected to a support plate, and a hook plate 431 is disposed on the support plate. The upper end of the hook plate 431 is wedge-shaped, and the inclined surface of the hook plate 431 faces upward and backward. The hook plate 431 moves from front to back. When the inclined surface of the hook plate 431 hits the front edge of the culture box, the hook plate 431 can drive the culture box to rise, so that the hook plate 431 passes over the front edge of the culture box and extends into the groove at the bottom of the culture box.

[0075] Reference Fig.10In some embodiments, the feeding mechanism 420 includes a second lower plate 421, a second upper plate 422 and a plurality of second surrounding rods 423. The second lower plate 421 and the second upper plate 422 are connected together by the plurality of second surrounding rods 423. The plurality of second surrounding rods 423 enclose a second limiting space for limiting the position of the culture box. The second lower plate 421 and the second upper plate 422 are both provided with a channel connected to the second limiting space, and a plurality of culture boxes can be placed from top to bottom in the second limiting space. The second lower plate 421 and the second upper plate 422 are both provided with a second avoidance opening 424 at the rear end. The second avoidance opening 424 can be used for hands and other components such as clamping components to pass through, so as to facilitate placing the culture box in the second limiting space.

[0076] Reference Figure 1 , 2 and Figure 6 A second support frame 180 is provided on the machine 100, and a second front-to-back driving mechanism 181 is provided on the second support frame 180. The output end of the second front-to-back driving mechanism 181 is connected to the second left-to-right driving mechanism 182, and the output end of the second left-to-right driving mechanism 182 is connected to the seventh lifting driving mechanism 183. The output end of the seventh lifting driving mechanism 183 is connected to the bottle opening mechanism 600. The bottle opening mechanism 600 is used to clamp the sample bottle. The second front-to-back driving mechanism 181, the second left-to-right driving mechanism 182 and the seventh lifting driving mechanism 183 respectively drive the bottle opening mechanism 600 to move in the front-to-back, left-to-right and up-to-down directions. The bottle opening mechanism 600 can transfer the sample bottle on the sample bottle positioning hole 113 to the sample bottle clamp 111. The sample bottle clamp 111 clamps the bottle body of the sample bottle, and the bottle opening mechanism 600 can rotate and unscrew the bottle cap of the sample bottle on the sample bottle clamp 111.

[0077] See also Figure 6 In some embodiments, the bottle opening mechanism 600 includes a mounting plate 610, a fourth rotating drive mechanism 620 and a second clamping jaw 630. The mounting plate 610 is connected to the output end of the seventh lifting drive mechanism 183. The fourth rotating drive mechanism 620 is arranged on the mounting plate 610. The output end of the fourth rotating drive mechanism 620 is connected to the second clamping jaw 630. The seventh lifting drive mechanism 183 can drive the mounting plate 610 and the fourth rotating drive mechanism 620 to rise and fall, thereby driving the second clamping jaw 630 to rise and fall. The fourth rotating drive mechanism 620 drives the second clamping jaw 630 to rotate, thereby realizing that the second clamping jaw 630 twists the bottle cap of the sample bottle. The second clamping jaw 630 is a common opening and closing clamping mechanism.

[0078] The second front-rear driving mechanism 181, the second left-right driving mechanism 182 and the seventh lifting driving mechanism 183 can all be cylinders, screw pairs or belt driving mechanisms. The fourth rotation driving mechanism 620 can be a fifth motor.

[0079] The technical features of the above embodiments may be combined arbitrarily. To make the description concise, not all possible combinations of the technical features in the above embodiments are described. However, as long as there is no contradiction in the combination of these technical features, they should be considered to be within the scope of this specification.

[0080] Of course, the present invention is not limited to the above-mentioned embodiments, and technicians familiar with the field may make equivalent modifications or substitutions without violating the spirit of the present invention. These equivalent modifications or substitutions are all included in the scope defined by the claims of this application.

Claims

1. A mycoplasma analysis system, characterized in that: include: The machine is provided with a limit plate, an incubator, a visual inspection mechanism and an incubator collection mechanism. The limit plate is provided with a paraffin oil bottle limit hole, a sample bottle clamp and a pipette tip carrier. The sample bottle clamp is used to clamp the sample bottle. The pipette tip carrier is used to set a plurality of liquid suction heads and a plurality of oil suction heads. The paraffin oil bottle limit hole is used to set the paraffin oil bottle. The culture box loading mechanism comprises a discharge track arranged on the machine platform, and a culture box station is arranged at the front end of the discharge track; A cover opening mechanism, provided on the machine platform, for lifting the cover of the culture box on the culture box station; A bottle opening mechanism, disposed on the machine platform, for removing the bottle cap of the sample bottle on the sample bottle fixture; The sample loading mechanism comprises a movable frame arranged on the machine platform, the movable frame can move in the front-back and left-right directions, and the movable frame is provided with a liquid suction component and an oil suction component which can be raised and lowered, the lower end of the liquid suction component is used to dock with the liquid suction head on the suction head carrier, the liquid suction head is used to suck the sample liquid in the sample bottle and inject the sample liquid into the culture well of the culture box, and the lower end of the oil suction component is used to dock with the oil suction head on the suction head carrier, the oil suction head is used to suck the paraffin oil in the paraffin oil bottle and inject the paraffin oil into the culture well of the culture box; The transfer mechanism includes a first clamp which can be raised and lowered on the machine platform, the first clamp is arranged between the culture box station, the incubator, the visual inspection mechanism and the culture box collection mechanism, and the first clamp can be rotated in a horizontal plane to transfer the culture box on the culture box station to the incubator, the visual inspection mechanism and the culture box collection mechanism in sequence.

2. A mycoplasma analysis system according to claim 1, characterized in that: The transfer mechanism also includes a first rotating drive mechanism, a support rod and a first lifting drive mechanism. The first rotating drive mechanism is arranged on the machine platform. The support rod is rotatably arranged on the machine platform and is transmission-connected to the first rotating drive mechanism. The first lifting drive mechanism is arranged on the support rod. The output end of the first lifting drive mechanism is connected to the first clamp to drive the first clamp to rise and fall.

3. A mycoplasma analysis system according to claim 2, characterized in that: The first clamping jaw includes a first clamping arm, a second clamping arm and a second lifting drive mechanism, the output end of the first lifting drive mechanism is connected to the first clamping arm, the second clamping arm and the second lifting drive mechanism are both arranged on the first clamping arm, the second clamping arm is above the first clamping arm, and the output end of the second lifting drive mechanism is connected to the second clamping arm to drive the second clamping arm to approach or move away from the first clamping arm.

4. A mycoplasma analysis system according to claim 1, characterized in that: The culture box collection mechanism includes a first lower plate, a first upper plate and a plurality of first surrounding rods, the first lower plate and the first upper plate are connected together by the plurality of first surrounding rods, the plurality of first surrounding rods enclose a first limiting space for limiting the culture box, the first lower plate and the first upper plate are both provided with a channel connected to the first limiting space, and the rear ends of the first lower plate and the first upper plate are both provided with a first avoidance opening for the first clamp to pass through.

5. A mycoplasma analysis system according to claim 1, characterized in that: The visual inspection mechanism includes a first horizontal plate, a second horizontal plate and a camera. The first horizontal plate and the second horizontal plate are both connected to the machine platform. The first horizontal plate is located above the second horizontal plate. The camera is arranged on the second horizontal plate. The first horizontal plate is provided with a stepped hole in the area corresponding to the camera. The stepped hole is used to support the culture box.

6. A mycoplasma analysis system according to claim 1, characterized in that: A first supporting frame is provided on the machine platform, a first front-rear driving mechanism is provided on the first supporting frame, an output end of the first front-rear driving mechanism is connected to a first left-right driving mechanism, an output end of the first left-right driving mechanism is connected to the moving frame, a third lifting driving mechanism and a fourth lifting driving mechanism are provided on the moving frame, and output ends of the third lifting driving mechanism and the fourth lifting driving mechanism are respectively connected to the liquid suction assembly and the oil suction assembly to respectively drive the liquid suction assembly and the oil suction assembly to rise and fall.

7. A mycoplasma analysis system according to claim 6, characterized in that: The liquid pipetting assembly includes a first liquid pipetting syringe and a fifth lifting drive mechanism, wherein the first liquid pipetting syringe and the fifth lifting drive mechanism are both connected to the output end of the third lifting drive mechanism via a first connecting plate, the lower end of the first liquid pipetting syringe faces downward and can be docked with the liquid pipetting head, and the output end of the fifth lifting drive mechanism is connected to the first piston rod of the first liquid pipetting syringe.

8. A mycoplasma analysis system according to claim 1, characterized in that: The lid opening mechanism includes a second rotary drive mechanism arranged on the machine platform, a first swing arm arranged on the output end of the second rotary drive mechanism, and a suction nozzle arranged on the swing end of the first swing arm. The output end of the second rotary drive mechanism is horizontally arranged so that the first swing arm swings in a vertical plane. The suction nozzle is used to adsorb the lid of the culture box on the culture box station.

9. A mycoplasma analysis system according to claim 1, characterized in that: A third rotary drive mechanism is provided on the machine platform, a second swing arm is provided on the output end of the third rotary drive mechanism, a cover plate is provided on the swing end of the second swing arm, the second swing arm swings in a horizontal plane, and the cover plate is used to cover the bottle mouth of the paraffin oil bottle on the limiting hole of the paraffin oil bottle.

10. A mycoplasma analysis system according to claim 9, characterized in that: A semi-enclosure is provided at the lower end of the cover plate, and the semi-enclosure is used to surround the bottle mouth of the paraffin oil bottle.

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