Sampling device for medicine dissolution instrument

Abstract

The utility model belongs to the technical field of medicine dissolution instruments, and particularly relates to a sampling device for a medicine dissolution instrument, which comprises a base and a dissolution instrument, the dissolution instrument is mounted at the top end of the base, adjusting mechanisms are arranged on the side edge and the top end of the dissolution instrument, and a sampling mechanism is arranged at the top end of the dissolution instrument. According to the sampling device for the medicine dissolution instrument, by arranging the adjusting structure, in the sampling process, the position of the sampling barrel can be automatically adjusted, then the sampling speed of experimenters can be increased, and the problems that according to a device proposed in the background technology, the position of a sampling needle needs to be manually adjusted, so that the burden of the experimenters is increased, and the sampling efficiency is improved are solved. According to the device, the problem that the device has certain limitation due to the fact that the device is provided with the sampling mechanism is solved, during sampling, liquid medicine can be stably sampled, the liquid medicine can be rapidly sampled, the sampling efficiency is improved, and the mechanism is simple in structure and easy to operate and has certain practical performance.

Description

Technical Field

[0001] The utility model relates to the technical field of drug dissolution instruments, in particular to a sampling device for drug dissolution instruments. Background Art

[0002] The drug dissolution instrument measures the dissolution rate and degree of drugs from solid preparations such as tablets and capsules in a specified medium under certain conditions. It is an effective means to check the quality of preparations and the level of production technology. It is also a standard for evaluating the bioavailability of active ingredients in preparations and the uniformity of preparations. It is an experiment that simulates the dissolution process of oral solid preparations in the gastrointestinal tract.

[0003] In the existing dissolution apparatus, the depth of the sampling needle is determined by using a ruler or a positioning plate, which has problems such as low positioning accuracy, large human operation errors, and the need for repeated positioning confirmation during the sampling process.

[0004] A drug dissolution instrument sampling device with a scale and positionability is proposed in the patent document with publication number CN206235487U. The device includes a dissolution cup cover, a sampling needle with a scale and a sampling needle positioning device, wherein the sampling needle positioning device is composed of a sampling needle pad, a locking nut and a fastening washer. The lower end of the sampling needle pad is concave, with gear columns around it, which fits and fixes with the sampling needle hole of the dissolution cup cover; the locking nut and the internal thread of the sampling needle pad are tightened to squeeze the fastening washer to fix the position of the sampling needle. This drug dissolution instrument sampling device can read the positioning height through the sampling needle scale, and can adjust the height intuitively and conveniently, which is convenient for the positioning and adjustment of the sampling needle during dissolution tests with different media volumes. This device has accurate positioning and simple operation, and is a reliable verification method for experiments and researchers.

[0005] However, the device requires manual adjustment of the position of the sampling needle, which increases the burden on the experimenter and causes certain limitations to the device.

[0006] For this reason, we urgently need to provide a sampling device for a drug dissolution instrument. Utility Model Content

[0007] The utility model aims to provide a sampling device for a drug dissolution instrument to solve the problem that the device proposed in the above background technology requires manual adjustment of the position of the sampling needle, thereby increasing the burden on the experimenter and causing the device to have certain limitations.

[0008] To achieve the above-mentioned purpose, the utility model provides the following technical solutions: a sampling device for a drug dissolution instrument, comprising a base and a dissolution instrument, wherein the dissolution instrument is installed at the top of the base, the side and the top of the dissolution instrument are provided with adjustment mechanisms, and the top of the dissolution instrument is provided with a sampling mechanism.

[0009] The regulating mechanism comprises an adjusting unit and a lifting unit.

[0010] The adjustment unit includes a connecting box, a first transmission member, a fixed column, a magnetic disk, a supporting column, a fixing frame and a second transmission member. The connecting box is movably mounted on the side of the base, the first transmission member is arranged on the side of the base, the fixed column is fixedly mounted on the fixed end of the first transmission member, the magnetic disk is connected to the outer wall of the fixed column, the supporting column is fixedly mounted on the top of the magnetic disk, the fixing frame is fixedly mounted on the top of the supporting column, and the second transmission member is arranged on the top of the dissolution instrument.

[0011] Preferably, the lifting unit comprises a mounting plate and an electrically controlled lifting rod, the mounting plate is fixedly mounted on the mounting end of the second transmission member, and the electrically controlled lifting rod is mounted on the top of the mounting plate.

[0012] Preferably, the sampling mechanism includes a connecting part, a connecting shaft, a fixing clamp, a sampling tube, a fixing part, a pressure rod, a connecting spring and an extrusion part, the connecting part is connected to the bottom end of the electric lifting rod, the connecting shaft is connected to the inside of the connecting part, the fixing clamp is installed on the outer wall of the connecting shaft, the sampling tube is arranged inside the fixing clamp, the fixing part is installed on the outer wall of the sampling tube, the pressure rod is connected to the inside of the fixing part, the connecting spring is arranged on the inner side of the fixing part, and the extrusion part is connected to the other end of the pressure rod.

[0013] Preferably, the first transmission member is distributed inside the connecting box, so that the connecting box plays a protective role for the first transmission member, and the first transmission member includes a motor, a rotating rod and a mounting seat. The operation of the motor causes the rotating rod to rotate, and the interior of the mounting seat is threadedly connected to the outer wall of the rotating rod, and then through the rotation of the rotating rod, the mounting seat moves back and forth on its outer wall, so that the longitudinal position of the sampling tube can be automatically adjusted. The connecting end of the connecting box is snap-connected with the inside of the side of the base to facilitate the installation and replacement of the adjustment structure.

[0014] Preferably, the material of the fixed column is a magnetic material, so that the magnetic disk and the fixed column can fit more closely, improving the rotation stability. The magnetic disk and the fixed column are rotationally connected, and the rotation of the magnetic disk facilitates the taking of the sample.

[0015] Preferably, the connecting shaft is rotatably connected to the inside of the connecting piece, and the rotation of the connecting shaft drives the two sets of fixing clamps to rotate, and the sampling tube is fixed by the mutual attraction of the two sets of fixing clamps, so that the fixing clamp fixes the sampling tube more firmly.

[0016] Preferably, the pressure rod is slidably connected to the inside of the fixing part. By pushing the pressure rod, the extrusion part squeezes the suction bag at the top of the sampling tube, thereby sampling the liquid medicine inside the container. One end of the connecting spring is connected to the inner side of the fixing part, and the other end is connected to the connection of the pressure rod, so that the pressure rod has a certain ductility, which speeds up the sampling rate to a certain extent.

[0017] Compared with the prior art, the beneficial effects of the utility model are:

[0018] 1. The sampling device for the drug dissolution instrument can automatically adjust the position of the sampling cylinder during the sampling process by setting an adjustment structure, thereby improving the sampling rate of the experimenter, solving the problem that the device proposed in the background technology requires manual adjustment of the position of the sampling needle, thereby increasing the burden on the experimenter and causing the device to have certain limitations.

[0019] 2. The sampling device used in the drug dissolution instrument can stably and quickly sample the drug solution by setting a sampling mechanism, thereby improving the sampling efficiency. In addition, the mechanism has a simple structure and is easy to operate, so it has certain practical performance. BRIEF DESCRIPTION OF THE DRAWINGS

[0020] Figure 1 This is a schematic diagram of the appearance structure of the utility model;

[0021] Figure 2 It is a schematic diagram of the oblique structure of the utility model;

[0022] Figure 3 This is a schematic diagram of the structure of the adjustment mechanism of the utility model;

[0023] Figure 4 It is a schematic diagram of the sampling mechanism structure of the utility model.

[0024] In the figure: 1, base; 2, dissolution instrument; 301, connecting box; 302, first transmission member; 303, fixing column; 304, magnetic disk; 305, supporting column; 306, fixing frame; 307, second transmission member; 308, mounting plate; 309, electric lifting rod; 401, connecting member; 402, connecting shaft; 403, fixing clamp; 404, sampling tube; 405, fixing member; 406, pressure rod; 407, connecting spring; 408, extrusion member. DETAILED DESCRIPTION

[0025] The following will be combined with the drawings in the embodiments of the utility model to clearly and completely describe the technical solutions in the embodiments of the utility model. Obviously, the described embodiments are only part of the embodiments of the utility model, not all of the embodiments. Based on the embodiments in the utility model, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the utility model.

[0026] See also Figure 1-Figure 4 , the utility model provides a technical solution:

[0027] Embodiment 1:

[0028] A sampling device for a drug dissolution instrument comprises a base 1 and a dissolution instrument 2. The dissolution instrument 2 is mounted on the top of the base 1. The side and top of the dissolution instrument 2 are provided with adjustment mechanisms. The top of the dissolution instrument 2 is provided with a sampling mechanism.

[0029] The regulating mechanism comprises an adjusting unit and a lifting unit.

[0030] The adjustment unit includes a connection box 301, a first transmission member 302, a fixed column 303, a disk 304, a support column 305, a fixed frame 306 and a second transmission member 307. The connection box 301 is movably installed on the side of the base 1. The connection end of the connection box 301 is engaged with the inside of the side of the base 1 to facilitate the installation and replacement of the adjustment structure. The first transmission member 302 is arranged on the side of the base 1. The first transmission member 302 is distributed inside the connection box 301, so that the connection box 301 plays a protective role for the first transmission member 302, and the first transmission member 302 includes a motor, a rotating rod and a mounting seat. The operation of the motor causes the rotating rod to rotate, and the inside of the mounting seat is threadedly connected to the outer wall of the rotating rod, thereby By rotating the rotating rod, the mounting seat moves back and forth on its outer wall, so that the longitudinal position of the sampling tube 404 can be automatically adjusted. The fixed column 303 is fixedly installed on the fixed end of the first transmission member 302. The material of the fixed column 303 is a magnetic material, so that the magnetic disk 304 and the fixed column 303 can be more closely fitted, thereby improving the stability of rotation. The magnetic disk 304 is connected to the outer wall of the fixed column 303, and the connection between the magnetic disk 304 and the fixed column 303 is rotatably connected. The rotation of the magnetic disk 304 facilitates the removal of the sample. The support column 305 is fixedly installed on the top of the magnetic disk 304, and the fixing frame 306 is fixedly installed on the top of the support column 305. The second transmission member 307 is arranged on the top of the dissolution instrument 2.

[0031] Embodiment 2:

[0032] On the basis of the first embodiment: the lifting unit includes a mounting plate 308 and an electric lifting rod 309 , the mounting plate 308 is fixedly mounted on the mounting end of the second transmission member 307 , and the electric lifting rod 309 is mounted on the top of the mounting plate 308 .

[0033] The sampling mechanism includes a connecting member 401, a connecting shaft 402, a fixing clamp 403, a sampling tube 404, a fixing member 405, a pressure rod 406, a connecting spring 407 and an extruding member 408. The connecting member 401 is connected to the bottom end of the electric control lifting rod 309, and the connecting shaft 402 is connected to the inside of the connecting member 401. The connecting shaft 402 is rotatably connected to the inside of the connecting member 401. The two groups of fixing clamps 403 are driven to rotate by the rotation of the connecting shaft 402. The fixing clamps 403 are installed on the outer wall of the connecting shaft 402. The sampling tube 404 is arranged inside the fixing clamps 403. The sampling tube 404 is fixed by the mutual attraction of the two groups of fixing clamps 403, so that the fixing clamps 403 can hold the sampling tube 404. 4 is fixed more firmly, the fixing part 405 is installed on the outer wall of the sampling tube 404, the pressure rod 406 is connected to the inside of the fixing part 405, the pressure rod 406 is slidably connected to the inside of the fixing part 405, and the pressing part 408 squeezes the suction bag at the top of the sampling tube 404 by pushing the pressing rod 406, so that the liquid medicine inside the container can be sampled, and the connecting spring 407 is arranged on the inner side of the fixing part 405, one end of the connecting spring 407 is connected to the inner side of the fixing part 405, and the other end is connected to the connection of the pressure rod 406, so that the pressure rod 406 can have a certain ductility, which speeds up the sampling rate to a certain extent, and the squeezing part 408 is connected to the other end of the pressure rod 406.

[0034] When in use, the fixing clamp 403 is driven to rotate by the rotation of the connecting shaft 402, and the fixing magnetic strip at the other end of the fixing clamp 403 is used to fix the sampling tube 404 with the two fixing clamps 403. The operation of the first transmission member 302 and the second transmission member 307 is controlled by an external controller, so that the position of the sampling tube 404 can be adjusted, so as to facilitate sampling of the liquid inside the container at different positions. The first transmission member 302 includes a motor, a rotating rod and a mounting seat. The operation of the motor causes the rotating rod to rotate, and the interior of the mounting seat is threadedly connected to the outer wall of the rotating rod, and then the rotation of the rotating rod causes the mounting seat to move back and forth on its outer wall, thereby The longitudinal position of the sampling tube 404 can be automatically adjusted. The second transmission member 307 includes a motor, a rotating rod and a connecting block. The operation of the motor causes the rotating rod to rotate, and the interior of the connecting block is threadedly connected to the outer wall of the rotating rod. Then, through the rotation of the rotating rod, the connecting block moves back and forth on its outer wall, so that the lateral position of the sampling tube 404 can be automatically adjusted, thereby improving the sampling rate. The sampling needle is inserted into the container inside the dissolution instrument 2 by utilizing the extension and retraction of the electrically controlled lifting rod 309. As long as the pressure rods 406 are pushed on both sides of the box, the extrusion member 408 squeezes the suction bag at the top of the sampling tube 404, thereby enabling the quick and convenient completion of the sampling of the liquid medicine.

[0035] It should be noted that, in this article, relational terms such as first and second, etc. are only used to distinguish one entity or operation from another entity or operation, and do not necessarily require or imply any such actual relationship or order between these entities or operations. Moreover, the terms "include", "comprise" or any other variants thereof are intended to cover non-exclusive inclusion, so that a process, method, article or device including a series of elements includes not only those elements, but also other elements not explicitly listed, or also includes elements inherent to such process, method, article or device. In the absence of further restrictions, the elements defined by the statement "comprise a ..." do not exclude the presence of other identical elements in the process, method, article or device including the elements.

Claims

1. A sampling device for a drug dissolution instrument, comprising a base (1) and a dissolution instrument (2), wherein the dissolution instrument (2) is mounted on the top of the base (1), and is characterized in that: The dissolution apparatus (2) is provided with adjustment mechanisms on the side and top, and a sampling mechanism is provided on the top of the dissolution apparatus (2); The regulating mechanism comprises an adjusting unit and a lifting unit; The adjustment unit comprises a connection box (301), a first transmission member (302), a fixed column (303), a magnetic disk (304), a support column (305), a fixed frame (306) and a second transmission member (307); the connection box (301) is movably mounted on the side of the base (1); the first transmission member (302) is arranged on the side of the base (1); the fixed column (303) is fixedly mounted on the fixed end of the first transmission member (302); the magnetic disk (304) is connected to the outer wall of the fixed column (303); the support column (305) is fixedly mounted on the top of the magnetic disk (304); the fixed frame (306) is fixedly mounted on the top of the support column (305); and the second transmission member (307) is arranged on the top of the dissolution instrument (2).

2. The sampling device for a drug dissolution instrument according to claim 1, characterized in that: The lifting unit comprises a mounting plate (308) and an electrically controlled lifting rod (309); the mounting plate (308) is fixedly mounted on the mounting end of the second transmission member (307); and the electrically controlled lifting rod (309) is mounted on the top of the mounting plate (308).

3. The sampling device for a drug dissolution instrument according to claim 1, characterized in that: The sampling mechanism comprises a connecting member (401), a connecting shaft (402), a fixing clamp (403), a sampling tube (404), a fixing member (405), a pressure rod (406), a connecting spring (407) and an extrusion member (408), wherein the connecting member (401) is connected to the bottom end of the electric-controlled lifting rod (309), the connecting shaft (402) is connected to the inside of the connecting member (401), the fixing clamp (403) is installed on the outer wall of the connecting shaft (402), the sampling tube (404) is arranged inside the fixing clamp (403), the fixing member (405) is installed on the outer wall of the sampling tube (404), the pressure rod (406) is connected to the inside of the fixing member (405), the connecting spring (407) is arranged on the inner side of the fixing member (405), and the extrusion member (408) is connected to the other end of the pressure rod (406).

4. The sampling device for a drug dissolution instrument according to claim 1, characterized in that: The first transmission member (302) is distributed inside the connection box (301), and the connection end of the connection box (301) is snap-connected to the inside of the side of the base (1).

5. The sampling device for a drug dissolution instrument according to claim 1, characterized in that: The material of the fixing post (303) is a magnetic material, and the magnetic disk (304) is rotatably connected to the fixing post (303) at a connection point.

6. The sampling device for a drug dissolution instrument according to claim 3, characterized in that: The connecting shaft (402) is rotatably connected to the inside of the connecting member (401), and the sampling tube (404) is fixed by the mutual attraction of two sets of fixing clamps (403).

7. The sampling device for a drug dissolution instrument according to claim 3, characterized in that: The pressure rod (406) is slidably connected to the inside of the fixing member (405); one end of the connection spring (407) is connected to the inner side of the fixing member (405), and the other end is connected to the connection point of the pressure rod (406).

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