Stem cell microsyringe

Abstract

The utility model discloses a stem cell microsyringe which comprises a first injection cavity, a second injection cavity, an injection needle, a spring assembly and a sliding separation assembly. The first injection cavity is located on the lower portion of the second injection cavity, the first injection cavity is communicated with the second injection cavity, and the inner diameter of the first injection cavity is larger than that of the second injection cavity; a piston is arranged in the first injection cavity and is connected with a push rod; the bottom of the second injection cavity is fixedly connected with an injection needle, and the second injection cavity is communicated with the injection needle; the spring assembly comprises a plurality of springs and contraction pieces, the inner sides of the springs are fixedly arranged on the surface of the second injection cavity, and the outer sides of the springs are fixedly connected with the contraction pieces; a plurality of through holes are formed in the bottom of the sliding separation assembly, the sliding separation assembly is slidably arranged on the second injection cavity in a surrounding mode, and the sliding separation assembly slides to enable the contraction pieces to be inserted into the through holes to fix the sliding separation assembly. The stem cell injector is suitable for injecting stem cells into the rat marrow cavity and can avoid infection.

Description

Technical Field

[0001] The utility model belongs to the technical field of medical equipment, and in particular relates to a stem cell micro-injector. Background Art

[0002] Stem cells are a type of primitive cells that have the ability to self-renew and can differentiate into a variety of tissue cell types. They are also the progenitor cells that form various tissues and organs in the human body. In medical research, osteoporotic mammals are usually treated by bone marrow puncture and injection of stem cells. At present, for bone marrow puncture and injection of stem cells, a bone puncture needle is usually used to make a hole, and then the stem cells are injected into the rat's bone marrow cavity with an ordinary syringe. However, for rats, their bone marrow cavity is small, and the commonly used bone puncture needle is difficult to accurately penetrate the bone cortex, and the bone puncture needle is not easy to control the operating force, and it is easy to penetrate the rat femur, causing infection; in addition, in the process of injecting drugs, if the bone puncture needle is used after the hole is made, since the two steps of bone puncture and injection are operated separately, there is a certain interval between the two steps, which will increase the probability of infection.

[0003] Therefore, there is an urgent need for a device that is suitable for rat bone marrow cavity injection and is not prone to infection. Utility Model Content

[0004] The utility model aims to overcome the defects of the existing stem cell injection device that it is easy to cause infection in rats and is not suitable for stem cell injection in rats.

[0005] In order to achieve the above-mentioned object, the utility model provides a stem cell micro-injector, comprising a first injection cavity, a second injection cavity, an injection needle, a spring assembly, and a sliding partition assembly;

[0006] The first injection cavity is located at the lower part of the second injection cavity, the first injection cavity is connected with the second injection cavity, and the inner diameter of the first injection cavity is larger than the inner diameter of the second injection cavity; a piston is provided inside the first injection cavity, and the piston is connected to a push rod;

[0007] The injection needle is fixedly connected to the bottom of the second injection cavity, and the second injection cavity is in communication with the injection needle;

[0008] The spring assembly comprises a plurality of springs and a contraction member, the inner side of the spring is fixedly arranged on the surface of the second injection cavity, and the outer side of the spring is fixedly connected to the contraction member;

[0009] A plurality of through holes are provided at the bottom of the sliding partition component. The sliding partition component is slidably arranged around the second injection cavity. The sliding partition component is fixed by sliding so that the contraction member is inserted into the through hole.

[0010] Optionally, the first injection cavity has a length of 5 cm to 8 cm and an inner diameter of 20 mm to 25 mm.

[0011] Optionally, the second injection cavity has a length of 1 cm to 2 cm and an inner diameter of 10 mm to 15 mm.

[0012] Optionally, the injection needle has a length of 50 mm to 60 mm and an inner diameter of 5 mm to 7 mm.

[0013] Optionally, the needle hole of the injection needle is located in the middle of the needle head of the injection needle, and the inner diameter of the needle hole is 4 mm to 5 mm.

[0014] Optionally, the cross-section of the sliding partition assembly is an inverted trapezoid that is wide at the top and narrow at the bottom, the upper base length of the inverted trapezoid is 16mm to 21mm, the lower base length of the inverted trapezoid is 11mm to 16mm, and the height of the inverted trapezoid is 1cm to 2cm.

[0015] Optionally, six springs and six contraction members are provided, and two of them are symmetrically arranged on the second injection cavity.

[0016] Optionally, there are two through holes, which are symmetrically opened at the bottom of the sliding partition component.

[0017] Optionally, a scale mark is provided on the side of the second injection cavity.

[0018] Optionally, the stem cell micro-injector is made of titanium alloy.

[0019] Technical effects of the utility model:

[0020] (1) The first injection cavity, the second injection cavity and the injection needle of the utility model are an integrated structure. A sliding partition assembly is arranged around the outside of the second injection cavity. The sliding partition assembly can be moved up and down on the second injection cavity through the spring assembly on the second injection cavity and is fixed through the through hole on the sliding partition assembly, so that the injection needle is exposed to different puncture depths. Different needle insertion depths can be achieved according to the specific requirements of the experiment, and different puncture depths can be achieved. Puncture can be performed immediately after injection, and there is no time interval and space interval between injection and puncture, which reduces the intermediate steps and greatly reduces the risk of infection.

[0021] (2) The sliding partition assembly of the utility model is designed as an inverted trapezoid that is wider at the top and narrower at the bottom. The lower part of the inverted trapezoid is narrower, and the lower part is not completely in contact with the second injection cavity, but there is a certain gap between the lower part and the outer wall of the second injection cavity. When the sliding partition assembly moves up and down, the retracting part on the spring assembly can be quickly inserted into the through hole on the sliding partition assembly, so that the sliding partition assembly can be fixed in multiple stages, thereby exposing injection needles of different depths. In addition, it can be pressed against the bone during puncture to prevent the puncture from being too deep.

[0022] (3) The stem cell micro-injector of the utility model is made of titanium alloy, which has extremely high specific strength and can withstand greater mechanical stress; it can resist the erosion of various chemical substances and is not easily oxidized; the density of titanium alloy is relatively light, which can achieve a smaller dead weight and excellent structural performance, as well as withstand pressure; it has better biocompatibility and is non-toxic, harmless, and has no rejection reaction to cell tissues. BRIEF DESCRIPTION OF THE DRAWINGS

[0023] Figure 1 This is a front view of a structural schematic diagram of a stem cell micro-injector of the utility model.

[0024] Figure 2 This is a detailed enlarged view of a side view of a stem cell micro-injector of the present invention.

[0025] Among them, 1-first injection cavity, 2-second injection cavity, 21-spring, 22-contraction member, 3-sliding partition assembly, 31-through hole, 4-injection needle, 5-push rod. DETAILED DESCRIPTION

[0026] The technical solution of the utility model will be described clearly and completely below in conjunction with the accompanying drawings. Obviously, the described embodiments are part of the embodiments of the utility model, not all of the embodiments. Based on the embodiments of the utility model, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the utility model.

[0027] The structures, proportions, sizes, etc. illustrated in the drawings of this specification are only used to match the contents disclosed in the specification for people familiar with this technology to understand and read, and are not used to limit the limiting conditions for the implementation of the utility model, so they have no substantial technical significance. Any modification of the structure, change of the proportion relationship or adjustment of the size, without affecting the effect and purpose that can be achieved by the utility model, should still fall within the scope of the technical content disclosed by the utility model. At the same time, the terms such as "upper", "lower", "left", "right", "middle" and "one" quoted in this specification are only for the convenience of description, and are not used to limit the scope of the implementation of the utility model. The change or adjustment of the relative relationship, without substantial change of the technical content, should also be regarded as the scope of the implementation of the utility model.

[0028] like Figure 1 As shown, the utility model provides a stem cell micro-injector, comprising a first injection cavity 1, a second injection cavity 2, an injection needle 4, a spring assembly, and a sliding partition assembly 3; the first injection cavity 1 is located at the lower part of the second injection cavity 2, the first injection cavity 1 is connected to the second injection cavity 2, and the inner diameter of the first injection cavity 1 is greater than the inner diameter of the second injection cavity 2; a piston is provided inside the first injection cavity 1, and the piston is connected to a push rod 5; the injection needle 4 is fixedly connected to the bottom of the second injection cavity 2, and the second injection cavity 2 is connected to the injection needle 4; the spring assembly comprises a plurality of springs 21 and a contraction member 22, the inner side of the spring 21 is fixedly arranged on the surface of the second injection cavity 2, and the outer side of the spring 21 is fixedly connected to the contraction member 22; a plurality of through holes 31 are opened at the bottom of the sliding partition assembly 3, the sliding partition assembly 3 is slidably arranged around the second injection cavity 2, and the sliding partition assembly 3 fixes the sliding partition assembly 3 by sliding so that the contraction member 22 is inserted into the through hole 31.

[0029] The stem cell micro-injector is used for puncturing and injecting stem cells into the rat bone marrow cavity. Since the rat bone marrow cavity is small and thin as a whole, the size of the stem cell micro-injector of the utility model is small as a whole. In some embodiments, the length of the first injection cavity 1 is 5cm to 8cm, and the inner diameter is 20mm to 25mm. The length of the second injection cavity 2 is 1cm to 2cm, and the inner diameter is 10mm to 15mm. In order to prevent the injection needle from penetrating the rat's femur, the size of the injection needle is designed to be more precise. Optionally, the length of the injection needle 4 is 50mm to 60mm, and the inner diameter is 5mm to 7mm.

[0030] The needle hole of the injection needle 4 of the utility model is located in the middle of the needle head of the injection needle 4, and the inner diameter of the needle hole is 4mm to 5mm. Compared with the commonly used multi-stage injection needle, the injection needle 4 of the utility model adopts a one-stage type, and the needle hole is located in the middle of the needle head. During the experiment, there is no need to manually adjust the length of the needle head to achieve the depth change during injection. According to the scale mark on the side of the second injection cavity 2, the insertion depth of the injection needle 4 is exposed by moving the sliding partition component 3 up and down.

[0031] In order to avoid rat infection, the depth of puncture of the injection needle 4 is controlled by the sliding partition component 3. The sliding partition component 3 can slide up and down on the second injection cavity 2. When the sliding partition component 3 slides down to the first level depth on the second injection cavity 2, since the outer side of the spring 21 is connected with a contraction piece 22, the contraction piece 22 is squeezed and inserted into the through hole 31 at the bottom of the sliding partition component 3 under the action of the external force of the sliding partition component 3. The through holes 31 are symmetrically arranged at both ends of the bottom of the sliding partition component 3, so that the sliding partition component 3 is fixed at the first level depth. In order to facilitate the spring 21 and the contraction piece 22 to be smoothly inserted into the through hole 31, the spring 21 of the present application is thinner and softer, and the contraction piece 22 has a larger contractility. Under the action of external force, the sliding partition component 3 squeezes the spring 21 and the contraction piece 22. Since the contraction piece 22 shrinks rapidly, the contraction piece 22 squeezes the spring 21, so that the spring 21 is deformed, and the spring 21 and the contraction piece 22 are rapidly shortened, and then squeezed into the through hole 31. It is understandable that, since the second injection cavity 2 is provided with scale marks on the side, the sliding partition component 2 can be moved up and down to different levels of depth on the second injection cavity 2 according to the requirements of the experiment. For example, when the needle needs to be inserted deeper, the sliding partition component 3 is further downwardly moved, and the sliding partition component 3 is moved downward to the spring farther from the needle head, so that the retracting member 22 farther away is inserted into the through hole 31 at the bottom of the sliding partition component 3 under the action of the external force of the sliding partition component 3, and the remaining springs 21 and retracting members 22 are squeezed, deformed and shortened.

[0032] The cross section of the sliding partition component 3 is an inverted trapezoid that is wide at the top and narrow at the bottom. The length of the upper bottom of the inverted trapezoid is 16mm-21mm, the length of the lower bottom of the inverted trapezoid is 11mm-16mm, and the height of the inverted trapezoid is 1cm-2cm. The lower bottom of the sliding partition component 3 is not completely attached to the second injection cavity 2. There is a certain gap between the lower bottom and the outer wall of the second injection cavity 2. When the sliding partition component 3 moves up and down, the contraction member 22 on the spring component can be quickly inserted into the through hole 31 on the sliding partition component 3, so that the sliding partition component 3 is fixed in multiple stages, thereby exposing injection needles 4 of different depths. In addition, it is convenient to resist the bone during puncture. Specifically, during puncture, the sliding partition component 3 is first slid to a fixed position, and then puncture is performed. Since the femur of rats is thin, it is not easy to retract the force after using the puncture needle in the prior art, and it is easy to penetrate the femur. After the sliding partition component 3 slides to a certain depth, its lower part contacts the bone skin, which can prevent the needle from continuing to penetrate.

[0033] In summary, the first injection cavity, the second injection cavity, and the injection needle of the utility model are an integrated structure, and a sliding partition assembly is arranged around the outside of the second injection cavity. The sliding partition assembly can be moved up and down on the second injection cavity through the spring assembly on the second injection cavity, and is fixed through the through hole on the sliding partition assembly, so that the injection needle is exposed to different puncture depths, and different needle insertion depths can be achieved according to the specific requirements of the experiment to achieve different puncture depths; puncture can be performed immediately after injection, and there is no time interval and space interval between injection and puncture, which reduces the intermediate steps and greatly reduces the risk of infection. The stem cell micro-injector of the utility model can be used for stem cell injection and puncture in rats, without intermediate steps, which can greatly avoid infection.

[0034] In summary, although the content of the utility model has been described in detail through the above preferred embodiments, it should be recognized that the above description should not be considered as a limitation of the utility model. After reading the above content, various modifications and substitutions of the utility model will be obvious to those skilled in the art. Therefore, the protection scope of the utility model should be defined by the attached claims.

Claims

1. A stem cell microinjector, characterized in that: It comprises a first injection cavity, a second injection cavity, an injection needle, a spring assembly, and a sliding partition assembly; The first injection cavity is located at the lower part of the second injection cavity, the first injection cavity is connected with the second injection cavity, and the inner diameter of the first injection cavity is larger than the inner diameter of the second injection cavity; a piston is provided inside the first injection cavity, and the piston is connected to a push rod; The injection needle is fixedly connected to the bottom of the second injection cavity, and the second injection cavity is in communication with the injection needle; The spring assembly comprises a plurality of springs and a contraction member, the inner side of the spring is fixedly arranged on the surface of the second injection cavity, and the outer side of the spring is fixedly connected to the contraction member; A plurality of through holes are provided at the bottom of the sliding partition component. The sliding partition component is slidably arranged around the second injection cavity. The sliding partition component is fixed by sliding so that the contraction member is inserted into the through hole.

2. The stem cell microinjector according to claim 1, characterized in that: The first injection cavity has a length of 5 cm to 8 cm and an inner diameter of 20 mm to 25 mm.

3. The stem cell microinjector according to claim 1, characterized in that: The second injection cavity has a length of 1 cm to 2 cm and an inner diameter of 10 mm to 15 mm.

4. The stem cell microinjector according to claim 1, characterized in that: The injection needle has a length of 50 mm to 60 mm and an inner diameter of 5 mm to 7 mm.

5. The stem cell microinjector according to claim 1, characterized in that: The needle hole of the injection needle is located in the middle of the needle head of the injection needle, and the inner diameter of the needle hole is 4mm to 5mm.

6. The stem cell microinjector according to claim 1, characterized in that: The cross section of the sliding partition component is an inverted trapezoid that is wide at the top and narrow at the bottom. The length of the upper base of the inverted trapezoid is 16mm to 21mm, the length of the lower base of the inverted trapezoid is 11mm to 16mm, and the height of the inverted trapezoid is 1cm to 2cm.

7. The stem cell microinjector according to claim 1, characterized in that: There are six springs and six contraction members, each of which is symmetrically arranged in pairs on the second injection cavity.

8. The stem cell microinjector according to claim 1, characterized in that: There are two through holes, which are symmetrically arranged at the bottom of the sliding partition component.

9. The stem cell microinjector according to claim 1, characterized in that: The side of the second injection cavity is provided with a scale mark.

10. The stem cell microinjector according to claim 1, characterized in that: The material of the stem cell micro-injector is titanium alloy.

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