Sampling and post-processing integrated collection device and sample detection device

Abstract

The utility model discloses a sampling and post-processing integrated acquisition device and a sample detection device. The sampling and post-processing integrated collecting device comprises a hollow holding part and a sampling part. One end of the hollow holding part is open, and the other end of the hollow holding part is closed. The sampling part is arranged at the open end of the hollow holding part. The hollow holding part is provided with a weak part which can form an opening through bending, extruding or puncturing. The hollow holding part is filled with a diluent, a lysis solution or a buffer solution. The hollow holding part of the sampling and post-processing integrated collecting device is filled with diluent (or lysate or buffer solution), and the closed tail end of the swab is provided with the weak part; by breaking off the weak part, the diluent can flow out to wash a sample in the sampling part, dilution or splitting decomposition of the sample and output of the sample are automatically completed, the operation steps of sample detection are simplified, and meanwhile, detection consumables are saved.

Description

Technical Field

[0001] The utility model belongs to the technical field of sample collection and processing, and in particular relates to a sampling and post-processing integrated collection device and a sample detection device. Background Art

[0002] At present, in in vitro diagnostic tests, conventional lysate (or buffer, diluent) devices and sampling devices are separate. When in use, it is necessary to first collect samples with a sampling device, and then place the sampling device with the collected samples in a lysate device to dissolve or lyse, and then drop the treated sample and the mixed solution of the lysate in the detection device through the lysate device for detection. Or when in use, it is necessary to first collect the sample with a sample collection device and then drop it into the detection device, and then drop the lysate (or buffer, or diluent) device into the detection device to start the detection reaction (such as Figure 3 of the patent CN113702643B specification, Figure 6 of the CN112858675B specification, etc.); Therefore, the operation is cumbersome and the use of the two devices separately also causes waste of consumables. Summary of the invention

[0003] The utility model aims to provide a sampling and post-processing integrated collection device and sample detection device in view of the deficiencies of the existing technologies and products.

[0004] In a first aspect, the utility model provides a sampling and post-processing integrated collection device, which comprises a hollow gripping portion and a sampling portion. One end of the hollow gripping portion is open, and the other end is closed. The sampling portion is arranged at the open end of the hollow gripping portion. A weak portion capable of forming an opening by bending, squeezing or puncturing is arranged on the hollow gripping portion. The hollow gripping portion is filled with a diluent, a lysate or a buffer solution.

[0005] Preferably, a marking line is provided at the weak portion.

[0006] Preferably, the sampling part is made of any one of absorbent cotton, polyester fiber, polyurethane foam and nylon fiber.

[0007] Preferably, the inner cavity of the hollow gripping portion is connected as one; along the direction from the open end to the closed end, the hollow gripping portion is a liquid output section, an isolation section, a liquid filling section, a weak section and a closed section arranged in sequence along the length direction. The sampling portion is wrapped around the liquid output section.

[0008] Preferably, the liquid filling section is filled with a diluent, the isolation section is filled with an oily sealing liquid, and when the weak portion is not broken, the diluent remains stationary in the liquid filling section.

[0009] Preferably, one or more side output ports are arranged on the outer side surface of the liquid output section; all the side output ports are wrapped by the sampling portion.

[0010] Preferably, a striped anti-slip structure is provided on the liquid filling section.

[0011] Preferably, the striped anti-slip structure is arranged at a position close to the weak portion of the liquid filling section.

[0012] Preferably, the hollow gripping portion adopts a tubular structure.

[0013] Preferably, the outer side surface of the weak portion is provided with a groove surrounding the weak portion.

[0014] Preferably, a thinning groove is provided on one side of the outer side surface of the weak portion.

[0015] Preferably, a thin film structure is provided on the weak portion.

[0016] Preferably, the weak portion is a thin-walled structure that can be broken by extrusion.

[0017] In a second aspect, the utility model provides a sample detection device, which includes a detection plate and the aforementioned sampling and post-processing integrated collection device. A reagent strip is arranged in the detection plate. A card slot structure is arranged on one side of the detection plate. The hollow gripping portion of the sampling and post-processing integrated collection device is engaged with the card slot structure on the detection plate.

[0018] The beneficial effects of the utility model are:

[0019] 1. The utility model fills a diluent (or a lysing solution, a buffer solution) in the hollow gripping portion, and provides a weak portion at the closed tail end of the swab; by breaking the weak portion, the diluent can flow out to flush the sample in the sampling portion, automatically completing the dilution or lysis of the sample, as well as the output of the sample, simplifying the operating steps of the sample detection, being easy to use, and saving consumables.

[0020] 2. The utility model can directly introduce the diluent into the inner side of the collection part where sampling is completed; when the diluent flows from the inner side of the collection part to the outside, the collection part can be fully rinsed, thereby reducing the residual sample in the collection part, improving the degree of sample release, and reducing the requirement for the sampling amount. BRIEF DESCRIPTION OF THE DRAWINGS

[0021] Figure 1 This is a schematic diagram of the structure of Example 1 of the utility model.

[0022] Figure 2 This is a schematic diagram of the structure of Example 5 of the present utility model.

[0023] Figure numerals: 1, liquid output section; 1-1, liquid outflow port; 1-2, side output port; 2, isolation section; 3, sampling section; 4, liquid filling section; 5, weak portion; 6, closed section. DETAILED DESCRIPTION

[0024] The following will be combined with the drawings in the embodiments of the utility model to clearly and completely describe the technical solutions in the embodiments of the utility model. The embodiments described below with reference to the drawings are exemplary and are only used to explain the utility model, and cannot be understood as limiting the utility model.

[0025] Example 1

[0026] like Figure 1 As shown, a sampling and post-processing integrated collection device includes a hollow gripping portion and a sampling portion 3 installed at the end of the hollow gripping portion. The hollow gripping portion adopts a cylindrical hollow hard plastic tube. The inner cavity of the hollow gripping portion is connected as a whole, and one end is open and the other end is closed; the hollow gripping portion is divided into a liquid output section 1, an isolation section 2, a liquid filling section 4, a weak section 5, and a closed section 6 arranged in sequence along the length direction along the direction from the open end to the closed end.

[0027] The sampling part 3 is wrapped on the liquid output section 1. The end of the liquid output section 1 is open and is a liquid outflow outlet 1-1 of a hollow hard plastic tube. The end of the closed section 6 is the closed end of the hollow gripping part.

[0028] In this embodiment, the weak portion 5 is a structure that is easy to break; for example, a groove surrounding the weak portion 5 is provided on the outer side surface of the weak portion 5 .

[0029] In addition, the weak portion 5 can also adopt the following structure: a thinning groove is provided on one side of the outer side of the weak portion 5; when in use, the thinning groove can be broken by simply bending the closed section 6 to the side away from the thinning groove, and the closed section of the hollow gripping portion can be opened. Under this structure, the weak portion 5 will not be completely separated from the main body of the hollow gripping portion after being bent, thereby improving the convenience of discarding the collection device integrating sampling and post-processing.

[0030] In some other embodiments, the weak portion 5 may also be a thin film structure that can be punctured by a sharp object, or a thin-walled brittle structure that can be broken by extrusion.

[0031] The liquid filling section 4 is filled with a diluent. The isolation section 2 is filled with an oily sealing liquid. When the weak portion 5 is not broken, the diluent is kept stationary in the liquid filling section 4 under the action of atmospheric pressure. The oily sealing liquid uses the oil seal principle to ensure that the diluent can maintain a stable position when the sampling and post-processing integrated collection device is rotated to any posture.

[0032] In this embodiment, the sampling part 3 is made of absorbent cotton (cotton swab). In some other embodiments, the sampling part 3 can also be made of one of polyester fiber, polyurethane foam (sponge swab), and nylon fiber (flocking swab).

[0033] The working principle of the utility model is as follows:

[0034] The user holds the hollow holding portion of the sampling and post-processing integrated collection device, and uses the sampling portion 3 to contact the target sample to complete the sampling; the target sample includes but is not limited to urine, saliva, nasal fluid, feces, etc.

[0035] After sampling is completed, the sampling and post-processing integrated collection device is transferred to the designated location. The hollow grip is adjusted to a vertical state and the weak portion 5 is broken; the top of the hollow grip is opened, and under the action of atmospheric pressure and gravity, the diluent (or buffer, lysate) flows out from the liquid filling section 4 of the hollow grip to the sampling portion 3. At this time, the diluent flushes the target sample on the sampling portion 3, so that the target sample flows out together with the diluent.

[0036] Since the diluent flows through the sampling portion 3, it can play a role in washing the sample while diluting or lysing the sample, so that the sample is fully released and the demand for sample volume is reduced.

[0037] Example 2

[0038] A collection device integrating sampling and post-processing. The difference between this embodiment and embodiment 1 is that a color identification line is provided at the weak portion 5 to facilitate the user to identify the position of the weak portion 5.

[0039] Example 3

[0040] A collection device integrating sampling and post-processing, the difference between this embodiment and embodiment 1 is that the sampling portion 3 is hollow elliptical in cross section.

[0041] In some other embodiments, the sampling portion 3 may also adopt other regular geometric shapes corresponding to the sample loading port of the detection device.

[0042] Example 4

[0043] A collection device integrating sampling and post-processing. The difference between this embodiment and embodiment 1 is that a striped anti-skid structure is provided on the outer side of the liquid filling section 4 near the weak portion 5; the striped anti-skid structure serves as a hand-holding area during sampling and adding samples, and is used to increase the friction between the user's fingers and the hollow gripping portion of the collection device integrating sampling and post-processing when the user takes samples and breaks the weak portion 5, so that the swab is not easy to slip during use.

[0044] Example 5

[0045] like Figure 2 As shown, a sampling and post-processing integrated collection device, the difference between this embodiment and embodiment 1 is: Figure 2 As shown, one or more side output ports 1-2 are arranged on the outer surface of the liquid output section 1; the side output ports 1-2 are completely covered by the sampling portion 3; the side output ports 1-2 penetrate the side wall of the hollow gripping portion, so that the target samples at different positions on the sampling portion 3 can be more fully flushed, thereby further improving the adequacy of the target sample output.

[0046] Example 6

[0047] A sample detection device includes a detection plate and a sampling and post-processing integrated collection device as described in Example 1. A reagent strip is arranged in the detection plate. A card slot structure is arranged on one side of the detection plate. The hollow gripping portion of the sampling and post-processing integrated collection device is engaged with the card slot structure on the detection plate.

[0048] The working principle of the utility model is as follows:

[0049] The user holds the hollow holding portion of the sampling and post-processing integrated collection device, and uses the sampling portion 3 to contact the target sample to complete the sampling; the target sample includes but is not limited to urine, saliva, nasal fluid, feces, etc.

[0050] After sampling is completed, the sampling and post-processing integrated collection device is transferred to the top of the reagent device injection port. The hollow grip is adjusted to a vertical state and broken at the weak part 5, so that the top of the hollow grip is open. Under the action of atmospheric pressure and gravity, the diluent (or buffer, lysate) flows out from the liquid filling section 4 of the hollow grip to the sampling part 3. At this time, the diluent flushes the target sample on the sampling part 3, so that the target sample is mixed with the diluent and enters the detection device for detection.

[0051] Wait for the reagent strip to react and display the test results.

[0052] The above schematically describes the present invention and its implementation methods, which are not restrictive. The drawings show only one implementation method of the present invention, and the actual structure is not limited thereto. Therefore, if ordinary technicians in this field are inspired by it and design structural methods and embodiments similar to the technical solution without creativity without departing from the purpose of the present invention, they should all fall within the protection scope of the present invention.

Claims

1. A sampling and post-processing integrated collection device, comprising a hollow gripping portion and a sampling portion (3); characterized in that: One end of the hollow gripping portion is open and the other end is closed; the sampling portion (3) is arranged at the open end of the hollow gripping portion; a weak portion (5) is arranged on the hollow gripping portion, which can be opened by bending, squeezing or puncturing; and the hollow gripping portion is filled with a diluent, a lysate or a buffer solution.

2. The sampling and post-processing integrated collection device according to claim 1, characterized in that: The weak portion (5) is provided with a marking line.

3. The sampling and post-processing integrated collection device according to claim 1, characterized in that: The inner cavity of the hollow gripping portion is connected as a whole; along the direction from the open end to the closed end, the hollow gripping portion is a liquid output section (1), an isolation section (2), a liquid filling section (4), a weak portion (5) and a closed section (6) arranged in sequence along the length direction; the sampling portion (3) is wrapped on the liquid output section (1); the liquid filling section (4) is filled with a diluent, a lysate or a buffer solution; and the isolation section (2) is filled with an oily sealing liquid.

4. The sampling and post-processing integrated collection device according to claim 3, characterized in that: One or more side output ports (1-2) are arranged on the outer side surface of the liquid output section (1); all the side output ports (1-2) are wrapped by the sampling portion (3).

5. The sampling and post-processing integrated collection device according to claim 3, characterized in that: The liquid filling section (4) is provided with a striped anti-skid structure; the striped anti-skid structure is arranged at a position of the liquid filling section (4) close to the weak portion (5).

6. The sampling and post-processing integrated collection device according to claim 1, characterized in that: The hollow gripping portion adopts a tubular structure.

7. A sampling and post-processing integrated collection device according to claim 1 or 3, characterized in that: The outer side surface of the weak portion (5) is provided with a groove surrounding the weak portion (5).

8. The sampling and post-processing integrated collection device according to claim 1 or 3, characterized in that: A thinning groove is provided on one side of the outer side surface of the weak portion (5).

9. A sampling and post-processing integrated collection device according to claim 1 or 3, characterized in that: The weak portion (5) is a thin-walled structure that can be broken by extrusion.

10. A sample detection device, comprising a detection plate; characterized in that: It also includes the sampling and post-processing integrated collection device as described in claim 1; a reagent strip is arranged in the detection plate; a card slot structure is arranged on one side of the detection plate; and the hollow gripping portion of the sampling and post-processing integrated collection device is snap-fitted with the card slot structure on the detection plate.

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