Oscillator for stem cell amplification

Abstract

The utility model discloses an oscillator for stem cell amplification, which belongs to the technical field of stem cell oscillation and comprises a bottom plate, a first mounting box is mounted on one side of the upper end of the bottom plate, a second mounting box is mounted on the other side of the upper end of the bottom plate, a control panel is mounted on one side of the second mounting box, and an oscillation mechanism is mounted on the other side of the second mounting box. According to the stem cell oscillation device, the oscillation mechanism is arranged and can drive the cam to rotate through the driving assembly, the cam rotates to drive the lifting plate to ascend and descend, and the lifting plate ascends and descends to drive the cell container at the upper end of the mounting plate to vibrate, so that effective oscillation work of stem cells can be guaranteed; according to the mechanism, a cell container can be conveniently installed and fixed, the cell container can be conveniently detached, the cell container can be conveniently cleaned, and a sealing cover can be conveniently opened by arranging a handle.

Description

Technical Field

[0001] The utility model belongs to the technical field of stem cell oscillation, and in particular relates to an oscillator for stem cell amplification. Background Art

[0002] Stem cells are a type of cell with unlimited or immortal self-renewal capabilities and can produce at least one type of highly differentiated daughter cells. In biological cell experiments, stem cells often need to be cultured. Under static culture conditions, stem cells adhere to the bottom bottle wall, and dissolved oxygen and nutrients will form a concentration gradient. Under mild oscillating culture conditions, the concentration gradient is eliminated, the dissolved oxygen concentration is increased, and it is more conducive to growth. Therefore, when amplifying and culturing stem cells, the stem cells need to be oscillated.

[0003] Chinese patent application No. 202322029663.3 discloses an oscillator for stem cell amplification, including a base, a docking seat installed at one end of the top of the base, a protective shell installed at one end of the top of the base away from the docking seat, a control panel installed on the outer surface of the protective shell, and a mounting seat installed at one end of the top of the base located inside the protective shell. The utility model designs an oscillator for stem cell amplification. The paddle plate is used to continuously pull the baffle upward and then separate during rotation, so that the oscillation rod rotates back and forth, so that the cell container on the support plate oscillates back and forth within a certain frequency, thereby effectively improving the efficiency of stem cell oscillation, accelerating the amplification and culture process of stem cells, and effectively solving the problem that traditional cell oscillators can only oscillate one stem cell container at a time.

[0004] Although the above-mentioned patent has realized the oscillation work for stem cells, the vibration effect of the oscillation structure is relatively poor, and it cannot ensure that the mounting plate can vibrate up and down. The existing mounting plate will swing left and right, which will affect the oscillation effect of the stem cells; the cell container set therein is not convenient to disassemble and clean. Utility Model Content

[0005] In order to solve the problems raised in the above background technology, the utility model provides an oscillator for stem cell amplification, which has the characteristics of better oscillation effect on cells and convenient disassembly and cleaning of cell containers.

[0006] To achieve the above-mentioned purpose, the utility model provides the following technical solution: an oscillator for stem cell expansion, comprising a base plate, a mounting box 1 is mounted on one side of the upper end of the base plate, a mounting box 2 is mounted on the other side of the upper end of the base plate, a control panel is mounted on one side of the mounting box 2, an oscillation mechanism is mounted on the other side of the mounting box 2, a mounting plate is arranged between the mounting box 2 and the mounting box 1, and a cell container fixing mechanism is mounted on the upper end of the mounting plate.

[0007] Preferably, the oscillation mechanism includes a lifting plate, a center rod, a spring, a cam and a driving assembly. The driving assembly is installed on the other side of the mounting box 2, and a cam is installed on the side of the driving assembly. A lifting plate is placed on the upper end of the cam. A center rod is installed through the interior of the lifting plate, and a spring is provided on the surface of the center rod located at the lower end of the lifting plate.

[0008] Preferably, the oscillation mechanism further comprises a slide groove, a slide rod and a slider, the other side of the mounting plate is provided with a slider inside the mounting box one, a slide groove corresponding to the slider is provided inside the mounting box one, and a slide rod is installed through the inside of the slider.

[0009] Preferably, a sliding rod is provided inside the sliding block and is slidably connected thereto through the through hole.

[0010] Preferably, the driving assembly includes a rotating rod, a driven gear, a motor, a pinion and a gear box. The gear box is installed on the other side of the mounting box 2. The motor is arranged inside the gear box. The pinion is installed on the output end of the motor. The driven gear is meshed and installed on the side of the pinion. The rotating rod is installed on the side of the driven gear.

[0011] Preferably, the connection between the rotating rod and the gear box is rotatably connected via a bearing.

[0012] Preferably, the cell container fixing mechanism comprises a mounting hole, an ear plate, a screw, a cell container and a sealing cover, the cell container is mounted on the upper end of the mounting plate, the ear plate is mounted on the side of the cell container, the ear plate and the mounting plate are fixedly connected by screws, a mounting hole corresponding to the screw is opened on the upper end of the mounting plate, and a sealing cover is mounted on the upper end of the cell container.

[0013] Preferably, a handle is installed on the upper end of the sealing cover, and a sealing gasket is fixedly provided on the lower end of the sealing cover.

[0014] Compared with the prior art, the beneficial effects of the utility model are:

[0015] 1. The utility model is provided with an oscillating mechanism, which can drive a cam to rotate through a driving component, and the rotation of the cam drives the lifting plate to move up and down, and the lifting plate drives the cell container on the upper end of the mounting plate to vibrate, so as to ensure the effective oscillation of the stem cells.

[0016] 2. The utility model is provided with a cell container fixing mechanism, which can facilitate installation and fixation of the cell container, and convenient disassembly of the cell container for cleaning. The sealing cover can be conveniently opened by providing a handle. BRIEF DESCRIPTION OF THE DRAWINGS

[0017] Figure 1 It is a three-dimensional diagram of the utility model;

[0018] Figure 2 It is a three-dimensional cutaway view of the oscillating mechanism of the utility model;

[0019] Figure 3 It is a three-dimensional diagram of the cell container fixing mechanism of the utility model.

[0020] In the figure: 1. bottom plate; 2. installation box one; 3. installation plate; 4. cell container fixing mechanism; 41. installation hole; 42. ear plate; 43. screw; 44. cell container; 45. sealing cover; 46. handle; 5. installation box two; 6. oscillation mechanism; 61. lifting plate; 62. center rod; 63. slide groove; 64. slide rod; 65. slider; 66. spring; 67. cam; 68. drive assembly; 681. rotating rod; 682. driven gear; 683. motor; 684. pinion; 685. gear box; 7. control panel. DETAILED DESCRIPTION

[0021] The following will be combined with the drawings in the embodiments of the utility model to clearly and completely describe the technical solutions in the embodiments of the utility model. Obviously, the described embodiments are only part of the embodiments of the utility model, not all of the embodiments. Based on the embodiments in the utility model, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the utility model.

[0022] Example 1

[0023] See also Figure 1-3 The utility model provides the following technical solutions: an oscillator for stem cell expansion, comprising a base plate 1, a mounting box 1 2 is mounted on one side of the upper end of the base plate 1, a mounting box 2 5 is mounted on the other side of the upper end of the base plate 1, a control panel 7 is mounted on one side of the mounting box 2 5, an oscillation mechanism 6 is mounted on the other side of the mounting box 2 5, a mounting plate 3 is arranged between the mounting box 2 5 and the mounting box 1 2, and a cell container fixing mechanism 4 is mounted on the upper end of the mounting plate 3.

[0024] Specifically, the oscillation mechanism 6 includes a lifting plate 61, a center rod 62, a spring 66, a cam 67 and a driving assembly 68. The driving assembly 68 is installed on the other side of the installation box 2 5. The cam 67 is installed on the side of the driving assembly 68. The lifting plate 61 is placed on the upper end of the cam 67. The center rod 62 is installed through the inside of the lifting plate 61. The surface of the center rod 62 is located at the lower end of the lifting plate 61 and is sleeved with a spring 66.

[0025] By adopting the above technical solution, by opening the driving component 68, the driving component 68 drives the cam 67 to rotate, and the rotation of the cam 67 drives the lifting plate 61 to rise and fall. When the lifting plate 61 rises and falls, it will drive the spring 66 on the surface of the center rod 62 to stretch. In order to ensure that the lifting plate 61 can drive the spring 66 to stretch, it is necessary to weld the spring 66 at the position between the installation box 2 5 and the lifting plate 61 accordingly. The reciprocating lifting of the lifting plate 61 can drive the installation plate 3 to vibrate up and down, thereby driving the stem cells inside the cell container 44 to oscillate.

[0026] Specifically, the oscillation mechanism 6 further includes a slide groove 63 and a slider 65. The other side of the mounting plate 3 is located inside the mounting box 1 2 and a slider 65 is provided. The mounting box 1 2 is provided with a slide groove 63 corresponding to the slider 65.

[0027] By adopting the above technical solution, when the mounting plate 3 vibrates up and down, the slider 65 is driven to slide inside the slide groove 63, thereby improving the stability of the mounting plate 3 during the lifting process.

[0028] Specifically, a slide bar 64 is provided inside the slide block 65 and is slidably connected to the slide bar 64 through a through hole.

[0029] By adopting the above technical solution, the stability of the installation plate 3 during the lifting process can be further improved.

[0030] Specifically, the driving assembly 68 includes a rotating rod 681, a driven gear 682, a motor 683, a pinion 684 and a gear box 685. The gear box 685 is installed on the other side of the mounting box 685. The motor 683 is arranged inside the gear box 685. The output end of the motor 683 is installed with a pinion 684. The side of the pinion 684 is meshed with the driven gear 682. The side of the driven gear 682 is installed with the rotating rod 681.

[0031] By adopting the above technical solution, the motor 683 is turned on, and the motor 683 drives the pinion 684 to rotate through the output end. The rotation of the pinion 684 drives the driven gear 682 to rotate. The rotation of the driven gear 682 drives the rotating rod 681 to rotate. The rotation of the rotating rod 681 drives the cam 67 to rotate.

[0032] Specifically, the connection between the rotating rod 681 and the gear box 685 is rotatably connected via a bearing.

[0033] By adopting the above technical solution, the problem of gear meshing misalignment between the pinion 684 and the driven gear 682 can be avoided.

[0034] When the present embodiment is in use, the motor 683 is turned on, and the motor 683 drives the pinion 684 to rotate through the output end, and the rotation of the pinion 684 drives the driven gear 682 to rotate, and the rotation of the driven gear 682 drives the rotating rod 681 to rotate, and the rotation of the rotating rod 681 drives the cam 67 to rotate, and the rotation of the cam 67 drives the lifting plate 61 to rise and fall. When the lifting plate 61 is lifted and lowered, the spring 66 on the surface of the center rod 62 will be stretched. In order to ensure that the lifting plate 61 can drive the spring 66 to stretch, it is necessary to weld the spring 66 between the installation box 2 5 and the lifting plate 61 accordingly. The lifting plate 61 can be lifted and lowered reciprocatingly to drive the installation plate 3 to vibrate up and down, thereby driving the stem cells inside the cell container 44 to oscillate. When the installation plate 3 vibrates up and down, it will drive the slider 65 to slide inside the slide groove 63, and at the same time, the slider 65 slides on the surface of the slide rod 64, thereby improving the stability of the lifting process of the installation plate 3.

[0035] Example 2

[0036] The present embodiment is different from the embodiment 1 in that: the cell container fixing mechanism 4 comprises a mounting hole 41, an ear plate 42, a screw 43, a cell container 44 and a sealing cover 45; the cell container 44 is mounted on the upper end of the mounting plate 3; the ear plate 42 is mounted on the side of the cell container 44; the ear plate 42 is fixedly connected to the mounting plate 3 by screws 43; the upper end of the mounting plate 3 is provided with a mounting hole 41 corresponding to the screw 43; the upper end of the cell container 44 is mounted with a sealing cover 45;

[0037] By adopting the above technical solution, the ear plate 42 on the side of the cell container 44 is fixed to the mounting plate 3 by screws 43, so that the cell container 44 can be easily cleaned. The stem cells are placed in the cell container 44 and then tightly closed by the sealing cover 45, so that the subsequent oscillation of the stem cells can be facilitated.

[0038] Specifically, a handle 46 is installed at the upper end of the sealing cover 45, and a sealing gasket is fixedly installed at the lower end of the sealing cover 45.

[0039] By adopting the above technical solution, the provision of the handle 46 can facilitate opening of the sealing cover 45 , and the provision of the sealing gasket can improve the sealing performance of the cell container 44 after the sealing cover 45 is tightly closed.

[0040] When the present embodiment is in use, the ear plate 42 on the side of the cell container 44 is fixed to the mounting plate 3 by means of screws 43, so as to facilitate the cleaning of the cell container 44. The stem cells are placed in the cell container 44 and then tightly closed by means of the sealing cover 45, so as to facilitate the subsequent oscillation of the stem cells. The setting of the handle 46 can facilitate the opening of the sealing cover 45, and the setting of the sealing gasket can improve the sealing performance of the cell container 44 after the sealing cover 45 is tightly closed.

[0041] The working principle and use process of the utility model: when the utility model is in use, the motor 683 is turned on, the motor 683 drives the pinion 684 to rotate through the output end, the pinion 684 rotates to drive the driven gear 682 to rotate, the driven gear 682 rotates to drive the rotating rod 681 to rotate, the rotating rod 681 rotates to drive the cam 67 to rotate, the cam 67 rotates to drive the lifting plate 61 to rise and fall, and the lifting plate 61 will drive the spring 66 on the surface of the center rod 62 to stretch when it is lifted and lowered. In order to ensure that the lifting plate 61 can drive the spring 66 to stretch, it is necessary to weld the spring 66 to the position between the installation box 2 5 and the lifting plate 61 accordingly. The lifting plate 61 can be lifted and lowered reciprocatingly to drive the installation plate 3 to vibrate up and down. The mounting plate 3 moves, thereby driving the stem cells inside the cell container 44 to oscillate. When the mounting plate 3 vibrates up and down, the slider 65 is driven to slide inside the slide groove 63. At the same time, the slider 65 slides on the surface of the slide rod 64, thereby improving the stability of the mounting plate 3 during the lifting and lowering process. The ear plate 42 on the side of the cell container 44 is fixed to the mounting plate 3 by the screw 43, so as to facilitate the cleaning of the cell container 44. The stem cells are placed in the cell container 44 and then tightly closed by the sealing cover 45, which can facilitate the subsequent oscillation of the stem cells. The setting of the handle 46 can facilitate the opening of the sealing cover 45, and the setting of the sealing gasket can improve the sealing of the cell container 44 after the sealing cover 45 is tightly closed.

[0042] Although embodiments of the present invention have been shown and described, it will be appreciated by those skilled in the art that various changes, modifications, substitutions and variations may be made to the embodiments without departing from the principles and spirit of the present invention, and that the scope of the present invention is defined by the appended claims and their equivalents.

Claims

1. An oscillator for stem cell expansion, comprising a base plate, characterized in that: An installation box 1 is installed on one side of the upper end of the base plate, an installation box 2 is installed on the other side of the upper end of the base plate, a control panel is installed on one side of the installation box 2, an oscillation mechanism is installed on the other side of the installation box 2, a mounting plate is arranged between the installation box 2 and the installation box 1, and a cell container fixing mechanism is installed on the upper end of the mounting plate.

2. An oscillator for stem cell proliferation according to claim 1, characterized in that: The oscillation mechanism includes a lifting plate, a center rod, a spring, a cam and a driving assembly. The driving assembly is installed on the other side of the mounting box 2, and a cam is installed on the side of the driving assembly. The lifting plate is placed on the upper end of the cam. The center rod is installed through the inside of the lifting plate, and the surface of the center rod is located at the lower end of the lifting plate and is sleeved with a spring.

3. An oscillator for stem cell proliferation according to claim 2, characterized in that: The oscillation mechanism further comprises a slide groove and a slider. The other side of the mounting plate is provided with a slider inside the mounting box 1, and a slide rod is installed through the inside of the slider.

4. The oscillator for stem cell proliferation according to claim 3, characterized in that: A sliding rod is provided inside the sliding block and is slidably connected with the sliding block through the through hole.

5. The oscillator for stem cell proliferation according to claim 2, characterized in that: The driving assembly includes a rotating rod, a driven gear, a motor, a pinion and a gear box. The gear box is installed on the other side of the mounting box 2. The motor is arranged inside the gear box. The pinion is installed on the output end of the motor. The driven gear is meshed and installed on the side of the pinion. The rotating rod is installed on the side of the driven gear.

6. The oscillator for stem cell proliferation according to claim 5, characterized in that: The connection between the rotating rod and the gear box is rotatably connected via a bearing.

7. The oscillator for stem cell proliferation according to claim 1, characterized in that: The cell container fixing mechanism comprises a mounting hole, an ear plate, a screw, a cell container and a sealing cover. The cell container is mounted on the upper end of the mounting plate, the ear plate is mounted on the side of the cell container, the ear plate and the mounting plate are fixedly connected by screws, a mounting hole corresponding to the screw is opened on the upper end of the mounting plate, and a sealing cover is mounted on the upper end of the cell container.

8. The oscillator for stem cell proliferation according to claim 7, characterized in that: A handle is installed on the upper end of the sealing cover, and a sealing gasket is fixedly arranged on the lower end of the sealing cover.

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