Fixing device for perfusion of animal in-vitro tissue blood vessel cavity

Abstract

The utility model relates to a fixing device for perfusion of animal in-vitro tissue blood vessel cavities, which comprises a first sleeve, threads are arranged at one end of the outer wall of the first sleeve, a second sleeve is sleeved at the other end of the outer wall of the first sleeve, and a third sleeve is in threaded connection with the threaded end of the first sleeve. The end, close to the third sleeve, of the second sleeve is attached to the end face of the third sleeve, the second sleeve is formed by splicing a fixing ring, a deformation ring and a connecting ring, the deformation ring is used for connecting the fixing ring and the connecting ring, the connecting ring is located at the end close to the third sleeve, and the deformation ring is formed by weaving metal wires. The deformation ring is formed by weaving metal wires and has certain ductility, under the condition that the fixing ring is fixed, the connecting ring is pushed by the second sleeve to extrude the deformation ring, the deformation ring begins to deform, the more extrusion is, the larger the deformation quantity is, and therefore the inner portion of the blood vessel is positioned, the device is prevented from being separated from the inner portion of the blood vessel during perfusion, and the perfusion efficiency is improved. And the deformation quantity is controllable, so that the device can adapt to blood vessels with various sizes.

Description

Technical Field

[0001] The utility model relates to the technical field of medical instruments, in particular to a fixing device for perfusing animal ex vivo tissue blood vessel cavities. Background Art

[0002] At present, a large number of animal experiments are required in medical experiments. In the study of intravenous drugs, it is necessary to understand the distribution and structure of blood vessels in order to set up drugs that meet the efficacy in a targeted manner. In the study of three-dimensional animal tissues, it is necessary to perfuse the blood vessels to visualize them. In biological experiments or some medical experiments, it is necessary to dissect animal corpses or some animals' isolated organs. During the dissection, in order to achieve certain experimental goals, it is necessary to perfuse liquids into the natural cavities of the animal's three-dimensional organs, such as the intestines, esophagus, bile ducts or blood vessels. It is even required that the liquid perfused in the organ cavity or blood vessel needs to maintain a certain pressure. Usually, when we need to perfuse liquids during experiments or dissections, we use a silicone tube to insert into the blood vessel or cavity, and tie the rear end of the tube with a cable tie or wire. The previous method of inserting silicone tubes into blood vessels or cavities has several disadvantages.

[0003] 1. There is tissue fluid in the tissue cavity or blood vessel. When the silicone tube is inserted, it is very slippery. When the liquid is poured in, especially when there is a certain pressure, there will be a reverse thrust. Timely tying will also cause the silicone tube to withdraw from the cavity or blood vessel.

[0004] 2. Since the cavities and blood vessels in the organ tissue are usually buried in fat or membrane, they cannot be directly tied. Usually, the cavities or blood vessels need to be peeled off from various tissue membranes and fat before they can be tied. Peeling off cavities and blood vessels requires a lot of time and experience. Once the blood vessels or cavities are damaged during peeling, the entire organ will be unusable.

[0005] 3. Use some plastic pagoda heads to insert into blood vessels. The diameter of the pagoda heads needs to be larger than the diameter of the blood vessels or cavities. It is very difficult to insert due to tissue fluid. If the diameter is smaller than the blood vessels or cavities, it will also be pulled out due to slipperiness. Utility Model Content

[0006] The utility model aims to provide a fixing device for perfusing the vascular cavity of animal ex vivo tissue, so as to solve the problems existing in the above-mentioned prior art.

[0007] The above technical objectives of the utility model are achieved through the following technical solutions:

[0008] A fixing device for perfusing animal ex vivo tissue vascular cavities comprises a first sleeve, wherein one end of the outer wall of the first sleeve is provided with a thread, and the other end of the outer wall of the first sleeve is sleeved with a second sleeve, a third sleeve is screwed on the threaded end of the first sleeve, and the end of the second sleeve close to the third sleeve is in contact with the end face of the third sleeve, the second sleeve is composed of a fixing ring, a deformation ring and a connecting ring, the deformation ring is used to connect the fixing ring and the connecting ring, the connecting ring is located at the end close to the third sleeve, the deformation ring is formed by braiding metal wire, the outer wall of the first sleeve is provided with anti-slip grooves for fixing the fixing ring, and the end of the third sleeve that is not in contact with the end face of the second sleeve is provided with a protrusion.

[0009] By adopting the above technical solution, the deformation ring has a certain ductility because it is woven from metal wires. When the fixed ring is stationary, the connecting ring is pushed by the second sleeve to squeeze the deformation ring, and the deformation ring begins to deform, and the local outer diameter becomes larger. The more it is squeezed, the greater the deformation, thereby positioning the inside of the blood vessel to prevent the device from detaching from the blood vessel during perfusion. Moreover, because the deformation is controllable, it can adapt to blood vessels of various sizes and will not fall off due to loose external binding.

[0010] In a further embodiment, a push ring is provided between the connecting ring and the third sleeve, and the push ring is slidably sleeved on the first sleeve.

[0011] In a further embodiment, a first reinforcement ring and a second reinforcement ring are arranged on the deformation ring at equal intervals.

[0012] In a further embodiment, an end of the fixing ring away from the deformation ring is provided with an acute-angled blunt shape.

[0013] In a further embodiment, the inner wall of the first sleeve is provided with an anti-crystallization coating.

[0014] In a further embodiment, both ends of the protrusion are provided with an acute-angled blunt shape.

[0015] In summary, the utility model has the following beneficial effects:

[0016] 1. The deformation ring is woven from metal wires and has a certain degree of ductility. When the fixed ring does not move, the connecting ring is pushed by the second sleeve to squeeze the deformation ring, and the deformation ring begins to deform, and the local outer diameter becomes larger. The more it is squeezed, the greater the deformation, thereby positioning the inside of the blood vessel to prevent the device from detaching from the blood vessel during perfusion. Because the deformation is controllable, it can adapt to blood vessels of various sizes and will not fall off due to loose external binding. BRIEF DESCRIPTION OF THE DRAWINGS

[0017] Figure 1 It is a schematic diagram of the overall structure of the utility model;

[0018] Figure 2 It is a structural schematic diagram of the utility model in use state.

[0019] In the figure, 1, first sleeve; 2, second sleeve; 21, fixing ring; 22, deformation ring; 23, connecting ring; 3, third sleeve. DETAILED DESCRIPTION

[0020] The utility model is further described in detail below in conjunction with the accompanying drawings.

[0021] The same parts are denoted by the same reference numerals. It should be noted that the words "front", "rear", "left", "right", "upper" and "lower" used in the following description refer to the attached Figure 1 In the description of this specification, the words "bottom" and "top", "inside" and "outside" refer to directions toward or away from a particular component geometry, respectively. In addition, the terms "first" and "second" are used for descriptive purposes only and should not be understood as indicating or implying relative importance or implicitly indicating the number of technical features indicated. Therefore, features defined as "first" and "second" may explicitly or implicitly include one or more of the features. In the description of this specification, the meaning of "multiple" is two or more, unless otherwise clearly and specifically defined.

[0022] Embodiment 1:

[0023] like Figure 1-2As shown, a fixing device for perfusion of animal ex vivo tissue vascular cavity comprises a first sleeve 1, one end of the outer wall of the first sleeve 1 is provided with a thread, the other end of the outer wall of the first sleeve 1 is sleeved with a second sleeve 2, a third sleeve 3 is screwed on the threaded end of the first sleeve 1, one end of the second sleeve 2 close to the third sleeve 3 is fitted with the end surface of the third sleeve 3, the second sleeve 2 is composed of a fixing ring 21, a deformation ring 22 and a connecting ring 23, and the deformation ring 22 is used to connect the fixing ring 21 and the connecting ring 23 The connecting ring 23 is located at one end close to the third sleeve 3, the deformation ring is woven by metal wire, the outer wall of the first sleeve 1 is provided with anti-slip grooves for fixing the fixing ring 21, the end of the third sleeve 3 that is not in contact with the end surface of the second sleeve 2 is provided with a protrusion, a push ring is provided between the connecting ring and the third sleeve 3, the push ring is slidably sleeved on the first sleeve 1, and the first reinforcement ring and the second reinforcement ring are equidistantly provided on the deformation ring 22. The deformation ring is woven by metal wire, so it has a certain extension. The invention has the advantages of ductility, when the fixing ring is stationary, the connecting ring is pushed and squeezed by the second sleeve to squeeze the deformation ring, the deformation ring begins to deform, the local outer diameter becomes larger, the more it is squeezed, the larger the deformation amount is, thereby positioning the inside of the blood vessel, and preventing the device from detaching from the inside of the blood vessel during perfusion. Because the deformation amount is controllable, it can adapt to blood vessels of various sizes, and there will be no problem of falling off caused by loose external binding. The first reinforcement ring and the second reinforcement ring limit part of the deformation direction, so that the deformation ring in the device can only change in radial size, that is, under the action of the pushing ring and the third sleeve, the outer diameter of some areas of the deformation ring in the device will become larger or smaller, thereby adapting to the inner diameter of different blood vessels. The end of the fixing ring 21 away from the deformation ring 22 is provided with an acute-angled blunt shape to facilitate the insertion of the device. The inner wall of the first sleeve 1 is provided with an anti-crystallization coating to prevent the inner wall of the first sleeve from crystallizing and blocking the perfusion liquid. Both ends of the protrusion are provided with acute-angled blunt shapes.

[0024] Specific implementation process: When in use, insert one end of the fixing ring of the device into the blood vessel, and then screw the third sleeve. Due to the thread on the outer wall of the first sleeve, the third sleeve squeezes the deformation ring through the action of the pushing ring and the connecting ring, so that the outer diameter of the deformation ring becomes larger, the blood vessel is blocked, and the device is fixed inside the blood vessel. When the perfusion is completed, only the bolt needs to be screwed in the opposite direction, and the deformation ring will automatically return to its original shape under the action of the internal stress of the metal, thereby detaching from the blood vessel.

[0025] In the embodiments disclosed in the present invention, the terms "install", "connect", "connect", "fix" and the like should be understood in a broad sense. For example, "connect" can be a fixed connection, a detachable connection, or an integral connection; "connect" can be a direct connection or an indirect connection through an intermediate medium. For those skilled in the art, the specific meanings of the above terms in the embodiments disclosed in the present invention can be understood according to specific circumstances.

[0026] This specific embodiment is merely an explanation of the present invention and is not a limitation of the present invention. After reading this specification, those skilled in the art may make non-creative modifications to the present embodiment as needed, but such modifications are protected by patent law as long as they are within the scope of the claims of the present invention.

Claims

1. A fixation device for perfusion of animal ex vivo tissue vascular cavity, characterized in that: The invention comprises a first sleeve (1), wherein one end of the outer wall of the first sleeve (1) is provided with a thread, and the other end of the outer wall of the first sleeve (1) is sleeved with a second sleeve (2), and a third sleeve (3) is screwed on the threaded end of the first sleeve (1), and one end of the second sleeve (2) close to the third sleeve (3) is in contact with the end face of the third sleeve (3), and the second sleeve (2) is composed of a fixing ring (21), a deformation ring (22) and a connecting ring (23), and the deformation ring (22) is used to connect the fixing ring (21) and the connecting ring (23), and the connecting ring (23) is located at one end close to the third sleeve (3), and the deformation ring (22) is formed by braiding metal wires, and the outer wall of the first sleeve (1) is provided with anti-slip grooves for fixing the fixing ring (21), and the end of the third sleeve (3) not in contact with the end face of the second sleeve (2) is provided with a protrusion.

2. A fixation device for perfusion of animal ex vivo tissue vascular cavity according to claim 1, characterized in that: A push ring is provided between the connecting ring (23) and the third sleeve (3), and the push ring is slidably sleeved on the first sleeve (1).

3. A fixation device for perfusion of animal ex vivo tissue vascular cavity according to claim 1, characterized in that: The deformation ring (22) is provided with a first reinforcement ring and a second reinforcement ring at equal intervals.

4. The fixing device for perfusion of vascular cavity of isolated animal tissue according to claim 1, characterized in that: An end of the fixing ring (21) away from the deformation ring (22) is provided with an acute-angled blunt shape.

5. The fixing device for perfusion of animal ex vivo tissue vascular cavity according to claim 1, characterized in that: The inner wall of the first sleeve (1) is provided with an anti-crystallization coating.

6. The fixing device for perfusion of animal ex vivo tissue vascular cavity according to claim 1, characterized in that: Both ends of the protrusion are provided with an acute-angled blunt shape.

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