Body fluid collecting device

Abstract

The utility model belongs to the technical field of medical instruments, and provides a body fluid collecting device which comprises an outer pipe used for containing filtered body fluid, an inner pipe used for containing unfiltered body fluid and a filtering component used for filtering the body fluid in the inner pipe and guiding the body fluid into the outer pipe. The filtering part can filter out specific components (such as human nucleic acid and karyocyte) from the body fluid, so that a better analysis or detection effect is realized; after the inner pipe is connected with the base, the distance between the lower end of the inner pipe and the base is smaller than the thickness of the filtering component, so that the filtering component is pressed and limited on the base, the filtering component can be effectively fixed, and a filtering membrane is prevented from collapsing; after the inner tube and the base are detached, the filtering part is convenient to take out, taking of the collected body fluid sample is not affected, and the filtering part can be replaced or replaced with filtering parts with different pore diameters when damaged so as to filter out unwanted nucleic acid or cells.

Description

Technical Field

[0001] The utility model belongs to the technical field of medical equipment, and in particular relates to a body fluid collection device. Background Art

[0002] The body fluid collection device is used to store body fluids to be analyzed or tested, such as blood. Such body fluid collection devices may be vacuum body fluid collection devices, such as vacuum collection tubes, such as vacuum blood collection tubes. However, such body fluid collection devices are usually whole body fluid collection devices. Since only some components in the body fluid need to be analyzed or tested in some cases, the collected body fluid needs to be processed before testing or analysis, which will take extra time and require special processing equipment.

[0003] With the rapid development of high-throughput sequencing technology, detection projects based on free DNA in blood and detection projects of pathogens in blood have gradually been carried out, such as non-invasive prenatal free DNA screening, early cancer screening, pathogen nucleic acid detection, etc. The objects to be detected in these detection projects are: fetal free DNA (cffDNA) contained in the peripheral blood of pregnant women, free DNA (ctDNA) released by tumor cell apoptosis in the peripheral blood of tumor patients, which is different from normal cell DNA, and pathogen nucleic acid in the blood. The content of these free DNA and nucleic acids to be tested in the blood is extremely low, so removing interfering components will improve the detection sensitivity. Common NIPT and tumor NGS experiments use differential centrifugation to absorb supernatant plasma to remove white blood cells, but there are still a small number of white blood cells in body fluids that are invisible to the naked eye, which can easily lead to unintentional absorption of a few white blood cells due to operational errors. Common pathogen nucleic acid detection usually adds a step of using chemical reagents to remove the host before nucleic acid extraction, including differential lysis method and methylation method, but this method is time-consuming and easy to cause sample loss or introduce contamination. Among them, the most commonly used differential lysis method is easy to "accidentally injure" bacteria without cell walls, and the operation is cumbersome and time-consuming. In addition, because only a small number of hospitals are qualified for Next-Generation Sequencing (NGS), when the blood is sent for testing, some white blood cells will still undergo apoptosis due to normal metabolism during transportation and release human nucleic acids that become a source of interference.

[0004] Although there are body fluid collection devices with filtering functions on the market, for example, in the prior art (patent number CN202110621206.6), a vacuum blood collection tube is disclosed, including a tube body, a filter membrane and a tube cover sealed on the open end of the tube body, the filter membrane is covered with equidistant filter holes, and the tube body is a hollow structure with an opening on the top; the filter membrane is arranged in the inner cavity of the tube body and includes a top wall, a bottom wall and an annular wall between the top wall and the bottom wall forming a bag, the bottom wall is connected to the bottom of the tube body, the top wall is connected to the tube cover, and an annular groove is formed between the annular wall and the inner wall of the tube body. However, existing body fluid collection devices usually have problems such as slow body fluid circulation speed, inability to fix the filter membrane well, and easy collapse of the filter membrane. Utility Model Content

[0005] The purpose of the utility model is to overcome the deficiencies of the prior art and provide a body fluid collection device that can quickly filter out specific substances, so as to support a faster body fluid circulation speed, effectively fix the filter component, and prevent the filter component from collapsing.

[0006] The utility model is implemented as follows: a body fluid collection device, comprising:

[0007] an outer tube for containing filtered body fluids;

[0008] an inner tube for holding unfiltered body fluids;

[0009] A filter component, used for filtering the body fluid in the inner tube and then introducing it into the outer tube;

[0010] The base is used for being detachably connected to the inner tube. After the base is connected to the inner tube, the distance between the lower end of the inner tube and the base is smaller than the thickness of the filter component, so that the filter component is pressed and limited on the base.

[0011] Preferably, the inner tube and the outer tube are connected with each other in a damping sliding seal.

[0012] Preferably, the inner tube is entirely slidably disposed inside the outer tube or a portion of the inner tube is slidably disposed inside the outer tube.

[0013] Furthermore, the internal cavity of the inner tube includes an upper cavity and a lower cavity, the cross-sectional area of ​​the lower cavity is smaller than the cross-sectional area of ​​the upper cavity, and the wall thickness of the inner tube wall corresponding to the lower cavity is greater than the wall thickness of the inner tube wall corresponding to the upper cavity.

[0014] Furthermore, the internal cavity of the inner tube also includes a transition cavity located between the upper end cavity and the lower end cavity, the upper end of the transition cavity is transitionally connected to the upper end cavity, and the lower end of the transition cavity is transitionally connected to the lower end cavity.

[0015] Preferably, the inner tube wall surface of the transition cavity is an inclined surface or a curved surface.

[0016] Preferably, the wall surface of the inner cavity of the inner tube is coated with a siliconized layer.

[0017] Preferably, the filter component is a single-layer or multi-layer filter membrane, and the filter membrane is covered with filter ports.

[0018] Furthermore, the base comprises:

[0019] The supporting guide structure is used to support the filtering component and evenly guide the body fluid filtered by the filtering component into the outer tube.

[0020] Preferably, the supporting and guiding structure comprises a body, and at least one first liquid discharge port provided on the body and a plurality of second liquid discharge ports located at the periphery of the first liquid discharge port.

[0021] Preferably, the first liquid discharge port is located in the middle of the supporting and guiding structure, and the second liquid discharge port is arranged in a ring shape around the first liquid discharge port.

[0022] Preferably, the first liquid discharge port is a circular hole penetrating the supporting flow-guiding structure, and the second liquid discharge port is an elongated hole radially arranged along the supporting flow-guiding structure.

[0023] Preferably, the inner tube is provided with a first connection structure, and the base is provided with a second connection structure for cooperation and connection with the first connection structure.

[0024] Preferably, the first connection structure is an annular boss arranged along the outer surface of the inner tube, or a plurality of raised portions arranged in sequence and in an annular shape.

[0025] Preferably, the second connection structure is an annular recessed position arranged along the inner surface of the base, or a plurality of grooves arranged in sequence and spaced apart and arranged in an annular shape.

[0026] Furthermore, a sealing cap is connected to the top of the inner tube and / or the outer tube.

[0027] Preferably, when a portion of the inner tube is located inside the outer tube, the cap seals the inner surface of the inner tube;

[0028] When the upper end of the inner tube is located inside the outer tube and away from the upper end of the outer tube, the cap seals the inner surface of the outer tube;

[0029] When the upper end opening of the inner tube is located inside the outer tube and adjacent to the upper end opening of the outer tube, the cap seals the inner surfaces of the outer tube and the inner tube.

[0030] Preferably, the cap plug has an interference fit with the inner surface of the inner tube, or the cap plug has an interference fit with the inner surface of the inner tube and the inner surface of the outer tube.

[0031] Furthermore, the cap plug has a first plug body for sealing the inner tube, and a second plug body for sealing the outer tube.

[0032] The utility model belongs to the technical field of medical devices, and provides a body fluid collection device, comprising an outer tube for accommodating filtered body fluid, an inner tube for accommodating unfiltered body fluid, and a filter component for filtering the body fluid in the inner tube and then introducing it into the outer tube, the filter component can filter out specific components (such as human nucleic acid and nucleated cells) from the body fluid to achieve better analysis or detection effects; after the inner tube is connected to a base, since the distance between the lower end of the inner tube and the base is less than the thickness of the filter component, the filter component is pressed and limited on the base, the filter component can be effectively fixed to prevent the filter membrane from collapsing; after the inner tube is disassembled from the base, it is convenient to take out the filter component without affecting the use of the collected body fluid sample, and the filter component can be replaced when damaged, or a filter component with a different pore size can be replaced to filter out unnecessary nucleic acid or cells. BRIEF DESCRIPTION OF THE DRAWINGS

[0033] In order to more clearly illustrate the technical solution of the present utility model, the drawings required for use in the embodiments will be briefly introduced below. Obviously, the drawings described below are only some embodiments of the present utility model. For ordinary technicians in this field, other drawings can be obtained based on these drawings without paying creative work.

[0034] Figure 1 It is a schematic diagram of the structure of the body fluid collection device provided in an embodiment of the utility model.

[0035] Figure 2 It is a schematic diagram of the structure of the inner tube in the body fluid collection device provided in an embodiment of the utility model.

[0036] Figure 3 It is a cross-sectional schematic diagram of an inner tube in a body fluid collection device provided in an embodiment of the utility model.

[0037] Figure 4 It is a structural schematic diagram of a base in a body fluid collection device provided in an embodiment of the utility model.

[0038] Figure 5 It is a cross-sectional schematic diagram of a base and a supporting guide structure in a body fluid collection device provided in an embodiment of the utility model.

[0039] Figure 6 It is a cross-sectional schematic diagram of a base and a supporting guide structure in a body fluid collection device provided in an embodiment of the utility model.

[0040] Figure 7 It is a schematic structural diagram of a cap plug in a body fluid collection device provided in an embodiment of the utility model.

[0041] Figure 8 It is a cross-sectional schematic diagram of a cap plug in a body fluid collection device provided in an embodiment of the utility model.

[0042] The realization of the purpose, functional features and advantages of the utility model will be further explained in conjunction with embodiments and with reference to the accompanying drawings. DETAILED DESCRIPTION

[0043] In the present invention, the terms "upper", "lower", "left", "right", "front", "back", "top", "bottom", "inside", "outside", "middle", "vertical", "horizontal", "lateral", "longitudinal" and the like indicate positions or state relationships based on the positions or state relationships shown in the drawings. These terms are mainly used to better describe the present invention and its embodiments, and are not used to limit the indicated devices, elements or components to have a specific position, or to be constructed and operated in a specific position.

[0044] In addition, some of the above terms may be used to express other meanings in addition to indicating a position or state relationship. For example, the term "on" may also be used to express a certain dependency or connection relationship in some cases. For those skilled in the art, the specific meanings of these terms in this utility model can be understood according to specific circumstances.

[0045] In addition, the terms "installed", "set", "provided with", "connected", and "connected" should be understood in a broad sense. For example, it can be a fixed connection, a detachable connection, or an integral structure; it can be a mechanical connection, or an electrical connection; it can be a direct connection, or an indirect connection through an intermediate medium, or it can be an internal connection between two devices, elements, or components. For those of ordinary skill in the art, the specific meanings of the above terms in this utility model can be understood according to specific circumstances.

[0046] In addition, the terms "first", "second", etc. are mainly used to distinguish different devices, elements or components, which may be the same or different in specific types and configurations, and are not used to indicate or imply the relative importance and quantity of the indicated devices, elements or components. Unless otherwise specified, "plurality" means two or more.

[0047] The technical solutions in the embodiments of the present invention will be described clearly and completely below in conjunction with the accompanying drawings in the embodiments of the present invention.

[0048] Overview of Exemplary Body Fluid Collection Devices

[0049] like Figure 1As shown, a body fluid collection device provided by an embodiment of the utility model includes:

[0050] The outer tube 100 is used to contain the filtered body fluid;

[0051] An inner tube 200 for containing unfiltered body fluids;

[0052] The filter component 300 is used to filter the body fluid in the inner tube 200 and then introduce it into the outer tube 100;

[0053] The base 400 is used for detachably connecting with the inner tube 200. After the base 400 is connected with the inner tube 200, the distance between the lower end of the inner tube 200 and the base 400 is smaller than the thickness of the filter component 300, so that the filter component 300 is pressed and limited on the base 400.

[0054] The body fluid collection device provided by the present invention, wherein the filter component 300 can filter out specific components (such as human nucleic acid and nucleated cells) from the body fluid to achieve better analysis or detection effects; after the inner tube 200 is connected to the base 400, the inner tube 200 is used to press and limit the filter component 300 on the base 400, which can effectively fix the filter component 300 to prevent the filter membrane from collapsing; after the inner tube 200 and the base 400 are disassembled, it is convenient to remove the filter component 300 without affecting the use of the collected body fluid sample, and the filter component 300 can be replaced when damaged, or a filter component 300 with a different pore size can be replaced to filter out unnecessary nucleic acids or cells.

[0055] Furthermore, the outer tube 100 contains a functional fluid (not shown) for maintaining the temporarily stored liquid. The functional fluid is preferably a blood preservative fluid or an anticoagulant to extend the use time of the body fluid.

[0056] Overview of the inner tube as an example

[0057] like Figure 2 and Figure 3 As shown, preferably, the inner tube 200 and the outer tube 100 are connected by a damping sliding seal. With this structural design, a part of the inner tube 200 can be slid inside the outer tube 100, which can increase the body fluid capacity of the outer tube 100, or the inner tube 200 can be completely slid inside the outer tube 100, which can reduce the body fluid capacity in the outer tube 100. It can be suitable for occasions with different capacities, especially for emergency blood drawing occasions, and is easy to use. In addition, with this structural design, the inner tube 200 can support and protect the outer tube 100, increase the hardness resistance of the outer tube 100, and reduce the risk of damage.

[0058] Exemplarily, a portion of the inner tube 200 is slidably disposed inside the outer tube 100 , or the inner tube 200 is entirely slidably disposed inside the outer tube 100 . In this embodiment, the inner tube 200 is entirely slidably disposed inside the outer tube 100 .

[0059] Preferably, the internal cavity of the inner tube 200 includes an upper cavity 210 and a lower cavity 220, the cross-sectional area of ​​the lower cavity 220 is smaller than the cross-sectional area of ​​the upper cavity 210, and the wall thickness of the inner tube wall corresponding to the lower cavity 220 is greater than the wall thickness of the inner tube wall corresponding to the upper cavity 210. By adopting this design, the wall thickness of the lower end of the inner tube 200 can be increased, thereby supporting the outer tube 100 while ensuring sufficient hardness to press-fit and support the filter component 300, thereby extending the service life of the inner tube 200 and the outer tube 100.

[0060] Preferably, in one embodiment of the utility model, the internal cavity of the inner tube 200 further includes a transition cavity 230 located between the upper cavity 210 and the lower cavity 220, the upper end of the transition cavity 230 is transitionally connected to the upper cavity 210, and the lower end of the transition cavity 230 is transitionally connected to the lower cavity 220. The function of the transition cavity 230 is to prevent the accumulation of body fluids at the bottom edge of the inner tube 200. At the same time, due to the existence of the transition cavity 230, the inner tube wall corresponding to the upper cavity 210 and the inner tube wall corresponding to the lower cavity 220 directly have a physical extension transition, thereby improving the hardness resistance of the joint between the upper cavity 210 and the lower cavity 220. In this embodiment, the inner tube wall surface of the transition cavity 230 is preferably a slope or a curved surface.

[0061] Furthermore, the wall surface of the inner cavity of the inner tube 200 is coated with a siliconized layer (not shown), which can improve the hardness and wear resistance of the inner tube 200 and thus extend the service life of the inner tube 200.

[0062] Overview of the filter components as an example

[0063] like Figure 1 As shown, preferably, the filter component 300 is a single-layer filter membrane, and the filter membrane is covered with filter ports. The filter hole parameter specifications (e.g., shape, pore size, etc.) on the filter membrane are related to the specific substances to be filtered (e.g., human nucleic acid and nucleated cells), and different substances to be filtered can correspond to different filter membranes. In this embodiment, the filter port is preferably a circular hole, a polygonal hole, a conical hole or a step hole. The aperture of the circular hole is preferably 0.1mm to 0.5mm.

[0064] In another embodiment, the filter component 300 is a multi-layer filter membrane, and each layer of the filter membrane is covered with filter ports. With this structural design, multiple substances can be filtered at one time, and the filtering effect is better.

[0065] Overview of the base as an example

[0066] like Figures 4 to 6 As shown, further, the base 400 also includes:

[0067] The support and guide structure 410 is used to support the filter component 300 and evenly guide the body fluid filtered by the filter component 300 into the outer tube 100. The support and guide structure 410 can effectively support the filter component 300, thereby preventing the filter component 300 from being stretched and deformed due to the impact force formed by the flow of body fluids, and further preventing the filter port of the filter component 300 from deforming and expanding, thereby causing poor filtering effect of the filter port.

[0068] Furthermore, the supporting guide structure 410 includes a body 401 , and at least one first drainage port 411 disposed on the body 401 , and a plurality of second drainage ports 412 located at the periphery of the first drainage port 411 , and the first drainage port 411 and the second drainage port 412 are disposed corresponding to the filter component 300 .

[0069] Preferably, the first liquid discharge port 411 is located in the middle of the supporting guide structure 410 , and the second liquid discharge port 412 is arranged in a ring shape around the outer periphery of the first liquid discharge port 411 .

[0070] Preferably, the supporting flow guiding structure 410 is a columnar body, the first drainage port 411 is a circular hole 411 penetrating the supporting flow guiding structure 410 , and the second drainage port 412 is an elongated hole 412 radially arranged along the supporting flow guiding structure 410 .

[0071] In the present invention, the added support and guide structure 410 not only plays the role of supporting the filter membrane, but also plays the role of guiding the flow, so that the liquid can flow to the bottom end of the outer tube 100 more easily.

[0072] Preferably, the outer surface of the base 400 is in damping sliding cooperation with the inner surface of the outer tube 100, and the inner surface of the outer tube 100 is in sliding cooperation with or spaced apart from the outer surface of the inner tube 200. This design reduces the resistance between the outer tube 100 and the inner tube 200, and facilitates rapid adjustment of the position of the base 400 in the outer tube 100, thereby quickly adjusting the height between the tube opening of the inner tube 200 and the tube opening of the outer tube 100, and facilitates the cap 500 to seal the tube openings of the outer tube 100 and the inner tube 200 at the same time.

[0073] Preferably, the base 400 has a first through hole 410 and a second through hole 420 which are coaxially arranged from top to bottom, the inner diameter of the first through hole 420 is larger than the inner diameter of the second through hole 430, a support surface 450 is formed between the first through hole 410 and the second through hole 420, the filtering structure 300 is located in the first through hole, and the supporting flow guiding structure 410 is located at the connection between the first through hole 420 and the second through hole 430. In this embodiment, the second through hole 430 is connected to the first liquid discharge port 411 and is coaxially arranged. In this embodiment, the inner diameter of the first liquid discharge port 411 is smaller than the inner diameter of the first through hole 420 and larger than the inner diameter of the second through hole 430, and the first liquid discharge port 411 plays a role of guiding, so as to facilitate the rapid outflow of body fluids.

[0074] In this embodiment, an annular support platform 460 for placing the filter component 300 is provided on the support surface 450. The annular support platform 460 is located on the periphery of the support guide structure 410. This structural design facilitates the support guide structure 410 to quickly guide the body fluid filtered by the filter component 300.

[0075] Preferably, the supporting guide structure 410 and the base 400 are integrally formed, and the materials of the two are plastics, and they are integrally formed by mold injection, which is convenient for processing and reduces production costs.

[0076] like Figure 3 and Figure 5 As shown, further, the inner tube 200 is provided with a first connection structure 240 , and the base 400 is provided with a second connection structure 440 for connecting with the first connection structure 200 .

[0077] Preferably, the first connection structure 240 is an annular boss disposed along the outer surface of the inner tube 200 , or the first connection structure 240 is a plurality of raised portions that are disposed in sequence and spaced apart and arranged in an annular shape.

[0078] Preferably, the second connection structure 440 may be an annular recessed position arranged along the inner surface of the base 400, or the second connection structure 440 may be a plurality of grooves arranged in sequence and arranged in an annular manner and used to cooperate with the plurality of protrusions. In this embodiment, the first connection structure 240 is preferably made of an elastic material, which is easy to disassemble and install due to the elastic force of the elastic material.

[0079] In another embodiment, the first connection structure 240 and the second connection structure 440 are mutually attracted N-pole magnets and S-pole magnets, which can also realize quick disassembly and assembly between the inner tube 200 and the base 400, and are simple to operate and easy to install. The N-pole magnet and the S-pole magnet can also be used in conjunction with the annular boss and the annular recess to strengthen the connection.

[0080] Overview of the cap as an example

[0081] like Figure 7 and Figure 8 As shown, further, a sealing cap 500 is connected to the top of the inner tube 200 and / or the outer tube 100 .

[0082] Preferably, when a portion of the inner tube 200 is located inside the outer tube 100 , the cap plug 500 seals the inner surface of the inner tube 200 ;

[0083] When the upper end of the inner tube 200 is located inside the outer tube 100 and away from the upper end of the outer tube 100, the cap plug 500 seals the inner surface of the outer tube;

[0084] When the upper end of the inner tube 200 is located in the outer tube 100 and adjacent to the upper end of the outer tube 100 , the cap 500 seals the inner surfaces of the outer tube 100 and the inner tube 200 .

[0085] Preferably, the cap plug 500 has an interference fit with the inner surface of the inner tube 200, or the cap plug 500 has an interference fit with the inner surface of the inner tube 200 and the inner surface of the outer tube 100. After the cap plug 500 and the inner tube 200, and the cap plug 500 and the outer tube 100 are matched, the air-tightness requirement can be met. The tight fit size between the cap plug 500 and the inner tube 200 is larger than the tight fit size between the cap plug 500 and the outer tube 100, which facilitates the removal of the inner tube 200 from the outer tube 100 through the cap plug 500, thereby separately transporting the outer tube 100 and the body fluids in the outer tube 100.

[0086] Preferably, the cap plug 500 has a second plug body 520 for sealing the inner tube 200, and a first plug body 510 for sealing the outer tube 100; in this embodiment, the first plug body 510 and the second plug body 520 are preferably columnar plug bodies, and the use of a columnar plug body can rotate the cap plug 500 circumferentially, so that the cap plug 500 can discharge the gas between the outer tube 100 and the inner tube 200, and the sealing effect is good; the cap plug 500 is preferably made of elastic material, and the elastic material can be deformed to further enhance the sealing effect.

[0087] In another embodiment, the first plug body 510 and the second plug body 520 are conical bodies with a large upper end and a small lower end. With this structural design, as the cap plug 500 rotates to a greater depth inside the outer tube 100 and the inner tube 200, the sealing effect is correspondingly enhanced.

[0088] Furthermore, the cap plug 500 has a hand-held portion 530 located on the periphery of the first plug body 510 and the second plug body 520. The outer surface of the hand-held portion 530 is provided with an anti-slip area 540. The anti-slip area 540 facilitates manual operation of the cap plug 500. The outer surface of the hand-held portion 530 is sealed and fitted with the outer surface of the outer tube 100. This structural design further plays a role in sealing the outer tube 100.

[0089] In this embodiment, the anti-slip area 540 is composed of a plurality of convex strips that are sequentially spaced apart, which is simple to process and convenient for one-time molding, thus saving production time and improving production efficiency.

[0090] Furthermore, the top of the cap plug 500 has an upper avoidance opening 550 for reducing the thickness of the cap plug 500, and the bottom of the cap plug 500 also has a lower avoidance opening 560 for reducing the thickness of the cap plug 500. The upper avoidance opening 550 and the lower avoidance opening 560 are arranged correspondingly to further reduce the thickness of the cap plug 500, making it easier for the puncture needle to quickly puncture the cap plug 500, thereby improving the puncture speed of the puncture needle.

[0091] The cap plug 500 provided by the utility model is integrally formed by injection molding of a mold, is easy to produce, has good air tightness, and is easy to puncture.

[0092] The body fluid collection tube provided by the utility model is mainly composed of an outer tube 100, an inner tube 200, a filter component 300, a base 400 and a cap 500. The second plug body 520 inside the cap 500 is interference fit with the inner tube 200, and the first plug body 510 of the cap 500 is interference fit with the outer tube 100. The cap 500 is tightly connected with the inner tube 200 and the outer tube 100 by friction and has airtightness. There is a base 400 inside the outer tube 100, and the position of the base 400 moves up and down in the outer tube 100 according to the requirements of the supporting products (in this embodiment, the outer surface of the base 400 and the inner surface of the outer tube 100 are damped and slidably matched), and the height between the tube mouth of the inner tube 200 and the tube mouth of the outer tube 100 can be adjusted, so that the cap 500 can seal the outer tube 100 and the inner tube 200 at the same time. The supporting guide structure 410 arranged on the base plays a role in rapid liquid conduction.

[0093] After the body fluid is collected by the collection needle, the body fluid is pushed into the inner tube 200 through the puncture cap 500 (the surface of the cap is made of a material that is easy to penetrate), and the filter component 300 is placed on the base 400. The bottom of the inner tube 200 and the base 400 are interference-fitted to fix the filter component 300 between the two. The filter component 300 can filter out more than 95% of specific components such as nucleated cells within a few minutes (preferably 5 minutes in this embodiment), achieving the effect of removing human sources. For example: inflammatory substances, excess sugar, fat, etc. can be filtered out from the collected blood in a targeted manner. Finally, the liquid to be tested flows downward from the inner tube 200 through the filter component 300 into the outer tube 100. There is a functional fluid at the bottom of the outer tube 100 to maintain the quality of the filtered body fluid temporarily stored in the collection device. After the outer tube 100 in the body fluid collection device collects the body fluid, it can be transported directly or the inner tube can be taken out and the cap can be screwed on for transportation.

[0094] The above is a preferred embodiment of the present invention. It should be pointed out that a person skilled in the art can make several improvements and modifications without departing from the principle of the present invention. These improvements and modifications are also considered to be within the protection scope of the present invention.

Claims

1. A body fluid collection device, characterized in that: include: an outer tube for containing filtered body fluids; an inner tube for holding unfiltered body fluids; A filter component, used for filtering the body fluid in the inner tube and then introducing it into the outer tube; The base is used for being detachably connected to the inner tube. After the base is connected to the inner tube, the distance between the lower end of the inner tube and the base is smaller than the thickness of the filter component, so that the filter component is pressed and limited on the base.

2. The body fluid collection device according to claim 1, characterized in that: The inner tube and the outer tube are connected with each other in a damping sliding seal.

3. The body fluid collection device according to claim 2, characterized in that: The inner tube is entirely slidably disposed inside the outer tube or a portion of the inner tube is slidably disposed inside the outer tube.

4. The body fluid collection device according to claim 1, characterized in that: The internal cavity of the inner tube includes an upper cavity and a lower cavity, the cross-sectional area of ​​the lower cavity is smaller than the cross-sectional area of ​​the upper cavity, and the wall thickness of the inner tube wall corresponding to the lower cavity is greater than the wall thickness of the inner tube wall corresponding to the upper cavity.

5. The body fluid collection device according to claim 4, characterized in that: The internal cavity of the inner tube also includes a transition cavity located between the upper cavity and the lower cavity, the upper end of the transition cavity is transitionally connected to the upper cavity, and the lower end of the transition cavity is transitionally connected to the lower cavity.

6. The body fluid collection device according to claim 5, characterized in that: The inner tube wall surface of the transition cavity is an inclined surface or a curved surface.

7. The body fluid collection device according to claim 1, characterized in that: The tube wall surface of the inner cavity of the inner tube is coated with a siliconized layer.

8. The body fluid collection device according to claim 1, characterized in that: The base comprises: The supporting guide structure is used to support the filtering component and evenly guide the body fluid filtered by the filtering component into the outer tube.

9. The body fluid collection device according to claim 8, characterized in that: The supporting and guiding structure comprises a body, at least one first liquid discharge port arranged on the body, and a plurality of second liquid discharge ports located at the periphery of the first liquid discharge port.

10. The body fluid collection device according to claim 9, characterized in that: The first liquid discharge port is located in the middle of the supporting guide structure, and the second liquid discharge port is arranged in a ring around the first liquid discharge port.

11. The body fluid collection device according to claim 10, characterized in that: The first liquid discharge port is a circular hole penetrating the supporting flow-guiding structure, and the second liquid discharge port is a long strip hole arranged along the radial direction of the supporting flow-guiding structure.

12. The body fluid collection device according to claim 1, characterized in that: The inner tube is provided with a first connection structure, and the base is provided with a second connection structure for cooperation and connection with the first connection structure.

13. The body fluid collection device according to claim 12, characterized in that: The first connection structure is an annular boss arranged along the outer surface of the inner tube, or a plurality of raised portions arranged in sequence and in a ring shape; the second connection structure is an annular recessed position arranged along the inner surface of the base, or a plurality of grooves arranged in sequence and in a ring shape.

14. The body fluid collection device according to claim 1, characterized in that: The top of the inner tube and / or the outer tube is connected with a sealing cap; When a portion of the inner tube is located inside the outer tube, the cap seals the inner surface of the inner tube; When the upper end of the inner tube is located inside the outer tube and away from the upper end of the outer tube, the cap seals the inner surface of the outer tube; When the upper end opening of the inner tube is located inside the outer tube and adjacent to the upper end opening of the outer tube, the cap seals the inner surfaces of the outer tube and the inner tube.

15. The body fluid collection device according to claim 14, characterized in that: The cap plug is interference fit with the inner surface of the inner tube, or the cap plug is interference fit with the inner surface of the inner tube and the inner surface of the outer tube.

Images