Liquid chromatography infusion pump with cleaning function

Abstract

The utility model relates to a liquid chromatogram infusion pump with a cleaning function. The liquid chromatogram infusion pump comprises a driving assembly; the moving assembly is connected with the driving assembly, the moving assembly comprises a plunger, the driving assembly can drive the plunger to do reciprocating motion, and the plunger comprises a first plunger rod and a second plunger rod connected with the first plunger rod; the pump head comprises a pump head body, a first sealing cavity and a second sealing cavity, the first sealing cavity and the second sealing cavity are located in the pump head, the first sealing cavity is communicated with a working medium to be conveyed through a first one-way valve, the end of the first plug rod is located in the first sealing cavity, and the second sealing cavity is communicated with cleaning fluid to be used through a second one-way valve. The end of the second plug rod is located in the second sealing cavity, and when the first plug rod is in a retracting state, part of the first plug rod is located in the second sealing cavity. According to the liquid chromatography infusion pump with the cleaning function, the cost can be reduced, and the size is small.

Description

Technical Field

[0001] The utility model relates to the technical field of infusion pumps, in particular to a liquid chromatography infusion pump with a cleaning function. Background Art

[0002] At present, the liquid chromatography infusion pump is sealed by the sealing ring located in the pump head and the plunger. In order to ensure the sealing, the sealing ring is usually made of non-metallic material with low hardness. The plunger makes linear reciprocating motion in the working fluid cavity formed by the sealing ring and the pump head. The part of the plunger in the cavity will be in direct contact with the working fluid. Although the surface finish of the plunger is very high, there will still be uneven positions on the microscopic upper surface. Therefore, the working fluid will form a working fluid film on the surface of the plunger. During the reciprocating movement of the plunger, part of the plunger that has been in contact with the working fluid will pass through the sealing ring and move to the space on the other side of the sealing ring and contact with the air. Some working fluids will crystallize after contacting the air. After the crystals are precipitated, the reciprocating movement of the plunger will cause scratches on the sealing ring, thereby reducing the life of the sealing ring and causing working fluid leakage.

[0003] In order to clean the working fluid on the plunger that comes into contact with the air, the plunger is currently mainly cleaned through an external independent cleaning device. This method is costly, requires additional space for fixing, and occupies a large volume. Utility Model Content

[0004] Therefore, the technical problem to be solved by the utility model is to provide a liquid chromatography infusion pump with a cleaning function, which can reduce costs and has a small size.

[0005] To solve the above technical problems, the utility model provides a liquid chromatography infusion pump with a cleaning function, comprising: a driving component; a moving component connected to the driving component, the moving component comprising a plunger, the driving component can drive the plunger to move back and forth, the plunger comprising a first plug rod and a second plug rod connected to the first plug rod; a pump head, comprising a pump head body and a first sealed cavity and a second sealed cavity located in the pump head, the first sealed cavity is connected to the working fluid to be delivered through a first one-way valve, the end of the first plug rod is located in the first sealed cavity, the second sealed cavity is connected to the cleaning fluid to be used through a second one-way valve, the end of the second plug rod is located in the second sealed cavity, and when the first plug rod is in a retracted state, part of the first plug rod is located in the second sealed cavity.

[0006] In one embodiment of the utility model, it also includes a mounting seat, the mounting seat includes a first accommodating cavity, the driving assembly includes a rotating driving member connected to the mounting seat, the output end of the rotating driving member is connected to a rotating shaft, a cam is sleeved on the rotating shaft, the cam is against the moving assembly, and the cam is located in the first accommodating cavity.

[0007] In one embodiment of the utility model, a sensor is connected to the end of the rotating shaft, a detection member capable of detecting the sensor is provided on the mounting seat, and the detection member is connected to a controller.

[0008] In one embodiment of the utility model, the mounting seat also includes a second accommodating cavity, the moving assembly includes a sliding rod, an elastic member is sleeved on the sliding rod, the elastic member abuts against the side wall of the second accommodating cavity, one end of the sliding rod abuts against the cam, and the other end of the sliding rod is connected to the plunger.

[0009] In an embodiment of the present invention, one end of the sliding rod close to the cam is rotatably connected to a roller, and the cam abuts against the roller.

[0010] In an embodiment of the present utility model, the roller is rotatably connected to the connecting shaft, a sliding groove is provided on the side wall of the first accommodating cavity, and the end of the connecting shaft is located in the sliding groove.

[0011] In one embodiment of the utility model, one end of the elastic member abuts against a first baffle ring, and the other end of the elastic member abuts against a second baffle ring. The first baffle ring is connected to the side wall of the second accommodating chamber close to the pump head, and the second baffle ring is connected to the side wall of the sliding rod.

[0012] In one embodiment of the present invention, a clamping block is connected to one end of the second plug rod away from the first plug rod, and a clamping groove is provided at the end of the slide rod, and the clamping block abuts against the clamping groove.

[0013] In an embodiment of the present invention, a side of the clamping block abutting against a side wall of the clamping slot is arc-shaped.

[0014] In one embodiment of the utility model, a first seal is provided at one end of the first sealed cavity close to the second sealed cavity, and the first plug rod is slidably connected to the first seal; a second seal is provided at one end of the second sealed cavity away from the first sealed cavity, and the second plug rod is slidably connected to the second seal.

[0015] The above technical solution of the utility model has the following advantages compared with the prior art:

[0016] The utility model discloses a liquid chromatography infusion pump with a cleaning function, in which the first sealing chamber for conveying the working fluid and the second sealing chamber for cleaning the plunger are both arranged in the pump head, and the reciprocating movement of the plunger is driven by a driving assembly, so that the working fluid conveying and the plunger cleaning are carried out simultaneously, without the need for an external cleaning device, thereby reducing costs and having a smaller volume. The side where the block abuts against the side wall of the card slot is in an arc shape, so that the angle between the plunger and the slide rod can be adjusted, thereby enabling the plunger to better cooperate with the pump head; avoiding the misalignment of the slide rod and the plunger caused by installation problems, thereby avoiding the risk of leakage caused by poor sealing between the plunger and the pump head. BRIEF DESCRIPTION OF THE DRAWINGS

[0017] In order to make the content of the utility model more clearly understood, the utility model is further described in detail below based on specific embodiments of the utility model in combination with the accompanying drawings.

[0018] Figure 1 This is a schematic diagram of the structure of a liquid chromatography infusion pump with a cleaning function of the utility model;

[0019] Figure 2 yes Figure 1 A cross-sectional view of

[0020] Figure 3 yes Figure 1 A schematic diagram of the structure from another angle;

[0021] Figure 4 It is a schematic diagram of the drive component structure;

[0022] Figure 5 It is a schematic diagram of the mobile component structure;

[0023] Figure 6 It is a schematic diagram of the pump head structure.

[0024] Explanation of the reference numerals in the specification: 1. mounting seat; 2. driving assembly; 3. moving assembly; 4. pump head; 11. first accommodating chamber; 12. second accommodating chamber; 13. third accommodating chamber; 14. slide groove; 21. driven wheel; 22. sensing member; 23. detecting member; 24. cam; 25. rotating driving member; 26. rotating shaft; 31. first plug rod; 32. second plug rod; 33. block; 34. slide rod; 35. elastic member; 36. connecting shaft; 37. roller; 38. first retaining ring; 39. second retaining ring; 41. second inlet non-return valve; 42. second outlet non-return valve; 43. conduit; 44. first inlet non-return valve; 45. first outlet non-return valve; 46. fastening nut; 47. first sealing chamber; 48. second sealing chamber; 221. sensing connecting seat; 251. mounting plate; 471. first sealing member; 481. second sealing member. DETAILED DESCRIPTION

[0025] The present invention will be further described below in conjunction with the accompanying drawings and specific embodiments so that those skilled in the art can better understand the present invention and implement it, but the embodiments are not intended to limit the present invention.

[0026] Reference Figure 1 and Figure 2 As shown, a liquid chromatography infusion pump with a cleaning function of the utility model comprises: a driving component 2; a moving component 3, connected to the driving component 2, the moving component 3 comprises a plunger, the driving component 2 can drive the plunger to move back and forth, the plunger comprises a first plug rod 31 and a second plug rod 32 connected to the first plug rod 31; a pump head 4, comprising a pump head 4 body and a first sealed cavity 47 and a second sealed cavity 48 located in the pump head 4, the first sealed cavity 47 is connected to the working medium to be transported through a first one-way valve, the end of the first plug rod 31 is located in the first sealed cavity 47, the second sealed cavity 48 is connected to the cleaning fluid to be used through a second one-way valve, the end of the second plug rod 32 is located in the second sealed cavity 48, and when the first plug rod 31 is in a retracted state, part of the first plug rod 31 is located in the second sealed cavity 48.

[0027] The utility model provides a liquid chromatography infusion pump with a cleaning function. The driving component 2 drives the plunger to realize reciprocating movement in the pump head 4. The first plug rod 31 moves in the first sealed cavity 47 to realize the function of conveying the working medium. The second plug rod 32 moves in the second sealed cavity 48 so that the cleaning liquid can enter the second sealed cavity 48, thereby cleaning the part of the first plug rod 31 that can enter the second sealed cavity 48. The first sealed cavity 47 for conveying the working medium and the second sealed cavity 48 for cleaning the plunger are both arranged in the pump head 4, and the reciprocating movement of the plunger is driven by a driving component 2, so that the working medium conveying and the plunger cleaning are carried out simultaneously, without the need for an external cleaning device, thereby reducing the cost and having a small volume.

[0028] The mounting seat 1 is connected with the driving assembly 2, the moving assembly 3 and the pump head 4, wherein the driving assembly 2 and the pump head 4 are located on opposite sides of the mounting seat 1, and the moving assembly 3 is located between the driving assembly 2 and the pump head 4. The mounting seat 1 includes a first accommodating chamber 11, a second accommodating chamber 12 and a third accommodating chamber 13 which are sequentially arranged from the driving assembly 2 to the pump head 4, and the first accommodating chamber 11, the second accommodating chamber 12 and the third accommodating chamber 13 are cylindrical as a whole.

[0029] Reference Figure 3 and Figure 4As shown, the driving assembly 2 includes a rotating driving member 25, a rotating shaft 26 and a cam 24. The rotating driving member 25 is a motor and is connected to the outer side wall of the mounting seat 1 through a mounting plate 251. A driven wheel 21 is rotatably connected to the mounting seat 1 near the output end of the rotating driving member 25. The output end of the rotating driving member 25 is connected to a driving wheel. The driving wheel and the driven wheel 21 are sleeved with a synchronous belt outside, so that the rotating driving member 25 can drive the driven wheel 21 to rotate through the synchronous belt. The center position of the driven wheel 21 is connected to a rotating shaft 26, which is rotatably connected to the mounting seat 1 through a rolling bearing, and the rotating shaft 26 is arranged through the first accommodating chamber 11. A cam 24 is sleeved on the rotating shaft 26, and the cam 24 is located in the first accommodating chamber 11. The cam 24 is against the moving assembly 3, and the rotating driving member 25 can drive the cam 24 to rotate. Preferably, a sensor 22 is connected to one end of the rotating shaft 26 away from the driven wheel 21, and the sensor 22 is an optical coupler. The sensor 22 is rotationally connected to the mounting base 1 through a sensor connecting base 221. A detection member 23 capable of detecting the sensor 22 is provided on the mounting base 1 at a position close to the sensor 22. The detection member 23 is connected to the controller, and the detection member 23 is an optical coupler. After the rotating shaft 26 drives the sensor 22 to rotate, the detection member 23 can detect the rotation speed of the sensor 22, thereby detecting the rotation speed of the motor.

[0030] Reference Figure 5As shown, the moving assembly 3 includes a slide bar 34, an elastic member 35 and a plunger. The slide bar 34 is slidably connected to the mounting seat 1 through a sliding sleeve, and the slide bar 34 is arranged to penetrate the second accommodating chamber 12, and the two ends of the slide bar 34 can be located in the first accommodating chamber 11 and the third accommodating chamber 13. The end of the slide bar 34 close to the cam 24 is rotatably connected to a roller 37, and the cam 24 abuts against the roller 37. Preferably, the end of the slide bar 34 is connected to a connecting shaft 36, and the roller 37 is rotatably sleeved on the connecting shaft 36. A slide groove 14 matching the connecting shaft 36 is provided on the side wall of the first accommodating chamber 11, and the end of the connecting shaft 36 is located in the slide groove 14 and can slide in the slide groove 14. After the cam 24 rotates, the slide bar 34 is driven to move through the roller 37. The setting of the slide groove 14 can prevent the slide bar 34 from rotating in a circle, thereby preventing the plunger from rotating in a circle. The elastic member 35 is a spring, which is sleeved on the slide bar 34 and located in the second accommodating chamber 12, and the end of the elastic member 35 abuts against the side wall of the second accommodating chamber 12. Specifically, one end of the elastic member 35 abuts against the first baffle ring 38, and the other end of the elastic member 35 abuts against the second baffle ring 39. The first baffle ring 38 is connected to the side wall of the second accommodating chamber 12 close to the pump head 4, and the second baffle ring 39 is positioned and connected to the side wall of the slide bar 34 through a retaining spring. The elastic member 35 is in a compressed state when it is in the initial state, that is, when the plunger is in a retracted state, the elastic member 35 is in a compressed state, so that the roller 37 and the cam 24 are in abutment state. When the cam 24 rotates to make the slide bar 34 reciprocate along a straight line, the cam 24 can always be in abutment with the roller 37 through the setting of the elastic member 35, thereby avoiding mutual collision caused by the gap between the cam 24 and the roller 37 when the cam 24 rotates at a high speed, thereby avoiding abnormal noise when the liquid chromatography infusion pump with a cleaning function is working. The cam 24 is always in contact with the roller 37, which can also make the reciprocating movement of the slide rod 34 smoother, and can reciprocate according to the curve characteristics of the cam 24, thereby realizing the overall flow and pressure curve characteristics of the pump. The plunger is connected to the end of the slide rod 34 away from the cam 24, and can reciprocate with the slide rod 34. The plunger includes a first plunger rod 31 and a second plunger rod 32, the second plunger rod 32 is connected to the end of the first plunger rod 31, and the diameter of the second plunger rod 32 is larger than the diameter of the first plunger rod 31, and the second plunger rod 32 is connected to the end of the slide rod 34. Preferably, the first plunger rod 31 is made of sapphire, and the second plunger rod 32 is made of stainless steel. Preferably, a block 33 is connected to the end of the second plug rod 32 away from the first plug rod 31, and a groove matching the block 33 is provided at the end of the slide rod 34. The block 33 can abut against the groove, and the side of the block 33 abutting against the side wall of the groove is arc-shaped, that is, the side of the block 33 close to the cam 24 is arc-shaped, so that the angle between the plunger and the slide rod 34 can be adjusted, so that the plunger can better cooperate with the pump head 4; avoid the slide rod 34 and the plunger being out of axial alignment due to installation problems, thereby avoiding the risk of leakage caused by poor sealing between the plunger and the pump head 4.

[0031] Reference Figure 6 As shown, the pump head 4 includes a pump head 4 body and a first sealed cavity 47 and a second sealed cavity 48 located in the pump head 4. The pump head 4 is connected to the mounting seat 1 through a screw, and the screw is synchronously connected with a fastening nut 46, so that the pump head 4 is fixed to the mounting seat 1. The first sealed cavity 47 is a high-pressure cavity, and the first sealed cavity 47 is connected to the working fluid bottle through a first one-way valve. The first one-way valve includes a first inlet one-way valve 44 and a first outlet one-way valve 45. The first inlet one-way valve 44 is connected to the working fluid bottle with the working fluid to be transported, and the first outlet one-way valve 45 is connected to the outside. The end of the first plug rod 31 is located in the first sealed cavity 47 and reciprocates in the first sealed cavity 47. The first sealed cavity 47 and the second sealed cavity 48 are arranged adjacent to each other. When the first plug rod 31 is in a retracted state, part of the first plug rod 31 is located in the second sealed cavity 48. The first sealing chamber 47 is provided with a first sealing member 471 at one end close to the second sealing chamber 48, and the first plug rod 31 is slidably connected to the first sealing member 471, and the first sealing member 471 is a high-pressure sealing member. When the first sealing chamber 47 is at low pressure, the first inlet check valve 44 is opened, and the first outlet check valve 45 is closed; when the first sealing chamber 47 is at high pressure, the first inlet check valve 44 is closed, and the first outlet check valve 45 is opened. The second sealing chamber 48 is a low-pressure chamber, and the second sealing chamber 48 is connected to the cleaning liquid to be used through the second check valve, and the second check valve includes a second inlet check valve 41 and a second outlet check valve 42, and the second inlet check valve 41 is connected to the cleaning liquid to be used, and the second outlet check valve 42 is connected to the cleaning liquid bottle. The second sealing chamber 48 is provided with a second sealing member 481 at one end away from the first sealing chamber 47, and the second plug rod 32 is slidably connected to the second sealing member 481, and the second sealing member 481 is a low-pressure sealing member. When the second sealed cavity 48 is at low pressure, the second inlet check valve 41 is opened and the second outlet check valve 42 is closed; when the second sealed cavity 48 is at high pressure, the second inlet check valve 41 is closed and the second outlet check valve 42 is opened. The second accommodating cavity 12 and the second sealing member 481 can reduce the contact between the first plug rod 31 and the air, thereby reducing the contact between the working fluid and the air. The first sealing member 471 and the second sealing member 481 can both be the sealing ring.

[0032] Preferably, multiple groups of moving components 3 and pump heads 4 can be arranged on the mounting seat 1, and multiple cams 24 are correspondingly arranged on the rotating shaft 26, and adjacent cams 24 are arranged with an angle difference of 180 degrees. After the cams 24 rotate, adjacent plungers are caused to move back and forth alternately. Preferably, only one pump head 4 among the multiple pump heads 4 is connected with a second inlet check valve 41 and a second outlet check valve 42, and the outlet and inlet ends of the second sealing chamber 48 of the remaining pump heads 4 are connected with joints, and the joint at the inlet end of one pump head is connected to the joint at the outlet end of another pump head in sequence through a conduit 43, and the second outlet check valve 42 is connected to the inlet end joint of one of the pump heads 4 through the conduit 43, so that the cleaning liquid can flow through multiple pump heads 4 in sequence through a single pump head 4 to complete the cleaning of multiple plungers.

[0033] When in use, the rotary drive member 25 drives the rotary shaft 26 to rotate, thereby driving the cam 24 to rotate, and the cam 24 drives the slide bar 34 to reciprocate through the roller 37, thereby driving the plunger to reciprocate. When the first plug rod 31 retracts toward the driving assembly 2 under the action of the slide bar 34, the overall volume of the first sealed cavity 47 becomes larger, and a negative pressure is formed in the cavity. Under the action of the negative pressure, the first outlet check valve 45 is closed, and the first inlet check valve 44 is opened, so that the working medium to be transported in the working medium bottle enters the first sealed cavity 47 through the first inlet check valve 44. When the first plug rod 31 retracts to the limit position, the slide bar 34 drives the first plug rod 31 to move toward the first sealed cavity 47. At this time, the overall volume of the first sealed cavity 47 becomes smaller, and a positive pressure is formed in the cavity. The first inlet check valve 44 is closed, and the first outlet check valve 45 is opened, so that the working medium flows out from the first outlet check valve 45, and the working medium is transported. When the second plug rod 32 retracts toward the drive assembly 2 under the action of the sliding rod 34, the overall volume of the second sealed chamber 48 becomes larger, and a negative pressure is formed in the chamber. Under the action of the negative pressure, the second outlet one-way valve 42 is closed, and the second inlet one-way valve 41 is opened, so that the cleaning liquid to be used enters the second sealed chamber 48 through the second inlet one-way valve 41, thereby cleaning the first plug rod 31 and the end of the first sealing member 471 located in the second sealed chamber 48. When the second plug rod 32 retracts to the extreme position, the sliding rod 34 drives the second plug rod 32 to move toward the second sealed chamber 48. At this time, the overall volume of the second sealed chamber 48 becomes smaller, and a positive pressure is formed in the chamber. The second outlet one-way valve 42 is opened, and the second inlet one-way valve 41 is closed, so that the cleaning liquid flows out from the second outlet one-way valve 42 to the next pump head 4 or the washing liquid bottle.

[0034] The utility model is a liquid chromatography infusion pump with a cleaning function. The first sealing chamber 47 for fluid delivery and the second sealing chamber 48 for cleaning the plunger are both arranged in the pump head 4, and the plunger is driven to and fro by a driving assembly 2, so that the fluid delivery and the plunger cleaning are carried out simultaneously, without the need for an external cleaning device, thereby reducing costs and having a smaller volume. The side of the block 33 that abuts against the side wall of the slot is arc-shaped, so that the angle between the plunger and the slide rod 34 can be adjusted, so that the plunger can better cooperate with the pump head 4; avoid the slide rod 34 and the plunger being out of axial alignment due to installation problems, thereby avoiding the risk of leakage caused by poor sealing between the plunger and the pump head 4.

[0035] Obviously, the above embodiments are merely examples for the purpose of clear explanation and are not intended to limit the implementation methods. For those skilled in the art, other different forms of changes or modifications can be made based on the above description. It is not necessary and impossible to list all the implementation methods here. The obvious changes or modifications derived from these are still within the scope of protection of the invention of the utility model.

Claims

1. A liquid chromatography infusion pump with a cleaning function, characterized in that: include: Drive components; A moving assembly connected to the driving assembly, the moving assembly comprising a plunger, the driving assembly being capable of driving the plunger to reciprocate, the plunger comprising a first plunger rod and a second plunger rod connected to the first plunger rod; A pump head comprises a pump head body and a first sealed cavity and a second sealed cavity located in the pump head, wherein the first sealed cavity is connected to the working fluid to be transported through a first one-way valve, the end of the first plug rod is located in the first sealed cavity, the second sealed cavity is connected to the cleaning fluid to be used through a second one-way valve, the end of the second plug rod is located in the second sealed cavity, and when the first plug rod is in a retracted state, part of the first plug rod is located in the second sealed cavity.

2. The liquid chromatography infusion pump with cleaning function according to claim 1, characterized in that: It also includes a mounting seat, which includes a first accommodating cavity. The driving assembly includes a rotating driving member connected to the mounting seat. The output end of the rotating driving member is connected to a rotating shaft. A cam is sleeved on the rotating shaft. The cam is against the moving assembly, and the cam is located in the first accommodating cavity.

3. The liquid chromatography infusion pump with cleaning function according to claim 2, characterized in that: The end of the rotating shaft is connected with a sensor, the mounting seat is provided with a detection member capable of detecting the sensor, and the detection member is connected with a controller.

4. The liquid chromatography infusion pump with cleaning function according to claim 2, characterized in that: The mounting seat also includes a second accommodating cavity, and the moving assembly includes a sliding rod, on which an elastic member is sleeved, the elastic member abuts against the side wall of the second accommodating cavity, one end of the sliding rod abuts against the cam, and the other end of the sliding rod is connected to the plunger.

5. The liquid chromatography infusion pump with cleaning function according to claim 4, characterized in that: One end of the slide bar close to the cam is rotatably connected to a roller, and the cam abuts against the roller.

6. The liquid chromatography infusion pump with cleaning function according to claim 5, characterized in that: The roller is rotatably connected to the connecting shaft, a sliding groove is provided on the side wall of the first accommodating cavity, and the end of the connecting shaft is located in the sliding groove.

7. The liquid chromatography infusion pump with cleaning function according to claim 4, characterized in that: One end of the elastic member abuts against the first baffle ring, and the other end of the elastic member abuts against the second baffle ring. The first baffle ring is connected to the side wall of the second accommodating cavity close to the pump head, and the second baffle ring is connected to the side wall of the sliding rod.

8. The liquid chromatography infusion pump with cleaning function according to claim 4, characterized in that: One end of the second plug rod away from the first plug rod is connected with a clamping block, and the end of the slide rod is provided with a clamping groove, and the clamping block abuts against the clamping groove.

9. The liquid chromatography infusion pump with cleaning function according to claim 8, characterized in that: The side of the clamping block abutting against the side wall of the clamping slot is arc-shaped.

10. The liquid chromatography infusion pump with cleaning function according to claim 1, characterized in that: A first seal is provided at one end of the first sealed cavity close to the second sealed cavity, and the first plug rod is slidably connected to the first seal. A second seal is provided at one end of the second sealed cavity away from the first sealed cavity, and the second plug rod is slidably connected to the second seal.

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