Sulbactam stirring, filtering and crystallizing device

Abstract

The utility model relates to a sulbactam stirring, filtering and crystallizing device which comprises a crystallizing kettle body, a first filter, a return pipeline, a cooler, a lifting pump and a second filter, and is technically characterized in that the starting end of the return pipeline is communicated with the side of a bottom discharge port of the crystallizing kettle body, and a first control valve is arranged at the starting end; the tail end of the return pipeline is communicated with the side of the upper part of the crystallization kettle body and is provided with a second control valve, the return pipeline is provided with a cleaning liquid inlet pipeline at the outlet side of the first control valve, the starting end of the cleaning liquid inlet pipeline is communicated with the water tank, and the tail end of the cleaning liquid inlet pipeline is provided with a third control valve; and the return pipeline is provided with a cleaning liquid outlet pipeline at the inlet side of the second control valve, the tail end of the cleaning liquid outlet pipeline is inserted into the water tank, and the starting end of the cleaning liquid outlet pipeline is provided with a fourth control valve. The device is convenient for timely cleaning pipelines through which materials flow in the backflow process, the cooler and the inner wall of the filter, the backflow resistance is reduced, and meanwhile, the materials are prevented from being polluted.

Description

Technical Field

[0001] The utility model relates to the technical field of sulbactam production equipment, in particular to a sulbactam stirring, filtering and crystallizing device. Background Art

[0002] Sulbactam, also known as sulbactam sodium, is a Western medicine name. It is an enzyme inhibitor and is generally used in combination with penicillins or cephalosporins to treat urinary tract infections, lung infections, bronchial infections, ENT infections, abdominal and pelvic infections, biliary tract infections, sepsis, skin and soft tissue infections, etc. caused by sensitive bacteria.

[0003] In the later stage of producing sulbactam sodium, it is necessary to absorb and filter impurities, and then introduce the filtrate into the crystallizer, slowly add the dissolving agent while lowering the temperature to form a crystal slurry, and finally discharge the crystal slurry to a separation device. CN 215822391 U discloses a dissolving crystallization device for sulbactam production, which includes a crystallization kettle body with a cooling interlayer, a straight-through pipe fixed at the center of the top surface of the crystallization kettle body, the straight-through pipe is connected and fixed to a flexible filter cartridge with a bottom seal, the flexible filter cartridge has uniformly distributed filtering pores, and the bottom discharge port of the crystallization kettle body is connected to an external cooling pipe, the external cooling pipe is connected to the inlet of the cooler, the outlet pipe of the cooler is connected to the inlet pipe of the circulation pump, the outlet pipe of the circulation pump is connected to two branch pipes, each branch pipe is respectively provided with a valve body and a secondary filter, the end of the branch pipe is commonly connected to the inlet of the distribution pipe, the outlet of the distribution pipe is connected to two reflux pipes, and the ends of the two reflux pipes are connected to two reflux ports opened on the upper part of the crystallization kettle body. The device is used to solve the problem that the existing crystallizer products contain impurities and have poor cooling effects, and significantly improve product quality and crystallization efficiency. However, the following problems still exist when using it: since the material cooled to a certain temperature is easy to adhere to the inner wall of the pipe, cooler and filter during the reflux process, on the one hand, the reflux resistance is increased, and on the other hand, the adhesive layer is not easy to clean. Utility Model Content

[0004] The purpose of the utility model is to provide a sulbactam stirring filtration crystallization device with a reasonable structure and reliable use to solve the above problems, so as to facilitate timely cleaning of the pipeline, cooler and filter inner wall through which the material flows during the reflux process, reduce the reflux resistance, and avoid contamination of the material.

[0005] The technical solution of the utility model is:

[0006] A sulbactam stirring and filtering crystallization device comprises a crystallization kettle body, a first filter arranged at a feed inlet on the top surface of the crystallization kettle body, a reflux pipeline connected between the bottom and the upper part of the crystallization kettle body, a cooler arranged on the reflux pipeline from bottom to top, a lifting pump, and a second filter. The technical key points are: the starting end of the reflux pipeline is communicated with the side of the bottom discharge port of the crystallization kettle body and a first control valve is arranged at the starting end, the end of the reflux pipeline is communicated with the upper side of the crystallization kettle body and a second control valve is arranged at the end, the reflux pipeline is provided with a cleaning liquid inlet pipeline at the outlet side of the first control valve, the starting end of the cleaning liquid inlet pipeline is communicated with a water pool, the end of the cleaning liquid inlet pipeline is provided with a third control valve, the reflux pipeline is provided with a cleaning liquid outlet pipeline at the inlet side of the second control valve, the end of the cleaning liquid outlet pipeline is inserted into the water pool, and the starting end of the cleaning liquid outlet pipeline is provided with a fourth control valve.

[0007] In the above-mentioned sulbactam stirring filtration crystallization device, a filter screen is provided in the middle of the water pool, the starting end of the cleaning liquid inlet pipeline is higher than the filter screen in the vertical direction, and the end of the cleaning liquid outlet pipeline is lower than the filter screen in the vertical direction.

[0008] The above-mentioned sulbactam stirring filtration crystallization device has a water supply pipeline disposed above the water pool.

[0009] In the above-mentioned sulbactam stirring filtration crystallization device, a concentration sensor is provided on the cleaning liquid outlet pipeline.

[0010] The beneficial effects of the utility model are:

[0011] 1. The device utilizes the first filter and the second filter to filter the feed, and utilizes the reflux pipeline, the lifting pump, etc. to realize the liquid stirring function, and is equipped with a cooler to improve the crystallization efficiency.

[0012] 2. This device can use a lifting pump to introduce the cleaning liquid into the reflux pipeline from bottom to top, and flow through the cooler, lifting pump and the second filter to clean the inner walls of the reflux pipeline, cooler, lifting pump and the second filter. After cleaning at the same time as set, it avoids the material from sticking to the inner wall of the above equipment, avoids increasing the reflux resistance, and avoids contamination of subsequent materials.

[0013] 3. The cleaning fluid is recycled through the filter to save water resources. BRIEF DESCRIPTION OF THE DRAWINGS

[0014] Figure 1 It is a structural schematic diagram of the utility model.

[0015] In the figure: 1. crystallization kettle, 2. first filter, 3. solvent addition port, 4. second control valve, 5. fourth control valve, 6. concentration sensor, 7. cleaning liquid outlet pipeline, 8. second filter, 9. reflux pipeline, 10. lifting pump, 11. cooler, 12. first control valve, 13. third control valve, 14. cleaning liquid inlet pipeline, 15. water tank, 16. water supply pipeline, 17. filter screen. DETAILED DESCRIPTION

[0016] The utility model is described in detail according to the accompanying drawings of the specification.

[0017] like Figure 1 As shown, the sulbactam stirring and filtering crystallization device comprises a crystallization kettle body 1, a first filter 2 arranged at the feed inlet on the top surface of the crystallization kettle body 1, a reflux pipeline 9 connected between the bottom and the top of the crystallization kettle body 1, a cooler 11 arranged on the reflux pipeline 9 from bottom to top, a lifting pump 10, and a second filter 8. A solvent addition port 3 is also provided on the top of the crystallization kettle body 1.

[0018] The starting end of the reflux pipeline 9 is connected to the side of the bottom discharge port of the crystallization kettle body 1 and is provided with a first control valve 12 at the starting end. The end of the reflux pipeline 9 is connected to the upper side of the crystallization kettle body 1 and is provided with a second control valve 4 at the end. The reflux pipeline 9 is provided with a cleaning liquid inlet pipeline 14 at the outlet side of the first control valve 12. The starting end of the cleaning liquid inlet pipeline 14 is connected to a water pool 15. The end of the cleaning liquid inlet pipeline 14 is provided with a third control valve 13. The reflux pipeline 9 is provided with a cleaning liquid outlet pipeline 7 at the inlet side of the second control valve 4. The end of the cleaning liquid outlet pipeline 7 is inserted into the water pool 15. The starting end of the cleaning liquid outlet pipeline 7 is provided with a fourth control valve 5.

[0019] In this embodiment, a filter screen 17 is provided in the middle of the water pool 15, the starting end of the cleaning liquid inlet pipeline 14 is higher than the filter screen 17 in the vertical direction, and the end of the cleaning liquid outlet pipeline 7 is lower than the filter screen 17 in the vertical direction. A water replenishment pipeline 16 is also provided above the water pool 15. A concentration sensor 6 is provided on the cleaning liquid outlet pipeline 7.

[0020] Working principle:

[0021] When in use, the filtrate at 20℃-30℃ after carbon adsorption and filtration is introduced into the crystallization kettle body 1 through the first filter 2 at the feed inlet, and impurities such as carbon residue are filtered out by the first filter 2; the cooling liquid is pre-introduced into the cooling interlayer of the crystallization kettle body 1 to cool the crystallization kettle body 1, and the filtrate falling in is first cooled by the cooling interlayer of the crystallization kettle body 1; the lifting pump 10 and the cooler 11 are started, and the filtrate is led out of the crystallization kettle body 1 through the first control valve 12, and after being cooled again by the cooler 11, it is refluxed to the crystallization kettle body 1 through the second filter 8 and the second control valve 4.

[0022] When it is necessary to clean the reflux pipeline 9 and the equipment thereon, close the first control valve 12 and the second control valve 4, open the third control valve 13 and the fourth control valve 5, start the lifting pump 10, and introduce the cleaning liquid from the pool 15 into the reflux pipeline 9 from bottom to top, and flow through the cooler 11, the lifting pump 10 and the second filter 8, so as to clean the inner walls of the reflux pipeline 9, the cooler 11, the lifting pump 10 and the second filter 8, and use the concentration sensor 6 to monitor the concentration of the cleaning liquid in real time. When the detection value of the concentration sensor 6 drops to the preset value and maintains the set time, the lifting pump 10 is shut down, the third control valve 13 and the fourth control valve 5 are closed, the first control valve 12 and the second control valve 4 are opened, and the crystallization operation can continue.

[0023] The above is a detailed description of the embodiments of the utility model, but the above contents are only preferred embodiments of the utility model and cannot be considered to limit the scope of implementation of the utility model. All equivalent changes and improvements made within the scope of the invention of the utility model should still fall within the scope of this patent.

Claims

1. A sulbactam stirring and filtering crystallization device, comprising a crystallization kettle, a first filter arranged at the inlet on the top surface of the crystallization kettle, a reflux pipeline connected between the bottom and the upper part of the crystallization kettle, a cooler arranged on the reflux pipeline from bottom to top, a lifting pump, and a second filter, characterized in that: The starting end of the reflux pipeline is connected to the side of the bottom discharge port of the crystallization kettle body and a first control valve is provided at the starting end. The end of the reflux pipeline is connected to the upper side of the crystallization kettle body and a second control valve is provided at the end. The reflux pipeline is provided with a cleaning liquid inlet pipeline at the outlet side of the first control valve. The starting end of the cleaning liquid inlet pipeline is connected to the water pool, and the end of the cleaning liquid inlet pipeline is provided with a third control valve. The reflux pipeline is provided with a cleaning liquid outlet pipeline at the inlet side of the second control valve. The end of the cleaning liquid outlet pipeline is inserted into the water pool, and the starting end of the cleaning liquid outlet pipeline is provided with a fourth control valve.

2. The sulbactam stirring filtration crystallization device according to claim 1, characterized in that: A filter screen is arranged in the middle of the water pool, the starting end of the cleaning liquid inlet pipeline is higher than the filter screen in the vertical direction, and the end of the cleaning liquid outlet pipeline is lower than the filter screen in the vertical direction.

3. The sulbactam stirring filtration crystallization device according to claim 1, characterized in that: A water supply pipeline is additionally arranged above the water pool.

4. The sulbactam stirring filtration crystallization device according to claim 1, characterized in that: A concentration sensor is arranged on the cleaning liquid outlet pipeline.

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