Dynamic split charging system

Abstract

The utility model relates to the technical field of biological product filling, in particular to a dynamic subpackaging system which comprises a storage stirring component, a peristaltic pump, a filling structure and a connecting hose. The storage stirring part is used as a storage end of the dynamic split charging system; the stirrer is used for storing and stirring liquid; one end of the peristaltic pump is connected with the storage stirring component through a connecting hose, and the other end is connected with the filling structure; the peristaltic pump is used for conveying the liquid in the storing and stirring component into the filling structure; the filling structure serves as the output end of the dynamic split charging system and is used for filling liquid into a final container. According to the utility model, the liquid to be filled is in a flowing state through the storage stirring part, and a uniform mixing effect is achieved, so that the uniformly mixed liquid is filled in a dynamic state, and the problem of split charging of vaccine products containing adjuvants and biological products easy to layer and precipitate is solved; and the uniformity of products is effectively ensured, so that the quality of the products is ensured.

Description

Technical Field

[0001] The utility model relates to the technical field of biological product filling, in particular to a dynamic filling system. Background Art

[0002] During the production process, vaccine products containing adjuvants, biological products that are prone to stratification and precipitation, and products that are prone to precipitate crystals when stationary, etc., these unstable liquid products have precipitation and stratification problems after preparation. Filling at this time will seriously affect the uniformity and quality of the product. Traditional stirring methods may destroy protein activity, and precipitation and stratification problems will still occur after stopping stirring.

[0003] Therefore, a new dynamic filling system is needed to keep the filled product in flow and prevent the product from sedimentation and stratification. Utility Model Content

[0004] The purpose of the utility model is to provide a dynamic filling system, which makes the filled product in a circulating flow, achieves a mixing effect, effectively improves the quality of the product, and thus solves the technical problems in the background technology.

[0005] In order to achieve the above-mentioned object, the utility model provides the following technical solution: a dynamic filling system, comprising: a storage stirring component, a peristaltic pump, a filling structure and a connecting hose;

[0006] The storage and stirring component serves as the storage end of the dynamic dispensing system and is used to store and stir the liquid;

[0007] The peristaltic pump is connected to the storage stirring component through one end of the connecting hose, and is connected to the filling structure at the other end; the peristaltic pump transfers the liquid in the storage stirring component to the filling structure;

[0008] The filling structure serves as an output end of the dynamic filling system and is used to fill the liquid into the final container.

[0009] Furthermore, the filling structure includes: a filling bag, a liquid dispenser, a filling pump and a filling needle;

[0010] The upper end of the filling bag is connected to the peristaltic pump through a connecting hose; the lower end of the filling bag is connected to the liquid dispenser through a connecting hose; the filling bag is used to temporarily store the liquid to be filled;

[0011] The liquid dispenser is provided with an input end and two output ends; the input end of the liquid dispenser is connected to the lower end of the filling bag; the first output end of the liquid dispenser is connected to the filling pump, and the second output end is connected to the storage stirring component;

[0012] One end of the filling pump is connected to the liquid dispenser, and the other end is connected to the filling needle;

[0013] The filling needle serves as the outflow end of the liquid and is used to fill the liquid into the final container.

[0014] Furthermore, it also includes a weighing monitoring component; the weighing monitoring component includes a bracket and a weighing device; the filling bag is fixed on the bracket, the bracket is arranged on the weighing device, and the weighing device is used to weigh the weight of the liquid in the filling bag.

[0015] Furthermore, the storage and stirring component includes a 3D bag and a stirring device;

[0016] The 3D bag is used as a storage structure for liquid; the 3D bag is connected to a peristaltic pump via a connecting hose;

[0017] The 3D bag is provided with a stirring device, which is used to keep the liquid in motion and prevent the liquid from settling and stratifying.

[0018] Furthermore, the stirring device is a magnetic stirrer; the magnetic stirrer includes a base and a magnetic stirrer; the 3D bag is arranged on the base, and the magnetic stirrer is placed in the liquid in the 3D bag; the magnetic stirrer is pushed to rotate in the liquid through the base to make the liquid evenly mixed.

[0019] Furthermore, it also includes a sterile filtering component; the sterile filtering component is a sterilizing grade filter; the sterilizing grade filter is installed after the peristaltic pump and between the filling bag to filter the liquid.

[0020] Beneficial Effects

[0021] The utility model makes the liquid to be filled flow by storing and stirring components, and achieves a mixing effect, so that the evenly mixed liquid is filled in a dynamic state, thereby solving the problem of packaging of adjuvant vaccine products and biological products that are easy to be layered and precipitated; it effectively ensures the uniformity of the product, thereby ensuring the product quality. BRIEF DESCRIPTION OF THE DRAWINGS

[0022] In order to more clearly illustrate the embodiments of the present application or the technical solutions in the prior art, the drawings required for use in the embodiments will be briefly introduced below. Obviously, the drawings described below are only some embodiments recorded in the present utility model. For ordinary technicians in this field, other drawings can also be obtained based on these drawings.

[0023] Figure 1 It is a schematic diagram of the overall structure of the dynamic packaging system disclosed in the utility model;

[0024] Figure 2 It is a partial structural schematic diagram of the dynamic packaging system disclosed in the utility model;

[0025] Figure 3 It is a structural schematic diagram of the filling structure of the dynamic filling system disclosed in the utility model;

[0026] Figure 4 The utility model discloses a structural schematic diagram of a storage and stirring component of a dynamic filling system.

[0027] In the figure:

[0028] 1. Storage stirring component, 2. Peristaltic pump, 3. Filling structure, 4. Filling bag, 5. Dispenser, 6. Filling pump, 7. Filling needle, 8. Bracket, 9. Weighing device, 10. 3D bag, 11. Base, 12. Magnetic stirring bar. DETAILED DESCRIPTION

[0029] The following will be combined with the drawings in the embodiments of the utility model to clearly and completely describe the technical solutions in the embodiments of the utility model. Obviously, the described embodiments are only part of the embodiments of the utility model, not all of the embodiments. Based on the embodiments in the utility model, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the utility model.

[0030] In order to achieve the above-mentioned purpose, the utility model provides the following technical solutions: Figure 1-4 As shown, a dynamic filling system comprises: a storage stirring component 1, a peristaltic pump 2, a filling structure 3 and a connecting hose; the storage stirring component 1, the peristaltic pump 2 and the filling structure 3 are all fixedly installed on a workbench;

[0031] The storage and stirring component 1 is used as the storage end of the dynamic dispensing system and is used to store and stir the liquid;

[0032] The peristaltic pump 2 is connected to the storage stirring component 1 through one end of the connecting hose, and is connected to the filling structure 3 through the other end; the peristaltic pump 2 transfers the liquid in the storage stirring component 1 to the filling structure 3; the peristaltic pump 2 is an existing structure, and a rotor is arranged inside the peristaltic pump 2, and the connecting hose is squeezed by the rotation of the rotor to make the liquid flow in the connecting hose; the advantage of selecting the peristaltic pump 2 is that the peristaltic pump 2 itself does not contact the liquid to be transferred, thereby preventing contamination of the liquid; the specific structure of the peristaltic pump 2 is a prior art and will not be repeated in this application;

[0033] The filling structure 3 serves as the output end of the dynamic filling system and is used to fill the semi-finished liquid into the final container.

[0034] The utility model makes the liquid to be filled flow by storing the stirring component 1, and controls the force to be moderate, so as to achieve a mixing effect without destroying the activity of the protein, so that the liquid is filled in a dynamic state and the uniformity of the product is ensured.

[0035] Further, such as Figure 1-3 As shown, the filling structure 3 includes: a filling bag 4, a liquid dispenser 5, a filling pump 6 and a filling needle 7;

[0036] The upper end of the filling bag 4 is connected to the peristaltic pump 2 through a connecting hose; the lower end thereof is connected to the liquid dispenser 5 through a connecting hose; the filling bag 4 is used to temporarily store the liquid to be filled;

[0037] The dispenser 5 is provided with an input end and two output ends; the input end of the dispenser 5 is connected to the lower end of the filling bag 4; the first output end of the dispenser 5 is connected to the filling pump 6, and it should be noted that the first output end has multiple shunt pipes that can be connected to multiple filling pumps 6; the number of shunt pipes and filling pumps 6 is determined according to production conditions; the second output end is connected to the storage stirring component 1; when the filling work is in progress, the dispenser 5 distributes the liquid to different filling pumps 6; when the filling is stopped, the peristaltic pump 2 will continue to work and add liquid to the filling bag 4, and the excess liquid in the filling bag 4 will be squeezed into the dispenser 5; the excess liquid in the dispenser 5 flows back to the 3D stirring bag 10 from the second output end through the connecting hose, forming a closed loop, ensuring that the liquid is in a state of motion during the entire filling process.

[0038] One end of the filling pump 6 is connected to the liquid dispenser 5, and the other end is connected to the filling needle 7; the filling pump 6 can be a piston pump or a plunger pump; the filling pump 6 can control the filling amount of the liquid to ensure the filling accuracy;

[0039] The filling needle 7 is a slender needle tube structure made of stainless steel; the filling needle 7 serves as the outflow end of the liquid; and is used to accurately fill the liquid from the filling pump 6 into the final container.

[0040] Further, such as Figure 1-2 As shown, it also includes a weighing monitoring component; the weighing monitoring component includes a bracket 8 and a weighing device 9; the filling bag 4 is fixed on the bracket 8, and the bracket 8 is arranged on the weighing device 9, and the weighing device 9 is used to measure and control the weight of the liquid in the filling bag 4; the weighing device 9 adjusts the pump speed of the peristaltic pump 2 through feedback to maintain the stability of the weight of the liquid in the filling bag 4.

[0041] Further, such as Figure 4 As shown, the storage stirring component 1 includes a 3D bag 10 and a stirring device;

[0042] The 3D bag 10 used in this embodiment is a 3D sterile liquid storage bag, which is a sterile liquid storage container manufactured using 3D technology, and is particularly suitable for scenarios where the purity and sterility of the liquid need to be maintained. The 3D bag 10 is cylindrical or cubic in shape to accommodate different space and capacity requirements; the 3D bag 10 is connected to the peristaltic pump 2 through a connecting hose, and a stirring device is provided in the 3D bag 10, which is used to keep the liquid in motion to prevent liquid precipitation and stratification.

[0043] Furthermore, the stirring device is a magnetic stirrer; the magnetic stirrer includes a base 11 and a magnetic stirrer 12; the 3D bag 10 is arranged on the base 11, and the magnetic stirrer 12 is placed in the 3D bag 10; the magnetic stirrer is an instrument for liquid mixing, mainly used for stirring low-viscosity liquids or solid-liquid mixtures. Its basic principle is to use the principle of like charges repelling and opposite charges attracting in the magnetic field, and use the magnetic field to drive the magnetic stirrer 12 placed in the container to perform a circular movement, thereby achieving the purpose of stirring the liquid and ensuring that the liquid is evenly mixed to meet the use requirements.

[0044] Furthermore, it also includes a sterile filtering component; the sterile filtering component is a sterilizing grade filter; the sterilizing grade filter is installed after the peristaltic pump 2 and between the filling bag 4, and is used to filter the liquid to improve the sterility of the product.

[0045] Working principle:

[0046] The system uses a stirring device in the 3D bag 10 to keep the liquid in a dynamic state, prevent precipitation and stratification, and avoid destroying the activity of the protein. The peristaltic pump 2 is used as a power source to push the liquid out of the 3D bag 10, pass through the filling bag 4, and then pass through the dispenser 5 and the filling pump 6, and finally fill it into the final container through the filling needle 7. The weight of the liquid in the filling bag 4 is monitored in real time by a weighing device 9 with a bracket 8, and the pump speed of the peristaltic pump 2 is adjusted according to the weight feedback to ensure the filling accuracy and uniform distribution of the liquid. After filling or when filling is stopped, the excess liquid flows back to the 3D stirring bag 10 from the second output end of the dispenser 5 through the connecting hose, forming a closed loop to ensure the continuity and stability of the entire filling process.

[0047] The usage process is as follows:

[0048] First, the liquid product to be packaged is loaded into the 3D stirring bag 10. The magnetic stirring device is turned on to keep the liquid in a dynamic state; the peristaltic pump 2 is started, and the liquid flows from the bottom of the 3D stirring bag 10 into the peristaltic pump 2 through the connecting hose, and then is transported to the filling bag 4. The filling bag 4 is suspended on a weighing device 9 with a bracket 8 to receive the liquid from the peristaltic pump 2; the target liquid weight is set on the weighing device 9, which should be equal to or slightly higher than the sum of the filling volume and the reflux volume. According to the feedback from the weighing device 9, the pump speed of the peristaltic pump 2 is adjusted to keep the weight of the liquid in the filling bag 4 stable. The liquid flows from the filling bag 4 into the dispenser 5, and the liquid is distributed to the filling pump 6 through the dispenser 5, and the filling pump 6 is connected to the filling needle 7; the filling volume of the liquid is controlled by the filling pump 6 to ensure that the amount of liquid in each final container is accurate and consistent.

[0049] When filling is stopped, the peristaltic pump 2 continues to work, and the excess liquid in the dispenser 5 flows back into the 3D stirring bag 10 through the connecting hose, forming a closed-loop system; during the entire filling process, the magnetic stirring device in the 3D stirring bag 10 continues to work to ensure that the liquid remains in motion.

[0050] The embodiments of the present invention are provided for the purpose of illustration and description, and are not intended to be exhaustive or to limit the present invention to the disclosed forms. Many modifications and variations will be apparent to those of ordinary skill in the art. The embodiments are selected and described to better illustrate the principles and practical applications of the present invention, and to enable those of ordinary skill in the art to understand the present invention and thereby design various embodiments with various modifications suitable for specific uses.

Claims

1. A dynamic packaging system, characterized in that: include: storing a stirring component (1), a peristaltic pump (2), a filling structure (3) and a connecting hose; The storage and stirring component (1) serves as a storage end of the dynamic packaging system; Used to store and stir liquids; The peristaltic pump (2) is connected to the storage stirring component (1) through one end of a connecting hose, and is connected to the filling structure (3) at the other end; the peristaltic pump (2) transfers the liquid in the storage stirring component (1) to the filling structure (3); The filling structure (3) serves as the output end of the dynamic filling system; The storage stirring component (1) comprises a 3D bag (10) and a stirring device; The 3D bag (10) serves as a liquid storage structure; the 3D bag (10) is connected to the peristaltic pump (2) via a connecting hose; The 3D bag (10) is provided with a stirring device; The stirring device is a magnetic stirrer; the magnetic stirrer comprises a base (11) and a magnetic stirrer (12); the 3D bag (10) is arranged on the base (11), and the magnetic stirrer (12) is placed in the liquid in the 3D bag (10); the magnetic stirrer is driven by the base (11) to rotate in the liquid, so that the liquid is evenly mixed.

2. The dynamic packaging system according to claim 1, characterized in that: The filling structure (3) comprises: a filling bag (4), a liquid dispenser (5), a filling pump (6) and a filling needle (7); The upper end of the filling bag (4) is connected to the peristaltic pump (2) via a connecting hose; the lower end of the filling bag (4) is connected to the liquid dispenser (5) via a connecting hose; the filling bag (4) is used to temporarily store the liquid to be filled; The liquid distributor (5) is provided with an input end and two output ends; the input end of the liquid distributor (5) is connected to the lower end of the filling bag (4); the first output end of the liquid distributor (5) is connected to the filling pump (6), and the second output end is connected to the storage stirring component (1); One end of the filling pump (6) is connected to the liquid dispenser (5), and the other end is connected to the filling needle (7); The filling needle (7) serves as the outflow end of the liquid.

3. The dynamic packaging system according to claim 2, characterized in that: It also comprises a weighing monitoring component; the weighing monitoring component comprises a bracket (8) and a weighing device (9); the filling bag (4) is fixed on the bracket (8), and the bracket (8) is arranged on the weighing device (9).

4. The dynamic packaging system according to claim 1, characterized in that: It also includes a sterile filtering component; the sterile filtering component is a sterilizing grade filter; the sterilizing grade filter is installed after the peristaltic pump (2) and between the filling bag (4).

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