Cryopreservation device and equipment

Abstract

The utility model discloses a cryopreservation device and equipment, which are applied to the technical field of cryopreservation and are used for solving the problem that biological samples in a biological sample library cannot be accurately identified and positioned in the prior art. An electronic tag is arranged on the outer wall of the cryopreservation tube, and the cryopreservation tube is placed in the tube groove of the cryopreservation box; wherein identification information of a biological sample is stored in the electronic tag; the label identification circuit comprises at least one identification chip, each identification chip is arranged at the bottom of the corresponding pipe groove, and the power supply end of the label identification circuit is electrically connected with an external power supply. Therefore, the identification chip identifies the electronic tag arranged on the outer wall of the cryopreservation tube, so that the biological sample stored in the cryopreservation tube can be determined; moreover, the identification chip and the tube groove are correspondingly arranged, so that when the identification chip obtains the identification information, the tube groove for placing the cryopreservation tube for storing the corresponding biological sample can be determined, and accurate identification and positioning of the biological sample are realized.

Description

Technical Field

[0001] The utility model relates to the technical field of cryopreservation, and in particular to a cryopreservation device and equipment. Background Art

[0002] A biobank, also known as a biobank, mainly refers to the standardized collection, processing, storage and application of samples of biological macromolecules, cells, tissues and organs of healthy and diseased organisms, including human organ tissues, whole blood, plasma, serum, biological fluids or processed biological samples.

[0003] At present, biological sample banks rely only on ultra-low temperature (-80℃) refrigerators for storage, that is, biological samples in the biological sample bank are placed in freezing boxes and then stored in ultra-low temperature refrigerators. When the number of samples in the biological sample bank reaches a certain scale, it is impossible to accurately identify and locate the biological samples in the biological sample bank. It is time-consuming and laborious to search for biological samples. Long-term searches require the ultra-low temperature refrigerator to be opened for a long time, causing the temperature of the biological sample bank to rise, wasting energy, and causing the biological samples in the biological sample bank to melt or even deteriorate, causing huge losses. Utility Model Content

[0004] The embodiment of the utility model provides a freezing device to solve the problem in the prior art that biological samples in a biological sample library cannot be accurately identified and located.

[0005] The technical solution provided by the embodiment of the utility model is as follows:

[0006] On the one hand, the embodiment of the utility model provides a cryopreservation device, including: a cryopreservation box, a cryopreservation tube, an electronic tag, and a tag identification circuit;

[0007] The interior of the cryopreservation box is provided with at least one tube groove; the outer wall of the cryopreservation tube is provided with an electronic tag, and the cryopreservation tube is placed in the tube groove of the cryopreservation box; wherein the electronic tag stores the identification information of the biological sample;

[0008] The tag identification circuit includes at least one identification chip, each identification chip is arranged at the bottom of the corresponding tube groove, and the power supply end of the tag identification circuit is electrically connected to the external power supply.

[0009] In a possible implementation, the electronic tag includes: a tag chip, a coil, and a flexible substrate;

[0010] The tag chip is electrically connected to the coil, and the tag chip and the coil are arranged on a flexible substrate.

[0011] In a possible implementation, the electronic label further includes: a printable layer;

[0012] The printable layer is attached to the surface of the flexible substrate, and identification information is printed on the surface of the printable layer.

[0013] In a possible implementation, a plurality of tube grooves with openings facing upward are disposed inside the freezing box, and the plurality of tube grooves are arranged in an array.

[0014] In a possible implementation, the identification chip is a reader / writer, and the tag identification circuit further includes: a controller;

[0015] Each reader is arranged below a corresponding tube slot in the freezing box, and the plurality of readers are electrically connected to the controller respectively. The power supply ends of the plurality of readers and the controller are both connected to an external power supply.

[0016] In a possible implementation, the freezing device further includes: a plurality of gravity sensors;

[0017] Each of the multiple gravity sensors is arranged below a corresponding tube slot in the freezing box, the multiple gravity sensors are electrically connected to the controller respectively, and the power supply ends of the multiple gravity sensors are connected to an external power supply.

[0018] In a possible implementation, the freezing device further includes: a voltage stabilizing circuit;

[0019] The power supply ends of the multiple gravity sensors, the power supply ends of the multiple readers and writers, and the power supply end of the controller are respectively connected to the external power supply via the voltage stabilizing circuit.

[0020] In a possible implementation, the cryopreservation device further includes: an interface circuit;

[0021] The first end of the interface circuit is connected to the controller, and the second end of the interface circuit is connected to an external host computer.

[0022] In a possible implementation, the cryopreservation box is made of polycarbonate material.

[0023] On the other hand, the embodiment of the utility model provides a freezing device, including: the above freezing device, a label information input and printing device and a host computer;

[0024] The freezing device and the label information input and printing device are connected to the external host computer for communication.

[0025] The beneficial effects of the embodiments of the utility model are as follows:

[0026] In an embodiment of the utility model, an identification chip is provided at the bottom of each tube slot of the cryogenic box, and an electronic tag is provided on the outer wall of the cryogenic tube. The electronic tag provided on the outer wall of the cryogenic tube can be identified by the identification chip, and the identification information stored in the electronic tag can be obtained to determine the biological sample stored in the cryogenic tube. Furthermore, since the identification chip and the tube slot are provided in correspondence, when the identification chip obtains the identification information stored in the electronic tag, the tube slot in which the cryogenic tube storing the corresponding biological sample is placed can be determined, thereby achieving accurate identification and positioning of the biological sample.

[0027] Other features and advantages of the utility model will be described in the subsequent description, and partly will become apparent from the description, or understood by practicing the utility model. The purpose and other advantages of the utility model can be realized and obtained by the structures specifically pointed out in the written description, claims, and drawings. BRIEF DESCRIPTION OF THE DRAWINGS

[0028] The drawings described herein are used to provide a further understanding of the present invention and constitute a part of the present invention. The exemplary embodiments of the present invention and their descriptions are used to explain the present invention and do not constitute an improper limitation on the present invention. In the drawings:

[0029] Figure 1 This is a schematic diagram of the first structure of the freezing device in the embodiment of the utility model;

[0030] Figure 2 This is a schematic diagram of the structure of the electronic tag in the freezing device in the embodiment of the utility model;

[0031] Figure 3 This is a schematic diagram of the structure of a freezing box in a freezing device in an embodiment of the utility model;

[0032] Figure 4 This is a schematic diagram of the second structure of the freezing device in the embodiment of the utility model;

[0033] Figure 5 This is a schematic diagram of the third structure of the freezing device in the embodiment of the utility model;

[0034] Figure 6 This is a schematic diagram of the fourth structure of the freezing device in the embodiment of the utility model;

[0035] Figure 7 This is a fifth structural schematic diagram of the freezing device in the embodiment of the utility model;

[0036] Figure 8 It is a schematic diagram of the structure of the freezing storage device in the embodiment of the utility model. DETAILED DESCRIPTION

[0037] The following will be combined with the drawings in the embodiments of the utility model to clearly and completely describe the technical solutions in the embodiments of the utility model. Obviously, the described embodiments are only part of the embodiments of the utility model, not all of the embodiments. Based on the embodiments of the utility model, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the utility model.

[0038] The present invention provides a freezing device 100. Figure 1 As shown, the freezing device 100 includes: a freezing box 110, a freezing tube 120, an electronic tag 130 and a tag identification circuit;

[0039] The cryopreservation box 110 is provided with at least one tube groove inside; the outer wall of the cryopreservation tube 120 is provided with an electronic tag 130, and the cryopreservation tube 120 is placed in the tube groove of the cryopreservation box 110; wherein the electronic tag 130 stores the identification information of the biological sample;

[0040] The tag identification circuit includes at least one identification chip 140 . Each identification chip 140 is disposed at the bottom of a corresponding tube slot. The power supply end of the tag identification circuit is electrically connected to an external power supply.

[0041] exist Figure 1 In the cryopreservation device 100 shown, at least one tube slot is provided in the cryopreservation box 110, and a cryopreservation tube 120 for storing biological samples can be placed in each tube slot. The outer wall of each cryopreservation tube 120 can be fixed with an electronic tag 130 by pasting or the like, and the electronic tag 130 stores the identification information of the biological sample. A label recognition circuit is provided at the bottom of the cryopreservation box 110. Specifically, the label recognition circuit includes at least one identification chip 140. The number of identification chips 140 in the label recognition circuit is the same as the number of tube slots in the cryopreservation box 110. An identification chip 140 is provided below each tube slot. The identification chip 140 is used to identify the electronic tag 130 provided on the outer wall of the cryopreservation tube 120 to obtain the identification information corresponding to the biological sample placed in the storage tube. Furthermore, since an identification chip 140 is disposed under each tube slot, the tube slot position identified by the identification chip 140 is fixed. When the identification chip 140 identifies the electronic tag 130, the tube slot in which the cryotube 120 containing the biological sample is placed can be determined, that is, the correspondence between the biological sample and the placement tube slot can be determined.

[0042] In this way, by setting an identification chip at the bottom of each tube slot of the cryogenic box and setting an electronic tag on the outer wall of the cryogenic tube, the electronic tag set on the outer wall of the cryogenic tube can be identified by the identification chip, and the identification information stored in the electronic tag can be obtained to determine the biological sample stored in the cryogenic tube; and, since the identification chip and the tube slot are set correspondingly, when the identification chip obtains the identification information stored in the electronic tag, the tube slot in which the cryogenic tube storing the corresponding biological sample is placed can be determined.

[0043] In specific implementation, in the freezing device provided in the embodiment of the present application, the electronic tag has a variety of structures to realize its function, such as Figure 2 As shown, the electronic tag 130 includes: a tag chip 131, a coil 132 and a flexible substrate;

[0044] The tag chip 131 is electrically connected to the coil 132 , and the tag chip 131 and the coil 132 are disposed on a flexible substrate.

[0045] exist Figure 2 In the electronic tag shown, the tag chip 131 and the coil 132 can be arranged on the same surface of the flexible substrate, and the tag chip 131 and the coil 132 can also be arranged on different surfaces of the flexible substrate. The setting of the flexible substrate can make the electronic tag more closely arranged on the outer wall of the cryogenic tube. The tag chip 131 is used to store the identification information of the biological sample. The antenna is used to receive the radio frequency signal sent by the identification chip or send the radio frequency signal to the identification chip. The antenna can transmit the identification information of the biological sample in the electronic tag to the identification chip of the tag identification circuit, thereby realizing the tag identification circuit to recognize the electronic tag set on the outer wall of the cryogenic tube and determine the biological sample in the cryogenic tube.

[0046] In one embodiment, see Figure 2 As shown, the electronic label also includes: a printable layer;

[0047] The printable layer is attached to the surface of the flexible substrate, and identification information is printed on the surface of the printable layer.

[0048] exist Figure 2 In the electronic tag shown, a printable layer is attached to one side of the flexible substrate, and the other side of the flexible substrate is fixed to the outer wall of the cryotube by pasting or the like. Specifically, the printable layer can be non-transparent, and the identification information is printed on the surface of the printable layer in at least one form of a QR code, a barcode, or a code. The identification information of the biological sample in the cryotube is obtained by scanning the QR code or barcode on the surface of the printable layer with an external scanning device to determine the biological sample in the cryotube; or the biological sample in the cryotube is directly determined according to the code on the surface of the printable layer.

[0049] In specific implementation, in the freezing device provided in the embodiment of the present application, the freezing box has a variety of structures to achieve its functions, such as Figure 3 As shown, the interior of the freezing box is provided with a plurality of tube grooves with openings facing upward, and the plurality of tube grooves are arranged in an array.

[0050] exist Figure 3 In the cryopreservation box shown, the cryopreservation box includes a cryopreservation box body, a cryopreservation box cover, and a plurality of tube grooves. The cryopreservation box body includes a bottom, a side wall, and a hollow cavity surrounded by the bottom and the side wall. The cavity is provided with a plurality of tube grooves with openings facing upward, and the plurality of tube grooves are arranged in an array. The cryopreservation box body is detachably connected to the cryopreservation box cover. It is worth mentioning that the cryopreservation box cover is provided with tube groove numbers, and the adjacent side walls of the cryopreservation box cover are respectively provided with row numbers and column numbers, so that the user can take and place the cryopreservation tubes containing biological samples when the position of the biological samples is known.

[0051] In one embodiment, the cryobox is made of polycarbonate material. Since the cryobox needs to be placed in an ultra-low temperature refrigerator for storage, and the temperature in the ultra-low temperature refrigerator is about -80°C, the polycarbonate material has a high melting point, can withstand low temperatures, and has good impact resistance and aging resistance. The cryobox made of polycarbonate material is more suitable for the storage environment of the ultra-low temperature refrigerator.

[0052] In specific implementation, in the freezing device provided in the embodiment of the present application, the tag identification circuit has a variety of structures to realize its function, such as Figure 4 As shown, the identification chip 140 is a reader / writer 141, and the tag identification circuit further includes: a controller 142;

[0053] Each reader / writer 141 is disposed below a corresponding tube slot in the freezing box 110 , and the plurality of readers / writers 141 are electrically connected to the controller 142 , respectively. The power supply ends of the plurality of readers / writers 141 and the power supply end of the controller 142 are both connected to an external power source.

[0054] exist Figure 4 In the freezing device 100 shown, the reader / writer 141 is an RFID reader / writer, and the electronic tag 130 is a radio frequency tag. The reader / writer 141 is used to read the identification information in the radio frequency tag, and can also erase the data stored in the tag chip in the electronic tag 130. The corresponding relationship between the identification information and the corresponding biological sample can be pre-stored in the controller 142. The controller 142 is used to control the operation of the identification chip 140, that is, to control the reader / writer 141 to read the identification information in the radio frequency tag, so as to determine the biological sample corresponding to the identified identification information according to the identification information; the controller 142 can also determine the position of the biological sample corresponding to the identified identification information according to the position of the connected identification chip 140; the controller 142 is also used to erase the data stored in the tag chip in the electronic tag 130.

[0055] In one embodiment, see Figure 5As shown, the freezing device may further include: a plurality of gravity sensors 150;

[0056] Each gravity sensor 150 of the multiple gravity sensors 150 is disposed below a corresponding tube slot in the freezing box 110 , the multiple gravity sensors 150 are electrically connected to the controller 142 , respectively, and power supply ends of the multiple gravity sensors 150 are connected to an external power source.

[0057] exist Figure 5 In the cryopreservation device 100 shown, the gravity sensor 150 may be a miniature gravity sensor 150. A gravity sensor 150 is provided below each tube slot in the cryopreservation box 110. The gravity sensor 150 is used to detect the quality of the tube slot position. The gravity sensor 150 detects in real time to obtain a quality signal and sends it to the controller 142, so that the controller 142 determines the quality of the cryopreservation tube 120 according to the quality signal. Further, the controller 142 can monitor the quality change of the biological sample in the corresponding cryopreservation tube 120 in real time according to the quality signal.

[0058] In one embodiment, see Figure 6 As shown, the freezing device may further include: a voltage stabilizing circuit 160;

[0059] The power supply ends of the plurality of gravity sensors 150 , the power supply ends of the plurality of readers / writers 141 , and the power supply end of the controller 142 are respectively connected to an external power source via a voltage stabilizing circuit 160 .

[0060] exist Figure 6 In the freezing device shown, the voltage stabilizing circuit 160 includes a voltage stabilizing chip and at least one element of a resistor, a capacitor, and an inductor matched with the voltage stabilizing chip. The voltage stabilizing chip can be selected according to parameters such as the external power supply voltage and the stabilized voltage. The external power supply is generally 3V to 3.5V, and the stabilized voltage is generally 3V.

[0061] In one embodiment, see Figure 7 As shown, the cryopreservation device may further include: an interface circuit 170;

[0062] A first end of the interface circuit 170 is connected to the controller 142 , and a second end of the interface circuit 170 is connected to an external host computer.

[0063] exist Figure 7 In the freezing device 100 shown, the interface circuit 170 is used to communicate with an external host computer in a wired or wireless manner to achieve data interaction between the host computer and the freezing device 100. The interface circuit 170 includes at least a serial port and a network port, the serial port is at least one of an RS232 serial port and an RS485 serial port, and the network port is at least one of an Ethernet interface and a CAN bus interface.

[0064] Based on the same concept, the present invention also provides a freezing device, see Figure 8 As shown, the freezing equipment 200 comprises: the freezing device 100 provided in the embodiment of the utility model, a label information input and printing device 210 and a host computer 220;

[0065] The freezing device 100 and the label information input and printing device 210 are connected to the external host computer 220 for communication.

[0066] In practical applications, the cryopreservation device 100 is used to identify the biological sample in the cryopreservation box 110 and determine the tube slot where the cryopreservation tube 120 storing the corresponding biological sample is placed, monitor the quality change of the biological sample in the corresponding cryopreservation tube 120, and send the identification information of the biological sample in the cryopreservation box 110, the tube slot position where the cryopreservation tube 120 storing the corresponding biological sample is placed, and the quality change data of the biological sample to the host computer 220. The label information input printing device 210 can generate unique identification information corresponding to the biological sample, send the identification information and the corresponding biological sample to the host computer 220, and print the identification information on the surface of the printable layer in at least one form of a two-dimensional code, a bar code or a code. The host computer 220 is used to receive the identification information of the biological sample in the cryopreservation box 110, the tube slot position where the cryopreservation tube 120 storing the corresponding biological sample is placed, and the quality change data of the biological sample sent by the cryopreservation device 100, so as to realize the digital management of the biological sample. In this way, the cryopreservation device 200 can realize digital management of biological samples, save sample management time, increase the life of the ultra-low temperature sample library, and save energy.

[0067] Although the preferred embodiments of the present invention have been described, those skilled in the art may make other changes and modifications to these embodiments once they have learned the basic creative concept. Therefore, the appended claims are intended to be interpreted as including the preferred embodiments and all changes and modifications falling within the scope of the present invention.

[0068] Obviously, those skilled in the art can make various changes and modifications to the embodiments of the present invention without departing from the spirit and scope of the embodiments of the present invention. Thus, if these modifications and variations of the embodiments of the present invention fall within the scope of the claims of the present invention and their equivalents, the present invention is also intended to include these modifications and variations.

Claims

1. A freezing device, characterized in that: include: Cryogenic boxes, cryogenic tubes, electronic tags, and tag identification circuits; The interior of the cryopreservation box is provided with at least one tube groove; the outer wall of the cryopreservation tube is provided with the electronic tag, and the cryopreservation tube is placed in the tube groove of the cryopreservation box; wherein the electronic tag stores identification information of the biological sample; The tag identification circuit includes at least one identification chip, each of which is arranged at the bottom of the corresponding tube slot, and the power supply end of the tag identification circuit is electrically connected to an external power supply.

2. The freezing device according to claim 1, characterized in that: The electronic tag comprises: a tag chip, a coil and a flexible substrate; The tag chip is electrically connected to the coil, and the tag chip and the coil are arranged on the flexible substrate.

3. The freezing device according to claim 2, characterized in that: The electronic label further comprises: a printable layer; The printable layer is attached to the surface of the flexible substrate, and identification information is printed on the surface of the printable layer.

4. The freezing device according to claim 1, characterized in that: The interior of the freezing box is provided with a plurality of tube grooves with openings facing upwards, and the plurality of tube grooves are arranged in an array.

5. The freezing device according to any one of claims 1 to 4, characterized in that: The identification chip is a reader / writer, and the tag identification circuit further includes: a controller; Each of the reader-writers is arranged below a corresponding tube slot in the freezing box, and a plurality of the reader-writers are electrically connected to the controller respectively, and power supply ends of the plurality of the reader-writers and the power supply end of the controller are both connected to an external power supply.

6. The freezing device according to claim 5, characterized in that: Also includes: Multiple gravity sensors; Each of the multiple gravity sensors is arranged below a corresponding tube slot in the freezing box, the multiple gravity sensors are electrically connected to the controller respectively, and power supply ends of the multiple gravity sensors are connected to an external power supply.

7. The freezing device according to claim 6, characterized in that: include: Voltage stabilizing circuit; The power supply ends of the plurality of gravity sensors, the power supply ends of the plurality of readers and writers, and the power supply end of the controller are respectively connected to an external power supply via the voltage stabilizing circuit.

8. The freezing device according to claim 7, characterized in that: include: Interface circuit; The first end of the interface circuit is connected to the controller, and the second end of the interface circuit is connected to an external host computer.

9. The freezing device according to claim 1, characterized in that: The freezing box is made of polycarbonate material.

10. A freezing device, characterized in that: include: The freezing device, label information input and printing device and host computer according to any one of claims 1 to 9; The freezing device and the label information input and printing device are connected to an external host computer for communication.

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