Rapid sterilization device for pharmaceutical isolator

Abstract

The utility model relates to a rapid sterilization device for a pharmaceutical isolator. The rapid sterilization device comprises a sealed plenum chamber, an operation cavity, a sterilization circulation assembly, a VHP assembly, a production circulation assembly, an air inlet assembly and an air exhaust assembly, an air return passageway and a cavity operation space are arranged in the operation cavity, and the cavity operation space is communicated with an inner cavity of the sealed plenum chamber through the air return passageway; the sterilization circulation assembly and the production circulation assembly are both arranged in the sealed static pressure box, the VHP assembly is arranged outside the sealed static pressure box, the exhaust assembly is communicated with an inner cavity of the sealed static pressure box, and the air inlet assembly is communicated with the production circulation assembly in the sealed static pressure box; according to the utility model, the sterilization time is shortened, the high activity of active medicines is ensured, the production efficiency is improved, and the energy consumption is reduced.

Description

Technical Field

[0001] The utility model relates to a rapid sterilization device for a pharmaceutical isolator. Background Art

[0002] During the production of drugs, the entire production process needs to be kept sterile. The production process must be carried out in a closed sterile environment. The closed system must be sterilized before use to ensure the sterility of its internal environment. In recent years, hydrogen peroxide steam sterilization drug preparation isolators have emerged. During sterilization, hydrogen peroxide is released above the circulating high-efficiency filter, and after passing through the high-efficiency filter, it enters the operation area of ​​the drug preparation isolator for sterilization. Since hydrogen peroxide is highly oxidizing and corrosive, after the colony is inactivated, the hydrogen peroxide gas inside the drug preparation isolator needs to be replaced into the external environment, so that the hydrogen peroxide concentration is reduced to the allowable value, reducing corrosion to the equipment and objects that need to be sterilized. Since the surface of the high-efficiency filter is fibrous, after the hydrogen peroxide gas is adsorbed on it, it takes a long time to be replaced by air during the sterilization and residual discharge stage, which directly leads to a relatively long sterilization time for the entire equipment.

[0003] For biological drugs and cell drugs with biological activity, the long sterilization time will cause hydrogen peroxide gas to penetrate the bags and containers where the drugs are stored, killing the active drugs and reducing their efficacy; the long sterilization time will shorten the time the equipment is used for production, resulting in low equipment utilization efficiency; the large circulation fan of the entire machine is turned on during sterilization, and the equipment consumes high energy during sterilization.

[0004] Therefore, a pharmaceutical isolator rapid sterilization device is proposed in response to the above problems. Utility Model Content

[0005] The utility model aims to overcome the existing defects and provide a pharmaceutical isolator rapid sterilization device, shorten the sterilization time, ensure that the active drugs have high activity, improve production efficiency and reduce energy consumption.

[0006] The technical solution to achieve the above object is: a pharmaceutical isolator rapid sterilization device, comprising: a sealed static pressure box, an operating chamber, a sterilization cycle component, a VHP component, a production cycle component, an air intake component and an exhaust component;

[0007] The operating cavity is provided with a return air channel and a cavity operating space, and the cavity operating space is connected with the inner cavity of the sealed static pressure box through the return air channel;

[0008] The sterilization cycle component and the production cycle component are both arranged inside the sealed static pressure box, the VHP component is arranged outside the sealed static pressure box, the exhaust component is communicated with the inner cavity of the sealed static pressure box, and the air intake component is communicated with the production cycle component in the sealed static pressure box;

[0009] The sealed static pressure box is located above the operating cavity, the production circulation component in the sealed static pressure box is communicated with the cavity operating space in the operating cavity, and the production circulation component is selectively communicated with the inner cavity of the sealed static pressure box;

[0010] The sterilization circulation assembly includes a sterilization circulation fan, a hydrogen peroxide evaporator, a first pipeline and a second pipeline, the hydrogen peroxide evaporator is connected to the cavity operation space through the first pipeline, the hydrogen peroxide evaporator is connected to the return air channel through the second pipeline, and the sterilization circulation fan is arranged on the second pipeline;

[0011] The VHP component is connected to the input end of the hydrogen peroxide vaporizer through a third pipeline.

[0012] Preferably, the VHP component includes an electronic scale, a hydrogen peroxide storage bottle, a peristaltic pump, a solenoid valve, a gas flow regulating valve and a compressed air pipeline, the hydrogen peroxide storage bottle is placed on the electronic scale, the input end of the peristaltic pump is connected to the hydrogen peroxide storage bottle, the output end of the peristaltic pump is connected to the input end of the hydrogen peroxide evaporator through the third pipeline, one end of the compressed air pipeline is connected to an air source, the other end of the compressed air pipeline is connected to the third pipeline, and the solenoid valve and the gas flow regulating valve are sequentially arranged on the compressed air pipeline.

[0013] Preferably, the air intake assembly includes an air intake duct, a fresh air valve, a fresh air fan and a fresh air high-efficiency filter, the fresh air valve, the fresh air fan and the fresh air high-efficiency filter are arranged on the air intake duct in sequence from top to bottom, the air outlet of the fresh air high-efficiency filter is connected with the production circulation assembly through the lower end of the air intake duct, an air inlet is opened on the sealed static pressure box, and the upper end of the air intake duct is connected with the air inlet.

[0014] Preferably, the fresh air fan and the fresh air high efficiency filter are both located inside the sealed static pressure box.

[0015] Preferably, the exhaust component includes an exhaust duct, an exhaust fan, an exhaust high-efficiency filter, an exhaust decomposition filter, an exhaust valve and a pressure relief valve, the exhaust fan, the exhaust high-efficiency filter, the exhaust decomposition filter and the exhaust valve are sequentially arranged on the exhaust duct from bottom to top, the air inlet of the exhaust fan is connected to the inner cavity of the sealed static pressure box, the sealed static pressure box is provided with an exhaust port, the upper end of the exhaust duct is connected to the exhaust port, and the pressure relief valve is arranged in parallel with the exhaust valve.

[0016] Preferably, the exhaust fan, the exhaust high efficiency filter and the exhaust decomposition filter are all located inside the sealed static pressure box.

[0017] Preferably, the production circulation component includes a circulation high-efficiency filter, a first circulation fan and a circulation switching door, the air outlet of the circulation high-efficiency filter is connected to the cavity operating space, the air inlet of the circulation high-efficiency filter is connected to the inner cavity of the sealed static pressure box through the circulation switching door, and the first circulation fan is arranged between the circulation high-efficiency filter and the circulation switching door.

[0018] The beneficial effects of the utility model are:

[0019] 1) Hydrogen peroxide vapor is generated after being transported to the hydrogen peroxide evaporator by the VHP component. The hydrogen peroxide vapor is directly sent into the operation chamber for sterilization under the action of a dedicated sterilization circulation component in the operation chamber. The entire sterilization process does not require the production circulation component to participate in the circulation, reducing the hydrogen peroxide adhesion area. After achieving the sterilization effect, the hydrogen peroxide vapor in the operation chamber is replaced through the air intake component and the exhaust component. The gas inside the chamber is 100% replaced and does not participate in the internal circulation. The concentration of hydrogen peroxide vapor in the operation chamber is quickly reduced to below the set safety concentration. A decomposition filter is installed on the exhaust pipeline to accelerate the decomposition of hydrogen peroxide vapor in the external exhaust pipeline, and the sterilization time can be shortened to 1 / 3 of that of the traditional drug preparation isolator.

[0020] 2) Hydrogen peroxide vapor is generated after the VHP component is transported to the hydrogen peroxide evaporator. The hydrogen peroxide vapor is directly sent into the operation chamber for sterilization using a dedicated sterilization cycle component in the operation chamber. The circulation fan in the production cycle component does not participate in the sterilization cycle, which shortens the sterilization time and reduces energy consumption. In addition, when the equipment is in production, the gas inside the chamber is replaced by the air inlet component and the exhaust component, and the production cycle component is turned on. The airflow inside the isolator is recycled, reducing the demand for fresh air and reducing energy consumption. BRIEF DESCRIPTION OF THE DRAWINGS

[0021] Figure 1 It is a front schematic diagram of the rapid sterilization device for pharmaceutical isolator of the utility model;

[0022] Figure 2 It is a schematic diagram of a sterilization cycle component of a rapid sterilization device for a pharmaceutical isolator of the utility model.

[0023] In the figure: 1. Sealed static pressure box; 2. Operating cavity; 3. Return air duct; 4. Sterilization circulation fan; 5. Hydrogen peroxide evaporator; 6. Cavity operating space; 7. Electronic scale; 8. Hydrogen peroxide storage bottle; 9. Peristaltic pump; 10. Solenoid valve; 11. Gas flow regulating valve; 12. Circulating high-efficiency filter; 13. First circulating fan; 14. Circulating switching door; 15. Fresh air valve; 16. Fresh air fan; 17. Fresh air high-efficiency filter; 18. Exhaust fan; 19. Exhaust high-efficiency filter; 20. Exhaust decomposition filter; 21. Exhaust valve; 22. Pressure relief valve. DETAILED DESCRIPTION

[0024] The technical solution of the present invention will be described clearly and completely below in conjunction with the accompanying drawings. In the description of the present invention, it should be noted that the terms "center", "upper", "lower", "left", "right", "vertical", "horizontal", "inside", "outside" and the like indicate directions or positional relationships based on the directions or positional relationships shown in the accompanying drawings, and are only for the convenience of describing the present invention and simplifying the description, and do not indicate or imply that the device or element referred to must have a specific direction, be constructed and operated in a specific direction, and therefore cannot be understood as a limitation on the present invention. In addition, the terms "first", "second", and "third" are used for descriptive purposes only, and cannot be understood as indicating or implying relative importance.

[0025] The utility model will be further described below in conjunction with the accompanying drawings.

[0026] like Figure 1-2 As shown, a pharmaceutical isolator rapid sterilization device comprises: a sealed static pressure box 1, an operating cavity 2, a sterilization cycle component, a VHP component, a production cycle component, an air intake component and an exhaust component; a return air channel 3 and a cavity operating space 6 are arranged in the operating cavity 2, and the cavity operating space 6 is connected with the inner cavity of the sealed static pressure box 1 through the return air channel 3; the sterilization cycle component and the production cycle component are both arranged inside the sealed static pressure box 1, the VHP component is arranged outside the sealed static pressure box 1, the exhaust component is connected with the inner cavity of the sealed static pressure box 1, and the air intake component is connected with the production cycle component in the sealed static pressure box 1; The sealed static pressure box 1 is located above the operating cavity 2, the production circulation component in the sealed static pressure box 1 is connected with the cavity operating space 6 in the operating cavity 2, and the production circulation component is selectively connected with the inner cavity of the sealed static pressure box 1; the sterilization circulation component includes a sterilization circulation fan 4, a hydrogen peroxide evaporator 5, a first pipeline and a second pipeline, the hydrogen peroxide evaporator 5 is connected with the cavity operating space 6 through the first pipeline, the hydrogen peroxide evaporator 5 is connected with the return air channel 3 through the second pipeline, and the sterilization circulation fan 4 is arranged on the second pipeline; the VHP component is connected with the input end of the hydrogen peroxide evaporator 5 through the third pipeline.

[0027] Specifically, the VHP component includes an electronic scale 7, a hydrogen peroxide storage bottle 8, a peristaltic pump 9, a solenoid valve 10, a gas flow regulating valve 11 and a compressed air pipeline. The hydrogen peroxide storage bottle 8 is placed on the electronic scale 7, the input end of the peristaltic pump 9 is connected to the hydrogen peroxide storage bottle 8, the output end of the peristaltic pump 9 is connected to the input end of the hydrogen peroxide evaporator 5 through a third pipeline, one end of the compressed air pipeline is connected to the air source, the other end of the compressed air pipeline is connected to the third pipeline, and the solenoid valve 10 and the gas flow regulating valve 11 are sequentially arranged on the compressed air pipeline.

[0028] Specifically, the air intake component includes an air intake duct, a fresh air valve 15, a fresh air fan 16 and a fresh air high-efficiency filter 17. The fresh air valve 15, the fresh air fan 16 and the fresh air high-efficiency filter 17 are arranged on the air intake duct from top to bottom. The air outlet of the fresh air high-efficiency filter 17 is connected with the production circulation component through the lower end of the air intake duct. An air inlet is opened on the sealed static pressure box 1, and the upper end of the air intake duct is connected with the air inlet.

[0029] Specifically, the fresh air fan 16 and the fresh air high efficiency filter 17 are both located inside the sealed static pressure box 1 .

[0030] Specifically, the exhaust component includes an exhaust duct, an exhaust fan 18, an exhaust high-efficiency filter 19, an exhaust decomposition filter 20, an exhaust valve 21 and a pressure relief valve 22. The exhaust fan 18, the exhaust high-efficiency filter 19, the exhaust decomposition filter 20 and the exhaust valve 21 are arranged on the exhaust duct from bottom to top, the air inlet of the exhaust fan 18 is connected to the inner cavity of the sealed static pressure box 1, the sealed static pressure box 1 is provided with an exhaust port, the upper end of the exhaust duct is connected to the exhaust port, and the pressure relief valve 22 is arranged in parallel with the exhaust valve 21.

[0031] Specifically, the exhaust fan 18 , the exhaust high efficiency filter 19 and the exhaust decomposition filter 20 are all located inside the sealed static pressure box 1 .

[0032] Specifically, the production circulation component includes a circulating high-efficiency filter 12, a first circulating fan 13 and a circulating switching door 14. The air outlet of the circulating high-efficiency filter 12 is connected to the cavity operating space 6, and the air inlet of the circulating high-efficiency filter 12 is connected to the inner cavity of the sealed static pressure box 1 through the circulating switching door 14. The first circulating fan 13 is arranged between the circulating high-efficiency filter 12 and the circulating switching door 14.

[0033] Specifically, the working process of the pharmaceutical isolator rapid sterilization device includes: sterilization stage and residual discharge stage;

[0034] In the sterilization stage, the amount of hydrogen peroxide is set, the peristaltic pump 9 is turned on, and the solenoid valve 10 is opened to respectively deliver the hydrogen peroxide solution and the compressed air to the hydrogen peroxide evaporator 5, and the hydrogen peroxide evaporator 5 vaporizes the hydrogen peroxide solution into hydrogen peroxide gas, and the mixed gas of the hydrogen peroxide gas and the compressed air is delivered to the cavity operation space 6 via the first pipeline to sterilize the cavity operation space 6; at this time, the sterilization circulation fan 4 is turned on, and the hydrogen peroxide gas in the cavity operation space 6 is returned to the cavity operation space 6 via the return air channel 3, the second pipeline, the first pipeline, and the hydrogen peroxide evaporator 5 in sequence under the action of the sterilization circulation fan 4;

[0035] In the exhaust stage, the fresh air valve 15 and the fresh air fan 16 are opened, and the exhaust valve 21 and the exhaust fan 18 are opened at the same time. The external air is filtered by the fresh air high-efficiency filter 17 and enters the production circulation system and the cavity operation space 6 connected to the production circulation system. The air containing hydrogen peroxide gas in the cavity operation space 6 enters the inner cavity of the sealed static pressure box 1 through the return air duct 3, and then is filtered by the exhaust high-efficiency filter 19 and the exhaust decomposition filter 20 and then discharged.

[0036] Specifically, during the sterilization stage, the pressure relief valve 22 is opened, and the air pressure in the operation chamber 2 is controlled by adjusting the opening of the pressure relief valve 22 .

[0037] Specifically, the working process of the pharmaceutical isolator rapid sterilization device also includes a production stage. In the production stage, the circulation switching door 14 is automatically opened, and the circulation high-efficiency filter 12 and the circulation fan 13 start working;

[0038] During the sterilization stage, the circulation switching door 14 is always in a closed state, and the circulation high-efficiency filter 12 and the circulation fan 13 are not working.

[0039] During the residual discharge stage, the circulation switching door 14 is always in a closed state, and the circulation high-efficiency filter 12 and the circulation fan 13 start to work.

[0040] The hydrogen peroxide evaporator 5 is a conventional system, so the working principle etc. will not be described.

[0041] Specifically, the air inlet assembly is connected with the production circulation assembly, the exhaust assembly is connected with the sealed static pressure box 1, the production circulation assembly is connected with the main cavity operation space 6 and is selectively connected with the sealed static pressure box 1. When the equipment is in the sterilization mode, the circulation switching door 14 on the production circulation assembly is in a closed state; when the sterilization ventilation is exhausted, the air inlet assembly sends clean air into the production circulation assembly, and enters the main cavity operation space 6 under the action of the first circulation fan 13 in the production circulation assembly. The hydrogen peroxide gas remaining in the main cavity operation space 6 after sterilization is completed enters the return air duct 3, In the static pressure box shell 1, the gas in the static pressure box shell 1 is discharged by the exhaust component, realizing full delivery and full exhaust, without circulating airflow, and the peroxidizer external exhaust efficiency is very high; when the equipment is in production mode, the circulation switching door 14 on the production circulation component is in an open state, at this time, there is airflow generating internal circulation inside the equipment, and the energy utilization rate is higher. The sterilization circulation system is connected with the main cavity operation space 6 and the return air channel 3 at the same time, and the VHP component is connected with the sterilization circulation component, which is used to transport liquid hydrogen peroxide to the hydrogen peroxide evaporator 5 to generate vaporized hydrogen peroxide for sterilization treatment;

[0042] Specifically, in order to solve the problems of long sterilization time, killing active drugs, reducing drug efficacy, long sterilization time, shortened actual production time of equipment and low production efficiency in the existing pharmaceutical isolator hydrogen peroxide sterilization system, hydrogen peroxide vapor is generated after the VHP component is transported to the hydrogen peroxide evaporator 5, and the hydrogen peroxide vapor is directly sent into the operation chamber 6 for sterilization under the action of a dedicated sterilization circulation component. The entire sterilization process does not require the production circulation component to participate in the circulation, reducing the hydrogen peroxide adhesion area, and after achieving the sterilization effect, the hydrogen peroxide vapor in the operation chamber is replaced by the air intake component and the exhaust component, the gas inside the chamber is 100% replaced and does not participate in the internal circulation, and the concentration of hydrogen peroxide vapor inside the operation chamber is quickly reduced to below the set safety concentration. A decomposition filter 20 is installed on the exhaust pipeline to accelerate the decomposition of hydrogen peroxide vapor in the external exhaust pipeline. Through the above, the sterilization time can be shortened to 1 / 3 of the traditional drug preparation isolator.

[0043] Specifically, before sterilization, the hydrogen peroxide dosage parameter is set and weighed in real time on the electronic scale 7. When sterilization starts, the peristaltic pump 9 starts working to squeeze hydrogen peroxide from the hydrogen peroxide storage bottle 8 into the pipeline, and then the compressed air is controlled and regulated by the compressed air control solenoid valve 10 and the gas flow regulating valve 11, and transported to the hydrogen peroxide evaporator 5 for evaporation to produce vaporized hydrogen peroxide. The vaporized hydrogen peroxide passes through the return air channel 3 under the action of the sterilization circulation fan 4 to sterilize the cavity operation space 6 of the operation cavity 2. At this time, the hydrogen peroxide gas does not need to pass through the circulation high-efficiency filter 12, the first circulation fan 13 does not need to be turned on, and the circulation switching door 14 is in a closed state. During the sterilization process, the pressure difference in the operating cabin is controlled by controlling the opening of the pressure relief valve 22 to avoid excessive pressure in the cavity due to continuous injection of hydrogen peroxide gas and compressed air. During sterilization and residual discharge, the circulation switching door 14 is kept closed, the fresh air valve 15 is opened, and the air is filtered through the fresh air high-efficiency filter 17 by the fresh air fan 16 and enters the production circulation component. Under the action of the circulation fan 13, the air enters the cavity operation space 6 through the circulation high-efficiency filter 12. When the air inlet component is turned on, the exhaust component is turned on synchronously, and the exhaust valve 21 is opened. Under the action of the exhaust fan 18, the air containing hydrogen peroxide gas in the cavity operation space 6 is discharged through the exhaust high-efficiency filter 19 and the exhaust decomposition filter 20. When the entire cavity is in a full delivery and full discharge state, there is no gas internal circulation inside the equipment, the residual discharge speed is fast, the residual discharge time is short, and the rapid sterilization of the drug preparation isolator cavity can be achieved, the sterilization time is short, and the sterilization time is 1 / 3 of the traditional drug preparation isolator. The sterilization time is shortened, which can be used to extend the production time accordingly, thereby improving production efficiency. In the production state, the circulation switching door 14 is opened, and part of the air flow inside the equipment is internally circulated, which helps to control the temperature and humidity of the gas for secondary use, which is conducive to reducing energy consumption and reducing equipment operating costs.

[0044] Specifically, in order to solve the problems of high energy consumption of the equipment when all circulating fans are turned on during sterilization, hydrogen peroxide vapor is generated after being transported to the hydrogen peroxide evaporator by the VHP component. The hydrogen peroxide vapor is directly sent into the operating chamber for sterilization using a special sterilization circulation component in the operating chamber. The circulating fan in the production circulation component does not participate in the sterilization cycle, which shortens the sterilization time and reduces energy consumption. In addition, when the equipment is in production, the gas inside the chamber is replaced by the air intake component and the exhaust component, while the production circulation component is turned on, and the airflow inside the isolator is recycled, reducing the demand for fresh air and lowering energy consumption.

[0045] The above embodiments are only used to illustrate the technical solution of the utility model, rather than to limit it. Although the utility model is described in detail with reference to the above embodiments, ordinary technicians in this field should understand that they can still modify the technical solutions recorded in the above embodiments, or replace some or all of the technical features therein with equivalents. These modifications or replacements do not make the essence of the corresponding technical solutions deviate from the scope of the technical solutions of the embodiments of the utility model.

Claims

1. A pharmaceutical isolator rapid sterilization device, characterized in that: include: A sealed static pressure box (1), an operating chamber (2), a sterilization cycle component, a VHP component, a production cycle component, an air intake component, and an exhaust component; The operating cavity (2) is provided with a return air duct (3) and a cavity operating space (6), and the cavity operating space (6) is connected to the inner cavity of the sealed static pressure box (1) through the return air duct (3); The sterilization cycle component and the production cycle component are both arranged inside the sealed static pressure box (1), the VHP component is arranged outside the sealed static pressure box (1), the exhaust component is communicated with the inner cavity of the sealed static pressure box (1), and the air intake component is communicated with the production cycle component in the sealed static pressure box (1); The sealed static pressure box (1) is located above the operating cavity (2), the production circulation component in the sealed static pressure box (1) is connected to the cavity operating space (6) in the operating cavity (2), and the production circulation component is selectively connected to the inner cavity of the sealed static pressure box (1); The sterilization circulation assembly comprises a sterilization circulation fan (4), a hydrogen peroxide evaporator (5), a first pipeline and a second pipeline, wherein the hydrogen peroxide evaporator (5) is connected to the cavity operation space (6) through the first pipeline, and the hydrogen peroxide evaporator (5) is connected to the return air channel (3) through the second pipeline, and the sterilization circulation fan (4) is arranged on the second pipeline; The VHP component is connected to the input end of the hydrogen peroxide evaporator (5) via a third pipeline.

2. The pharmaceutical isolator rapid sterilization device according to claim 1, characterized in that: The VHP assembly comprises an electronic scale (7), a hydrogen peroxide storage bottle (8), a peristaltic pump (9), a solenoid valve (10), a gas flow regulating valve (11) and a compressed air pipeline. The hydrogen peroxide storage bottle (8) is placed on the electronic scale (7). The input end of the peristaltic pump (9) is connected to the hydrogen peroxide storage bottle (8). The output end of the peristaltic pump (9) is connected to the input end of the hydrogen peroxide evaporator (5) through the third pipeline. One end of the compressed air pipeline is connected to an air source, and the other end of the compressed air pipeline is connected to the third pipeline. The solenoid valve (10) and the gas flow regulating valve (11) are sequentially arranged on the compressed air pipeline.

3. The pharmaceutical isolator rapid sterilization device according to claim 1, characterized in that: The air intake component comprises an air intake duct, a fresh air valve (15), a fresh air fan (16) and a fresh air high-efficiency filter (17); the fresh air valve (15), the fresh air fan (16) and the fresh air high-efficiency filter (17) are arranged on the air intake duct in sequence from top to bottom; the air outlet of the fresh air high-efficiency filter (17) is connected to the production circulation component through the lower end of the air intake duct; an air inlet is provided on the sealed static pressure box (1); and the upper end of the air intake duct is connected to the air inlet.

4. The pharmaceutical isolator rapid sterilization device according to claim 3, characterized in that: The fresh air fan (16) and the fresh air high efficiency filter (17) are both located inside the sealed static pressure box (1).

5. The pharmaceutical isolator rapid sterilization device according to claim 1, characterized in that: The exhaust assembly comprises an exhaust duct, an exhaust fan (18), an exhaust high-efficiency filter (19), an exhaust decomposition filter (20), an exhaust valve (21) and a pressure relief valve (22); the exhaust fan (18), the exhaust high-efficiency filter (19), the exhaust decomposition filter (20) and the exhaust valve (21) are arranged on the exhaust duct in sequence from bottom to top; the air inlet of the exhaust fan (18) is connected to the inner cavity of the sealed static pressure box (1); an exhaust port is provided on the sealed static pressure box (1); the upper end of the exhaust duct is connected to the exhaust port; the pressure relief valve (22) and the exhaust valve (21) are arranged in parallel.

6. The pharmaceutical isolator rapid sterilization device according to claim 5, characterized in that: The exhaust fan (18), the exhaust high efficiency filter (19) and the exhaust decomposition filter (20) are all located inside the sealed static pressure box (1).

7. The pharmaceutical isolator rapid sterilization device according to claim 1, characterized in that: The production circulation component comprises a circulation high-efficiency filter (12), a first circulation fan (13) and a circulation switching door (14); the air outlet of the circulation high-efficiency filter (12) is connected to the cavity operation space (6); the air inlet of the circulation high-efficiency filter (12) is connected to the inner cavity of the sealed static pressure box (1) through the circulation switching door (14); and the first circulation fan (13) is arranged between the circulation high-efficiency filter (12) and the circulation switching door (14).

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