Double-piston mixing device

Abstract

The utility model discloses a double-piston mixing device which comprises a first cylinder body, a first piston, a first driving device, a second cylinder body, a second piston, a second driving device and a connector, the first cylinder body and the second cylinder body are hollow cylinders, one end of each cylinder body is provided with a discharge port, and the other end of each cylinder body is provided with an opening. A discharging port of the first cylinder body is in butt joint with a discharging port of the second cylinder body through the connector, and the first piston is arranged in the first cylinder body through an opening of the first cylinder body and connected with a first driving device on the outer side of the first cylinder body. And the second piston is arranged in the second cylinder body through the opening of the second cylinder body and is connected with a second driving device on the outer side of the second cylinder body. According to the utility model, a double-piston mixing mode is adopted, the two cylinder bodies are matched with each other for use, materials to be mixed are driven by the pistons to circulate and mix for multiple times between the two cylinder bodies, and then the materials can be uniformly mixed, so that the mixing efficiency is high, the effect is good, and the discharging rate is high.

Description

Technical Field

[0001] The utility model relates to the technical field of mixing, in particular to a double-piston mixing device. Background Art

[0002] Hyaluronic acid (HA) is a linear polyanionic mucopolysaccharide composed of repeated D-glucuronic acid and N-acetyl-D-glucosamine disaccharide units. It is widely present in connective tissues such as synovial fluid, vitreous body, skin, and intercellular space of animals and humans. It is an important component of synovial fluid, vitreous body, skin, and cartilage tissue, and has unique physical and chemical properties and a wide range of biological functions. Hyaluronic acid usually exists in the form of sodium hyaluronate (SH). Due to its good biocompatibility, unique viscoelasticity, and excellent water retention, HA is often used to inject into facial skin to reduce wrinkles, improve skin appearance, and prevent skin aging.

[0003] However, the half-life of hyaluronic acid in the skin is very short. Under the action of hyaluronidase in the body, hyaluronic acid is rapidly degraded into small molecular fragments, which then enter the circulatory system and are metabolized and absorbed. In view of the above defects, sodium hyaluronate is usually prepared into gels of different molecular weights using appropriate cross-linking agents. The molecular weight of the cross-linked sodium hyaluronate gel is increased. On the basis of retaining the original biocompatibility, a sodium hyaluronate cross-linked gel with a more complex molecular structure, stronger viscoelasticity, and significantly improved enzymatic resistance and mechanical properties can be developed, thereby making it more widely used.

[0004] In the preparation process of sodium hyaluronate cross-linked gel, there is usually a mixing step, such as Chinese patent documents CN102731801A and CN103923328A. Both patents disclose that sodium hyaluronate dry powder is first dispersed in a mixed solution consisting of sodium hydroxide aqueous solution and acetone to obtain a sodium hyaluronate alkaline suspension, and then a cross-linking agent BDDE is added. After mixing, a reaction material is obtained, and then placed at a specific temperature to generate a reaction of sodium hyaluronate cross-linked gel. In addition, the prepared sodium hyaluronate cross-linked gel also needs to be compounded with polypeptides, amino acids, etc. into a cross-linked sodium hyaluronate composite solution preparation when it is actually used, as disclosed in Chinese patent document CN111467568. But this compounding process also has a mixing step.

[0005] Existing mixing technology mainly achieves the mixing of multiple materials by stirring with paddles, but for materials with high viscosity such as sodium hyaluronate solution and its gel solution, it takes a long time to mix them evenly, and there are problems of low mixing efficiency and poor effect. In addition, especially for materials with high added value and small batches such as sodium hyaluronate and its gel, the adhesion of the materials on the paddles and the wall after mixing leads to a significant reduction in yield (discharge rate), resulting in a huge waste of production costs. Therefore, a new type of mixing device is urgently needed. Summary of the invention

[0006] The utility model aims to overcome the defects of the prior art and provide a double-piston mixing device to solve the problems of low mixing efficiency, poor effect and low discharge rate in the prior art mixing devices.

[0007] To achieve the above purpose, the utility model provides a double-piston mixing device, including a first cylinder, a first piston, a first driving device, a second cylinder, a second piston, a second driving device and a connector, wherein the first cylinder and the second cylinder are both hollow cylinders, and a discharge port is provided at one end and an opening is provided at the other end, and the discharge port of the first cylinder is connected with the discharge port of the second cylinder through the connector, so that the discharge port of the first cylinder is connected with the discharge port of the second cylinder; the first piston is placed in the first cylinder through the opening of the first cylinder, and is connected to the first driving device outside the first cylinder, and the first driving device is used to drive the first piston to reciprocate in the first cylinder; the second piston is placed in the second cylinder through the opening of the second cylinder, and is connected to the second driving device outside the second cylinder, and the second driving device is used to drive the second piston to reciprocate in the second cylinder. The discharge port of the first cylinder is circular, and the diameter of the discharge port of the first cylinder is smaller than the cylindrical diameter of the first cylinder; the discharge port of the second cylinder is circular, and the diameter of the discharge port of the second cylinder is smaller than the cylindrical diameter of the second cylinder.

[0008] Furthermore, the first driving device and the second driving device work alternately.

[0009] Furthermore, the center of the discharge port of the first cylinder is not located in the extension direction of the cylindrical axis of the first cylinder; the center of the discharge port of the second cylinder is not located in the extension direction of the cylindrical axis of the second cylinder.

[0010] Furthermore, a discharge pipe integrally formed with the first cylinder body is provided at the discharge port of the first cylinder body, and a discharge pipe integrally formed with the second cylinder body is provided at the discharge port of the second cylinder body, and the connector is connected to the discharge port of the first cylinder body and the discharge port of the second cylinder body through the discharge pipe of the first cylinder body and the discharge pipe of the second cylinder body.

[0011] Furthermore, one end of the connector is sleeved on the outside of the discharge pipe of the first cylinder body, and the other end is sleeved on the outside of the discharge pipe of the second cylinder body.

[0012] Furthermore, threaded sleeves are provided on the outer sides of the discharge port of the first cylinder body and the discharge port of the second cylinder body, and external threads are provided on both ends of the connector. The connector is connected to the threaded sleeves through the external threads at both ends, so that the connector is sleeved on the outer sides of the discharge pipe of the first cylinder body and the discharge pipe of the second cylinder body.

[0013] Furthermore, a screen is installed at the center of the connector.

[0014] Furthermore, the connector includes a discharge pipe sleeve section with the first cylinder body and a discharge pipe sleeve section with the second cylinder body, and the discharge pipe sleeve section with the first cylinder body and the discharge pipe sleeve section with the second cylinder body are connected through a flange or a clamp, and a screen is clamped in the flange or the clamp.

[0015] Furthermore, the sieve is replaced according to different mesh sizes.

[0016] Furthermore, the first cylinder body, the second cylinder body and the connector are all made of stainless steel, and the first piston and the second piston are both made of ceramic.

[0017] Further, the cylindrical diameter of the first cylinder body is greater than the cylindrical diameter of the second cylinder body, and the cylindrical volume of the first cylinder body is the same as that of the second cylinder body.

[0018] Furthermore, a bracket is included, and the bracket is used to make the first cylinder body and the second cylinder body be in an upright position.

[0019] Compared with the prior art, the utility model has the following beneficial technical effects:

[0020] 1. The utility model adopts a double-piston mixing method. The two cylinders are used in conjunction with each other. The materials to be mixed are driven by the piston to circulate and mix between the two cylinders for multiple times, so that the materials can be mixed evenly. The mixing efficiency is high and the effect is good. After the mixing is completed, the materials are easy to discharge and not easy to remain. The discharge rate is high and the material waste is small. In addition, there is no paddle stirring, which can avoid the inclusion of bubbles when mixing high-viscosity materials.

[0021] 2. The discharge ports of the two cylinders in the utility model are preferably arranged at eccentric positions. Compared with those arranged at the central position, when mixing materials, the difference in the speed of each particle is greater, which is more conducive to mixing between materials and improves mixing efficiency. BRIEF DESCRIPTION OF THE DRAWINGS

[0022] In order to more clearly illustrate the implementation of the utility model or the technical solution in the prior art, the following is a brief introduction to the drawings required for the implementation or the prior art description. Obviously, the drawings in the following description are only exemplary, and for ordinary technicians in this field, other implementation drawings can be derived from the provided drawings without creative work.

[0023] The structures, proportions, sizes, etc. illustrated in this specification are only used to match the contents disclosed in the specification so as to facilitate understanding and reading by persons familiar with the technology. They are not used to limit the conditions under which the present invention can be implemented, and therefore have no substantial technical significance. Any structural modification, change in proportion or adjustment in size shall still fall within the scope of the technical contents disclosed in the present invention without affecting the effects and purposes that can be achieved by the present invention.

[0024] Figure 1 is a schematic structural diagram of Example 1;

[0025] Figure 2 is a schematic diagram of the use state of Example 1;

[0026] Figure 3 is a schematic structural diagram of Example 2;

[0027] Figure 4 is a schematic structural diagram of Example 3;

[0028] Figure 5 is a schematic structural diagram of Example 4;

[0029] Figure 6 is an enlarged schematic diagram of part A in Example 5;

[0030] Figure 7 It is a structural schematic diagram of Example 5.

[0031] In the figure: 1. first cylinder body; 2. first piston; 3. first driving device; 4. second cylinder body; 5. second piston; 6. second driving device; 7. connector; 71. sleeve section of discharge pipe connected to first cylinder body; 72. sleeve section of discharge pipe connected to second cylinder body; 73. flange or clamp; 8. threaded sleeve; 9. screen; 10. bracket. DETAILED DESCRIPTION

[0032] The following is a specific embodiment of the present invention. People familiar with the technology can easily understand the other advantages and functions of the present invention from the contents disclosed in this specification. Obviously, the described embodiment is a part of the present invention, not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the present invention.

[0033] In order to make the purpose of the utility model and the advantages of the technical solution more clearly understood, the utility model is further described in detail below in conjunction with the accompanying drawings and embodiments.

[0034] Example 1

[0035] like Figure 1 As shown, a double-piston mixing device in an embodiment of the first aspect of the utility model includes a first cylinder body 1, a first piston 2, a first driving device 3, a second cylinder body 4, a second piston 5, a second driving device 6 and a connector 7.

[0036] The first cylinder body 1 and the second cylinder body 4 are both hollow cylinders, and are provided with a discharge port at one end and an opening at the other end. The discharge port of the first cylinder body 1 and the discharge port of the second cylinder body 4 are connected through a connector 7, so that the discharge port of the first cylinder body 1 is connected with the discharge port of the second cylinder body 4.

[0037] The first piston 2 is placed in the first cylinder body 1 through the opening of the first cylinder body 1 and is connected to the first driving device 3 outside the first cylinder body 1. The first driving device 3 is used to drive the first piston 2 to reciprocate in the first cylinder body 1; the second piston 5 is placed in the second cylinder body 4 through the opening of the second cylinder body 4 and is connected to the second driving device 6 outside the second cylinder body 4. The second driving device 6 is used to drive the second piston 5 to reciprocate in the second cylinder body 4.

[0038] The discharge port of the first cylinder body 1 is circular, and the diameter of the discharge port of the first cylinder body 1 is smaller than the cylinder diameter of the first cylinder body 1 ; the discharge port of the second cylinder body 4 is circular, and the diameter of the discharge port of the second cylinder body 4 is smaller than the cylinder diameter of the second cylinder body 4 .

[0039] In the above embodiment, it should be noted that the first driving device 3 and the second driving device 6 can be driven by a piston rod through a hydraulic telescopic rod or an electric telescopic rod. The first driving device 3 and the second driving device 6 work alternately.

[0040] Furthermore, the usage status of the entire device is as follows: Figure 2As shown, the second piston 5 is pushed to the bottom of the second cylinder 4, the first piston 2 is removed, the material to be mixed is added to the first cylinder 1 through the opening of the first cylinder 1, the first piston 2 is installed, and the first driving device 3 drives the first piston 2 so that the material to be mixed passes through the discharge port of the first cylinder 1 and the connector 7 and enters the second cylinder 4. Then the first driving device 3 stops working, and the second driving device 6 starts working, driving the second piston 5 so that the material passes through the discharge port of the second cylinder 4 and the connector and enters the first cylinder 1. This process is repeated until the mixture is uniform. After the mixing is completed, the connector 7 is disconnected from the discharge port of the first cylinder 1, so that the material is discharged from the discharge port of the first cylinder 1.

[0041] The technical effect achieved by the above embodiment is: a double-piston mixing method is adopted, and the two cylinders are used in conjunction with each other. The material to be mixed is driven by the piston to circulate and mix between the two cylinders for multiple times, so that the material can be mixed evenly, the mixing efficiency is high, and the effect is good. After the mixing is completed, the material is easy to discharge and not easy to remain, the discharge rate is high, and the material waste is small. In addition, there is no paddle stirring, which can avoid the inclusion of bubbles when high-viscosity materials are mixed.

[0042] Example 2

[0043] like Figure 3 As shown, different from Example 1, the center of the discharge port of the first cylinder body 1 is not located in the extension direction of the cylindrical axis of the first cylinder body 1; the center of the discharge port of the second cylinder body 4 is not located in the extension direction of the cylindrical axis of the second cylinder body 4, that is, the discharge port is set at an eccentric position.

[0044] The technical effect achieved by the above embodiment is that the discharge ports of the two cylinders are set at eccentric positions. Compared with setting them at central positions, when mixing materials, the difference in the velocities of each particle is greater, which is more conducive to mixing between materials and improves mixing efficiency.

[0045] Furthermore, a discharge pipe integrally formed with the first cylinder 1 is provided at the discharge port of the first cylinder 1, and a discharge pipe integrally formed with the second cylinder 4 is provided at the discharge port of the second cylinder 4, and the connector 7 is connected to the discharge port of the first cylinder 1 and the discharge port of the second cylinder 4 through the discharge pipe of the first cylinder 1 and the discharge pipe of the second cylinder 4. The one-piece design can increase the strength of the discharge pipe, thereby bearing a greater pushing force.

[0046] In addition, it should be noted that the discharge port of the first cylinder body 1 is consistent in size with the discharge port of the second cylinder body 4, and the discharge pipe of the first cylinder body 1 is consistent in diameter with the discharge pipe of the second cylinder body 4, so as to facilitate discharge docking.

[0047] Furthermore, one end of the connector 7 is sleeved on the outside of the discharge pipe of the first cylinder 1, and the other end is sleeved on the outside of the discharge pipe of the second cylinder 4. The two discharge pipes are arranged relative to each other, and can be completely connected or have a gap between them. The connector 7 is on the outside of the two discharge pipes, so that the material can reciprocate between the two discharge pipes.

[0048] The connector 7 can be connected to the two discharge pipes via threads.

[0049] Example 3

[0050] like Figure 4 As shown, different from Example 2, threaded sleeves 8 are provided on the outer sides of the discharge port of the first cylinder body 1 and the discharge port of the second cylinder body 4, and external threads are provided at both ends of the connector 7. The connector 7 is connected to the threaded sleeves 8 through the external threads at both ends, so that the connector 7 is sleeved on the discharge pipe of the first cylinder body 1 and the discharge pipe of the second cylinder body 4. The threaded connection not only meets the requirements of being strong and durable, but also makes the structure simple and easy to use.

[0051] Example 4

[0052] like Figure 5 and 6 As shown, different from Example 3, a screen 9 is installed at the center of the connector 7. The connector 7 includes a discharge pipe sleeve section 71 with the first cylinder body 1 and a discharge pipe sleeve section 72 with the second cylinder body 4. The discharge pipe sleeve section 71 with the first cylinder body 1 and the discharge pipe sleeve section 72 with the second cylinder body 4 are connected by a flange or a clamp 73, and a screen 9 is clamped in the flange or the clamp 73. The screen 9 can be replaced according to different mesh numbers.

[0053] The utility model adds a detachable and replaceable screen 9 to the mixing device, which can not only greatly compress the material when passing through the screen 9, intensify the diffusion of the internal material and promote mixing, but also meet the demand for material particle size in actual production.

[0054] For example, in the preparation process of sodium hyaluronate cross-linked gel, the gel obtained by the cross-linking reaction needs to be sieved through a 100-mesh, 200-mesh or 500-mesh sieve to obtain gels of different particle sizes. By adding a sieve 9 to the mixing device, the material sieving operation is conveniently completed through the squeezing effect of the first piston 2 or the second piston 5 during sieving.

[0055] Furthermore, the first cylinder body 1, the second cylinder body 4 and the connector 7 are all made of stainless steel, and the first piston 2 and the second piston 5 are both made of ceramic. In the production process of medicines, there are strict requirements on the materials that contact the medicines. The surfaces of stainless steel and ceramic materials are smooth, flat, and easy to clean, which can meet the production requirements.

[0056] Example 5

[0057] like Figure 7 As shown, different from the embodiment 4, the cylinder diameter of the first cylinder body 1 is larger than the cylinder diameter of the second cylinder body 4, and the cylinder volume of the first cylinder body 1 is the same as that of the second cylinder body 4. This arrangement can make the first cylinder body 1 more convenient to add materials.

[0058] In this embodiment, the mixing device further comprises a bracket 10, which is used to keep the first cylinder body 1 and the second cylinder body 4 in an upright position, so that the first cylinder body 1 is convenient for adding materials and the materials are convenient for discharging after mixing.

[0059] The mixing devices disclosed in Examples 1-5 are more suitable for the mixing step in the preparation process of sodium hyaluronate cross-linked gel and the mixing step in the preparation process of cross-linked sodium hyaluronate composite solution. At the same time, they are also suitable for mixing other materials with relatively high viscosity.

Claims

1. A double piston mixing device, characterized in that: The invention comprises a first cylinder (1), a first piston (2), a first driving device (3), a second cylinder (4), a second piston (5), a second driving device (6) and a connector (7). The first cylinder body (1) and the second cylinder body (4) are both hollow cylinders, and are provided with a discharge port at one end and an opening at the other end. The discharge port of the first cylinder body (1) and the discharge port of the second cylinder body (4) are connected via the connector (7), so that the discharge port of the first cylinder body (1) and the discharge port of the second cylinder body (4) are connected. The first piston (2) is placed in the first cylinder (1) through an opening of the first cylinder (1) and is connected to a first driving device (3) outside the first cylinder (1), wherein the first driving device (3) is used to drive the first piston (2) to reciprocate in the first cylinder (1); The second piston (5) is placed in the second cylinder (4) through the opening of the second cylinder (4) and is connected to a second driving device (6) outside the second cylinder (4), and the second driving device (6) is used to drive the second piston (5) to reciprocate in the second cylinder (4); the discharge port of the first cylinder (1) is circular, and the diameter of the discharge port of the first cylinder (1) is smaller than the diameter of the cylinder of the first cylinder (1); the discharge port of the second cylinder (4) is circular, and the diameter of the discharge port of the second cylinder (4) is smaller than the diameter of the cylinder of the second cylinder (4).

2. The mixing device according to claim 1, characterized in that The center of the discharge port of the first cylinder (1) is not located in the extension direction of the cylindrical axis of the first cylinder (1); the center of the discharge port of the second cylinder (4) is not located in the extension direction of the cylindrical axis of the second cylinder (4).

3. The mixing device according to claim 1, characterized in that The discharge port of the first cylinder body (1) is provided with a discharge pipe integrally formed with the first cylinder body (1), and the discharge port of the second cylinder body (4) is provided with a discharge pipe integrally formed with the second cylinder body (4), and the connector (7) is connected to the discharge port of the first cylinder body (1) and the discharge port of the second cylinder body (4) via the discharge pipe of the first cylinder body (1) and the discharge pipe of the second cylinder body (4).

4. The mixing device according to claim 3, characterized in that One end of the connector (7) is sleeved on the outside of the discharge pipe of the first cylinder (1), and the other end is sleeved on the outside of the discharge pipe of the second cylinder (4).

5. The mixing device according to claim 4, characterized in that The outer side of the discharge port of the first cylinder (1) and the outer side of the discharge port of the second cylinder (4) are both provided with threaded sleeves (8), and both ends of the connector (7) are provided with external threads. The connector (7) is connected to the threaded sleeves (8) via the external threads at both ends, so that the connector (7) is sleeved on the outer side of the discharge pipe of the first cylinder (1) and the discharge pipe of the second cylinder (4).

6. The mixing device according to any one of claims 1 to 5, characterized in that A screen (9) is installed at the center of the connector (7).

7. The mixing device according to claim 6, characterized in that The connector (7) comprises a discharge pipe sleeve section (71) connected to the first cylinder body (1) and a discharge pipe sleeve section (72) connected to the second cylinder body (4), and is connected to the discharge pipe sleeve section (71) of the first cylinder body (1) and the discharge pipe sleeve section (72) of the second cylinder body (4) via a flange or a clamp (73), and a screen (9) is clamped in the flange or the clamp (73).

8. The mixing device according to claim 7, characterized in that The sieve (9) is replaced according to different mesh sizes.

9. The mixing device according to claim 1, characterized in that The cylindrical diameter of the first cylinder (1) is greater than the cylindrical diameter of the second cylinder (4), and the cylindrical volumes of the first cylinder (1) and the second cylinder (4) are the same.

10. The mixing device according to claim 1, characterized in that It also comprises a bracket (10), wherein the bracket (10) is used to place the first cylinder body (1) and the second cylinder body (4) in an upright position.

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