Sample detection apparatus

Abstract

The utility model discloses sample detection equipment which comprises a plurality of sample detection modules which are sequentially arranged along the X direction, each sample detection module comprises a rack, a pushing mechanism, a processing mechanism, a detection mechanism and a pipetting mechanism, the rack is provided with a base, and the base is sequentially provided with a processing area and a detection area along the Y direction; the pushing mechanism is arranged on the base and is used for driving the loaded kits to move; the treatment mechanism is arranged in the treatment area and is used for carrying out detection pretreatment on a sample in the kit; the detection mechanism is arranged in the detection area and is used for detecting the treated sample in the kit; the pipetting mechanism is arranged above the processing area and is used for sucking samples or reagents in the kit and transferring the samples or the reagents. In the sample detection module, a plurality of functional mechanisms are closely arranged, the size is small, the occupied space is small, and in the sample detection equipment, a plurality of sample detection modules can respectively detect samples in a plurality of kits, so that the detection efficiency and the space utilization rate are greatly improved.

Description

Technical Field

[0001] The utility model belongs to the technical field of sample detection, and in particular relates to a sample detection device. Background Art

[0002] Molecular diagnosis is the foundation of precision medicine and the fastest growing track in in vitro diagnostic technology. Molecular diagnosis can be applied to a wide range of diseases, including the detection and diagnosis of tumors, genetic diseases, infectious diseases, etc. Nucleic acid detection equipment using molecular diagnostic methods has gradually become the mainstream detection method for in vitro diagnosis due to its advantages of good sensitivity, high accuracy and short detection time.

[0003] Nucleic acid testing equipment generally uses PCR (Polymerase Chain Reaction) technology to detect nucleic acids. Before testing, other functional components in the equipment are also needed to extract, transfer, mix and perform other pre-testing pretreatments on the samples in the test kit. The large number of functional components in the nucleic acid testing equipment results in a large overall size of the nucleic acid testing equipment, which occupies a lot of space, and can only test samples in one test kit at a time, resulting in low detection efficiency. Utility Model Content

[0004] In view of the above-mentioned defects or shortcomings, the utility model provides a sample detection device, aiming to solve the technical problems that the existing nucleic acid detection equipment occupies a lot of space and has low detection efficiency.

[0005] In order to achieve the above object, the utility model provides a sample detection device, which includes a plurality of sample detection modules arranged in sequence along the X direction, each sample detection module includes:

[0006] The frame is provided with a base, and a processing area and a detection area are sequentially provided on the base along the Y direction;

[0007] A pushing mechanism, disposed on the base and used to drive the loaded reagent kit to move;

[0008] A processing mechanism, which is located in the processing area and is used to perform pre-test processing on the samples in the test kit;

[0009] A testing mechanism, which is located in the testing area and is used to test the samples processed in the test kit;

[0010] The liquid transfer mechanism is arranged on the frame and located above the processing area. The liquid transfer mechanism is used to absorb the sample or reagent in the test kit and transfer it.

[0011] In an embodiment of the utility model, the pushing mechanism includes a loading seat and a sliding drive assembly, the loading seat is provided with a card slot for placing the test kit, the sliding drive assembly is drivingly connected to the loading seat and is used to drive the loading seat to move; the processing mechanism includes an ultrasonic transducer, a magnetic suction component and a lifting drive assembly, the lifting drive assembly is drivingly connected to the ultrasonic transducer and the magnetic suction component respectively and is used to drive the ultrasonic transducer and the magnetic suction component to rise and fall, an ultrasonic avoidance hole for the ultrasonic transducer to pass through and a magnetic avoidance hole for the magnetic suction component to pass through are provided on the bottom wall of the card slot, the ultrasonic transducer is used to perform ultrasonic processing on the samples in the test kit, and the magnetic suction component is used to perform magnetic processing on the samples in the test kit.

[0012] In an embodiment of the utility model, the lifting drive assembly includes a lifting seat and a lifting drive member, the ultrasonic transducer and the magnetic attraction member are both arranged on the lifting seat, and the lifting drive member is connected to the base and is used to drive the lifting seat to rise and fall.

[0013] In an embodiment of the utility model, the sliding drive assembly includes a rack, a gear set and a sliding drive member, the loading seat is connected to the rack, the sliding drive member is arranged on the frame, and the rack and the sliding drive member are driven and connected by the gear set.

[0014] In an embodiment of the utility model, the pushing mechanism also includes a sliding guide assembly, which includes a first slide rail, a first slider, a second slide rail and a second slider. The first slide rail is connected to the rack and is consistent with the extension direction of the rack. The second slide rail is connected to the side of the loading seat facing away from the rack. The first slider and the second slider are both arranged on the frame, and the first slider and the second slider are respectively slidably connected to the first slide rail and the second slide rail one by one.

[0015] In the embodiment of the utility model, a heating plate is provided on the bottom wall of the card slot, and the heating plate is used to heat the reagent box. A heating positioning block is provided on the heating plate, and the heating positioning block is used to position and cooperate with the reagent box.

[0016] In an embodiment of the utility model, the pipetting mechanism includes a pipetting pump, a rotating seat, a movable drive assembly and a rotating drive assembly. The pipetting pump is arranged on the rotating seat and is used to absorb samples or reagents in the test kit. The movable drive assembly and the rotating drive assembly are both arranged on the frame and are both driven and connected to the rotating seat. The movable drive assembly is used to drive the rotating seat to rise and fall, and the rotating drive assembly is used to drive the rotating seat to rotate.

[0017] In an embodiment of the utility model, the mobile driving assembly includes a mobile plate and a mobile driving member. The mobile plate is provided with an installation opening, the rotating seat is rotatably arranged in the installation opening, and the mobile driving member is arranged on the frame and is used to drive the mobile plate to rise and fall.

[0018] In an embodiment of the utility model, the rotary drive assembly includes a driving gear, a driven gear and a rotary drive member, the rotary drive member is arranged on the movable plate, the driving gear is drivingly connected to the driving end of the rotary drive member, and the driven gear is arranged on the rotating seat and drivingly connected to the driving gear.

[0019] In an embodiment of the utility model, the frame also includes a frame body, a first partition plate and a second partition plate. The frame body is connected to the base, the first partition plate is vertically arranged on the frame body, and two sides of the first partition plate respectively form a processing area and a detection area, the detection mechanism is provided with a detection port for inserting the reaction tube of the test kit, and a detection avoidance hole is opened on the first partition plate at a position corresponding to the detection port. The second partition plate is horizontally arranged on the frame body and connected to the upper end of the first partition plate, and an installation area for installing the pipetting mechanism is formed on the upper side of the second partition plate.

[0020] Through the above technical solution, the sample detection device provided by the embodiment of the utility model has the following beneficial effects:

[0021] In the technical solution of the utility model, the sample detection equipment includes a plurality of sample detection modules, and the plurality of sample detection modules are arranged in sequence along the X direction, the sample detection module includes a frame provided with a base, a processing area and a detection area are formed on the base, and the processing area and the detection area are arranged in sequence along the Y direction, a processing mechanism capable of performing ultrasonic and magnetic treatment on the sample is arranged in the processing area, a pipetting mechanism capable of transferring the sample and the reagent is arranged on the upper side of the processing area, a detection mechanism capable of detecting the sample is arranged in the detection area, the pushing mechanism can drive the reagent box to move along the Y direction to push the reagent box to the processing area for sample extraction, transfer, mixing, ultrasonic and magnetic treatment, and the pushing mechanism can also drive the reagent box to move along the Y direction until the reaction tube of the reagent box is docked with the detection mechanism in the detection area, and the detection mechanism can detect the sample after the sample processing in the reagent box is completed. In the sample detection module, the processing area and the detection area are arranged in sequence along the Y direction, and the pipetting mechanism is arranged on the upper side of the processing area, so that the multiple functional mechanisms of the sample detection module are arranged tightly, with a small volume and a small occupied space. In the sample detection device, multiple sample detection modules are arranged in sequence along the X direction, so that multiple sample detection modules can respectively perform synchronous detection on samples in multiple test kits, and each sample detection module does not interfere with each other, which greatly improves the detection efficiency and space utilization.

[0022] Other features and advantages of the embodiments of the present invention will be described in detail in the subsequent specific implementation section. BRIEF DESCRIPTION OF THE DRAWINGS

[0023] The accompanying drawings are used to provide a further understanding of the embodiments of the present utility model and constitute a part of the specification. Together with the following specific embodiments, they are used to explain the embodiments of the present utility model, but do not constitute a limitation on the embodiments of the present utility model. For ordinary technicians in this field, other drawings can be obtained based on the structures shown in these drawings without creative work. In the drawings:

[0024] Figure 1 It is a structural schematic diagram of a sample detection device according to an embodiment of the utility model;

[0025] Figure 2 It is a structural schematic diagram of a sample detection module according to an embodiment of the utility model at a viewing angle;

[0026] Figure 3 is a schematic structural diagram of a sample detection module according to an embodiment of the utility model at another viewing angle;

[0027] Figure 4 It is a partial structural schematic diagram of a sample detection module according to an embodiment of the utility model;

[0028] Figure 5 It is a schematic diagram of the assembly structure of the pushing mechanism and the processing mechanism in the sample detection module according to an embodiment of the utility model;

[0029] Figure 6 It is a schematic diagram of the decomposed structure of the pushing mechanism and the processing mechanism in the sample detection module according to an embodiment of the utility model;

[0030] Figure 7 It is a structural schematic diagram of a liquid transfer mechanism in a sample detection module according to an embodiment of the utility model;

[0031] Figure 8 It is a schematic structural diagram of a test kit according to an embodiment of the utility model.

[0032] Description of Reference Numerals

[0033] 10 Sample detection module 36 Second slider

[0034] 20 racks 40 handling mechanisms

[0035] 21 base 41 ultrasonic transducer

[0036] 22 Processing area 42 Magnetic parts

[0037] 23 Detection area 43 Lifting drive assembly

[0038] 24 frame body 431 lifting seat

[0039] 25 first partition plate 432 lifting drive member

[0040] 251 Detection avoidance hole 44 Fixing bracket

[0041] 26 Second partition plate 45 Elastic member

[0042] 27 Mounting area 46 Guide rod

[0043] 28 third partition plate 50 detection mechanism

[0044] 30 Pushing mechanism 51 Detection port

[0045] 31 Loading seat 60 Liquid transfer mechanism

[0046] 311 Card slot 61 Pipette pump

[0047] 312 Ultrasonic avoidance hole 62 Rotating seat

[0048] 313 Magnetic avoidance hole 63 Mobile drive assembly

[0049] 314 heating plate 631 moving plate

[0050] 315 Heating positioning block 632 Moving drive part

[0051] 32 Sliding drive assembly 633 mounting port

[0052] 321 rack 64 rotation drive assembly

[0053] 322 gear set 641 driving gear

[0054] 3221 First gear 642 Driven gear

[0055] 3222 second gear 643 rotation drive member

[0056] 323 Sliding drive 65 Claw

[0057] 33 First Slide 200 Kit

[0058] 34 First slider 201 Reaction tube

[0059] 35 Second slide rail DETAILED DESCRIPTION

[0060] The specific implementation of the present invention is described in detail below in conjunction with the accompanying drawings. It should be understood that the specific implementation described here is only used to illustrate and explain the present invention, and is not used to limit the present invention.

[0061] The sample detection device of the present invention is described below with reference to the accompanying drawings.

[0062] like Figures 1 to 4 As shown, the utility model provides a sample detection device, which includes a plurality of sample detection modules 10 arranged in sequence along the X direction, each sample detection module 10 includes a frame 20, a pushing mechanism 30, a processing mechanism 40, a detection mechanism 50 and a pipetting mechanism 60, the frame 20 is provided with a base 21, and a processing area 22 and a detection area 23 are arranged in sequence along the Y direction on the base 21, the X direction is the left-right direction, and the Y direction is the front-back direction; the pushing mechanism 30 is arranged on the base 21 and is used to drive the loaded reagent kit 200 to move; the processing mechanism 40 is arranged in the processing area 22 and is used to perform pre-detection processing on the sample in the reagent kit 200; the detection mechanism 50 is arranged in the detection area 23 and is used to detect the processed sample in the reagent kit 200; the pipetting mechanism 60 is arranged on the frame 20 and is located above the processing area 22, and the pipetting mechanism 60 is used to absorb the sample or reagent in the reagent kit 200 and transfer it.

[0063] Specifically, the sample detection device includes a plurality of sample detection modules 10, and the plurality of sample detection modules 10 are arranged in sequence along the X direction. The sample detection module 10 includes a frame 20 provided with a base 21, a processing area 22 and a detection area 23 are formed on the base 21, and the processing area 22 and the detection area 23 are arranged in sequence along the Y direction. A processing mechanism 40 capable of performing pre-detection processing on the sample is arranged in the processing area 22, a pipetting mechanism 60 capable of transferring the sample and the reagent is arranged on the upper side of the processing area 22, a detection mechanism 50 capable of detecting the sample is arranged in the detection area 23, the pushing mechanism 30 can drive the reagent box 200 to move along the Y direction, so as to push the reagent box 200 to the processing area 22 for sample extraction, transfer, mixing, ultrasonic and magnetic absorption and other processing, and the pushing mechanism 30 can also drive the reagent box 200 to move along the Y direction until the reaction tube 201 of the reagent box 200 is docked with the detection mechanism 50 in the detection area 23, and the detection mechanism 50 can detect the sample after the sample processing in the reagent box 200 is completed. In the sample detection module 10, the processing area 22 and the detection area 23 are arranged in sequence along the Y direction, and the pipetting mechanism 60 is provided on the upper side of the processing area 22, so that the multiple functional mechanisms of the sample detection module 10 are arranged tightly, with a small volume and a small occupied space. In the sample detection device, multiple sample detection modules 10 are arranged in sequence along the X direction, so that the multiple sample detection modules 10 can respectively perform synchronous detection on the samples in the multiple test kits 200, and each sample detection module 10 does not interfere with each other, which greatly improves the detection efficiency and space utilization.

[0064] In the embodiment of the utility model, the pushing mechanism 30 includes a loading seat 31 and a sliding drive assembly 32. The loading seat 31 is provided with a card slot 311 for placing the reagent kit 200. The sliding drive assembly 32 is drivingly connected to the loading seat 31 and is used to drive the loading seat 31 to move; the processing mechanism 40 includes an ultrasonic transducer 41, a magnetic suction member 42 and a lifting drive assembly 43. The lifting drive assembly 43 is drivingly connected to the ultrasonic transducer 41 and the magnetic suction member 42 respectively and is used to drive the ultrasonic transducer 41 and the magnetic suction member 42 to rise and fall. An ultrasonic avoidance hole 312 for the ultrasonic transducer 41 to pass through and a magnetic avoidance hole 313 for the magnetic suction member 42 to pass through are provided on the bottom wall of the card slot 311. The ultrasonic transducer 41 is used to perform ultrasonic treatment on the sample in the reagent kit 200 and the magnetic suction member 42 is used to perform magnetic treatment on the sample in the reagent kit 200.

[0065] like Figures 2 to 6 As shown, the ultrasonic transducer 41 can adopt the ultrasonic lysis instrument in the prior art, and the magnetic suction member 42 can adopt the magnet in the prior art. The processing mechanism 40 has two pre-test processing functions of magnetic suction and ultrasonic lysis. When the sample in the reagent box 200 needs to be subjected to ultrasonic and magnetic suction treatment, the sliding drive component 32 drives the loading seat 31 to drive the reagent box 200 placed in the card slot 311 to move to the processing area 22, and the lifting drive component 43 drives the ultrasonic transducer 41 and the magnetic suction member 42 to rise, so that the ultrasonic head of the ultrasonic transducer 41 performs ultrasonic treatment on the sample, and the magnetic suction member 42 absorbs the magnetic beads in the reagent box 200 to perform magnetic treatment on the sample. The processing mechanism 40 installs the ultrasonic transducer 41 and the magnetic suction member 42 in the processing area 22, and both are driven to rise and fall by the lifting drive component 43, which saves internal space, and does not require additional instruments for ultrasonic treatment, simplifies the sample extraction process, and improves the detection efficiency.

[0066] Furthermore, the lifting drive assembly 43 includes a lifting seat 431 and a lifting drive member 432. The ultrasonic transducer 41 and the magnetic member 42 are both arranged on the lifting seat 431. The lifting drive member 432 is connected to the base 21 and is used to drive the lifting seat 431 to move up and down. Figures 2 to 6 As shown, the ultrasonic transducer 41 and the magnetic attraction member 42 are arranged on the lifting seat 431 at intervals along the Y direction, and the lifting drive member 432 and the ultrasonic transducer 41 are arranged on the lifting seat 431 at intervals along the X direction, which can avoid interference between the various components and have a compact arrangement, reducing the occupied space.

[0067] In the embodiment of the utility model, the processing mechanism 40 further includes a pressure regulating assembly, which includes a fixing frame 44, an elastic member 45 and a guide rod 46. The fixing frame 44 is arranged at intervals on the upper side of the lifting seat 431 and is connected to the lifting seat 431 through the guide rod 46, and the lower end of the guide rod 46 can telescopically pass through the lifting seat 431. The ultrasonic transducer 41 passes through the fixing frame 44 and is connected to the fixing frame 44. The elastic member 45 is sleeved on the outer side of the guide rod 46. Figures 2 to 6 As shown, when the lifting drive 432 drives the lifting seat 431 to rise, the lifting seat 431 drives the ultrasonic transducer 41 to abut the reagent box 200 through the fixing frame 44, and then the lifting drive 432 continues to drive the lifting seat 431 upward, and the lifting seat 431 can compress the elastic member 45 upward, and the elastic member 45 can apply an elastic pressing force to the fixing frame 44. In the process of the lifting seat 431 continuously rising, the elastic pressing force can be increased. When the elastic pressing force needs to be reduced, the lifting seat 431 can be driven down by the lifting drive 432, thereby reducing the compression of the elastic member 45 and reducing the elastic pressing force. The pressure regulating assembly drives the lifting seat 431 to rise and fall through the lifting drive 432 to increase or decrease the compression of the elastic member 45 and adjust the elastic pressing force. The structure is simple and easy to assemble, and the guide rod 46 can play a role in guiding the lifting and lowering, thereby improving the smoothness of the lifting and lowering.

[0068] In the embodiment of the utility model, the sliding drive assembly 32 includes a rack 321, a gear set 322 and a sliding drive member 323. The loading seat 31 is connected to the rack 321. The sliding drive member 323 is arranged on the frame 20. The rack 321 and the sliding drive member 323 are connected by the gear set 322. Figures 2 to 6 As shown, the sliding drive member 323 is arranged on the frame 20, and the gear group 322 is respectively connected to the driving end of the sliding drive member 323 and the rack 321, and the loading seat 31 is arranged on the rack 321, so that the sliding drive member 323 can drive the loading seat 31Y to move through the gear group 322 and the rack 321, thereby driving the reagent box 200 to move to the processing area 22 to process the sample and move to the reaction tube 201 of the reagent box 200 to dock with the detection mechanism 50; and the gear group 322 includes a first gear 3221 and a second gear 3222 that are meshed with each other, the first gear 3221 is connected to the driving end of the sliding drive member 323, and the second gear 3222 is meshed with the rack 321, thereby realizing the driving of the rack 321, and the structure is compact, which improves the space utilization.

[0069] Furthermore, the pushing mechanism 30 also includes a sliding guide assembly, which includes a first slide rail 33, a first slider 34, a second slide rail 35 and a second slider 36. The first slide rail 33 is connected to the rack 321 and is consistent with the extension direction of the rack 321. The second slide rail 35 is connected to the side of the loading seat 31 facing away from the rack 321. The first slider 34 and the second slider 36 are both arranged on the frame 20, and the first slider 34 and the second slider 36 are respectively slidably connected to the first slide rail 33 and the second slide rail 35 in a one-to-one correspondence.

[0070] like Figures 2 to 6 As shown, the first slider 34 and the second slider 36 are respectively arranged on both sides of the frame 20 and are arranged opposite to each other, the first slide rail 33 and the second slide rail 35 are respectively arranged on both sides of the loading seat 31, the first slide rail 33 is connected to the rack 321 and slidably cooperates with the first slider 34, and the second slide rail 35 slidably cooperates with the second slider 36, so that the rack 321 can drive the first slide rail 33 to slide relative to the first slider 34, and drive the second slide rail 35 to slide relative to the second slider 36 through the loading seat 31, thereby improving the smoothness of movement of the loading seat 31.

[0071] In the embodiment of the utility model, the bottom wall of the card slot 311 is provided with a heating plate 314, the heating plate 314 is used to heat the reagent box 200, and the heating plate 314 is provided with a heating positioning block 315, the heating positioning block 315 is used to position and cooperate with the reagent box 200. Figures 2 to 6 As shown, the heating positioning block 315 can position the reagent box 200, and the heating plate 314 is arranged corresponding to the heating positioning block 315, so that the heating plate 314 can heat the sample in the reagent box 200, and the pushing mechanism 30 can not only drive the reagent box 200 to move back and forth along the Y direction, but also heat the sample in the reagent box 200, thereby realizing a high degree of integration of multiple functions and expanding the application scenarios of the sample detection module 10.

[0072] In an embodiment of the utility model, the pipetting mechanism 60 includes a pipetting pump 61, a rotating seat 62, a moving drive assembly 63 and a rotating drive assembly 64. The pipetting pump 61 is disposed on the rotating seat 62 and is used to absorb samples or reagents in the reagent kit 200. The moving drive assembly 63 and the rotating drive assembly 64 are both disposed on the frame 20 and are both driven and connected to the rotating seat 62. The moving drive assembly 63 is used to drive the rotating seat 62 to rise and fall, and the rotating drive assembly 64 is used to drive the rotating seat 62 to rotate.

[0073] like Figure 4 , Figure 7 and Figure 8As shown, the pump head of the pipette pump 61 can pick up the pipette tip to absorb the sample through the pipette tip. The pipette pump 61 is arranged on the rotating seat 62. The moving drive component 63 can drive the rotating seat 62 to rise and fall, and the rotating drive component 64 can drive the rotating seat 62 to rotate, so that the rotating seat 62 can drive the pump head and the pipette tip of the pipette pump 61 to rotate to a position corresponding to any hole position of the reagent box 200, and drive the pipette tip to extend into the hole position to extract, transfer and mix the sample or reagent, and the pump head of the hydraulic pump can also pick up the plunger and drive the plunger to extend into the plunger hole of the reagent box 200 to inject the processed sample into the reaction tube 201 of the reagent box 200, so that the detection mechanism 50 detects the sample in the reaction tube 201; the pipette mechanism 60 extracts the sample by driving the pipette pump 61 to rotate, which greatly saves the installation space compared with the traditional method of lateral movement of the pipette pump 61, and the structural arrangement is more compact, which improves the space utilization rate.

[0074] Furthermore, the mobile driving assembly 63 includes a mobile plate 631 and a mobile driving member 632. The mobile plate 631 is provided with a mounting opening 633. The rotating seat 62 is rotatably disposed in the mounting opening 633. The mobile driving member 632 is disposed on the frame 20 and is used to drive the mobile plate 631 to move up and down. Figure 4 , Figure 7 and Figure 8 As shown, the mobile driving member 632 can adopt the screw motor in the prior art, and the mobile driving member 632 is arranged on the upper side of the detection area 23. The moving plate 631 is drivingly connected to the mobile driving member 632 and extends from the upper side of the detection area 23 to the upper side of the processing area 22. A mounting port 633 is opened on the moving plate 631 at the upper side of the detection area 23. The rotating seat 62 is arranged in the mounting port 633 and can rotate in the mounting port 633, so that the mobile driving member 632 can drive the rotating seat 62 to rise and fall through the moving plate 631, and then the rotating seat 62 drives the pipette pump 61 and the pipette tip to rise and fall to complete the transfer of samples and reagents; the mobile driving component 63 is arranged on the upper side of the processing mechanism 40 and the detection mechanism 50 along the Z direction, and the structural arrangement is compact, which reduces the volume and size of the sample detection module 10.

[0075] In the embodiment of the utility model, the rotary drive assembly 64 includes a driving gear 641, a driven gear 642 and a rotary drive member 643, the rotary drive member 643 is arranged on the moving plate 631, the driving gear 641 is drivingly connected to the driving end of the rotary drive member 643, and the driven gear 642 is arranged on the rotating seat 62 and drivingly connected to the driving gear 641. Figure 4 , Figure 7 and Figure 8As shown, the rotary drive member 643 is installed on the moving plate 631, the driving gear 641 and the driven gear 642 are meshed with each other, the driving gear 641 is connected to the driving end of the rotary drive member 643, and the driven gear 642 is connected to the upper end of the rotating seat 62, so that the rotary drive member 643 can drive the rotating seat 62 to rotate through the driving gear 641 and the driven gear 642, and then drive the pump head of the liquid transfer pump 61 to rotate to a position corresponding to any hole position of the reagent box 200; the lifting drive member 432, the rotary drive assembly 64 and the rotating seat 62 are arranged in sequence along the Y direction, which reasonably utilizes the internal space of the sample detection module 10, making the overall structure of the sample detection module 10 more compact. In addition, at least two spaced claws 65 are also provided on the rotating seat 62, and the rotating seat 62 can drive the claws 65 to extend into the reagent box 200 to drive the reagent box 200 to rotate in the card slot 311, realizing the high integration of multiple functions of the liquid transfer mechanism 60 and expanding the application scenarios of the sample detection module 10.

[0076] In an embodiment of the utility model, the frame 20 also includes a frame body 24, a first partition plate 25 and a second partition plate 26. The frame body 24 is connected to the base 21. The first partition plate 25 is vertically arranged on the frame body 24, and the two sides of the first partition plate 25 respectively form a processing area 22 and a detection area 23. The detection mechanism 50 is provided with a detection port 51 for inserting the reaction tube 201 of the reagent kit 200. A detection avoidance hole 251 is opened at a position corresponding to the detection port 51 on the first partition plate 25. The second partition plate 26 is horizontally arranged on the frame body 24 and connected to the upper end of the first partition plate 25. The upper side of the second partition plate 26 is formed with an installation area 27 for installing the pipetting mechanism 60.

[0077] like Figures 1 to 4As shown, the frame 20 includes a frame body 24 and a base 21, the frame body 24 is installed on the base 21, and a processing area 22 and a detection area 23 are formed on the base 21 along the Y direction. The first partition plate 25 is vertically arranged and connected to the frame body 24, so that the processing area 22 and the detection area 23 are distributed on both sides of the first partition plate 25, and the second partition plate 26 is connected to the upper end of the first partition plate 25 and is horizontally arranged. The processing area 22 and the detection area 23 are both located on the lower side of the second partition plate 26, and an installation area 27 is formed on the upper side of the second partition plate 26. The processing area 22, the detection area 23 and the installation area 27 are respectively used for the installation of the processing mechanism 40, the detection mechanism 50 and the pipetting mechanism 60, and the pushing mechanism 30 can drive the reagent kit 200 to move along the Y direction to the processing area 22. Multiple functional mechanisms are compactly arranged and reasonably laid out, so that the overall size and volume of the sample detection module 10 are small, which greatly reduces the occupied space and improves the space utilization rate. In addition, the frame 20 also includes a third partition plate 28, which is horizontally arranged and disposed on the upper side of the processing mechanism 40. The third partition plate 28 is used to separate the processing mechanism 40 and the loading seat 31. The first partition plate 25, the second partition plate 26 and the third partition plate 28 cooperate to realize the partitioning of multiple functional mechanisms. The structural layout is reasonable, which is convenient for later maintenance and inspection.

[0078] In the embodiment of the present utility model, Figures 1 to 8As shown, the sample detection device is suitable for extracting and detecting samples in multiple reagent kits 200, and each sample detection module 10 can perform fully automatic detection on the samples in the reagent kit 200, the sliding drive component 32 drives the loading seat 31 to move along the Y direction to the warehouse exit position, and the reagent kit 200 containing reagents and samples to be detected is placed in the card slot 311, and when the sensor arranged on the loading seat 31 detects that the reagent kit 200 is put in place, the sliding drive component 32 drives the loading seat 31 to drive the reagent kit 200 to move along the Y direction to the processing area 22, the rotating drive component 64 drives the rotating seat 62 to drive the pump head of the pipette pump 61 to rotate, and the moving drive component 63 drives the rotating seat 62 to drive the pump head of the pipette pump 61 to rise and fall, so that the pump head of the pipette pump 61 picks up the pipette tip and extracts, transfers, and mixes the sample and reagent through the rotation of the pipette tip, the ultrasonic transducer 41 performs ultrasonic treatment on the sample in the reagent kit 200, and the magnetic suction component 42 performs magnetic suction treatment on the sample in the reagent kit 200, After the processing is completed, the pump head of the pipette pump 61 picks up the sealing plug by rotating and lifting to seal the processed sample, and then the pump head of the pipette pump 61 picks up the plunger by rotating and lifting, and inserts the plunger into the plunger hole of the reagent kit 200, and then presses the processed sample into the reaction tube 201 of the reagent kit 200, and the loading seat 31 drives the reaction tube 201 to pass through the detection avoidance hole 251 and insert it into the detection port 51 of the detection mechanism 50, so that the detection mechanism 50 performs PCR amplification and optical detection on the sample and obtains the sample detection result, and after the detection is completed, the sliding drive assembly 32 drives the loading seat 31 to drive the reagent kit 200 to move in the opposite direction to the warehouse exit position, and the reagent kit 200 can be taken out, realizing fully automated detection of samples, effectively preventing sample contamination caused by contact between samples and the environment during the detection process, and multiple sample detection modules 10 can synchronously detect multiple samples, with high detection efficiency, and the functional mechanism of each sample detection module 10 is compactly arranged, with high functional integration and small space occupation.

[0079] In the description of the present invention, it should be understood that the terms "first" and "second" are used for descriptive purposes only and should not be understood as indicating or implying relative importance or implicitly indicating the number of technical features indicated. Therefore, a feature defined as "first" or "second" may explicitly or implicitly include at least one of the features. In the description of the present invention, "plurality" means at least two, such as two, three, etc., unless otherwise clearly and specifically defined.

[0080] In the present invention, unless otherwise clearly specified and limited, the terms "installed", "connected", "connected", "fixed" and the like should be understood in a broad sense, for example, it can be a fixed connection, a detachable connection, or an integral one; it can be a mechanical connection, an electrical connection, or communication with each other; it can be a direct connection, or an indirect connection through an intermediate medium, it can be the internal connection of two elements or the interaction relationship between two elements, unless otherwise clearly defined. For ordinary technicians in this field, the specific meanings of the above terms in the present invention can be understood according to specific circumstances.

[0081] In the description of this specification, the description with reference to the terms "one embodiment", "some embodiments", "example", "specific example", or "some examples" etc. means that the specific features, structures, materials or characteristics described in conjunction with the embodiment or example are included in at least one embodiment or example of the utility model. In this specification, the schematic representations of the above terms do not necessarily refer to the same embodiment or example. Moreover, the specific features, structures, materials or characteristics described may be combined in any one or more embodiments or examples in a suitable manner. In addition, those skilled in the art may combine and combine the different embodiments or examples described in this specification and the features of the different embodiments or examples, without contradiction.

[0082] Although the embodiments of the present invention have been shown and described above, it can be understood that the above embodiments are exemplary and cannot be understood as limitations of the present invention. Ordinary technicians in the field can change, modify, replace and modify the above embodiments within the scope of the present invention.

Claims

1. A sample detection device, characterized in that: The sample detection device comprises a plurality of sample detection modules (10) arranged in sequence along the X direction, each of the sample detection modules (10) comprising: The frame (20) is provided with a base (21), and a processing area (22) and a detection area (23) are sequentially provided on the base (21) along the Y direction; A pushing mechanism (30) is disposed on the base (21) and is used to drive the loaded reagent box (200) to move; A processing mechanism (40), disposed in the processing area (22) and used for performing pre-test processing on the sample in the reagent kit (200); A detection mechanism (50), disposed in the detection area (23) and used to detect the processed sample in the reagent kit (200); The liquid transfer mechanism (60) is arranged on the frame (20) and located above the processing area (22). The liquid transfer mechanism (60) is used to absorb the sample or reagent in the reagent box (200) and transfer it.

2. The sample detection device according to claim 1, characterized in that: The pushing mechanism (30) comprises a loading seat (31) and a sliding drive assembly (32), wherein the loading seat (31) is provided with a slot (311) for placing the reagent kit (200), and the sliding drive assembly (32) is drivingly connected to the loading seat (31) and used to drive the loading seat (31) to move; the processing mechanism (40) comprises an ultrasonic transducer (41), a magnetic attraction member (42) and a lifting drive assembly (43), wherein the lifting drive assembly (43) is respectively connected to the ultrasonic transducer (41) and the magnetic attraction member (42). The magnetic attraction component (42) is driven and connected to drive the ultrasonic transducer (41) and the magnetic attraction component (42) to rise and fall. The bottom wall of the slot (311) is provided with an ultrasonic avoidance hole (312) for the ultrasonic transducer (41) to pass through and a magnetic avoidance hole (313) for the magnetic attraction component (42) to pass through. The ultrasonic transducer (41) is used to perform ultrasonic treatment on the sample in the reagent box (200), and the magnetic attraction component (42) is used to perform magnetic treatment on the sample in the reagent box (200).

3. The sample detection device according to claim 2, characterized in that: The lifting drive assembly (43) comprises a lifting seat (431) and a lifting drive member (432), the ultrasonic transducer (41) and the magnetic attraction member (42) are both arranged on the lifting seat (431), and the lifting drive member (432) is connected to the base (21) and is used to drive the lifting seat (431) to rise and fall.

4. The sample detection device according to claim 2, characterized in that: The sliding drive assembly (32) comprises a rack (321), a gear set (322) and a sliding drive member (323); the loading seat (31) is connected to the rack (321); the sliding drive member (323) is arranged on the frame (20); and the rack (321) and the sliding drive member (323) are drivingly connected via the gear set (322).

5. The sample detection device according to claim 4, characterized in that: The pushing mechanism (30) also includes a sliding guide assembly, which includes a first slide rail (33), a first slider (34), a second slide rail (35) and a second slider (36), wherein the first slide rail (33) is connected to the rack (321) and is consistent with the extension direction of the rack (321), the second slide rail (35) is connected to the side of the loading seat (31) facing away from the rack (321), the first slider (34) and the second slider (36) are both arranged on the frame (20), and the first slider (34) and the second slider (36) are respectively slidably connected to the first slide rail (33) and the second slide rail (35) in a one-to-one correspondence.

6. The sample detection device according to claim 2, characterized in that: A heating plate (314) is provided on the bottom wall of the card slot (311), and the heating plate (314) is used to heat the reagent box (200). A heating positioning block (315) is provided on the heating plate (314), and the heating positioning block (315) is used to position and cooperate with the reagent box (200).

7. The sample detection device according to any one of claims 1 to 6, characterized in that: The liquid transfer mechanism (60) comprises a liquid transfer pump (61), a rotating seat (62), a movable drive component (63) and a rotating drive component (64); the liquid transfer pump (61) is arranged on the rotating seat (62) and is used to absorb samples or reagents in the reagent box (200); the movable drive component (63) and the rotating drive component (64) are both arranged on the frame (20) and are both drivingly connected to the rotating seat (62); the movable drive component (63) is used to drive the rotating seat (62) to rise and fall, and the rotating drive component (64) is used to drive the rotating seat (62) to rotate.

8. The sample detection device according to claim 7, characterized in that: The mobile driving assembly (63) comprises a mobile plate (631) and a mobile driving member (632); the mobile plate (631) is provided with a mounting opening (633); the rotating seat (62) is rotatably arranged in the mounting opening (633); the mobile driving member (632) is arranged on the frame (20) and is used for driving the mobile plate (631) to move up and down.

9. The sample detection device according to claim 8, characterized in that: The rotary drive assembly (64) comprises a driving gear (641), a driven gear (642) and a rotary drive member (643); the rotary drive member (643) is arranged on the movable plate (631); the driving gear (641) is drivingly connected to a driving end of the rotary drive member (643); and the driven gear (642) is arranged on the rotating seat (62) and drivingly connected to the driving gear (641).

10. The sample detection device according to any one of claims 1 to 6, characterized in that: The frame (20) further comprises a frame body (24), a first partition plate (25) and a second partition plate (26); the frame body (24) is connected to the base (21); the first partition plate (25) is vertically arranged on the frame body (24); and the two sides of the first partition plate (25) respectively form the processing area (22) and the detection area (23); the detection mechanism (50) is provided with a detection port (51) for inserting the reaction tube (201) of the reagent kit (200); a detection avoidance hole (251) is provided on the first partition plate (25) at a position corresponding to the detection port (51); the second partition plate (26) is horizontally arranged on the frame body (24) and connected to the upper end of the first partition plate (25); and an installation area (27) for installing the pipetting mechanism (60) is formed on the upper side of the second partition plate (26).

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