Adjustable needle holder
By designing an adjustable needle holder including a sliding table and a hydraulic system, the problem of cumbersome adjustment steps and low freedom in the prior art is solved, and the high accuracy and flexibility adjustment of the microneedle is achieved, reducing the difficulty of experimental operation.
Patent Information
- Application Number
- CN202420601243.X
- Authority / Receiving Office
- CN · China
- Patent Type
- Utility models(China)
- Current Assignee / Owner
- Filing Date
- 2024-03-26
- Publication Date
- 2025-03-11
- Estimated Expiration
- 2034-03-26
AI Technical Summary
The prior art has cumbersome steps and low freedom when adjusting the position of the microneedle, which limits the flexibility of experimental operations and increases the difficulty of experimental operations.
An adjustable needle holder is designed, including a sliding table and a clamping mechanism fixed to the sliding table. Through the combination of a hydraulic system and a control lever, the microneedle is accurately adjusted in multiple directions.
It improves the accuracy and flexibility of the adjustment of microneedles, simplifies the operation steps, and reduces the difficulty of experimental operations.
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Figure CN222593823U_ABST
Abstract
Description
Technical Field
[0001] The utility model relates to the technical field of biological experimental equipment, in particular to an adjustable needle holder. Background Art
[0002] Cell dissection experiment is an experimental method to study the structure and function of cells through microscopic observation and manipulation. This experiment is usually completed using a microscope and related equipment. In the cell dissection experiment, the experimenter can use a microscope to observe the structure and morphology of cells and understand the components and functions of cells. Micromanipulation techniques such as microneedle manipulation and microinjection can also be used to finely manipulate and intervene in cells to study the life activities and reactions of cells.
[0003] In experiments, microneedles are often needed. Microneedles have slender and sharp needles that can be used to perform subtle operations and experiments on cells or tissues. In cell biology and medical experiments, microneedles are usually used to puncture cell membranes, inject drugs or dyes, etc., in order to observe and study the structure and function of cells. Microneedles are usually fixed on a clamp. By adjusting the control mechanism of the clamp, the direction of the microneedle can be accurately adjusted to improve the operability of the experimenter. The prior art "A small manual five-dimensional needle tip adjustment frame for cell experiments" (publication number: CN112779119A) can adjust the microneedle in the horizontal, longitudinal and vertical directions through three adjustment mechanisms, but the prior art still has the following technical problems:
[0004] In the prior art, when adjusting the position of the microneedle, it is necessary to turn the buttons of the three adjustment mechanisms in sequence to determine the position of the microneedle. The operation steps are cumbersome. At the same time, the microneedle has only three degrees of freedom in three directions, which will limit the flexibility of the experimental operation and increase the difficulty of the experimental operation. Utility Model Content
[0005] The utility model provides an adjustable needle holder, which can solve the problems in the prior art that the needle holder has low degree of freedom, the steps of fixing the microneedle are complicated, and the experimental operation is difficult.
[0006] The present application provides the following technical solutions: an adjustable needle holder, comprising a slide and a clamping mechanism fixed on the slide;
[0007] The clamping mechanism comprises a fixed block fixed on the top of the slide table, the fixed block is provided with a sliding hole, a slider is vertically slidably connected in the sliding hole, a groove is provided on the slider, an elastic member is fixed in the groove, a ball is provided above the elastic member, the ball is movably connected to the slider, the elastic member can lock the active state of the ball, a connecting rod is fixed on the ball, and a clamping ring is fixed on the upper end of the connecting rod;
[0008] It also includes a control mechanism, which includes a shell and a mounting seat fixed in the shell, a control rod movably connected to the mounting seat, an oil groove is provided on the top of the control rod, hydraulic oil is injected into the oil groove, the oil groove is connected to the sliding hole through a hose, a plug is fixed on the top of the oil groove, a threaded hole is provided in the center of the plug, a stud is fitted in the threaded hole, a pressure head is fixed at the bottom of the stud, and the pressure head is located in the oil groove.
[0009] Beneficial effects:
[0010] By adjusting the amount of insertion of the stud into the threaded hole on the plug, the pressure head can be pushed up and down in the oil tank, and the thrust is transmitted to the slider in the sliding hole through the hydraulic oil in the hose, so that the slider slides synchronously when the stud is adjusted. Since the pitch or lead of the stud can be determined according to the number of rotations of the stud, the displacement of the slider and the clamping ring above the slider in the vertical direction can be accurately controlled, thereby improving the accuracy of microneedle adjustment. In addition, the ball is movably connected to the slider, and the user can directly twist the clamping ring to quickly adjust it to any desired angle. At the same time, after the angle adjustment of the clamping ring is completed, the elastic member can press the ball tightly to automatically lock the position of the entire clamping ring, with fewer adjustment steps and higher efficiency. The microneedle can be adjusted in more directions, effectively reducing the operating difficulty of the experimenter.
[0011] Furthermore, the mounting seat also includes a base connected to the bottom surface of the shell by screws and a top seat rotatably connected to the base, the control lever is rotatably connected to the top seat, and the rotation direction of the control lever relative to the top seat and the rotation direction of the top seat relative to the base are at right angles to each other; a plurality of pressing arms are fixed on the control lever, and the pressing arms are respectively fixed on the side walls of the direction in which the control lever can swing, and a plurality of moment switches are also fixed in the shell, and the pressing arms are located above the moment switches.
[0012] Beneficial effect: The control lever can swing in both the horizontal and vertical directions, so that the pressing arm on the control lever can touch the inching switch in the corresponding direction.
[0013] Furthermore, it also includes a driving mechanism, which includes a hydraulic pump, a hydraulic cylinder and an oil inlet pipeline connected between the hydraulic pump and the hydraulic cylinder, an electromagnetic valve is installed on the oil inlet pipeline, and the electromagnetic valve is connected in series with the inching switch; the end of the hydraulic cylinder piston rod is detachably connected to a transmission part, the transmission part includes a transmission chamber and a hydraulic pipe that are connected to each other, the end of the hydraulic pipe away from the transmission chamber is connected to the main slide, the hydraulic pipe is filled with hydraulic oil, the transmission chamber is slidably connected to a piston head, and the end of the piston rod extending into the transmission chamber is fixed to the piston head.
[0014] Beneficial effect: by swinging the control lever, the pressing arm of the control lever touches the inching switch, the on and off of the solenoid valve can be controlled, thereby controlling the flow of hydraulic oil flowing into the hydraulic cylinder from the oil inlet pipeline, accurately adjusting the movement of the piston rod in the hydraulic cylinder, and then the piston rod pushes the piston head to move, and relies on the hydraulic oil in the hydraulic pipe to transmit the driving force to the slide, so that the slide moves synchronously with the piston rod, which is convenient for accurately controlling the movement of the slide and the clamping mechanism on the slide; when the control lever is reset, the pressing arm is separated from the inching switch, the solenoid valve is closed, the slide cannot be subjected to the thrust from the hydraulic cylinder and will stop immediately, the position of the clamping mechanism and the microneedle fixed on the clamping mechanism is quickly determined, effectively reducing the difficulty of operation for the user.
[0015] Furthermore, the slide includes an upper slide, a middle slide and a lower slide which are slidably connected in sequence from top to bottom, the fixed block is located on the upper surface of the upper slide, and the sliding direction of the upper slide relative to the middle slide and the sliding direction of the middle slide relative to the lower slide are at right angles to each other.
[0016] Beneficial effects: The sliding combination of the upper slide plate, the middle slide plate and the lower slide plate enables the clamping mechanism to achieve horizontal movement in the lateral and longitudinal directions.
[0017] Furthermore, a first oil channel is provided on the lower sliding plate, and an end of the hydraulic pipe away from the transmission chamber is connected to the first oil channel. A first sliding column is slidably connected in the first oil channel, and a first strip opening is opened on the top of the first oil channel. A first connecting strip is fixed under the middle sliding plate, and the first connecting strip extends downward from the first strip opening into the first oil channel and has an interference fit with the first sliding column in the first oil channel.
[0018] Beneficial effect: The thrust of the hydraulic cylinder piston rod is transmitted to the first slide column in the first oil channel through the hydraulic oil in the hydraulic pipe, so that the first slide column and the middle slide plate can move synchronously with the hydraulic cylinder piston rod, thereby realizing precise control of the middle slide plate.
[0019] Furthermore, a second oil channel is provided on the middle slide plate, and the opening direction of the second oil channel is at right angles to the first oil channel. The end of the hydraulic pipe away from the transmission chamber is connected to the second oil channel. A second sliding column is slidably connected in the second oil channel. A second strip opening is opened on the top of the second oil channel, and a second connecting strip is fixed under the upper slide plate. The second connecting strip extends downward from the second strip opening into the second oil channel and has an interference fit with the second sliding column in the second oil channel.
[0020] Beneficial effect: Driven by the piston rod of the hydraulic cylinder, the second slide column and the upper slide plate can also move synchronously with the piston rod of the hydraulic cylinder, realizing precise control of the upper slide plate.
[0021] Furthermore, a cross hole is provided on the top of the shell, and the control rod extends from the cross hole.
[0022] Beneficial effect: The cross hole prevents the shaft of the control rod from interfering with the housing when the control rod is swinging.
[0023] Furthermore, a plurality of connection blocks are threadedly connected to the bottom of the shell, and the connection blocks are located in the direction in which the control rod can swing. A tension spring is fixed to the top of each connection block, and the other end of the tension spring is fixed to the side wall of the control rod.
[0024] Beneficial effect: when the control lever swings, the tension spring on the side opposite to the swinging direction of the control lever is pulled up, so that when the control lever is released, the control lever is automatically reset. BRIEF DESCRIPTION OF THE DRAWINGS
[0025] Figure 1 It is the front view of the utility model.
[0026] Figure 2 for Figure 1 Top view of the .
[0027] Figure 3 for Figure 1 A magnified view of center.
[0028] Figure 4 for Figure 1 Enlarged view of the clamping mechanism B.
[0029] Figure 5 for Figure 2 Top view of the clamping mechanism and slide. DETAILED DESCRIPTION
[0030] The following is further described in detail through specific implementation methods:
[0031] The marks in the drawings of the specification include: clamping ring 1, connecting rod 2, sphere 3, elastic member 4, slider 5, locking screw 6, upper slide plate 7, middle slide plate 8, second oil channel 81, lower slide plate 9, first oil channel 91, first slide column 92, first connecting strip 93, first strip opening 94, hydraulic pipe 10, fixing block 11, sliding hole 111, stud 12, pressure head 13, oil groove 14, control lever 15, plug 151, hose 152, mounting seat 16, cross hole 161, pressing arm 162, inching switch 163, connecting block 164, tension spring 165, base 166, top seat 167, transmission chamber 17, piston head 18, piston rod 19, hydraulic cylinder 20, oil inlet pipeline 21, solenoid valve 22, one-way valve 23.
[0032] Embodiment 1
[0033] like Figures 1 to 5 As shown, an adjustable needle holder includes a slide, a clamping mechanism, a control mechanism and a driving mechanism; the clamping mechanism is fixed above the slide, and the control mechanism can control the horizontal lateral and longitudinal movement of the slide through the driving mechanism.
[0034] like Figure 1 , Figure 2 and Figure 5 As shown, the slide comprises an upper slide 7, a middle slide 8 and a lower slide 9, and the middle slide 8 is located between the upper slide 7 and the lower slide 9; two first oil passages 91 are horizontally opened inside the lower slide 9, and the first oil passages 91 are symmetrically arranged relative to the center line of the lower slide 9; a first slide post 92 is slidably connected in the first oil passage 91, a first strip opening 94 is opened at the top of the first oil passage 91, a first connecting strip 93 integrally formed with the middle slide 8 is provided at the bottom of the middle slide 8, the first connecting strip 93 extends downward from the first strip opening 94 into the first oil passage 91, a strip groove is opened on the first slide post 92, and the first connecting strip 93 is interference fit with the strip groove on the first slide post 92, so that the first slide post 92 and the middle slide 8 can move synchronously.
[0035] Two second oil passages 81 are provided on the middle slide 8, and the second oil passages 81 are symmetrically arranged relative to the center line of the middle slide 8. The opening direction of the second oil passage 81 is at right angles to the first oil passage 91. A second sliding column is slidably connected in the second oil passage 81, and a second strip-shaped opening is opened at the top of the second oil passage 81. A second connecting strip integrally formed with the upper slide 7 is provided below the upper slide 7. The second connecting strip extends downward from the second strip opening into the second oil passage 81 and has an interference fit with the second sliding column in the second oil passage 81 (the connection method between the upper slide 7 and the middle slide 8 is the same as the connection method between the middle slide 8 and the lower slide 9. The only difference is that the opening direction of the second oil passage 81 is perpendicular to the first oil passage 91. Therefore, the marking of the internal structure of the upper slide 7 and the middle slide 8 has been omitted in the figure).
[0036] Clamping mechanism such as Figure 1 and Figure 4 As shown, it includes a fixing block 11 connected to the top of the upper slide plate 7 by screws, and a sliding hole 111 is provided on the fixing block 11, and a cylindrical slide block 5 is vertically slidably connected in the sliding hole 111. The slide block 5 is composed of two symmetrical halves spliced together and fixed by a locking screw 6. A groove is provided on the slide block 5, and an elastic member 4 is welded to the bottom of the groove. In this embodiment, the elastic member 4 is a compression spring, and a sphere 3 is provided above the elastic member 4. The top of the slide block 5 is spliced to form a spherical surface. The sphere 3 is located in the spherical surface and can rotate arbitrarily in the spherical surface. The elastic member 4 can press against the sphere 3 to ensure that the sphere 3 can be fixed by the elastic member 4 after rotating at any angle. An integrally formed connecting rod 2 is provided on the upper end of the sphere 3, and an integrally formed clamping ring 1 is provided on the upper end of the connecting rod 2. A fastening screw is radially penetrated through the clamping ring 1, and the microneedle in the clamping ring 1 can be locked by tightening the fastening screw.
[0037] Control agencies such as Figure 1 and Figure 3As shown, it includes a housing and a mounting seat 16 fixed in the housing, the mounting seat 16 includes a base 166 and a top seat 167, the base 166 is screwed to the bottom surface of the housing, a groove is formed on the base 166, the top seat 167 is pivoted in the groove, a groove is also formed on the top seat 167, and the direction in which the groove on the top seat 167 is formed is at right angles to the direction in which the groove on the base 166 is formed, a control rod 15 is pivoted in the groove on the top seat 167, a cross hole 161 is formed on the top of the housing, and the top of the control rod 15 extends upward from the cross hole 161 to the top of the housing;
[0038] The bottom of the shell is threadedly connected with a plurality of connection blocks 164, and the position of the connection blocks 164 is located in the direction in which the control rod 15 can swing. A tension spring 165 is welded to the top of each connection block 164, and the other end of the tension spring 165 is welded to the side wall of the control rod 15; a plurality of arc-shaped pressing arms 162 are welded to the lower end of the control rod 15; a moment switch 163 fixed to the bottom of the shell is also provided on both sides of each swinging direction of the control rod 15, and the moment switches 163 on both sides are respectively connected in series with the solenoid valve 22 of one of the branches on the two oil inlet pipelines 21. The moment switch 163 is a button-type switch, and the lower end of the pressing arm 162 is located above the moment switch 163. When the control rod 15 swings, the pressing arm 162 can press the corresponding moment switch 163, thereby opening the corresponding oil inlet pipeline 21. The solenoid valve 22 on it drives the piston rod 19 of the hydraulic cylinder 20 to move in the direction of the swing of the control rod 15; at the same time, the solenoid valve 22 of another branch on each oil inlet pipeline 21 can be connected in series with a button-type momentary switch 163, and this button switch can be fixed on the side wall of the control rod 15, so that when the user controls the control rod 15, the two solenoid valves 22 of the two branches on the oil inlet pipeline 21 can be opened at the same time, increasing the oil intake of this oil inlet pipeline 21, thereby accelerating the movement speed of the piston rod 19 of the hydraulic cylinder 20, so that when the user needs to control the middle slide 8 or the upper slide 7 to move a long distance, the movement speed of the middle slide 8 and the upper slide 7 can be accelerated, so that they can be quickly positioned, thereby reducing the control time and improving the overall experimental operation efficiency.
[0039] The top of the control rod 15 is provided with a Figure 3 The oil groove 14 shown in the figure has hydraulic oil injected into it. Figure 1The sliding hole 111 of the middle fixed block 11 is connected through a hose 152, and a plug 151 is interference fit at the top of the oil groove 14. A threaded hole is opened at the center of the plug 151, and a stud 12 is fitted in the threaded hole. The stud 12 can be a single-head stud 12 or a multi-head stud 12. A pressure head 13 is welded to the bottom of the stud 12, and the pressure head 13 is located in the oil groove 14. A semi-spherical depression is provided on the top of the stud 12. The depression is convenient for the user to hold the control lever 15, and the thumb can be pressed in the depression to rotate the stud 12. By rotating the stud 12, the pressure head 13 can be driven to move up and down in the oil groove 14.
[0040] Drive mechanism such as Figure 1 and Figure 2 As shown, it includes a hydraulic pump, a hydraulic cylinder 20 and an oil inlet pipeline 21 (connected between the hydraulic pump and the hydraulic cylinder 20) Figure 2 The end of the oil inlet pipeline 21 away from the hydraulic cylinder 20 is connected to the hydraulic pump, and the schematic diagram of the hydraulic pump has been omitted). The oil inlet pipeline 21 is installed with a one-way valve 23, which can prevent the oil in the pipe from flowing back. The oil inlet pipeline 21 is provided with two branches, which are used to drive the piston rod 19 of the hydraulic cylinder 20 to move back and forth. Each oil inlet pipeline 21 is divided into multiple branches. In this embodiment, two branches are taken as an example, and a solenoid valve 22 is installed on the branch. The end of the piston rod 19 of the hydraulic cylinder 20 is provided with a transmission part, and the transmission part includes a transmission chamber 17 and a hydraulic pipe 10 that are interconnected. The hydraulic pipe 10 is filled with hydraulic oil, a piston head 18 is slidably connected in the transmission chamber 17, and the end of the piston rod 19 extending into the transmission chamber 17 is threadedly connected to the piston head 18. In this scheme, two sets of drive mechanisms are provided, and the hydraulic pipes 10 in the two sets of drive mechanisms are respectively connected to the first oil channel 91 of the lower slide 9 and the second oil channel 81 of the middle slide 8, so that through the push of the piston rod 19, the thrust is transmitted to the first slide column 92 and the second slide column respectively through the hydraulic oil in the hydraulic pipe 10, thereby realizing the lateral and longitudinal movement of the middle slide 8 and the upper slide 7.
[0041] The method of using the device is as follows: pass the microneedle through the inner hole of the clamping ring 1, tighten the fastening screw on the clamping ring 1 to fix the microneedle, swing the connecting rod 2 until the tip of the microneedle is adjusted to the required direction, and then swing the control rod 15 in the direction of the required movement, so that the pressing arm 162 of the corresponding direction on the control rod 15 presses the inching switch 163, the solenoid valve 22 on the corresponding oil inlet pipeline is opened, and the piston rod 19 of the hydraulic cylinder 20 pushes the piston head 18 to start sliding, and the hydraulic oil in the hydraulic pipe 10 pushes the first sliding column 92 or the second sliding column to move, so that the middle slide 8 or the upper slide 7 moves synchronously, and after moving to the appropriate position, loosen the control rod 15, and the control rod 15 automatically resets under the action of the tension spring 165, and the head of the pressing arm 162 no longer presses the inching switch 163. The solenoid valve 22 is closed, the piston rod 19 stops moving, and the clamping device stops moving. At this time, the connecting rod 2 can be fine-tuned so that the needle tip of the microneedle points to the most suitable position, and the subsequent experimental operation can be started. If the height of the microneedle needs to be adjusted, the control rod 15 can be held by hand, and the thumb is pressed on the depression on the top of the stud 12 to rotate the stud 12. By rotating the stud 12, the pressure head 13 can be driven to move up and down in the oil groove 14. The hydraulic oil in the oil groove 14 is squeezed by the pressure head 13 and the squeezing force can be transmitted to the slider 5, thereby realizing the adjustment of the clamping ring 1 in the vertical direction. Since the pitch or lead of the stud 12 can be determined according to the number of rotations of the stud 12, the displacement of the slider 5 and the clamping ring 1 above the slider 5 in the vertical direction can be accurately controlled.
[0042] The above is only an embodiment of the utility model. The utility model is not limited to the field involved in this implementation case. The common knowledge such as the known specific structure and characteristics in the scheme is not described in detail here. It should be pointed out that for those skilled in the art, several deformations and improvements can be made without departing from the structure of the utility model, which should also be regarded as the protection scope of the utility model, and these will not affect the effect of the implementation of the utility model and the practicality of the patent. The scope of protection required by this application shall be based on the content of its claims, and the specific implementation methods and other records in the specification can be used to interpret the content of the claims.
Claims
1. An adjustable needle holder, comprising a slide and a clamping mechanism fixed on the slide, characterized in that: The clamping mechanism comprises a fixed block fixed on the top of the slide table, the fixed block is provided with a sliding hole, a slider is vertically slidably connected in the sliding hole, a groove is provided on the slider, an elastic member is fixed in the groove, a ball is provided above the elastic member, the ball is movably connected to the slider, the elastic member can lock the active state of the ball, a connecting rod is fixed on the ball, and a clamping ring is fixed on the upper end of the connecting rod; It also includes a control mechanism, which includes a shell and a mounting seat fixed in the shell, a control rod movably connected to the mounting seat, an oil groove is provided on the top of the control rod, hydraulic oil is injected into the oil groove, the oil groove is connected to the sliding hole through a hose, a plug is fixed on the top of the oil groove, a threaded hole is provided in the center of the plug, a stud is fitted in the threaded hole, a pressure head is fixed at the bottom of the stud, and the pressure head is located in the oil groove.
2. An adjustable needle holder according to claim 1, characterized in that: The mounting seat also includes a base connected to the bottom surface of the shell by screws and a top seat rotatably connected to the base, the control lever is rotatably connected to the top seat, and the rotation direction of the control lever relative to the top seat and the rotation direction of the top seat relative to the base are at right angles to each other; a plurality of pressing arms are fixed on the control lever, and the pressing arms are respectively fixed on the side walls of the swinging direction of the control lever, and a plurality of moment switches are also fixed in the shell, and the pressing arms are located above the moment switches.
3. An adjustable needle holder according to claim 2, characterized in that: It also includes a driving mechanism, which includes a hydraulic pump, a hydraulic cylinder and an oil inlet pipeline connected between the hydraulic pump and the hydraulic cylinder, an electromagnetic valve is installed on the oil inlet pipeline, and the electromagnetic valve is connected in series with a moment switch; the end of the hydraulic cylinder piston rod is detachably connected to a transmission part, the transmission part includes a transmission chamber and a hydraulic pipe that are connected to each other, the end of the hydraulic pipe away from the transmission chamber is connected to the main slide, the hydraulic pipe is filled with hydraulic oil, the transmission chamber is slidably connected to a piston head, and the end of the piston rod extending into the transmission chamber is fixed to the piston head.
4. An adjustable needle holder according to claim 3, characterized in that: The slide comprises an upper slide, a middle slide and a lower slide which are slidably connected in sequence from top to bottom. The fixed block is located on the upper surface of the upper slide. The sliding direction of the upper slide relative to the middle slide and the sliding direction of the middle slide relative to the lower slide are at right angles to each other.
5. An adjustable needle holder according to claim 4, characterized in that: A first oil channel is provided on the lower slide plate, and one end of the hydraulic pipe away from the transmission chamber is connected to the first oil channel. A first sliding column is slidably connected in the first oil channel, and a first strip-shaped opening is opened on the top of the first oil channel. A first connecting strip is fixed under the middle slide plate, and the first connecting strip extends downward from the first strip-shaped opening into the first oil channel and has an interference fit with the first sliding column in the first oil channel.
6. An adjustable needle holder according to claim 5, characterized in that: A second oil channel is provided on the middle slide plate, and the opening direction of the second oil channel is at a right angle to the first oil channel. One end of the hydraulic pipe away from the transmission chamber is connected to the second oil channel. A second sliding column is slidably connected in the second oil channel. A second strip opening is opened on the top of the second oil channel. A second connecting strip is fixed under the upper slide plate. The second connecting strip extends downward from the second strip opening into the second oil channel and has an interference fit with the second sliding column in the second oil channel.
7. An adjustable needle holder according to claim 6, characterized in that: A cross hole is provided on the top of the shell, and the control rod extends out of the cross hole.
8. An adjustable needle holder according to claim 7, characterized in that: The bottom of the shell is threadedly connected with a plurality of connection blocks, the connection blocks are located in the direction in which the control rod can swing, a tension spring is fixed on the top of each connection block, and the other end of the tension spring is fixed on the side wall of the control rod.
Citation Information
Patent Citations
Small manual five-dimensional needle tip adjusting frame for cell experiment
CN112779119A