Efficient filtering device for live vaccine distribution

Abstract

The utility model discloses an efficient filtering device for live vaccine distribution, which comprises a barrel body, a centrifugal barrel is arranged in the barrel body, a filter screen is arranged on the outer side of the centrifugal barrel, and a thermal insulation layer is arranged on the outer side of the filter screen; a liquid guide cavity is formed between the filter screen and the heat preservation layer, an annular box is arranged at the position, close to the top, in the liquid guide cavity, and the annular box can move up and down in the liquid guide cavity; a fan is arranged at the position, close to the top, of the outer side wall of the barrel, an air cavity is formed in the position, close to the top, in the barrel, the fan blows air into the air cavity, and air in the air cavity can enter the centrifugal barrel; the filtering efficiency of the vaccine is improved, the bonding amount of the vaccine on the wall of the centrifugal cylinder is reduced, a filter cake layer is prevented from being formed, and the cleanliness of the centrifugal cylinder is improved.

Description

Technical Field

[0001] The utility model belongs to the field of vaccine production equipment, in particular to a high-efficiency filtering device for live vaccine preparation. Background Art

[0002] As a preventive drug for animal diseases, veterinary vaccines are increasingly used in livestock and poultry farming. The preparation of vaccines usually includes the steps of culturing and proliferating pathogenic microorganisms, harvesting pathogenic microorganism stock solution, inactivation, concentration and purification, freeze drying, etc. The preparation process varies according to the characteristics of different vaccines. In the preparation of veterinary vaccines, in the method of preparing viral antigens obtained by cell suspension, it is necessary to filter the broken cells.

[0003] At present, in the process of vaccine filtration, centrifugal filtration is generally used, and an ultrafiltration membrane is set up to filter out the vaccine and broken cell residues. However, in the filtration process, after the vaccine carrier passes through the ultrafiltration membrane, part of it will adhere to the outer wall of the centrifuge cylinder, which is not only difficult to recover and reduce the amount of collected vaccine, but also forms a filter cake layer due to long-term adhesion to the wall of the centrifuge cylinder. The existence of the filter cake layer will affect the permeability of the filter mesh and the filtration efficiency, and it is difficult to clean by conventional water washing methods, which increases the difficulty of cleaning. Utility Model Content

[0004] In view of the shortcomings of the prior art, the purpose of the utility model is to provide a high-efficiency filtration device for live vaccine preparation, which at least solves one of the problems of the background technology, improves the filtration efficiency of the vaccine, reduces the amount of vaccine adhesion on the wall of the centrifuge cylinder, prevents the formation of a filter cake layer, and increases the cleanliness of the centrifuge cylinder.

[0005] The utility model provides the following technical solutions:

[0006] A high-efficiency filtering device for preparing live vaccines comprises a cylinder, a centrifugal cylinder is arranged inside the cylinder, a filter screen is arranged outside the centrifugal cylinder, and a heat preservation layer is arranged outside the filter screen;

[0007] A liquid conducting cavity is formed between the filter screen and the heat-insulating layer, and an annular box is provided near the top of the liquid conducting cavity, and the annular box can move up and down in the liquid conducting cavity;

[0008] A fan is provided near the top of the outer wall of the cylinder, and a wind cavity is provided near the top of the cylinder. The fan blows air into the wind cavity, and the gas in the wind cavity can enter the centrifugal cylinder.

[0009] The gas in the wind cavity can enter the liquid guide cavity through the annular box.

[0010] Preferably, a drive motor is connected to the bottom of the centrifuge cylinder, and the drive motor is connected to the outside of the cylinder body. A liquid hole is opened on the side wall of the centrifuge cylinder, and an annular connecting plate is connected to the outer wall of the centrifuge cylinder near the top and the bottom. The outer peripheral side of the annular connecting plate is sealed and connected to the filter screen; a discharge port is provided at the bottom of the centrifuge cylinder.

[0011] Preferably, a movable box is provided at the bottom of the centrifugal cylinder, a plurality of filter holes are provided on the side wall of the movable box, a screw is connected to the bottom of the movable box, a screw barrel is provided for matching rotation of the screw, and the screw barrel is connected to the centrifugal cylinder.

[0012] Preferably, the annular box is sealingly and slidingly connected to the liquid guiding cavity, the side wall of the annular box is connected to a moving block, the moving block is provided with a threaded hole, the outer side wall of the liquid guiding cavity is provided with a servo motor, the servo motor is provided with a screw, and the screw is rotatably arranged inside the insulation layer; the screw is arranged in the threaded hole of the moving block, the screw is matched and rotatably connected with the threaded hole, and the screw drives the annular box to move up and down through the threaded hole.

[0013] Preferably, an air inlet is provided on a side of the annular box away from the filter screen, and at least one air outlet is provided at the bottom of the annular box, and the air outlet is located inside the liquid guiding cavity.

[0014] Preferably, a sealing pressure pad is provided on the top of the annular box, and the sealing pressure pad is made of rubber material, and the sealing pressure pad can be tightly pressed against the top wall of the cylinder.

[0015] Preferably, a feed port is provided at the top of the cylinder, a sealing cover is provided above the feed port, and the sealing cover is sealed and crimped with the feed port.

[0016] Preferably, a second discharge port is provided below the liquid guiding cavity, and the liquid in the liquid guiding cavity is discharged through the second discharge port, and the discharge port is connected to the bottom of the cylinder.

[0017] Preferably, the insulation layer is a foam material, the outer layer of the foam material is provided with an external fixing plate, the screw is rotatably connected to the external fixing plate, and the vaccine concentrate is insulated by the provided foam to prevent the vaccine from being inactivated due to excessive temperature.

[0018] Preferably, the filter screen uses an ultrafiltration membrane package to filter the vaccine. The vaccine can pass through the ultrafiltration membrane package, while large molecular proteins and broken cell walls cannot pass through the ultrafiltration membrane package. Molecules larger than the membrane pore size are removed, and the permeate containing the vaccine is collected, so that the vaccine is purified and the purity of the vaccine is improved.

[0019] In addition, when filtering vaccines, the present technical solution adds the vaccine concentrate into the centrifuge barrel through the feed port, starts the drive motor to drive the centrifuge barrel to rotate, and when filtering, the default state of the movable box is inside the liquid guide cavity, and the movable box does not block the wind cavity. The gas blown out by the fan enters the centrifuge barrel through the wind cavity, and the pressure in the centrifuge barrel increases, which accelerates the passage of the vaccine concentrate through the filter net, so that the permeate containing the vaccine passes through the filter net quickly, reducing the volume of the vaccine, and filtering a large amount of impurity protein and broken cell walls, thereby improving the filtration efficiency in the vaccine production process. After the filtration is completed, the permeate containing the vaccine is recovered through the discharge port two, and the discharge port two is provided with a control valve.

[0020] After the permeate in the liquid guide cavity is discharged, the residual liquid in the centrifugal cylinder is opened, and the residual liquid is discharged through the discharge port 1 and the discharge port 2; and when the filtration stops, the speed of the driving motor is gradually slowed down to stop, and the residual liquid in the centrifugal cylinder is also subjected to the rotation effect, and the large molecular protein and broken cell wall in the residual liquid enter the movable box through the filter hole, and in the movable box, as the water flow stops rotating, the large molecular protein and broken cell wall are deposited at the bottom of the movable box. When the centrifugation stops, the screw of the movable box is unscrewed from the screw barrel, and the movable box is washed and cleaned with water to reduce the difficulty of cleaning, increase the degree of cleaning, and prevent the formation of filter cake on the filter net to a certain extent.

[0021] When the filtration is completed and the permeate containing the vaccine is collected, the servo motor is started to drive the screw to rotate clockwise. When the screw rotates, the threaded hole opened in the moving block drives the moving block to move upward, and the moving block drives the annular box to move upward until the sealing pressure pad is in full contact with the top wall of the cylinder and sealed and crimped. The servo motor is stopped. At this time, the annular box extends upward from the liquid guide cavity and is crimped with the top wall of the cylinder through the provided sealing pressure pad. The gas blown into the air cavity from the fan is blocked by the annular box and cannot enter the centrifugal cylinder. At the same time, the flowing airflow in the air cavity enters the air inlet, passes through the air guide cavity inside the annular box, and quickly enters the liquid guide cavity from the air outlet. It should be understood that the diameter of the air outlet is smaller than the diameter of the air inlet. Therefore, according to The flow law of air flow is that when the flow velocity of the air inlet remains unchanged and the diameter of the air outlet is smaller than that of the air inlet, the air flow velocity of the air outlet increases and the gas pressure increases. When the high-speed airflow enters the liquid guiding cavity, the residual permeate containing the vaccine remaining on the liquid guiding cavity wall and the filter net can be blown downward, reducing the residual permeate remaining on the liquid guiding cavity wall and the filter net. At the same time, the gas passes through the filter net in the reverse direction into the centrifugal cylinder, blowing off the large molecular residues deposited on the inside of the filter net to prevent the formation of a filter cake layer. It can not only collect the residual filtrate containing the vaccine and reduce the loss of the vaccine, but also clean and discharge the residual permeate in the liquid guiding cavity to prevent the formation of filter cake on the filter net, which helps to increase the permeability of the filter net and improve the filtration efficiency.

[0022] Compared with the prior art, the utility model has the following beneficial effects:

[0023] (1) The utility model relates to a high-efficiency filtration device for preparing live vaccines. The gas blown out by the fan is passed through the wind chamber into the centrifuge cylinder, and the pressure in the centrifuge cylinder is increased, which accelerates the passage of the vaccine concentrate through the filter screen, so that the permeate containing the vaccine passes through the filter screen quickly, reducing the volume of the vaccine, and filtering a large amount of impurity protein and broken cell walls, thereby improving the filtration efficiency in the vaccine production process.

[0024] (2) The utility model is a high-efficiency filtering device for preparing live vaccines. By setting a movable box, when centrifugation is terminated, the screw of the movable box is unscrewed from the screw barrel, and the inside of the movable box is washed with water to reduce the difficulty of cleaning, increase the degree of cleaning, and prevent the formation of filter cakes on the filter screen to a certain extent.

[0025] (3) The utility model is a high-efficiency filtration device for preparing live vaccines. By setting an annular box, the air flow velocity at the air outlet is accelerated and the gas pressure is increased. When the high-speed airflow enters the liquid guiding cavity, the residual permeate containing the vaccine remaining on the liquid guiding cavity wall and the filter net can be blown downward, thereby reducing the residual permeate remaining on the liquid guiding cavity wall and the filter net. At the same time, the gas passes through the filter net in the reverse direction and enters the centrifugal cylinder, blowing off the macromolecular residues deposited on the inner side of the filter net to prevent the formation of a filter cake layer. Not only can the residual filtrate containing the vaccine be collected to reduce the loss of the vaccine, but the residual permeate in the liquid guiding cavity can also be cleaned and discharged to prevent the formation of filter cake on the filter net, thereby helping to increase the permeability of the filter net and improve the filtration efficiency. BRIEF DESCRIPTION OF THE DRAWINGS

[0026] In order to more clearly illustrate the technical solution of the implementation mode of the utility model, the following is a brief introduction to the drawings required for use in the implementation mode. It should be understood that the following drawings only show certain embodiments of the utility model and therefore should not be regarded as limiting the scope. For ordinary technicians in this field, other related drawings can be obtained based on these drawings without paying creative work.

[0027] Figure 1 It is a schematic diagram of the overall structure of the utility model.

[0028] Figure 2 It is a schematic diagram of the internal structure of the utility model.

[0029] Figure 3 It is a schematic diagram of the cross-sectional structure of the utility model.

[0030] Figure 4 It is a schematic diagram of the enlarged structure of the A local structure of the utility model.

[0031] Figure 5It is a schematic diagram of the enlarged structure of the B local structure of the utility model. DETAILED DESCRIPTION

[0032] In order to make the purpose, technical solution and advantages of the implementation mode of the utility model clearer, the technical solution in the implementation mode of the utility model will be clearly and completely described below in conjunction with the drawings in the implementation mode of the utility model. Obviously, the described implementation mode is a part of the implementation mode of the utility model, not all the implementation modes. Based on the implementation mode in the utility model, all other implementation modes obtained by ordinary technicians in this field without creative work are within the scope of protection of the utility model.

[0033] Therefore, the following detailed description of the embodiments of the present invention provided in the accompanying drawings is not intended to limit the scope of the claimed invention, but merely represents selected embodiments of the present invention. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in the field without creative work are within the scope of protection of the present invention.

[0034] Embodiment 1

[0035] refer to Figure 1-3 A high-efficiency filtering device for preparing live vaccines comprises a cylinder 1, a centrifugal cylinder 2 is arranged inside the cylinder 1, a filter screen 5 is arranged outside the centrifugal cylinder 2, and a heat-insulating layer 7 is arranged outside the filter screen 5; a liquid conducting cavity 6 is formed between the filter screen 5 and the heat-insulating layer 7, a ring box 18 is arranged near the top of the liquid conducting cavity 6, and the ring box 18 can move up and down in the liquid conducting cavity 6; a fan 9 is arranged near the top of the outer wall of the cylinder 1, and a wind cavity 8 is arranged near the top of the cylinder 1, the fan 9 blows air into the wind cavity 8, and the gas in the wind cavity 8 can enter the centrifugal cylinder 2; the gas in the wind cavity 8 can enter the liquid conducting cavity 6 through the ring box 18.

[0036] The bottom of the centrifuge cylinder 2 is connected to a driving motor 3, which is connected to the outside of the cylinder body 1. The side wall of the centrifuge cylinder 2 is provided with a liquid hole 201. The outer wall of the centrifuge cylinder 2 is connected to an annular connecting plate 4 near the top and the bottom. The outer peripheral side of the annular connecting plate 4 is sealed and connected to the filter screen 5; the bottom of the centrifuge cylinder 2 is provided with a discharge port 12. The insulation layer 7 is a foam material, and the outer layer of the foam material is provided with an external fixed plate. The screw 20 is rotatably connected to the external fixed plate. The foam is provided to keep the vaccine stock solution warm to prevent the vaccine from being inactivated due to excessive temperature. The filter screen 5 uses an ultrafiltration membrane bag to filter the vaccine. The vaccine can pass through the ultrafiltration membrane bag, while large molecular proteins and broken cell walls cannot pass through the ultrafiltration membrane bag. The molecules larger than the membrane pore size are removed, and the permeate containing the vaccine is collected, so that the vaccine is purified and the purity of the vaccine is improved.

[0037] When filtering vaccines according to the present technical solution, the vaccine concentrate is added into the centrifuge barrel 2 through the feed port 10, and the drive motor 3 is started to drive the centrifuge barrel 2 to rotate. When filtering, the default state of the movable box 14 is to be inside the liquid guide cavity 6, and the movable box 14 does not block the wind cavity 8. The gas blown out by the fan 9 enters the centrifuge barrel 2 through the wind cavity 8, and the pressure inside the centrifuge barrel 2 increases, thereby accelerating the passage of the vaccine concentrate through the filter screen 5, allowing the permeate containing the vaccine to quickly pass through the filter screen 5, reducing the volume of the vaccine, and filtering a large amount of impurity proteins and broken cell walls, thereby improving the filtration efficiency in the vaccine production process. After the filtration is completed, the permeate containing the vaccine is recovered through the discharge port 13, and the discharge port 13 is provided with a control valve.

[0038] Embodiment 2:

[0039] Based on Example 1, refer to Figure 4-5 A movable box 14 is provided at the bottom of the centrifugal cylinder 2, and a plurality of filter holes 15 are provided on the side wall of the movable box 14. A screw 16 is connected to the bottom of the movable box 14, and a screw barrel 17 is provided for matching rotation of the screw 16, and the screw barrel 17 is connected to the centrifugal cylinder 2. An annular box 18 is sealed and slidably connected to the liquid guiding cavity 6, and a moving block 21 is connected to the side wall of the annular box 18, and a threaded hole is provided on the moving block 21. A servo motor 19 is provided on the outer wall of the liquid guiding cavity 6, and the servo motor 19 is provided with a screw 20, and the screw 20 is rotatably arranged inside the thermal insulation layer 7; the screw 20 is arranged in the threaded hole of the moving block 21, and the screw 20 is matched and rotatably connected with the threaded hole, and the screw 20 drives the annular box 18 to move up and down through the threaded hole. An air inlet 22 is provided on the side of the annular box 18 away from the filter screen 5, and at least one air outlet 23 is provided at the bottom of the annular box 18, and the air outlet 23 is located inside the liquid guiding cavity 6.

[0040] A sealing pad 25 is provided on the top of the annular box 18. The sealing pad 25 is made of rubber and can be tightly pressed against the top wall of the cylinder 1. A feed port 10 is provided on the top of the cylinder 1. A sealing cover 11 is provided above the feed port 10. The sealing cover 11 is sealed and pressed against the feed port 10. A discharge port 2 13 is provided below the liquid guiding cavity 6. The liquid in the liquid guiding cavity 6 is discharged through the discharge port 2 13. The discharge port is connected to the bottom of the cylinder 1.

[0041] After the permeate in the liquid guiding chamber 6 is discharged, the discharge port 12 is opened, and the residual liquid in the centrifugal cylinder 2 is discharged through the discharge port 12 and the discharge port 2 13; and when the filtration stops, the speed of the driving motor 3 is gradually slowed down to stop, and the residual liquid in the centrifugal cylinder 2 is also subjected to the rotation effect, and the macromolecular protein and broken cell wall in the residual liquid enter the movable box 14 through the filter hole 15, and in the movable box 14, as the water flow stops rotating, the macromolecular protein and broken cell wall are deposited at the bottom of the movable box 14. When the centrifugation stops, the screw 16 of the movable box 14 is unscrewed from the screw barrel 17, and the movable box 14 is washed and cleaned with water, which reduces the difficulty of cleaning, increases the degree of cleaning, and prevents the formation of filter cake on the filter screen 5 to a certain extent.

[0042] When the filtration is completed and the permeate containing the vaccine is collected, the servo motor 19 is started to drive the screw rod 20 to rotate clockwise. When the screw rod 20 rotates, the threaded hole opened in the moving block 21 drives the moving block 21 to move upward, and the moving block 21 drives the annular box 18 to move upward until the sealing pressure pad 25 is in full contact with the top wall of the cylinder 1 and sealed and crimped. The servo motor 19 is stopped. At this time, the annular box 18 extends upward from the liquid guide cavity 6 and is crimped with the inner top wall of the cylinder 1 through the provided sealing pressure pad 25. The gas blown into the air cavity 8 from the fan 9 is blocked by the annular box 18 and cannot enter the centrifugal cylinder 2. At the same time, the flowing airflow in the air cavity 8 enters the air inlet 22, passes through the air guide cavity 248 inside the annular box 18, and quickly enters the liquid guide cavity 6 from the air outlet 23. It should be understood that the diameter of the air outlet 23 is smaller than that of the inlet. The diameter of the air outlet 22, therefore, according to the flow law of the air flow, when the flow velocity of the air inlet 22 remains unchanged and the diameter of the air outlet 23 is smaller than the air inlet 22, the air flow velocity of the air outlet 23 is accelerated, and the gas pressure is increased. When the high-speed airflow enters the liquid guiding chamber 6, the residual permeate containing the vaccine remaining on the wall of the liquid guiding chamber 6 and the filter screen 5 can be blown downward, reducing the residual permeate remaining on the wall of the liquid guiding chamber 6 and the filter screen 5. At the same time, the gas passes through the filter screen 5 in reverse and enters the centrifugal cylinder 2, blowing off the macromolecular residues deposited on the inner side of the filter screen 5 to prevent the formation of a filter cake layer. It can not only collect the residual filtrate containing the vaccine to reduce the loss of the vaccine, but also clean and discharge the residual permeate in the liquid guiding chamber 6 to prevent the formation of filter cake on the filter screen 5, which helps to increase the permeability of the filter screen 5 and improve the filtration efficiency.

[0043] The above description is only a preferred embodiment of the present invention and is not intended to limit the present invention. For those skilled in the art, the present invention may have various modifications and changes. Any modifications, equivalent substitutions, improvements, etc. made within the spirit and principles of the present invention should be included in the protection scope of the present invention.

Claims

1. A high-efficiency filtration device for preparing live vaccines, characterized in that: It comprises a cylinder (1), a centrifugal cylinder (2) is arranged inside the cylinder (1), a filter screen (5) is arranged outside the centrifugal cylinder (2), and a heat-insulating layer (7) is arranged outside the filter screen (5); A liquid conducting cavity (6) is formed between the filter screen (5) and the heat-insulating layer (7), and an annular box (18) is provided near the top of the liquid conducting cavity (6), and the annular box (18) can move up and down in the liquid conducting cavity (6); A fan (9) is provided near the top of the outer wall of the cylinder (1), and a wind cavity (8) is provided near the top of the cylinder (1). The fan (9) blows air into the wind cavity (8), and the gas in the wind cavity (8) can enter the centrifugal cylinder (2); The gas in the air cavity (8) can enter the liquid guiding cavity (6) through the annular box (18).

2. A high-efficiency filtration device for preparing live vaccines according to claim 1, characterized in that: The bottom of the centrifugal cylinder (2) is connected to a driving motor (3), which is connected to the outside of the cylinder body (1). The side wall of the centrifugal cylinder (2) is provided with a liquid passage hole (201). The outer wall of the centrifugal cylinder (2) is connected to an annular connecting plate (4) near the top and the bottom. The outer peripheral wall of the annular connecting plate (4) is sealed and connected to the filter screen (5). The bottom of the centrifugal cylinder (2) is provided with a discharge port (12).

3. A high-efficiency filtration device for preparing live vaccines according to claim 1 or 2, characterized in that: A movable box (14) is provided at the bottom of the centrifugal cylinder (2), a plurality of filter holes (15) are provided on the side wall of the movable box (14), a screw rod (16) is connected to the bottom of the movable box (14), a screw barrel (17) is provided for matching rotation of the screw rod (16), and the screw barrel (17) is connected to the centrifugal cylinder (2).

4. The high-efficiency filtration device for preparing live vaccines according to claim 1, characterized in that: The annular box (18) is sealed and slidably connected to the liquid guiding cavity (6); a moving block (21) is connected to the side wall of the annular box (18); a threaded hole is formed in the moving block (21); a servo motor (19) is provided on the outer side wall of the liquid guiding cavity (6); the servo motor (19) is provided with a screw rod (20); the screw rod (20) is rotatably arranged inside the thermal insulation layer (7); the screw rod (20) is arranged in the threaded hole of the moving block (21); the screw rod (20) is matched and rotatably connected with the threaded hole; the screw rod (20) drives the annular box (18) to move up and down through the threaded hole.

5. A high-efficiency filtration device for preparing live vaccines according to claim 4, characterized in that: An air inlet (22) is provided on a side of the annular box (18) away from the filter screen (5), and at least one air outlet (23) is provided at the bottom of the annular box (18), wherein the air outlet (23) is located inside the liquid guiding cavity (6).

6. A high-efficiency filtration device for preparing live vaccines according to claim 4, characterized in that: A sealing pad (25) is provided on the top of the annular box (18). The sealing pad (25) is made of rubber material and can be tightly pressed against the top wall of the cylinder (1).

7. The high-efficiency filtration device for preparing live vaccines according to claim 1, characterized in that: A feed inlet (10) is provided at the top of the cylinder (1), a sealing cover (11) is provided above the feed inlet (10), and the sealing cover (11) is sealed and crimped with the feed inlet (10).

8. The high-efficiency filtration device for preparing live vaccines according to claim 1, characterized in that: A second discharge port (13) is provided below the liquid guiding cavity (6), and the liquid in the liquid guiding cavity (6) is discharged through the second discharge port (13), and the discharge port is connected to the bottom of the cylinder (1).

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