Reagent detection assembly
By designing a reagent detection component including a reagent kit and a detection box, the problem of cross contamination and sample flow in the test strips in the prior art when detecting nucleic acid amplification products is solved, and the uniform distribution of reagents and the accuracy of detection results are achieved.
Patent Information
- Application Number
- CN202420920863.X
- Authority / Receiving Office
- CN · China
- Patent Type
- Utility models(China)
- Current Assignee / Owner
- Filing Date
- 2024-04-29
- Publication Date
- 2025-03-21
- Estimated Expiration
- 2034-04-29
AI Technical Summary
In the prior art, when using test strips to detect nucleic acid amplification products, cross-contamination and sample flow are easily difficult to control, resulting in errors in the detection results.
A reagent detection component is designed, including a kit and a test box. The kit has a removable connection of the reagent tube and a reagent cover. The test box has a detection tube, a detection cover and a test strip. The active connection of the test strip can realize the active contact of the reagent after the reaction, ensuring uniform distribution of the reagents and improving the accuracy of the detection.
Through this component, the reagents are evenly distributed on the test strip, which improves the convenience of operation and detection accuracy, reduces detection errors, and improves the detection reliability of the reagent detection components.
Smart Images

Figure CN222647983U_ABST
Abstract
Description
Technical Field
[0001] The utility model belongs to the technical field of detection devices, and in particular relates to a reagent detection component. Background Art
[0002] Using test strips to detect nucleic acid amplification products is a simple and convenient way. It should be noted that after nucleic acid amplification, the concentration of the amplification product is very high, and opening the lid can easily cause cross contamination, affecting the next result.
[0003] In the related art, the reagent tube storing the amplification product is punctured to allow the amplification product liquid to flow onto the test strip, which is prone to leakage for small-volume samples, and the flow of the sample is difficult to control, resulting in errors in the test results. Utility Model Content
[0004] The technical purpose of the utility model is to provide a reagent detection component, aiming to solve the problem of errors in the detection results of the detection samples.
[0005] To solve the above technical problems, the utility model is implemented as follows: a reagent detection component, including a reagent kit and a detection box; wherein,
[0006] The reagent kit comprises a detachably connected reagent tube and a reagent cover, wherein a receiving cavity with an opening on one side is formed inside the reagent tube, the receiving cavity is used to place the reagent, and the reagent cover is used to block the opening of the receiving cavity;
[0007] The detection box comprises a detection tube, a detection cover and a test strip, wherein the detection cover is movably connected to one end of the detection tube, one end of the test strip is fixedly connected to the detection cover and extends into the detection tube, and one end of the detection tube away from the detection cover is detachably connected to the detection box, and the detection cover has a movement direction that drives the test strip to extend into or away from the accommodating cavity;
[0008] The reagent detection component has a packaging state and a detection state. When the reagent detection component is in the packaging state, the reagent cover is connected to the reagent tube, and the reagent tube is disconnected from the detection tube. When the reagent detection component is in the detection state, the reagent cover is disconnected from the reagent tube, and the reagent tube is connected to the detection tube.
[0009] In some embodiments of the utility model, at least two grooves are formed on the outer circumference of the detection cover, and at least two protrusions are formed on the inner wall of the detection tube, and each protrusion is plugged and matched with each groove in a one-to-one correspondence.
[0010] In some embodiments of the present utility model, the detection cover includes a cover body, a plug-in end and the abutment end, the plug-in end is plug-fitted with the detection tube, the diameter of the abutment end is larger than the diameter of the plug-in end, and the abutment end is used to abut the end face of the detection tube, each of the grooves is arranged on the outer peripheral surface of the cover body, each of the grooves includes a first section, a second section and a third section which are connected in sequence, the first section extends to the plug-in end and is provided with an inlet which is plug-fitted with the corresponding protrusion, the third section extends to the abutment end, when the protrusion is in the first section, the test strip is not in the accommodating cavity, and when the protrusion is in the third section, the test strip partially extends into the accommodating cavity.
[0011] In some embodiments of the present invention, the second section is extended along the circumference of the detection cover, and the extension direction of the first section and the extension direction of the third section are both perpendicular to the extension direction of the second section.
[0012] In some embodiments of the present invention, at least one blocking portion is protruding from the connection between the second section and the first section and the third section, and each of the blocking portions and the inner wall of the groove are smoothly transitioned.
[0013] In some embodiments of the present invention, the reagent cover includes a limiting portion that abuts against the open end surface of the reagent box, the area of the limiting portion is larger than the opening area of the accommodating cavity, the limiting portion is provided with a grabbing end extending along the circumferential direction of the main body, and the distance between the edge surface of the grabbing end and the outer surface of the main body is greater than the distance between the other edge surfaces of the limiting portion and the outer surface of the main body.
[0014] Compared with the prior art, the reagent detection component in the utility model has the following beneficial effects:
[0015] The reagent in the reagent tube is used to react with the sample to be tested, and the test strip in the test box is used to contact the reacted reagent to display the reaction result. By setting a movable detection cover, the test strip can actively contact the reacted reagent, which can ensure that the reagent is evenly distributed on the test paper, thereby improving the convenience of operation and the accuracy of detection. When the reagent detection component is in the detection state, the detection cover keeps the connecting space between the reagent tube and the detection tube sealed at all times. When in the dispensing state, the reagent cover can effectively seal the reagent tube, thereby effectively isolating the interference of the external environment, reducing detection errors, and improving the detection reliability of the reagent detection component. BRIEF DESCRIPTION OF THE DRAWINGS
[0016] Figure 1 This is a schematic diagram of the overall structure of a reagent detection assembly in one embodiment of the utility model;
[0017] Figure 2yes Figure 1 Schematic diagram of the explosion structure of the reagent detection component;
[0018] Figure 3 yes Figure 1 A schematic diagram of the structure of a detection cover in a reagent detection assembly;
[0019] Figure 4 yes Figure 1 A schematic diagram of the structure of the detection tube in the reagent detection assembly;
[0020] Figure 5 yes Figure 1 Schematic diagram of the structure of the reagent cover in the reagent detection component.
[0021] In the accompanying drawings, the various reference numerals represent: 100, reagent detection assembly; 11, reagent box; 111, reagent tube; 1111, accommodating chamber; 112, reagent cover; 1121, main body; 1122, limiting portion; 1123, grabbing end; 12, detection box; 121, detection tube; 122, bump; 123, detection cover; 1231, cover body; 1232, contact end; 1233, abutting end; 1234, socket; 124, groove; 1241, first section; 1242, second section; 1243, third section; 1244, blocking portion; 125, test strip. DETAILED DESCRIPTION
[0022] The embodiments of the utility model are described in detail below, and examples of the embodiments are shown in the accompanying drawings, wherein the same or similar reference numerals throughout represent the same or similar elements or elements having the same or similar functions. The embodiments described below with reference to the accompanying drawings are exemplary and are intended to be used to explain the utility model, and cannot be understood as limiting the utility model. Based on the embodiments in the utility model, all other embodiments obtained by ordinary technicians in the field without creative work are within the scope of protection of the utility model.
[0023] In the description of the present invention, it should be understood that the terms "center", "longitudinal", "lateral", "length", "width", "thickness", "up", "down", "front", "back", "left", "right", "vertical", "horizontal", "top", "bottom", "inside", "outside", "clockwise", "counterclockwise", "axial", "circumferential", "radial" and the like indicate orientations or positional relationships based on the orientations or positional relationships shown in the accompanying drawings, and are only for the convenience of describing the present invention and simplifying the description, and do not indicate or imply that the referred device or element must have a specific orientation, be constructed and operated in a specific orientation, and therefore should not be understood as a limitation on the present invention.
[0024] In addition, the terms "first" and "second" are used for descriptive purposes only and should not be understood as indicating or implying relative importance or implicitly indicating the number of the indicated technical features. Therefore, the features defined as "first" and "second" may explicitly or implicitly include one or more of the features. In the description of the present utility model, the meaning of "plurality" is two or more, unless otherwise clearly and specifically defined.
[0025] Please refer to Figures 1 to 5 The utility model provides a reagent detection assembly 100, including a reagent kit 11 and a detection box 12; wherein the reagent kit 11 includes a detachably connected reagent tube 111 and a reagent cover 112, wherein a receiving chamber 1111 with an opening on one side is formed inside the reagent tube 111, wherein the receiving chamber 1111 is used to place reagents, and the reagent cover 112 is used to block the opening of the receiving chamber 1111; the detection box 12 includes a detection tube 121, a detection cover 123 and a test strip 125, wherein the detection cover 123 is movably connected to one end of the detection tube 121, and one end of the test strip 125 is fixedly connected to the detection cover 123 and extends into In the detection tube 121, one end of the detection tube 121 away from the detection cover 123 is detachably connected to the detection box 12, and the detection cover 123 has a movement direction that drives the test strip 125 to extend into or away from the accommodating chamber 1111; the reagent detection component 100 has a packaging state and a detection state. When the reagent detection component 100 is in the packaging state, the reagent cover 112 is connected to the reagent tube 111, and the reagent tube 111 is disconnected from the detection tube 121. When the reagent detection component 100 is in the detection state, the reagent cover 112 is disconnected from the reagent tube 111, and the reagent tube 111 is connected to the detection tube 121.
[0026] The reagent in the reagent tube 111 is used to react with the sample to be tested, and the test strip 125 in the test box 12 is used to contact the reacted reagent to display the reaction result. By setting a movable detection cover 123, the test strip 125 can be manually and actively contacted with the reacted reagent, which can ensure that the reagent is evenly distributed on the test strip, thereby improving the convenience of operation and the accuracy of detection.
[0027] Please refer to Figure 1 When the reagent detection component 100 is in the detection state, the detection cover 123 keeps the connecting space between the reagent tube 111 and the detection tube 121 sealed at all times. When in the packaging state, the reagent cover 112 can effectively seal the reagent tube 111, thereby effectively isolating the interference from the external environment, reducing the detection error, and improving the detection reliability of the reagent detection component 100.
[0028] Please refer to Figure 3 and Figure 4In this embodiment, at least two grooves 124 are formed on the outer circumference of the detection cover 123, and at least two protrusions 122 are formed on the inner wall of the detection tube 121, and each protrusion 122 is plugged and matched with each groove 124 in a one-to-one correspondence. When the detection cover 123 is inserted into the detection tube 121, the groove 124 provides a track for the movement of the detection cover 123, plays a guiding role, and facilitates the user to press the detection cover 123 to contact the test strip 125 with the post-reaction reagent. At the same time, the design of the groove 124 and the protrusion 122 makes the connection between the detection cover 123 and the detection tube 121 more stable, ensuring that the detection cover 123 remains stable during the detection process, avoiding errors that may be caused by shaking, thereby ensuring the stability and reliability of the reagent detection process.
[0029] Specifically, the detection cover 123 includes a cover body 1231, a plug end and an abutment end 1233, the plug end is plugged with the detection tube 121, the diameter of the abutment end 1233 is larger than the diameter of the plug end, and the abutment end 1233 is used to abut the end surface of the detection tube 121, each groove 124 is provided on the outer peripheral surface of the cover body 1231, and each groove 124 includes a first section 1241, a second section 1242 and a third section 1243 which are connected in sequence, and the second section 1241 is connected to the detection tube 121. The two ends of 242 are connected to the first section 1241 and the third section 1243 respectively. The first section 1241 extends to the plug-in end and is provided with an inlet for plugging with the corresponding protrusion 122. The third section 1243 extends to the abutment end 1233. When the protrusion 122 is in the first section 1241, the test strip 125 is not in the accommodating cavity 1111. When the protrusion 122 is in the third section 1243, the test strip 125 partially extends into the accommodating cavity 1111.
[0030] The introduction port of the first section 1241 can be chamfered to facilitate the protrusion 122 to enter the first section 1241. After the first section 1241 is introduced, it enters the second section 1242. The protrusion 122 moves to the third section 1243 and contacts the abutment end 1233. The abutment end 1233 provides a stable supporting plane, which effectively prevents the protrusion 122 from escaping from the groove 124, thereby improving the stability of the fit between the detection cover 123 and the detection tube 121.
[0031] The matching state between the detection cover 123 and the detection tube 121 includes a detection preparation state and a detection start state. When in the detection preparation state, the detection cover 123 and the detection tube 121 are plugged and assembled, the protrusion 122 is in the first section 1241, and the test strip 125 is at a certain distance from the reagent in the accommodating chamber 1111. When in the detection start state, the detection cover 123 further extends into the detection tube 121, the protrusion 122 is in the third section 1243, and the test strip 125 enters the accommodating chamber 1111 to contact the reacted reagent.
[0032] The second section 1242 and the first section 1241 and the third section 1243 can be tilted to effectively separate the detection preparation state and the detection start state, that is, when the protrusion 122 enters the first section 1241, the tilted second section 1242 effectively prevents the protrusion 122 from continuing to slide into the second section 1242. When the user rotates the protrusion 122 to pass through the second section 1242 and enter the third section 1243, the detection cover 123 switches from the detection preparation state to the detection start state, and the test strip 125 enters the accommodating cavity 1111.
[0033] The guiding effect of the multi-segment groove 124 can ensure a more precise fit between the protrusion 122 and the groove 124, reducing improper fit caused by operational deviation. When the detection cover 123 is rotated until the groove 124 of the detection tube 121 is fully matched with the protrusion 122, the existence of the angle can increase additional friction. Such a fit can form a "self-locking" effect to ensure the stability of the detection during use. The correct installation of the detection cover 123 requires accurate fit, and the setting of the angle can serve as a directional guide to reduce errors made by the operator during installation and improve user friendliness.
[0034] The angle structure can usually provide a stronger fastening force than a straight line. Such a structural design helps to make the detection cover 123 more firmly on the detection tube 121, reducing reagent leakage or contamination caused by improper operation. In addition, by accurately guiding the detection cover 123 into place, the consistency and repeatability of the detection process are ensured, which is very important for ensuring the accuracy of the detection results.
[0035] Please refer to Figure 2 Specifically, the plug-in end of the detection cover 123 is provided with a socket 1234, and the test strip 125 is plugged into the socket 1234 to achieve the plug-in matching of the test strip 125 and the detection cover 123. The cross-sectional shape of the socket 1234 can be square or other polygonal, which effectively prevents the test strip 125 from rotating during the rotation of the detection cover 123, reduces the detection error, and improves the detection accuracy of the reagent detection component 100. At the same time, the detection tube 121 of the transparent material facilitates the observation of the detection result of the test strip 125.
[0036] In this embodiment, the second section 1242 is extended along the circumference of the detection cover 123, and the extension direction of the first section 1241 and the extension direction of the third section 1243 are both perpendicular to the extension direction of the second section 1242. The first section 1241 and the third section 1243 perpendicular to the second section 1242 make the rotation path more intuitive and easy to understand. Combined with the transparent detection tube 121, the user can more directly see the correct installation position of the detection cover 123. The vertical design helps to simplify the rotation operation between the detection cover 123 and the detection tube 121, because users usually tend to move straight up and down, and this design can reduce errors during operation.
[0037] Furthermore, at least one blocking portion 1244 is convexly provided at the connection between the second section 1242 and the first section 1241 and the third section 1243, and each blocking portion 1244 is smoothly transitioned with the inner wall of the groove 124. The convex blocking portion 1244 provides clear position feedback. When the user pushes the convex block 122 to move in the first section 1241 and contacts the blocking portion 1244, the diameter of the groove 124 decreases, and the user feels resistance, which prompts the user to reach the connection between the first section 1241 and the second section 1242, and can rotate to enter the second section 1242. At the same time, the blocking portion 1244 can also remind the user to pass through the second section 1242 and enter the third section 1243, and the detection box 12 is switched from the ready-to-detect state to the start-detection state.
[0038] The blocking portion 1244 provides stable support for the relative position of the fixed protrusion 122 in the groove 124, thereby stabilizing the position of the detection cover 123, especially when moving the reagent detection assembly 100, improving the stability and reliability of the overall structure. The smoothly transitioned blocking portion 1244 is conducive to the user applying pressure to rotate, reducing the resistance and friction when the detection cover 123 rotates, making the rotation action smoother and better for the user.
[0039] In some embodiments, the multiple protrusions 122 in the detection tube 121 can be symmetrically arranged on the same horizontal plane, and the multiple protrusions 122 must reach the connection between the first section 1241 and the second section 1242 to rotate, that is, the detection cover 123 needs to be kept in a horizontal state to rotate, thereby improving the connection strength and sealing effect between the detection cover 123 and the detection tube 121.
[0040] Please refer to Figure 5 In the present embodiment, the reagent cover 112 includes a limiting portion 1122 which abuts against the main body 1121 and the open end surface of the reagent reagent box 11, the area of the limiting portion 1122 is larger than the opening area of the accommodating cavity 1111, and the limiting portion 1122 is provided with a grabbing end 1123 extending along the circumferential direction of the main body 1121, and the distance between the edge surface of the grabbing end 1123 and the outer surface of the main body 1121 is larger than the distance between the other edge surfaces of the limiting portion 1122 and the outer surface of the main body 1121.
[0041] The limiting portion 1122 realizes the seal between the reagent cover 112 and the reagent tube 111, effectively preventing the internal reagent from being contaminated. The grabbing end 1123 provided on the limiting portion 1122 has a larger protruding area. The user can easily remove and install the reagent cover 112 by grabbing the grabbing end 1123 without the aid of additional tools, thereby improving the convenience of use. The user can more easily open or close the reagent cover 112 without the need for additional tools or force. During the detection operation, the user can complete the opening and closing of the reagent cover 112 more quickly and accurately, thereby improving the efficiency and reliability of the experiment.
[0042] In one embodiment, the reagent tube 111 is provided with a dripping channel with the accommodating chamber 1111, and the dripping channel has a dripping inlet which is in the same plane as the opening of the accommodating chamber 1111, and the diameter of the dripping inlet is smaller than the opening diameter of the accommodating chamber 1111. The grabbing end 1123 of the reagent cover 112 may be protrudingly provided with a plug portion, which is plugged into and fits with the dripping inlet, and a fold is provided between the grabbing end 1123 and other parts of the reagent cover 112 to realize the flipping function of the grabbing end 1123 and the reagent cover 112.
[0043] When the reagent in the reagent tube 111 needs to be added to the sample to be tested, the plug and the dripping port are separated by flipping the grabbing end 1123, and the opening of the accommodating chamber 1111 does not need to be separated from the reagent cover 112, so that the reaction between the sample to be tested and the reagent can be achieved. After the reaction between the sample to be tested and the reagent is completed, the reagent cover 112 and the reagent tube 111 are separated, and the reagent tube 111 is connected to the test tube 121. Such an arrangement effectively avoids the situation where the reagent and the sample to be tested are contaminated, improves the stability of the reaction, and further improves the accuracy of the test results of the subsequent test strip 125.
[0044] In some embodiments, the periphery of the reagent cover 112 extending into the accommodating cavity 1111 may be provided with a silicone seal, and the plug-in portion between the detection tube 121 and the reagent tube 111, and the plug-in portion between the detection tube 121 and the detection cover 123 may be provided with a silicone seal to improve the sealing performance of the reagent detection assembly 100. The detachable connection between the detection tube 121 and the reagent tube 111 may be a threaded connection, a snap connection, a latch connection, etc., which is not limited here.
[0045] The above description is only a preferred embodiment of the present invention and is not intended to limit the present invention. Any modifications, equivalent substitutions and improvements made within the spirit and principles of the present invention should be included in the protection scope of the present invention.
Claims
1. A reagent detection component, characterized in that: Comprising a test kit and a detection kit; wherein, The reagent kit comprises a detachably connected reagent tube and a reagent cover, wherein a receiving cavity with an opening on one side is formed inside the reagent tube, the receiving cavity is used to place the reagent, and the reagent cover is used to block the opening of the receiving cavity; The detection box comprises a detection tube, a detection cover and a test strip, wherein the detection cover is movably connected to one end of the detection tube, one end of the test strip is fixedly connected to the detection cover and extends into the detection tube, and one end of the detection tube away from the detection cover is detachably connected to the detection box, and the detection cover has a movement direction that drives the test strip to extend into or away from the accommodating cavity; The reagent detection component has a packaging state and a detection state. When the reagent detection component is in the packaging state, the reagent cover is connected to the reagent tube, and the reagent tube is disconnected from the detection tube. When the reagent detection component is in the detection state, the reagent cover is disconnected from the reagent tube, and the reagent tube is connected to the detection tube.
2. The reagent detection assembly according to claim 1, characterized in that: The outer circumferential surface of the detection cover is provided with at least two grooves, and the inner wall of the detection tube is provided with at least two protrusions, and each of the protrusions is plugged and matched with each of the grooves in a one-to-one correspondence.
3. The reagent detection assembly according to claim 2, characterized in that: The detection cover comprises a cover body, a plug-in end and an abutment end, the plug-in end is plugged and matched with the detection tube, the diameter of the abutment end is larger than the diameter of the plug-in end, the abutment end is used to abut the end surface of the detection tube, and each of the grooves is provided on the outer peripheral surface of the cover body; Each of the grooves includes a first section, a second section, and a third section that are connected in sequence. The first section extends to the plug-in end and is provided with an inlet that is plugged into and cooperates with the corresponding protrusion. The third section extends to the abutment end. When the protrusion is in the first section, the test strip is not in the accommodating cavity. When the protrusion is in the third section, the test strip partially extends into the accommodating cavity.
4. The reagent detection assembly according to claim 3, characterized in that: The second section is extended along the circumferential direction of the detection cover, and the extension direction of the first section and the extension direction of the third section are both perpendicular to the extension direction of the second section.
5. The reagent detection assembly according to claim 3 or 4, characterized in that: At least one blocking portion is protruding from the connection between the second section and the first section and the third section, and each of the blocking portions and the inner wall of the groove are smoothly transitioned.
6. The reagent detection assembly according to claim 1, characterized in that: The reagent cover includes a main body and a limiting portion that abuts against the open end surface of the reagent box, the area of the limiting portion is larger than the opening area of the accommodating cavity, the limiting portion is provided with a grabbing end extending along the circumference of the main body, and the distance between the edge surface of the grabbing end and the outer surface of the main body is greater than the distance between the other edge surfaces of the limiting portion and the outer surface of the main body.