Continuous liquid supply liquid preparation device for bioreactor

Abstract

The utility model relates to the technical field of liquid preparation devices, in particular to a continuous liquid supply liquid preparation device for a bioreactor. The continuous liquid supply liquid preparation device comprises a liquid preparation tank, a sterilization device and a change-over valve group, the liquid preparation tank comprises a tank A liquid preparation tank and a tank B liquid preparation tank; the A-tank liquid preparation tank and the B-tank liquid preparation tank are fixedly mounted on the ground side by side, liquid inlets are formed in the top ends of the two liquid preparation tanks, and liquid inlet control valves are mounted on the two liquid inlets; sterilization devices are arranged at the top ends of the two liquid preparation tanks, liquid outlets and waste liquid discharge ports are formed in the lower ends of the two liquid preparation tanks, waste liquid discharge pipes are fixedly mounted on the two waste liquid discharge ports, connecting pipes are fixedly mounted on the two liquid outlets, and the two connecting pipes are connected through a change-over valve group; according to the utility model, continuous liquid supply of different solutions is realized through the change-over valve group, the production efficiency and the production quality are improved, meanwhile, the functions of automatic liquid preparation, online cleaning, sterilization and disinfection are realized through the control system, the solution pollution is avoided, and the production quality is improved.

Description

Technical Field

[0001] This utility model relates to the field of liquid preparation device technology, specifically a liquid preparation device for continuous liquid supply in a bioreactor. Background Technology

[0002] A reagent preparation system is an automated reagent preparation device that mainly achieves efficient and high-precision reagent preparation by automatically adding and mixing reagents according to pre-set flow rates and volumes.

[0003] The solution preparation system mainly consists of a solution preparation tank, a delivery pipeline, valves, a metering device, and a control system. The solution is prepared by injecting raw materials into the solution preparation tank, and the raw materials are mixed evenly by the agitator inside the tank. Then, the flow rate of the solution is controlled by the metering device and valves, and the solution is delivered to the required reactor through the delivery pipeline.

[0004] However, when multiple solutions or solutions of different concentrations are required during the use of the batching system, the liquid supply needs to be interrupted to switch between different solutions, which leads to a decrease in production efficiency. At the same time, the interruption of the liquid supply will affect the production process in the reactor, which in turn leads to a decrease in production quality.

[0005] In view of this, we propose a liquid preparation device for continuous liquid supply in bioreactors. Utility Model Content

[0006] The purpose of this invention is to provide a liquid preparation device for continuous liquid supply in a bioreactor, so as to solve the problem of continuous liquid supply mentioned in the background art.

[0007] To achieve the above objectives, this utility model provides the following technical solution:

[0008] A continuous liquid supply preparation device for a bioreactor includes preparation tanks, a sterilization device, a switching valve assembly, and a control system. The preparation tanks consist of preparation tank A and preparation tank B, which are fixedly installed side-by-side on the ground. Preparation tanks A and B each contain different solutions required for production. Both preparation tanks have inlets at their top for feeding raw materials, which are then stirred to prepare the desired production solution. Inlet control valves are installed on both inlets to control the feeding rate and concentration of raw materials. A sterilization device is installed at the top of both preparation tanks to ensure sterility and purity of the raw materials, thereby improving production quality. Both preparation tanks have outlets and wastewater discharge points at their bottom. The prepared solution flows out from the outlet for subsequent production needs, while waste liquid generated during the preparation process is discharged from the waste liquid discharge outlet for further treatment. Waste liquid discharge pipes are fixedly installed on both waste liquid discharge outlets for transporting waste liquid. Connecting pipes are fixedly installed on both outlets for transporting the prepared solution. The two connecting pipes are connected to a switching valve group located between tank A and tank B. The connecting pipes transport the prepared solution to the switching valve group. When solution from tank A is needed, the switching valve group controls the connecting pipe of tank A to transport the solution; when solution from tank B is needed, the switching valve group controls the connecting pipe of tank B to transport the solution. By controlling the switching and transport of different solutions through the switching valve group, continuous batching and transport are achieved.

[0009] Preferably, the sterilization device includes an air filter and an activated carbon filter; the air filter is located on one side of the liquid inlet and is fixedly installed on the top of the A-tank and B-tank mixing tanks. The air filter is located on the top of the mixing tanks to filter the air entering the mixing tanks, ensuring a sterile environment inside the mixing tanks; the activated carbon filter is installed inside the liquid inlet and is located below the liquid inlet control valve. The activated carbon filter is used to filter impurities from the raw materials, removing impurities and bacteria from the raw materials, avoiding solution contamination, reducing waste liquid generation, and improving the solution preparation rate.

[0010] Preferably, the switching valve assembly has an inlet and an outlet. There are two inlets, each fixedly connected to the connecting pipes of mixing tank A and mixing tank B, respectively. The outlet is equipped with a discharge pipe for conveying the solution flowing from the switching valve assembly. By controlling the opening and closing of the two inlets, the switching valve assembly controls the connection and closure of the connecting pipes between mixing tanks A and B, thereby achieving the switching of different solutions and continuous solution delivery. Simultaneously, the discharge pipe is connected to bioreactors in different areas via a pipeline network, enabling continuous liquid supply to bioreactors in different areas, thus improving production efficiency and product quality.

[0011] Preferably, the A-tank, B-tank, connecting pipe, and waste liquid discharge pipe are all made of 316L stainless steel. 316L stainless steel has good corrosion resistance and oxidation resistance. Using 316L stainless steel to make the tanks and pipes ensures the overall quality and service life of the tanks and pipes, avoiding frequent maintenance and replacement. At the same time, the tanks and pipes are polished inside and out to improve the surface quality of the tanks and pipes, prevent the liquid from sticking to the wall, and improve the cleaning and maintenance level.

[0012] Preferably, both waste liquid discharge pipes are equipped with waste liquid discharge control valves. The waste liquid discharge control valves are used to control the waste liquid discharge process, which facilitates subsequent waste liquid treatment and reduces waste liquid pollution to the environment.

[0013] Preferably, it also includes a control system; the control system is used for automatic liquid preparation, online cleaning and sterilization. The control system adopts PLC fully automatic control to control and display in real time the pneumatic valves and the parameters such as temperature, pressure and pH value, realizing fully automatic control of the liquid preparation process. At the same time, it controls the disinfection and sterilization of the tank and pipeline and online cleaning. When it is necessary to clean or sterilize the tank and pipeline, it is only necessary to close the corresponding control valve and start the cleaning program.

[0014] Compared with the prior art, the beneficial effects of this utility model are: this utility model realizes continuous supply of different solutions through the switching valve group, which improves production efficiency and production quality. At the same time, the control system realizes automatic solution preparation, online cleaning and sterilization, which ensures the cleanliness of the tank and pipeline, avoids solution contamination and improves production quality. Attached Figure Description

[0015] Figure 1 This is a schematic block diagram of the liquid preparation device of this utility model;

[0016] Figure 2 This is a schematic diagram of the overall liquid preparation device of this utility model.

[0017] In the picture:

[0018] 1. Liquid preparation tank; 11. Liquid preparation tank A; 12. Liquid preparation tank B; 13. Liquid inlet; 131. Liquid inlet control valve; 14. Liquid outlet; 141. Connecting pipe; 15. Waste liquid discharge port; 151. Waste liquid discharge pipe; 152. Waste liquid discharge control valve;

[0019] 2. Sterilization device; 21. Air filter; 22. Activated carbon filter;

[0020] 3. Switching valve assembly; 31. Inlet end; 32. Outlet end; 321. Discharge pipe;

[0021] 4. Control system. Detailed Implementation

[0022] The technical solutions of the present utility model will be clearly and completely described below with reference to the accompanying drawings of the embodiments. Obviously, the described embodiments are only some embodiments of the present utility model, and not all embodiments. Based on the embodiments of the present utility model, all other embodiments obtained by those of ordinary skill in the art without creative effort are within the protection scope of the present utility model.

[0023] The solution preparation system mainly consists of a solution preparation tank, a delivery pipeline, valves, a metering device, and a control system. The solution is prepared by injecting raw materials into the solution preparation tank, and the raw materials are mixed evenly by the agitator inside the tank. Then, the flow rate of the solution is controlled by the metering device and valves, and the solution is delivered to the required reactor through the delivery pipeline.

[0024] However, when multiple solutions or solutions of different concentrations are required during the use of the batching system, the liquid supply needs to be interrupted to switch between different solutions to meet production needs, which leads to a decrease in production efficiency. At the same time, the interruption of the liquid supply will suspend the production process in the reactor, causing the solution in the tank to settle and precipitate, which in turn leads to a decrease in production quality.

[0025] like Figures 1 to 2As shown, a continuous liquid supply preparation device for a bioreactor includes a preparation tank 1, a sterilization device 2, a switching valve group 3, and a control system 4. The preparation tank 1 includes a preparation tank A 11 and a preparation tank B 12. The preparation tank A 11 and the preparation tank B 12 are fixedly installed side by side on the ground. Each of the two preparation tanks 1 has a liquid inlet 13 at its top, and a liquid inlet control valve 131 is installed on each of the two liquid inlets 13. The sterilization device 2 is installed at the top of each of the two preparation tanks 1. Each of the two preparation tanks 1 has a liquid outlet 14 and a waste liquid discharge outlet 15 at its lower end. Waste liquid discharge pipes 151 are fixedly installed on each of the two waste liquid discharge outlets 15, and connecting pipes 141 are fixedly installed on each of the two liquid outlets 14. The two connecting pipes 141 are connected by the switching valve group 3, which is located between the preparation tank A 11 and the preparation tank B 12.

[0026] Specifically, mixing tank A 11 and mixing tank B 12 are fixedly installed on the ground using a cement platform. Mixing tank A 11 and mixing tank B 12 each contain different solutions required for production. Inlet 13 is used for the entry of raw materials. The raw materials enter the mixing tank 1 and are stirred to prepare the required production solution. Because the solutions in mixing tank A 11 and mixing tank B 12 are different, the raw materials injected through inlet 13 are also different. Inlet control valves 131 are installed on both inlets 13 to control the entry rate and content of the raw materials. Sterilization device 2 is used to ensure the sterility of mixing tank A 11 and mixing tank B 12 and the purity of the raw materials, thereby improving production quality. Both mixing tanks 1 have outlet 14 and waste discharge 15 at their lower ends. The prepared solution flows out from outlet 14 for subsequent production needs. Waste liquid generated during the process is discharged from waste liquid discharge port 15 for subsequent treatment; waste liquid discharge pipes 151 are fixedly installed on the two waste liquid discharge ports 15. Waste liquid discharge pipes 151 are used for transporting waste liquid. Connecting pipe 141 is fixedly connected to switching valve group 3 by thread. Switching valve group 3 is located between A tank mixing tank 11 and B tank mixing tank 12. The location of switching valve group 3 between the two can reduce the use of pipelines and save costs. Connecting pipe 141 transports the prepared solution to switching valve group 3. When the solution in A tank mixing tank 11 is needed, switching valve group 3 controls the connecting pipe 141 of A tank mixing tank 11 to transport the solution. When the solution in B tank mixing tank 12 is needed, switching valve group 3 controls the connecting pipe 141 of B tank mixing tank 12 to transport the solution. By controlling the switching and transport of different solutions through switching valve group 3, continuous batching and transport is realized.

[0027] In this embodiment, the sterilization device 2 includes an air filter 21 and an activated carbon filter 22; the air filter 21 is located on one side of the liquid inlet 13 and is fixedly installed on the top of the A tank liquid preparation tank 11 and the B tank liquid preparation tank 12; the activated carbon filter 22 is installed inside the liquid inlet 13 and is located below the liquid inlet control valve 131.

[0028] Specifically, the air filter 21 is located at the top of the liquid preparation tank 1 to filter the air entering the liquid preparation tank 1, ensuring a sterile environment inside the liquid preparation tank 1. The activated carbon filter 22 is used to filter impurities from the raw materials, remove impurities and bacteria from the raw materials, avoid contamination of the solution, reduce the generation of waste liquid, and improve the solution preparation rate.

[0029] In this embodiment, the switching valve group 3 is provided with an inlet end 31 and an outlet end 32. There are two inlet ends 31, and the two inlet ends 31 are respectively fixedly installed with the connecting pipes 141 of the A tank liquid preparation tank 11 and the B tank liquid preparation tank 12. The outlet end 32 is provided with a liquid outlet pipe 321.

[0030] Specifically, the outlet pipe 321 is used to transport the solution flowing out of the switching valve assembly 3. The switching valve assembly 3 controls the opening and closing of the two inlet ends 31, thereby controlling the connection and closure of the connecting pipe 141 between the A-tank mixing tank 11 and the B-tank mixing tank 12, thus realizing the conversion of different solutions and the continuous transport of solutions. At the same time, the outlet pipe 321 is connected to the bioreactors in different areas through the pipeline network, thereby realizing the continuous supply of liquid to the bioreactors in different areas, improving production efficiency and product quality. When the solution in the A-tank mixing tank 11 is needed... The switching valve group 3 controls the opening of the inlet end 31 connected to the connecting pipe 141 of the A tank mixing tank 11 and the closing of the inlet end 31 connected to the connecting pipe 141 of the B tank mixing tank 12, so as to transport the solution in the A tank mixing tank 11; when the solution in the B tank mixing tank 12 is needed, the opposite is true, the inlet end 31 connected to the connecting pipe 141 of the A tank mixing tank 11 is closed and the inlet end 31 connected to the connecting pipe 141 of the B tank mixing tank 12 is opened, so as to transport the solution in the B tank mixing tank, thereby realizing the switching of different solutions and the continuous transport of solutions;

[0031] In this embodiment, the A-tank liquid preparation tank 11, the B-tank liquid preparation tank 12, the connecting pipe 141 and the waste liquid discharge pipe 151 are all made of 316L stainless steel.

[0032] Specifically, 316L stainless steel has excellent corrosion resistance and oxidation resistance. Using 316L stainless steel to make tanks and pipes ensures the overall quality and service life of the tanks and pipes, avoiding frequent maintenance and replacement. At the same time, the tanks and pipes are polished inside and out, which improves the surface quality of the tanks and pipes, prevents the liquid from sticking to the walls, and improves the cleaning and maintenance efficiency.

[0033] In this embodiment, waste liquid discharge control valves 152 are installed on both waste liquid discharge pipes 151;

[0034] Specifically, the waste liquid discharge control valve 152 is used to control the waste liquid discharge process, which facilitates the subsequent treatment of waste liquid and reduces the pollution of waste liquid to the environment; the two outlets 14 are fixedly installed with connecting pipes 141, which are used to transport the prepared solution.

[0035] In this embodiment, the control system 4 is used for automatic liquid preparation, online cleaning and sterilization, and the control system 4 adopts PLC fully automatic control;

[0036] Specifically, control system 4 controls and displays in real time the pneumatic valves and the parameters such as temperature, pressure, and pH value, realizing fully automatic control of the liquid preparation process. At the same time, it controls the disinfection and sterilization of tanks and pipelines and online cleaning. When cleaning or sterilization of tanks and pipelines is required, simply close the corresponding control valve and start the cleaning program. Cleaning and sterilization ensure the cleanliness of tanks and pipelines, avoiding residual solution in tanks and pipelines that could contaminate subsequent solution manufacturing and transportation.

[0037] Figure 1 This is a schematic diagram of the liquid preparation device of this utility model. Raw materials enter from the inlets 13 of liquid preparation tank 11 (tank A) and liquid preparation tank 12 (tank B), respectively. After being sterilized and inactivated by the sterilization device 2, they enter the liquid preparation tank 1. The raw materials are stirred and mixed evenly in the liquid preparation tank 1 to prepare the required solution. Waste liquid generated by the liquid preparation tank 1 is discharged from the waste liquid discharge port 15, and normal solution enters the connecting pipe 141. When the solution in liquid preparation tank 11 (tank A) is needed, the switching valve group 3 controls the inlet end 31 connected to the connecting pipe 141 of liquid preparation tank 11 (tank A) to open and the inlet end 31 connected to the connecting pipe 141 of liquid preparation tank 12 (tank B) to close, so as to transport the solution in liquid preparation tank 11 (tank A). When the solution in liquid preparation tank 12 (tank B) is needed, the inlet end 31 connected to the connecting pipe 141 of liquid preparation tank 11 (tank A) is closed and the inlet end 31 connected to the connecting pipe 141 of liquid preparation tank 12 (tank B) is opened, so as to transport the solution in liquid preparation tank 12 (tank B).

[0038] The foregoing has shown and described the basic principles, main features, and advantages of this utility model. Those skilled in the art should understand that this utility model is not limited to the above embodiments. The embodiments and descriptions in the specification are merely preferred examples and are not intended to limit the utility model. Various changes and modifications can be made to this utility model without departing from its spirit and scope, and all such changes and modifications fall within the scope of the claimed utility model. The scope of protection of this utility model is defined by the appended claims and their equivalents.

Claims

1. A liquid preparation device for continuously supplying liquid to a bioreactor, characterized by: It comprises a liquid preparation tank (1), a sterilization device (2) and a conversion valve group (3). The liquid preparation tank (1) comprises an A tank liquid preparation tank (11) and a B tank liquid preparation tank (12); the A tank liquid preparation tank (11) and the B tank liquid preparation tank (12) are fixedly installed side by side on the ground, liquid inlet openings (13) are formed at the top ends of the two liquid preparation tanks (1), liquid inlet control valves (131) are installed on the two liquid inlet openings (13); the two liquid preparation tanks (1) are each provided with a sterilization device (2), liquid outlet openings (14) and waste liquid discharge openings (15) are formed at the lower ends of the two liquid preparation tanks (1), waste liquid discharge pipes (151) are fixedly installed on the two waste liquid discharge openings (15), connecting pipes (141) are fixedly installed on the two liquid outlet openings (14), the two connecting pipes (141) are connected with the conversion valve group (3), and the conversion valve group (3) is located between the A tank liquid preparation tank (11) and the B tank liquid preparation tank (12).

2. The liquid preparation device according to claim 1, wherein: The sterilization device (2) comprises an air filter (21) and an activated carbon filter (22). The air filter (21) is located on one side of the liquid inlet opening (13) and is fixedly installed on the top of the A tank liquid preparation tank (11) and the B tank liquid preparation tank (12). The activated carbon filter (22) is installed in the liquid inlet opening (13) and is located below the liquid inlet control valve (131).

3. The liquid preparation device according to claim 1, wherein: The conversion valve group (3) is provided with inlet ends (31) and outlet ends (32), the inlet ends (31) are two, the two inlet ends (31) are fixedly installed with the connecting pipes (141) of the A tank liquid preparation tank (11) and the B tank liquid preparation tank (12) respectively, and the outlet ends (32) are provided with liquid outlet pipes (321).

4. The liquid preparation device according to claim 3, wherein: The A tank liquid preparation tank (11), the B tank liquid preparation tank (12), the connecting pipes (141) and the waste liquid discharge pipes (151) are all made of 316L stainless steel.

5. The liquid preparation device according to claim 4, wherein: The waste liquid discharge control valves (152) are installed on the waste liquid discharge pipes (151).

6. The liquid preparation device according to claim 1, wherein: The control system (4) is further provided, which is used for automatic liquid preparation, online cleaning and sterilization and disinfection and is controlled by PLC.

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