Material washing device for medical intermediate penem side chain

Abstract

The utility model provides a material washing device for a medical intermediate penem side chain. The material washing device comprises a material washing unit and a washing liquid supply unit, the washing unit comprises a plurality of washing tanks, a discharge pipeline and a washing liquid overflow pipeline; a stirring device is arranged in the washing tank, a discharge port is formed in the bottom, a feed port is formed in the lower end of the side wall, and an overflow port is formed in the upper end; a discharge port of the front tank is connected with a feed port of the rear tank through a discharge pipeline, and an overflow port of the rear tank is connected with a washing liquid inlet of the front tank through a washing liquid overflow pipeline, so that multi-stage washing of solid-phase downstream and liquid-phase countercurrent is formed; the washing liquid supply unit comprises a washing liquid storage tank, a washing liquid supply main pipeline and a washing liquid supply branch pipeline; the washing liquid storage tank supplies washing liquid to all the washing material tanks through the washing liquid supply main pipeline and the washing liquid supply branch pipelines. According to the material washing device, through countercurrent washing and dynamic mixing, efficient impurity removal and solvent recycling are achieved, the solvent consumption is small, the operation period is short, and efficiency is high.

Description

Technical Field

[0001] This utility model belongs to the technical field of pharmaceutical intermediate production equipment, and in particular relates to a washing device for the side chain of the pharmaceutical intermediate penem. Background Technology

[0002] The preparation of side chains for penem antibiotics (such as imipenem and meropenem) requires multiple washing processes to remove impurities (such as unreacted raw materials, byproducts, and catalyst residues). Traditional processes often employ single-tank batch operation, requiring multiple additions of liquid, stirring, settling, and waste liquid discharge. Fresh solvent must be added for each batch, resulting in high solvent consumption, cumbersome operation, significant manual intervention, long operation cycles, and low efficiency. Utility Model Content

[0003] In view of this, in order to solve the above-mentioned technical problems, this utility model proposes a washing device for the side chain of the pharmaceutical intermediate penem, which realizes the multiple use of the washing liquid, has low solvent consumption, effectively reduces production costs, shortens the operation cycle, and improves production efficiency through a multi-stage washing tank series connection and pipeline counterflow design.

[0004] To achieve the above objectives, the technical solution of this utility model is implemented as follows:

[0005] A washing device for the side chain of penem, a pharmaceutical intermediate, includes:

[0006] The washing unit includes multiple washing tanks, a discharge pipeline, and a washing liquid overflow pipeline. Each washing tank has an internal stirring device, a discharge port at the bottom, multiple baffles along its circumference on its inner sidewall, a feed inlet at the lower end of the sidewall, an overflow port at the upper end of the sidewall, and a washing liquid inlet on the inner wall opposite the overflow port. The outlet end of the washing liquid inlet extends into the lower part of the inner cavity of the washing tank. The discharge port of the preceding washing tank is connected to the feed inlet of the following washing tank via the discharge pipeline, and the overflow port of the following washing tank is connected to the washing liquid inlet of the preceding washing tank via the washing liquid overflow pipeline.

[0007] The washing liquid supply unit includes a washing liquid storage tank, a main washing liquid supply pipeline, and multiple washing liquid supply branch pipelines. The washing liquid storage tank has a washing liquid inlet at the top, and the lower end of its side wall is connected to the inlet end of the main washing liquid supply pipeline. The outlet end of the main washing liquid supply pipeline is connected to the inlet ends of the multiple washing liquid supply branch pipelines, and the outlet ends of the multiple washing liquid supply branch pipelines are correspondingly connected to the washing liquid inlet of each washing tank.

[0008] Multiple washing tanks are connected in series. The material to be washed enters from the inlet of the first tank and flows into the subsequent tanks through the discharge pipe. At the same time, the washing liquid flows in the opposite direction, being added from the last tank. The washing liquid, carrying dissolved impurities, flows back to the previous tank through the overflow pipe, thus forming a multi-stage countercurrent washing process. The high-impurity waste liquid overflowing from the first washing tank can be treated and returned to the washing liquid storage tank or directly entered into the recovery system, saving solvent, reducing waste liquid volume, and improving washing efficiency. The stirring device in each washing tank, together with the baffles (distributed circumferentially), creates turbulence, ensuring full contact between the material to be washed and the washing liquid. The material settles to the bottom of the tank under gravity, while the washing liquid carries impurities to the overflow port, achieving preliminary separation from the impurities.

[0009] Furthermore, the stirring device includes a vertically arranged stirring shaft and a stirring paddle mounted on the stirring shaft; the top end of the stirring shaft is connected to a drive device located at the top of the outer side of the washing tank; the stirring paddle is located in the lower part of the inner cavity of the washing tank; the inlet and the outlet of the washing liquid inlet are both located at the height of the stirring paddle.

[0010] The agitator uses inclined turbine or anchor blades with a diameter of approximately 1 / 3 to 1 / 2 of the tank diameter. The rotation of the agitator generates axial and radial flow, which pushes solid particles and cleaning liquid to form strong turbulence in the lower part of the tank, accelerating the dissolution and mass transfer of impurities. Solid particles are repeatedly suspended and settled in the agitation zone, ensuring that the surface of each particle is fully in contact with the cleaning liquid and avoiding uneven washing in certain areas. The feed inlet is located at the lower end of the side wall, and the outlet end is at the same height as the agitator, ensuring that the slurry containing solids enters the agitation zone directly. The washing liquid inlet is located at the upper end of the side wall, and the outlet end extends to the height of the agitator, so that the washing liquid and solid particles are in full contact in the agitation zone.

[0011] Furthermore, there are four baffles, which are evenly spaced along the circumference; the baffles are located in the lower middle part of the inner cavity of the washing tank.

[0012] The baffle plate can enhance the turbulent mixing effect.

[0013] Furthermore, an inclined plate settling layer is provided at the upper end of the inner cavity of the washing tank and below the overflow port.

[0014] The inclined plate settling layer consists of multiple sets of parallel polypropylene corrugated plates with a plate spacing of 20-30mm. It is fixed to the upper end of the inner cavity of the washing tank by a bracket. The clear liquid rises along the surface of the inclined plate and is discharged through the overflow pipe. The solid particles slide down the plate surface to the bottom of the cone. The inclined plate settling layer can extend the solid phase settling path and accelerate particle separation.

[0015] Furthermore, the top of the washing tank is equipped with a safety valve, a pressure gauge, and a spare port.

[0016] Furthermore, the discharge pipeline includes a discharge pipe and a regulating valve, a flow meter, and a material pump installed on the discharge pipe; the washing liquid overflow pipeline includes a washing liquid overflow pipe and a regulating valve, a flow meter, and a liquid pump installed on the washing liquid overflow pipe.

[0017] Furthermore, the main washing solution supply pipe includes a main washing solution supply pipe and a liquid pump, a flow meter, and an online pH and concentration detector installed on the main washing solution supply pipe near one end of the washing solution storage tank; the branch washing solution supply pipe includes a branch washing solution supply pipe and a regulating valve and a flow meter installed on the branch washing solution supply pipe.

[0018] Furthermore, it also includes a recycling unit, which includes a recycling filter tank, a multi-effect evaporator, and a buffer storage tank connected in series; the inlet end of the recycling filter tank is connected to the overflow port of the first washing tank through a recycling pipe one; the outlet end of the buffer storage tank is connected to the return port at the top of the washing liquid storage tank through a recycling pipe two.

[0019] By setting up a recycling unit, the high-impurity waste liquid overflowing from the first washing tank can be recycled and reused. After treatment, it is sent back to the washing liquid storage tank to enter the countercurrent washing cycle.

[0020] Compared with existing technologies, the washing device for penem side chains in pharmaceutical intermediates described in this utility model has the following advantages:

[0021] The washing device for penem side chains of the pharmaceutical intermediate described in this utility model achieves efficient washing of penem side chains through a synergistic design of solid-phase co-current and liquid-phase counter-current, combined with dynamic mixing and gravity sedimentation. Utilizing the counter-current concentration gradient, it maximizes the solvent's impurity removal capacity and reduces fresh solvent consumption. The rational arrangement of the inlets and outlets within the washing tank, along with the construction of baffles and a stirring device, effectively ensures thorough mixing and washing of the washing liquid and materials within the tank. Separation is achieved through dynamic sedimentation. Simultaneously, the overflow port and washing liquid overflow pipeline allow the washing liquid from the next stage to be reused in the previous stage washing tank, effectively reducing production costs, shortening the operation cycle, and improving production efficiency. Attached Figure Description

[0022] The accompanying drawings, which form part of this utility model, are used to provide a further understanding of the utility model. The illustrative embodiments of the utility model and their descriptions are used to explain the utility model and do not constitute an undue limitation of the utility model. In the drawings:

[0023] Figure 1 This is a schematic diagram of the washing device for the side chain of the pharmaceutical intermediate penem as described in Embodiment 1 of this utility model;

[0024] Figure 2 This is a schematic diagram of the washing tank described in Embodiment 1 of this utility model;

[0025] Figure 3 This is a schematic diagram of the washing device for the side chain of the pharmaceutical intermediate penem as described in Embodiment 2 of this utility model.

[0026] Explanation of reference numerals in the attached figures:

[0027] 1-Washing tank, 2-Discharge pipe, 3-Washing liquid overflow pipe, 4-Discharge port, 5-Baffle plate, 6-Inlet, 7-Overflow port, 8-Washing liquid inlet, 9-Inclined plate settling layer, 10-Agitator shaft, 11-Agitator paddle, 12-Drive device, 13-Washing liquid storage tank, 14-Washing liquid supply main pipe, 15-Washing liquid supply branch pipe, 16-Recovery filter tank, 17-Multi-effect evaporator, 18-Buffer storage tank, 19-Recovery pipe one, 20-Recovery pipe two. Detailed Implementation

[0028] It should be noted that, unless otherwise specified, the embodiments and features described in these embodiments of the present invention can be combined with each other.

[0029] In the description of this utility model, it should be understood that the terms "center," "longitudinal," "lateral," "upper," "lower," "front," "rear," "left," "right," "vertical," "horizontal," "top," "bottom," "inner," and "outer," etc., indicating the orientation or positional relationship, are based on the orientation or positional relationship shown in the accompanying drawings and are only for the convenience of describing this utility model and simplifying the description, and do not indicate or imply that the device or element referred to must have a specific orientation, or be constructed and operated in a specific orientation, and therefore should not be construed as a limitation of this utility model. In the description of this utility model, unless otherwise stated, "a plurality of" means two or more.

[0030] In the description of this utility model, it should be noted that, unless otherwise explicitly specified and limited, the terms "installation," "connection," and "joining" should be interpreted broadly. For example, they can refer to a fixed connection, a detachable connection, or an integral connection; they can refer to a mechanical connection or an electrical connection; they can refer to a direct connection or an indirect connection through an intermediate medium; and they can refer to the internal connection of two components. Those skilled in the art can understand the specific meaning of the above terms in this utility model based on the specific circumstances.

[0031] The present invention will now be described in detail with reference to the accompanying drawings and embodiments.

[0032] Example 1

[0033] like Figure 1 and 2 As shown, a washing device for the side chain of the pharmaceutical intermediate penem includes a washing unit and a washing solution supply unit.

[0034] The washing unit includes three washing tanks 1, three sets of discharge pipelines 2, and three sets of washing liquid overflow pipelines 3;

[0035] The washing tank 1 is equipped with a safety valve, a pressure gauge, and a spare port at the top. An agitator is installed inside the tank, and a discharge port 4 is located at the bottom. Four baffles 5 are evenly spaced along the circumference of the lower part of the inner side wall. An inlet 6 is located at the lower end of the side wall, and an overflow port 7 is located at the upper end of the side wall. A washing liquid inlet 8 is located on the inner wall opposite the overflow port 7. The outlet end of the washing liquid inlet 8 extends into the lower part of the inner cavity of the washing tank 1. An inclined plate settling layer 9 is located at the upper end of the inner cavity and below the overflow port 7. The agitator includes a vertically arranged agitator shaft 10 and an agitator paddle 11 mounted on the agitator shaft 10. The top end of the agitator shaft 10 is connected to a drive device 12 located at the top of the outer side of the washing tank 1. The agitator paddle 11 is located in the lower part of the inner cavity of the washing tank 1. The outlet ends of the inlet 6 and the washing liquid inlet 8 are both located at the height of the agitator paddle 11.

[0036] The discharge pipeline 2 includes a discharge pipe and a regulating valve, a flow meter and a material pump installed on the discharge pipe; the discharge port 4 of the previous washing tank 1 is connected to the inlet 6 of the next washing tank 1 through the discharge pipeline 2; the discharge port 4 of the last washing tank 1 is connected to the next process through the discharge pipeline 2.

[0037] The washing liquid overflow pipeline 3 includes a washing liquid overflow pipe and a regulating valve, a flow meter and a liquid pump installed on the washing liquid overflow pipe; the overflow port 7 of the subsequent washing tank 1 is connected to the washing liquid inlet 8 of the previous washing tank 1 through the washing liquid overflow pipeline 3; the overflow port 7 of the first washing tank 1 is connected to an external waste liquid recovery system through the washing liquid overflow pipeline 3.

[0038] The washing solution supply unit includes a washing solution storage tank 13, a main washing solution supply pipeline 14, and three washing solution supply branch pipelines 15;

[0039] The washing liquid storage tank 13 has a washing liquid inlet at the top, and the lower end of its side wall is connected to the inlet of the washing liquid supply main pipeline 14. The outlet of the washing liquid supply main pipeline 14 is connected to the inlet of three washing liquid supply branch pipelines 15, and the outlet of the three washing liquid supply branch pipelines 15 is connected to the washing liquid inlet 8 of each washing tank 1. The washing liquid supply main pipeline 14 includes a washing liquid supply main pipe and a liquid pump, a flow meter, and an online pH and concentration detector installed on the washing liquid supply main pipe. The washing liquid supply branch pipelines 15 include washing liquid supply branch pipes and regulating valves and flow meters installed on the washing liquid supply branch pipes 15.

[0040] The material to be washed enters from the inlet 6 of the first washing tank 1. The washing liquid supply branch pipe 15 connected to the first washing tank 1 is opened to inject fresh washing liquid. After washing for a period of time (the washing time is selected according to the actual working conditions), it enters the subsequent tanks through the discharge pipe 2, and is discharged from the last washing tank 1 to the next process. At the same time, the washing liquid flows in the reverse direction. The washing liquid is supplied from the washing liquid storage tank 13 and added from the last tank. It carries the dissolved impurities and flows back to the previous tank through the overflow pipe 3. This forms a multi-stage countercurrent washing. The high-impurity waste liquid overflowing from the first washing tank 1 directly enters the recovery system. The three washing liquid supply branch pipes 15 are used to send fresh washing liquid into the three washing tanks 1 respectively. The washing liquid supply branch pipes 15 connected to the first and second washing tanks 1 can be opened or closed according to the working conditions. When opened, it is carried out simultaneously with the countercurrent washing liquid as a supplement to the fresh washing liquid.

[0041] Example 2

[0042] like Figure 3 As shown, based on Embodiment 1, the difference from Embodiment 1 is that it also includes a recovery unit. The recovery unit includes a recovery filter tank 16, a multi-effect evaporator 17, and a buffer storage tank 18 connected in series. The inlet end of the recovery filter tank 16 is connected to the overflow port 7 of the first washing tank 1 through a recovery pipe 19. The outlet end of the buffer storage tank 17 is connected to the return port at the top of the washing liquid storage tank 13 through a recovery pipe 20.

[0043] The high-impurity waste liquid overflowing from the first washing tank 1 is processed in the recovery filter tank 16, and then the solvent is recovered by the multi-effect evaporator 17. The solvent is buffered in the buffer storage tank 18 and then sent to the washing liquid storage tank 13 to be added to the washing liquid circulation.

[0044] The above description is only a preferred embodiment of the present utility model and is not intended to limit the present utility model. Any modifications, equivalent substitutions, improvements, etc., made within the spirit and principles of the present utility model should be included within the protection scope of the present utility model.

Claims

1. A washing apparatus for the side chain of the pharmaceutical intermediate penem, characterized in that, It comprises: a washing unit, which comprises a plurality of washing tanks, a discharge pipeline and a washing liquid overflow pipeline; the inner cavity of the washing tank is provided with a stirring device, the bottom is provided with a discharge port, the inner side wall is provided with a plurality of baffle plates in the circumferential direction, the lower end of the side wall is provided with an inlet, and the upper end of the side wall is provided with an overflow port; the inner wall opposite to the overflow port is provided with a washing liquid inlet, and the outlet end of the washing liquid inlet extends into the lower part of the inner cavity of the washing tank; the discharge port of the previous washing tank is connected with the inlet of the next washing tank through the discharge pipeline, and the overflow port of the next washing tank is connected with the washing liquid inlet of the previous washing tank through the washing liquid overflow pipeline; a washing liquid supply unit, which comprises a washing liquid storage tank, a washing liquid supply main pipeline and a plurality of washing liquid supply branch pipelines; the top of the washing liquid storage tank is provided with a washing liquid adding port, the lower end of the side wall is connected with the inlet end of the washing liquid supply main pipeline, the outlet end of the washing liquid supply main pipeline is connected with the inlet end of a plurality of washing liquid supply branch pipelines, and the outlet end of each washing liquid supply branch pipeline is connected with the washing liquid inlet of each washing tank.

2. The washing material apparatus for the medical intermediate penam side chain according to claim 1, characterized by: The stirring device comprises a vertically arranged stirring shaft and a stirring paddle arranged on the stirring shaft; the top end of the stirring shaft is connected with a driving device arranged on the outer top of the washing tank; the stirring paddle is located in the lower part of the inner cavity of the washing tank; the outlet end of the inlet and the washing liquid inlet are both located at the height of the stirring paddle.

3. The washing material apparatus for imipenem side chain, an intermediate of medicine according to claim 1, characterized by: The baffle plate has four, which are distributed in the circumferential direction at equal intervals; the baffle plate is located in the middle and lower part of the inner cavity of the washing tank.

4. The material washing apparatus for the side chain of the pharmaceutical intermediate, imipenem, according to claim 1, characterized in that: The upper end of the inner cavity of the washing tank, and located below the overflow port, is provided with an inclined plate settling layer.

5. The material washing apparatus for the side chain of the pharmaceutical intermediate, imipenem, according to claim 1, characterized in that: The top of the washing tank is provided with a safety valve port, a pressure gauge and a standby port.

6. The material washing apparatus for the side chain of the pharmaceutical intermediate, imipenem, according to claim 1, characterized in that: The discharge pipeline comprises a discharge pipe and a regulating valve, a flow meter and a pump arranged on the discharge pipe; the washing liquid overflow pipeline comprises a washing liquid overflow pipe and a regulating valve, a flow meter and a pump arranged on the washing liquid overflow pipe.

7. The material washing apparatus for the side chain of the pharmaceutical intermediate, imipenem, according to claim 1, characterized in that: The washing liquid supply main pipeline comprises a washing liquid supply main pipeline and a liquid pump, a flow meter and a PH and concentration online detection meter arranged on one end close to the washing liquid storage tank; the washing liquid supply branch pipeline comprises a washing liquid supply branch pipeline and a regulating valve and a flow meter arranged on the washing liquid supply branch pipeline.

8. The apparatus for washing the side chain of the pharmaceutical intermediate, penam, according to any one of claims 1 to 7, characterized in that: It also comprises a recovery unit, which comprises a recovery filter tank, a multi-effect evaporation tank and a buffer storage tank connected in series; the inlet end of the recovery filter tank is connected with the overflow port of the first washing tank through a recovery pipe one; the outlet end of the buffer storage tank is connected with the reflux port at the top of the washing liquid storage tank through a recovery pipe two.

Images