Nano-liposome extrusion device

Abstract

The utility model provides a nano-liposome extrusion device which comprises a first connecting part and a second connecting part, and a closed buffer chamber is formed at the joint of the first connecting part and the second connecting part; the microporous film is arranged in the buffer chamber and divides the buffer chamber into a first buffer chamber and a second buffer chamber; the first connecting part and the second connecting part are each provided with a circulation channel, the circulation channels are communicated with the buffering cavities on the same side, and the buffering cavities are divided into the first buffering cavities and the second buffering cavities through the microporous films, so that input or output of the lipidosome can be achieved no matter which circulation channel the lipidosome passes through. By means of the structure, bidirectional reciprocating flow of the liposome in the extrusion device can be achieved, the treatment efficiency of the liposome is improved, and the use cost of the extrusion device is reduced.

Description

Technical Field

[0001] This application relates to the field of liposome processing, and more particularly to a nanoliposome extrusion device. Background Technology

[0002] Liposome extrusion devices, also known as film extruders, are mainly used in the fields of medicine, food, and cosmetics to reduce the particle size of liposomes and facilitate their absorption by the human body.

[0003] Existing disposable extrusion devices consist of a first structure, a second structure, and a microporous membrane. Both the first and second structures have channels for liposomes to pass through. During installation, the first and second structures clamp the microporous membrane, forming a buffer cavity between the first structure and the microporous membrane as the liposomes are introduced. The microporous membrane abuts against the end wall of the second structure. Existing disposable extrusion devices can only allow liposomes to flow in one direction and cannot perform bidirectional repeated extrusion operations, resulting in low liposome processing efficiency.

[0004] Therefore, how to design a bidirectional extrusion device to improve the homogenization efficiency of liposomes has become a technical problem that urgently needs to be solved by those skilled in the art. Utility Model Content

[0005] This application provides a nanoliposome extrusion device to at least solve the above-mentioned technical problems existing in the prior art.

[0006] A nanoliposome extrusion device is provided, including a first connecting part and a second connecting part, wherein the connection between the first connecting part and the second connecting part forms a sealed buffer chamber.

[0007] A microporous membrane is disposed within a buffer chamber and divides the buffer chamber into a first buffer chamber and a second buffer chamber.

[0008] Both the first and second connecting parts are provided with flow channels, which are respectively connected to the buffer chamber on the same side.

[0009] In one embodiment, the device includes a first snap-fit ​​ring and a second snap-fit ​​ring. The first snap-fit ​​ring and the second snap-fit ​​ring are concentrically arranged and fixedly disposed on the end wall of one of the first connecting portion or the second connecting portion. The first snap-fit ​​ring and the second snap-fit ​​ring are located on the side close to the microporous membrane. An insertion groove is left between the first snap-fit ​​ring and the second snap-fit ​​ring. An insertion ring is fixedly disposed on the other end wall of the first connecting portion or the second connecting portion. When the insertion ring pushes the microporous membrane into the insertion groove, the microporous membrane is fixed.

[0010] In one embodiment, a first snap-fit ​​ring and a second snap-fit ​​ring are disposed on the first connecting portion, and a plug-in ring is disposed on the end wall of the second connecting portion near the microporous membrane.

[0011] In one embodiment, the length of the first snap ring along the axial direction of the first connecting portion is greater than the length of the second snap ring along the axial direction of the first connecting portion.

[0012] In one embodiment, the second connecting part has a pressing area on the end wall near the microporous membrane. The pressing area is located outside the insertion ring. When the first connecting part and the second connecting part are installed, the first locking ring pushes the microporous membrane to the pressing area and abuts against the end wall of the second connecting part.

[0013] In one embodiment, the first connecting part and the second connecting part are detachably connected. Both the first connecting part and the second connecting part have a flow-dividing groove on the end wall near the microporous membrane side, and the flow-dividing groove is connected to the flow-dividing hole on the same side.

[0014] In one embodiment, one of the first connecting part and the second connecting part is provided with a mounting groove; the inner wall of the mounting groove is provided with an internal thread; the other outer wall of the first connecting part and the second connecting part is provided with an external thread, and when the first connecting part and the second connecting part are connected, the external thread and the internal thread are threadedly connected.

[0015] In one embodiment, the mounting slot and internal thread are provided on the second connecting part, and the external thread is provided on the first connecting part.

[0016] In one embodiment, the second connecting part is provided with a limiting groove communicating with the mounting slot, and the outer wall of the first connecting part is provided with a limiting edge extending radially outward. When the first connecting part and the second connecting part are installed, the bottom wall of the limiting edge abuts against the bottom wall of the limiting groove.

[0017] In one embodiment, the flow channel includes a plurality of circumferentially distributed diversion holes, and Luer connectors are provided on both the first connecting part and the second connecting part, with the diversion holes communicating with the Luer connectors on the same side.

[0018] Compared with the prior art, the nanoliposome extrusion device of this application has the following advantages:

[0019] This application injects liposomes into a buffer chamber through a flow channel on one of the first and second connecting parts. Then, the liposomes in the buffer chamber flow out of the extrusion device through a microporous membrane and another flow channel, achieving one-time homogenization of the liposomes. Since the microporous membrane separates the buffer chamber into a first buffer chamber and a second buffer chamber, the liposomes can be input or output from either flow channel. This structure enables bidirectional reciprocating flow of liposomes in the extrusion device, accelerating the processing efficiency of liposomes and reducing the operating cost of the extrusion device.

[0020] It should be understood that the description in this section is not intended to identify key or essential features of the embodiments of this application, nor is it intended to limit the scope of this application. Other features of this application will become readily apparent from the following description. Attached Figure Description

[0021] The above and other objects, features, and advantages of exemplary embodiments of this application will become readily apparent from the following detailed description taken in conjunction with the accompanying drawings. Several embodiments of this application are illustrated in the drawings by way of example and not limitation, in which:

[0022] In the accompanying drawings, the same or corresponding reference numerals indicate the same or corresponding parts.

[0023] Figure 1 A schematic diagram of the overall structure of this application is shown;

[0024] Figure 2 A cross-sectional view of this application is shown;

[0025] Figure 3 This application shows Figure 2 A magnified structural diagram of A in the middle;

[0026] Figure 4 A schematic diagram of the unfolded form of this application is shown;

[0027] Figure 5 A schematic diagram of the structure of the first connecting part of this application is shown;

[0028] Figure 6 A schematic diagram of the structure of the second connecting part of this application is shown;

[0029] Figure 7 A schematic diagram of the extrusion apparatus of this application in use is shown.

[0030] Explanation of the labels in the diagram:

[0031] 1. First connecting part; 11. First snap-fit ​​ring; 12. Second snap-fit ​​ring; 13. Insertion slot;

[0032] 2. Second connecting part; 21. Insertion ring; 22. Pressing area;

[0033] 3. Buffer chamber; 31. First buffer chamber; 32. Second buffer chamber;

[0034] 4. Microporous membrane; 41. Drainage membrane; 42. Filter membrane;

[0035] 5. Flow channel; 51. Diversion hole;

[0036] 6. Mounting slot; 61. Internal thread; 62. External thread;

[0037] 71. Limiting groove; 72. Limiting edge;

[0038] 8. Luer connector; 9. Diverter channel. Detailed Implementation

[0039] To make the objectives, features, and advantages of this application more apparent and understandable, the technical solutions in the embodiments of this application will be clearly and completely described below with reference to the accompanying drawings. Obviously, the described embodiments are only some embodiments of this application, and not all embodiments. Based on the embodiments of this application, all other embodiments obtained by those skilled in the art without creative effort are within the scope of protection of this application.

[0040] like Figure 1 As shown, the extrusion device includes a first connecting part 1 and a second connecting part 2, wherein the first connecting part 1 and the second connecting part 2 are detachably connected.

[0041] like Figure 2 and Figure 4 As shown, it also includes a microporous membrane 4, wherein the microporous membrane 4 is installed between the first connecting part 1 and the second connecting part 2.

[0042] In order to achieve homogenization of liposomes, in this embodiment, both the first connecting part 1 and the second connecting part 2 are provided with flow channels 51 for liposomes to pass through. When the liposomes flow through the flow channel 5 of one of the first connecting part 1 or the second connecting part 2, the liposomes enter the microporous membrane 4 and then pass through the microporous membrane 4 for homogenization. The processed liposomes flow out through the other flow channel 5 of the first connecting part 1 or the second connecting part 2, thus completing one homogenization of the liposomes.

[0043] Specifically, such as Figure 2 As shown, in order to facilitate the homogenization of liposomes, after the first connecting part 1 and the second connecting part 2 are assembled, a closed buffer chamber 3 is formed between the first connecting part 1 and the second connecting part 2. The microporous membrane 4 is installed in the buffer chamber 3 and separates the buffer chamber 3 into a first buffer chamber 31 and a second buffer chamber 32.

[0044] In this embodiment, as Figure 2 As shown, the first buffer cavity 31 is located near the first connecting part 1, and the second buffer cavity 32 is located near the second connecting part 2.

[0045] In order to assemble the first connecting part 1 and the second connecting part 2, as follows: Figure 4 As shown, the second connecting part 2 is provided with a mounting slot 6, wherein the inner wall of the mounting slot 6 is provided with an internal thread 61, and the outer wall of the first connecting part 1 is provided with an external thread 62. When the first connecting part 1 and the second connecting part 2 are assembled, the external thread 62 and the internal thread 61 are threadedly connected.

[0046] It is worth noting that the microporous membrane 4 can be placed in the mounting slot 6 of the second connecting part 2 firstly, and then the first connecting part 1 and the second connecting part 2 can be threaded together. As the first connecting part 1 is inserted into the mounting slot 6 of the second connecting part 2, after the first connecting part 1 rotates, the first connecting part 1 feeds into the mounting slot 6 along the axis of the second connecting part 2, thereby extruding the microporous membrane 4 and finally completing the assembly of the extrusion device. The detachable connection between the first connecting part 1 and the second connecting part 2 facilitates the replacement of the microporous membrane 4.

[0047] In order to limit the depth of the first connecting part 1 entering the mounting slot 6 of the second connecting part 2, in this embodiment, as follows: Figure 2 and Figure 4 As shown, the second connecting part 2 is provided with a limiting groove 71 that communicates with the mounting slot 6, and the outer wall of the first connecting part 1 is provided with a limiting edge 72 that extends radially outward along the first connecting part 1. When the first connecting part 1 is installed on the second connecting part 2, the bottom wall of the limiting edge 72 abuts against the bottom wall of the limiting groove 71, thereby restricting the first connecting part 1 from continuing to enter into the mounting slot 6.

[0048] Conventional extrusion devices typically use a separate channel to transport liposomes to the microporous membrane 4. Due to the high flow rate of the liposomes, they can be directly sprayed onto the microporous membrane 4, which can easily cause damage to the microporous membrane 4 and thus affect the homogenization effect of the liposomes.

[0049] To address this issue, in this embodiment, as follows: Figure 2 , Figure 5 and Figure 6 As shown, both the first connecting part 1 and the second connecting part 2 are provided with a plurality of diversion holes 51 communicating with the buffer chamber 3 on the same side. Specifically, the first connecting part 1 and the second connecting part 2 each have six diversion holes 51, and the six diversion holes 51 are distributed in a circular pattern. The side of the first connecting part 1 and the second connecting part 2 away from the microporous membrane 4 is also provided with a Luer connector 8 communicating with the diversion holes 51. Each diversion hole 51 is connected to the Luer connector 8 on the same side. Liposomes can be injected into the diversion holes 51 through the Luer connector 8. The diversion holes 51 divert the liposomes and allow them to enter the buffer chamber 3 on the same side, reducing the impact force of the liposomes on the microporous membrane 4, reducing the risk of damage to the microporous membrane 4, and thus improving the service life of the microporous membrane 4.

[0050] Since both ends of the first connecting part 1 and the second connecting part 2 are provided with Luer connectors 8, and the first buffer cavity 31 and the second buffer cavity 32 are formed on both sides of the microporous membrane 4 respectively, therefore, as Figure 7As shown, the Luer connectors 8 on both sides of the extrusion device can be connected to syringes. The alternating extrusion of the syringes on both sides can achieve rapid homogenization of liposomes and improve the homogenization efficiency of liposomes.

[0051] To further reduce the risk of the microporous membrane 4 being damaged by liposome impact, in this embodiment, as follows: Figure 5 and Figure 6 As shown, the end walls of the first connecting part 1 and the second connecting part 2 near the microporous membrane 4 are both provided with flow dividers 9. The flow dividers 9 are connected to the flow dividers 51. When the liposomes flow out of the flow dividers 51, they will flow rapidly into the first buffer chamber 31 or the second buffer chamber 32 through the flow dividers 9 to disperse the liposomes, reduce the impact of the liposomes on the microporous membrane 4, and thus reduce the risk of damage to the microporous membrane 4.

[0052] Normally, when the microporous membrane 4 is located in the buffer chamber 3, with the connection of the first connecting part 1 and the second connecting part 2, the end wall of the first connecting part 1 will push against the microporous membrane 4 and abut against the end wall of the second connecting part 2. At this time, the first buffer chamber 31 and the second buffer chamber 32 will not exist. At this time, the liposomes injected from the diversion hole 51 will only be dispersed from the diversion groove 9 to the entire surface of the microporous membrane 4. The liposomes still have the risk of breaking through the microporous membrane 4.

[0053] In this embodiment, due to the presence of the first buffer cavity 31 and the second buffer cavity 32, it is necessary to adjust the fixing method of the microporous film 4.

[0054] Therefore, as Figure 3 , Figure 5 and Figure 6 As shown, it also includes a first snap-fit ​​ring 11 and a second snap-fit ​​ring 12, wherein the first snap-fit ​​ring 11 and the second snap-fit ​​ring 12 are concentrically arranged, and the first snap-fit ​​ring 11 and the second snap-fit ​​ring 12 are disposed on the end wall of the first connecting part 1 or the second connecting part 2 near the microporous membrane 4. The axis of the first snap-fit ​​ring 11 coincides with the axis of the first connecting part 1, and the first snap-fit ​​ring 11 is located outside the second snap-fit ​​ring 12. An insertion groove 13 is formed between the first snap-fit ​​ring 11 and the second snap-fit ​​ring 12.

[0055] Specifically, in this embodiment, the first snap ring 11 and the second snap ring 12 are disposed on the end wall of the first connecting part 1, and the end wall of the second connecting part 2 near the microporous film 4 is provided with a snap ring 21 that is inserted into the snap groove 13.

[0056] When the microporous membrane 4 is installed, the insertion ring 21 pushes the microporous membrane 4 into the insertion groove 13, thereby fixing the microporous membrane 4.

[0057] In order to achieve the formation of the first buffer cavity 31 and the second buffer cavity 32, such as Figure 3and Figure 5 As shown, the length of the first snap ring 11 along the axial direction of the first connecting part 1 is greater than the length of the second snap ring 12 along the axial direction of the first connecting part 1. The end wall of the second connecting part 2 near the microporous membrane 4 is provided with a pressing area 22. The pressing area 22 is located outside the insertion ring 21. After the first connecting part 1 and the second connecting part 2 are assembled, the first snap ring 11 pushes the microporous membrane 4 so that the end wall of the first snap ring 11 abuts against the pressing area 22 of the second connecting part 2. At this time, the microporous membrane 4 abuts against the second snap ring 12, thereby enabling the buffer chamber 3 to be separated into the first buffer chamber 31 and the second buffer chamber 32.

[0058] By releasing the pressure on the liposomes through the first buffer chamber 31 and the second buffer chamber 32, the risk of damage to the microporous membrane 4 can be reduced.

[0059] It is worth noting here that three microporous films 4 are provided between the first connecting part 1 and the second connecting part 2, such as... Figure 4 As shown, it includes two drainage films 41 and a filter film 42. The filter film 42 is sandwiched between the drainage films 41. The drainage films 41 are used to distribute the impact force of the liposomes, and the filter film 42 is used to homogenize the liposomes. Then, the microporous film 4 is installed by the cooperation of the insertion ring 22 and the insertion groove 13.

[0060] It should be understood that the various forms of processes shown above can be used to rearrange, add, or delete steps. For example, the steps described in this disclosure can be executed in parallel, sequentially, or in different orders, as long as the desired result of the technical solution disclosed in this application can be achieved, and this is not limited herein.

[0061] Furthermore, the terms "first" and "second" are used for descriptive purposes only and should not be construed as indicating or implying relative importance or implicitly specifying the number of technical features indicated. Thus, a feature defined as "first" or "second" may explicitly or implicitly include at least one of that feature. In the description of this application, "a plurality of" means two or more, unless otherwise explicitly specified.

[0062] The above description is merely a specific embodiment of this application, but the scope of protection of this application is not limited thereto. Any variations or substitutions that can be easily conceived by those skilled in the art within the scope of the technology disclosed in this application should be included within the scope of protection of this application. Therefore, the scope of protection of this application should be determined by the scope of the claims.

Claims

1. A nanoliposome extrusion device, characterized in that, It includes a first connecting part (1) and a second connecting part (2), and the connection between the first connecting part (1) and the second connecting part (2) forms a closed buffer chamber (3); A microporous membrane (4) is disposed in the buffer chamber (3) and divides the buffer chamber (3) into a first buffer chamber (31) and a second buffer chamber (32); Both the first connecting part (1) and the second connecting part (2) are provided with flow channels (5), and the flow channels (5) are respectively connected to the buffer chamber (3) on the same side.

2. A nanoliposome extrusion device according to claim 1, wherein, Includes a first snap-fit ​​ring (11) and a second snap-fit ​​ring (12). The first snap-fit ​​ring (11) and the second snap-fit ​​ring (12) are concentrically arranged and fixedly arranged on the end wall of one of the first connecting part (1) or the second connecting part (2). The first snap-fit ​​ring (11) and the second snap-fit ​​ring (12) are located on the side close to the microporous membrane (4). An insertion groove (13) is left between the first snap-fit ​​ring (11) and the second snap-fit ​​ring (12). An insertion ring (21) is fixedly provided on the other end wall of the first connecting part (1) or the second connecting part (2). When the insertion ring (21) pushes the microporous membrane (4) into the insertion groove (13), the microporous membrane (4) is fixed.

3. A nanoliposome extrusion device according to claim 2, wherein, The first snap ring (11) and the second snap ring (12) are disposed on the first connecting part (1), and the insertion ring (21) is disposed on the end wall of the second connecting part (2) near the microporous membrane (4).

4. A nanoliposome extrusion device according to claim 2 or 3, wherein, The length of the first snap ring (11) along the axial direction of the first connecting part (1) is greater than the length of the second snap ring (12) along the axial direction of the first connecting part (1).

5. A nanoliposome extrusion device according to claim 4, wherein, The second connecting part (2) has a pressing area (22) on the end wall near the microporous membrane (4). The pressing area (22) is located outside the insertion ring (21). When the first connecting part (1) and the second connecting part (2) are installed, the first snap ring (11) pushes the microporous membrane (4) to the pressing area (22) and abuts against the end wall of the second connecting part (2).

6. The nanoliposome extrusion device of claim 1, wherein, The first connecting part (1) and the second connecting part (2) are detachably connected. Both the first connecting part (1) and the second connecting part (2) have a diversion groove (9) on the end wall near the microporous membrane (4). The diversion groove (9) is connected to the diversion hole (51) on the same side.

7. A nanoliposome extrusion device according to claim 6, wherein, One of the first connecting part (1) and the second connecting part (2) is provided with a mounting slot (6); the inner wall of the mounting slot (6) is provided with an internal thread (61); the other outer wall of the first connecting part (1) and the second connecting part (2) is provided with an external thread (62). When the first connecting part (1) and the second connecting part (2) are connected, the external thread (62) is threadedly connected with the internal thread (61).

8. A nanoliposome extrusion device according to claim 7, wherein, The mounting slot (6) and the internal thread (61) are provided on the second connecting part (2), and the external thread (62) is provided on the first connecting part (1).

9. The nanoliposome extrusion device of claim 7, wherein, The second connecting part (2) is provided with a limiting groove (71) that communicates with the mounting slot (6). The outer wall of the first connecting part (1) is provided with a limiting edge (72) that extends radially outward. When the first connecting part (1) and the second connecting part (2) are installed, the bottom wall of the limiting edge (72) abuts against the bottom wall of the limiting groove (71).

10. The nanoliposome extrusion device of claim 2, wherein, The flow channel (5) includes several circumferentially distributed diversion holes (51). Luer connectors (8) are provided on the first connecting part (1) and the second connecting part (2). The diversion holes (51) are connected to the Luer connectors (8) on the same side.

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