A solution preparation device for medical detection experiments

Abstract

The utility model discloses a kind of solution's liquid preparation device for medical detection experiment, by integrating multiple liquid preparation tanks in integrated shell, layout is neat, greatly save laboratory operation space, avoid the mess and dumping risk brought by multiple independent containers. Through the special water injection cylinder with scale and liquid injection pipe, the accurate measurement of solvent and the independent addition of solute during the preparation of each solution are realized, the accuracy of solution concentration is guaranteed from the source, pollution is effectively prevented, the use amount of experimental consumables is reduced, and the batch difference of solution preparation is reduced by the built-in mixing device in the liquid preparation tank. In addition, through the bottom drainage groove and waste liquid recovery system, the dripping liquid or cleaning wastewater in the operation can be collected and diverted in time, the workbench is kept dry and clean, which meets the laboratory safety and environmental protection standards.

Description

Technical Field

[0001] This utility model relates to the field of medical testing solution preparation device technology, and in particular to a solution preparation device for medical testing experiments. Background Technology

[0002] In medical laboratory testing, various solutions are frequently prepared. For example, in the hybridization and signal detection stages of HPV detection, four solutions—A, B, C, and D (hybridization buffer, washing solution, detection antibody (or conjugate), and chemiluminescent substrate)—are used. A simplified procedure can be summarized as follows: 1. Hybridization: Sample + Solution A → Incubate at a specific temperature → Form HPV DNA-RNA probe hybrids. 2. Capture and Washing: Transfer the mixture to a capture plate, incubate, then discard the liquid → Add Solution B and wash several times → The hybrids are immobilized on the plate, and impurities are washed away. 3. Signal Labeling: Add Solution C and incubate → Enzyme-labeled antibody binds to the hybrids → Discard the liquid → Wash again with Solution B to remove unbound antibodies. 4. Signal Detection: Add Solution D → Enzyme catalyzes the substrate to produce chemiluminescence → Read the luminescence value using an instrument.

[0003] Because a single hybridization instrument has limited processing capacity, typically handling only 48 samples at a time, while actual experiments often require processing far more than this number, it is necessary to use multiple hybridization instruments simultaneously. This significantly increases the demand for solutions, naturally leading to a greater number of solution bottles to be prepared, and consequently increasing the workload and complexity of the entire preparation process.

[0004] Currently, the specific operational details for solution preparation typically involve carefully pouring a certain amount of concentrated solution into a specific container, then precisely measuring the required volume of pure water using a graduated cylinder and slowly adding it to the container to mix with the concentrated solution for dilution. However, due to the inherent capacity of the containers used, a single preparation often cannot meet all needs, necessitating multiple repetitions of the preparation process. After each preparation, the diluted solution must be transferred one by one to dedicated dispensing bottles, and finally, these dispensing bottles are neatly placed into the hybridization apparatus to prepare for subsequent hybridization reactions.

[0005] The demand for solutions increases significantly with the number of hybridization instruments, leading to more preparation bottles and repeated preparation steps (such as pouring concentrate and measuring pure water with a graduated cylinder). Each operation may result in slight differences in solution concentration due to human factors (such as inaccurate graduated cylinder readings or inconsistent pouring volumes), affecting solution consistency. When multiple hybridization instruments are running simultaneously, concentration discrepancies between different batches of solutions may lead to inconsistent hybridization reaction conditions on different instruments, thus affecting the accuracy of experimental results. Furthermore, during multiple preparation processes, small amounts of reagent residue or loss may occur during container cleaning and reagent handling, potentially resulting in reagent waste in the long run. To meet the demands of multiple preparations, more containers and dispensing bottles may be needed, increasing the consumption of experimental consumables.

[0006] Therefore, it is necessary to design a solution preparation device for medical testing experiments to reduce batch-to-batch variability in solution preparation and the amount of experimental consumables used. Utility Model Content

[0007] This invention addresses the problems of existing technology by providing a solution preparation device for medical testing experiments.

[0008] To achieve the above objectives, this utility model provides the following technical solution: A solution preparation device for medical testing experiments, comprising: The shell has multiple placement slots at the top for accommodating multiple liquid dispensing tanks, and a recess with through holes at the bottom. The through holes correspond one-to-one with the placement slots and are interconnected, allowing the outlet of the liquid dispensing tank to pass through and be exposed in the recess. A liquid preparation tank, the tank body of which is embedded in the placement groove of the shell, the top of the liquid preparation tank is provided with a liquid inlet and a water inlet respectively, and the bottom of the liquid preparation tank is provided with a water outlet, the water outlet passing through the through hole of the shell and exposed in the recess at the bottom of the shell; A drain trough is located at the bottom of the recess, and a drain plate is provided on the top of the drain trough. The bottom of the drain trough is connected to the waste liquid recycling tank through a drain pipe.

[0009] Furthermore, in the above-mentioned solution preparation device for medical testing experiments, the water inlet is connected to a water inlet pipe via a rubber stopper. The water inlet pipe is equipped with a first valve. The top of the water inlet pipe is connected to a graduated water inlet cylinder. The water inlet cylinder is supported and fixed by a bracket. The bottom of the bracket is fixed to the solution preparation tank. The top of the bracket forms a snap-fit ​​part for clamping the body of the water inlet cylinder. The top of the water inlet cylinder is movably connected to a first cap.

[0010] Furthermore, in the above-mentioned solution preparation device for medical testing experiments, the injection port is connected to an injection tube via a rubber stopper, and a second cap is movably connected to the top of the injection tube.

[0011] Furthermore, in the above-mentioned solution preparation device for medical testing experiments, the preparation tank is equipped with a mixing device.

[0012] Furthermore, in the above-mentioned solution preparation device for medical testing experiments, the mixing device includes a rotating shaft and a stirring paddle. The upper end of the rotating shaft is connected to a motor through a sealed bearing, and the motor is fixed on the solution preparation tank through a frame. Multiple sets of stirring paddles are distributed at equal intervals from top to bottom at the lower end of the rotating shaft. Each set of stirring paddles is at the same height and is evenly distributed along the circumference of the rotating shaft.

[0013] Furthermore, in the above-mentioned solution preparation device for medical testing experiments, the bottom wall of the preparation tank is inverted conical and gradually converges to the outlet.

[0014] Furthermore, in the above-mentioned solution preparation device for medical testing experiments, a second valve is installed at the outlet.

[0015] Furthermore, in the above-mentioned solution preparation device for medical testing experiments, the preparation tank is provided with a first viewing window with graduations, and the front side of the shell is provided with a second viewing window, with each second viewing window corresponding to a placement slot.

[0016] Furthermore, in the above-mentioned solution preparation device for medical testing experiments, the edge of the draining trough has a stepped upper edge, and the draining plate overlaps the stepped upper edge.

[0017] Furthermore, in the above-mentioned solution preparation device for medical testing experiments, the bottom wall of the drain tank is inclined, and the drain pipe is connected to the lowest point of the bottom wall of the drain tank.

[0018] Compared with the prior art, the beneficial effects of this utility model are as follows: This utility model provides a solution preparation device for medical testing experiments. By integrating multiple preparation tanks into a single housing, the device boasts a neat layout, significantly saving laboratory operating space and avoiding the clutter and spillage risks associated with multiple independent containers. Dedicated graduated water cylinders and injection tubes ensure precise solvent measurement and independent solute addition for each solution preparation, guaranteeing accurate solution concentrations from the source and effectively preventing contamination. This reduces the consumption of experimental consumables, and the built-in mixing device in the preparation tank minimizes batch-to-batch variations in solution preparation. Furthermore, the bottom drain and wastewater recovery system promptly collect and divert drips or cleaning wastewater during operation, keeping the work surface dry and clean, complying with laboratory safety and environmental protection regulations. Attached Figure Description

[0019] To more clearly illustrate the technical solutions in the embodiments of this application or the prior art, the drawings used in the embodiments will be briefly introduced below. Obviously, the drawings described below are only some embodiments recorded in this utility model. For those skilled in the art, other drawings can be obtained based on these drawings.

[0020] Figure 1 A front view of a solution preparation device for medical testing provided in an embodiment of this utility model.

[0021] Figure 2 A top view of a solution preparation device for medical testing provided in an embodiment of this utility model.

[0022] Figure 3 This is a front view of the liquid preparation tank provided in an embodiment of the present utility model.

[0023] Figure 4 A cross-sectional view of the liquid preparation tank provided in an embodiment of this utility model.

[0024] Explanation of reference numerals in the attached figures: 1-Shell, 2-Placement groove, 3-Liquid mixing tank, 4-Recess, 5-Outlet, 6-Injection port, 7-Water inlet, 8-Draining trough, 9-Draining plate, 10-Drain pipe, 11-Injection pipe, 12-First valve, 13-Injection cylinder, 14-Support, 15-First cover, 16-Injection pipe, 17-Second cover, 18-Rotating shaft, 19-Agitator, 20-Motor, 21-Frame, 22-Second valve, 23-First viewing window, 24-Second viewing window. Detailed Implementation

[0025] To enable those skilled in the art to better understand the technical solution of this utility model, the present utility model will be further described in detail below with reference to the accompanying drawings and embodiments.

[0026] like Figure 1-4 As shown.

[0027] This utility model provides a solution preparation device for medical testing experiments, including a shell 1, a solution preparation tank 3, a draining tank 8, and other components. Wherein: The housing 1 has multiple placement slots 2 at its top to accommodate multiple dispensing tanks 3, and a recess 4 with through holes at its bottom. These through holes correspond one-to-one with and communicate with the placement slots 2, allowing the outlets 5 of the dispensing tanks 3 to pass through and be exposed in the recess 4. The housing 1 can be made of high-density, corrosion-resistant polypropylene or ABS engineering plastic to ensure structural stability and resistance to common chemical reagents. Silicone or elastic rubber buffer gaskets can be added inside the placement slots 2 to dampen and stabilize the dispensing tanks 3, effectively preventing accidental sliding and impacts during operation. The recess 4 design allows the outlets of the dispensing tanks to be "suspended" and exposed, leaving space for the drain below and perfectly solving the problem of dripping contamination of the countertop.

[0028] In order to facilitate observation of the liquid preparation tank 3 in the placement tank 2, in a preferred embodiment, a second viewing window 24 is provided on the front side of the housing 1, and the second viewing window 24 corresponds one-to-one with the placement tank 2.

[0029] For easy identification, a label can be set on the housing 1, such as marking the front of the housing corresponding to the first placement slot as solution A (abbreviated as A), the front of the housing corresponding to the second placement slot as solution B (abbreviated as B), the front of the housing corresponding to the third placement slot as solution C (abbreviated as C), the front of the housing corresponding to the fourth placement slot as solution D (abbreviated as D), and so on.

[0030] The solution preparation tank 3 is the core container for solution preparation, mixing, and temporary storage. The solution preparation tank 3 can be made of high borosilicate glass or medical-grade polycarbonate, possessing excellent chemical inertness, transparency, and mechanical strength. Its body is embedded in the placement groove 2 of the shell. The top of the solution preparation tank 3 is respectively provided with a liquid inlet 6 and a water inlet 7. The liquid inlet 6 is used to add concentrated solution, and the water inlet 7 is used to add pure water. The bottom of the solution preparation tank 3 is provided with a water outlet 5, which passes through the through hole of the shell 1 and is exposed at the recess 4 at the bottom of the shell 1.

[0031] In a preferred embodiment, the water inlet 7 is connected to a water inlet pipe 11 via a rubber stopper. A first valve 12 is provided on the water inlet pipe 11. The first valve can be a precision shut-off valve or a piston valve to achieve fine-tuning control of the flow rate. A graduated water inlet cylinder 13 is connected to the top of the water inlet pipe 11. The capacity of the water inlet cylinder can be 500mL or 1000mL, with a graduation value of at least 1mL. It can be made of high-transparency glass or plastic to ensure accurate readings. The water inlet cylinder is supported and fixed by a bracket 14. The bottom of the bracket 14 is fixed to the dispensing tank, and the top of the bracket 14 forms a snap-fit ​​part for clamping the body of the water inlet cylinder 13. The snap-fit ​​part can be optimized as a U-shaped elastic clamp or a clamp with a locking knob to ensure the water inlet cylinder remains stable and does not fall off under various operations. A first cover 15 is movably connected to the top of the water inlet cylinder 13. This prevents dust from entering and causing contamination when the water inlet cylinder 13 is not in use.

[0032] In a preferred embodiment, the injection port 6 is connected to an injection tube 16 via a rubber stopper, and a second cap 17 is movably connected to the top of the injection tube 16. The second cap 17 can be a rubber stopper cap, which has good sealing performance and prevents changes in the properties of volatile or hygroscopic reagents.

[0033] To ensure rapid and complete dissolution of the solute and uniform mixing of solutions prepared in different batches, in a preferred embodiment, the mixing tank 3 is equipped with a mixing device inside.

[0034] In a preferred embodiment, the mixing device includes a rotating shaft 18 and a stirring paddle 19. The upper end of the rotating shaft 18 is connected to a motor 20 via a sealed bearing. The motor 20 is fixed to the mixing tank 3 via a frame 21. The motor 20 can be a low-speed, high-torque stepper motor or a DC geared motor, with an adjustable speed range of 50-500 rpm to accommodate solutions of different viscosities. Multiple sets of stirring paddles 19 are evenly spaced at the lower end of the rotating shaft 18, with each set at the same height and evenly distributed circumferentially along the rotating shaft 18. The stirring paddles 19 can be made of polytetrafluoroethylene (PTFE) or 316L stainless steel to ensure chemical compatibility and durability. The stirring paddles 19 can employ a blade design combining axial and radial flow (e.g., an upper layer of inclined blades for axial circulation and a lower layer of flat blades for radial shearing), forming a highly efficient three-dimensional flow field and eliminating dead zones in the mixing process.

[0035] In a preferred embodiment, the bottom wall of the liquid preparation tank 3 is inverted conical and gradually converges to the outlet 5. This fluid dynamics design guides the liquid to naturally converge at the outlet, achieving near-zero dead zone complete drainage.

[0036] In a preferred embodiment, a second valve 22 is installed at the outlet 5. The second valve 22 can be a diaphragm valve or a plunger valve made of polytetrafluoroethylene (PTFE), which ensures unobstructed flow, leaves no residue, and has excellent corrosion resistance. Alternatively, the second valve 22 can be a corrosion-resistant flow control solenoid valve, which can communicate with the controller. By setting the target flow rate on the controller, manual valve operation can be avoided, improving the level of automation. The controller can be integrated into the housing and connected to a display screen. The display screen allows for operation settings and parameter adjustment, and can also be configured with switches to start and stop the solenoid valve and motor.

[0037] In a preferred embodiment, the liquid preparation tank 3 is provided with a first viewing window 23 with graduations, which facilitates macroscopic monitoring and rough estimation of the total volume of the solution in the tank, so as to replenish it in a timely manner.

[0038] The drain trough 8 is located at the bottom of the recess 4. The top of the drain trough 8 is provided with a drain plate 9, and the bottom of the drain trough 8 is connected to the waste liquid recycling tank through a drain pipe 10. The drain plate 9 can be made of PP or stainless steel perforated plate with a hole diameter of about 3-5mm, which can effectively drain water and bear weight.

[0039] In a preferred embodiment, the edge of the drain groove 8 is formed with a stepped upper edge, and the drain plate 9 overlaps the stepped upper edge.

[0040] In a preferred embodiment, the bottom wall of the drain trough 8 is inclined, and the drain pipe 10 is connected to the lowest point of the bottom wall of the drain trough 8. This design utilizes gravity flow to ensure that waste liquid is completely and quickly drained and does not accumulate in the trough.

[0041] This device innovatively adopts a modular, integrated, and user-friendly design concept, completely solving a series of problems in traditional solution preparation processes, such as cluttered containers, cross-contamination during operation, insufficient weighing accuracy, uneven mixing, and inconvenient waste disposal. Its core advantages are: 1. High efficiency and integration, neat and safe: Multiple liquid preparation tanks are integrated into a single shell, with a neat layout, which greatly saves laboratory operating space and avoids the mess and tipping risks caused by multiple independent containers.

[0042] 2. Precise quantification, eliminating contamination: Through a dedicated graduated water injection cylinder and liquid injection tube, the precise measurement of solvent and independent addition of solute are achieved when preparing each solution, ensuring the accuracy of solution concentration from the source and effectively preventing contamination.

[0043] 3. Forced mixing for superior results: The built-in mechanical mixing device in the mixing tank replaces the inefficient and inconsistent manual shaking, ensuring that the solution reaches a high degree of homogeneity in a short time. It is especially suitable for poorly soluble reagents or experiments that require extremely high uniformity (such as HPV detection hybridization solution).

[0044] 4. Waste collection and environmental compliance: The unique bottom drain and waste liquid recycling system can collect and divert dripping liquid or cleaning wastewater in a timely manner, keeping the work surface dry and clean, in compliance with laboratory safety and environmental protection standards.

[0045] 5. Full visibility and convenient operation: The set-in viewing window allows operators to monitor the liquid level, mixing process and dewatering tank status in real time, improving the intuitiveness and controllability of operation.

[0046] This device is particularly suitable for units that require frequent and precise preparation of various solutions, such as medical testing departments, molecular biology laboratories, and pharmaceutical research and development centers. For example, in an HPV testing experiment: This device can be used to accurately prepare hybridization buffer (solution A), and its mixing device ensures that viscous reagents such as formamide are completely and evenly mixed with salts.

[0047] When preparing the washing solution (solution B), ultrapure water can be accurately measured through the water injection tube, and the final volume can be controlled through the first viewing window.

[0048] In summary, this utility model is not only a simple solution preparation tool, but also a complete solution preparation solution. Through meticulous design, it comprehensively improves the efficiency, safety, and standardization of basic laboratory operations.

[0049] It should be noted that, in this document, relational terms such as "first" and "second" are used only to distinguish one entity or operation from another, and do not necessarily require or imply any such actual relationship or order between these entities or operations. Furthermore, the terms "comprising," "including," or any other variations thereof are intended to cover non-exclusive inclusion, such that a process, method, article, or apparatus that comprises a list of elements includes not only those elements but also other elements not expressly listed, or elements inherent to such a process, method, article, or apparatus. Without further limitations, an element defined by the phrase "comprising one..." does not exclude the presence of other identical elements in the process, method, article, or apparatus that includes said element.

[0050] The embodiments described above are merely specific implementations of this application, used to illustrate the technical solutions of this application, and not to limit them. The protection scope of this application is not limited thereto. Although this application has been described in detail with reference to the foregoing embodiments, those skilled in the art should understand that any person skilled in the art can still modify or easily conceive of changes to the technical solutions described in the foregoing embodiments within the scope of the technology disclosed in this application, or make equivalent substitutions for some of the specific technologies; and these modifications, changes, or substitutions do not cause the essence of the corresponding technical solutions to deviate from the spirit and scope of the technical solutions of the embodiments of this application. All should be covered within the protection scope of this application. Therefore, the protection scope of this application should be determined by the protection scope of the claims.

Claims

1. A solution preparation device for medical testing experiments, characterized in that, include: The shell (1) has multiple placement slots (2) at the top for accommodating multiple liquid preparation tanks (3), and a recess (4) with through holes is formed at the bottom. The through holes correspond one-to-one with the placement slots (2) and are interconnected, so that the outlet (5) of the liquid preparation tank (3) can pass through and be exposed at the recess (4). The liquid preparation tank (3) is embedded in the placement groove (2) of the shell. The top of the liquid preparation tank (3) is provided with a liquid injection port (6) and a water injection port (7). The bottom of the liquid preparation tank (3) is provided with a water outlet (5). The water outlet (5) passes through the through hole of the shell (1) and is exposed at the recess (4) at the bottom of the shell (1). The drain trough (8) is located at the bottom of the recess (4). The top of the drain trough (8) is provided with a drain plate (9). The bottom of the drain trough (8) is connected to the waste liquid recycling tank through a drain pipe (10).

2. The solution preparation device for medical testing experiments according to claim 1, characterized in that, The water inlet (7) is connected to a water inlet pipe (11) via a rubber stopper. A first valve (12) is provided on the water inlet pipe (11). The top of the water inlet pipe (11) is connected to a graduated water inlet cylinder (13). The water inlet cylinder is supported and fixed by a bracket (14). The bottom of the bracket (14) is fixed on the liquid preparation tank. The top of the bracket (14) forms a snap-fit ​​part for clamping the body of the water inlet cylinder (13). The top of the water inlet cylinder (13) is movably connected to a first cover (15).

3. The solution preparation device for medical testing experiments according to claim 1, characterized in that, The injection port (6) is connected to an injection tube (16) via a rubber stopper, and a second cover (17) is movably connected to the top of the injection tube (16).

4. The solution preparation device for medical testing experiments according to claim 1, characterized in that, The mixing tank (3) is equipped with a mixing device inside.

5. The solution preparation device for medical testing experiments according to claim 4, characterized in that, The mixing device includes a rotating shaft (18) and a stirring paddle (19). The upper end of the rotating shaft (18) is connected to a motor (20) through a sealed bearing. The motor (20) is fixed on the liquid preparation tank (3) through a frame (21). Multiple sets of stirring paddles (19) are distributed at equal intervals from top to bottom at the lower end of the rotating shaft (18). Each set of stirring paddles (19) is at the same height and is evenly distributed along the circumference of the rotating shaft (18).

6. The solution preparation device for medical testing experiments according to claim 1, characterized in that, The bottom wall of the liquid preparation tank (3) is inverted cone-shaped and gradually converges to the outlet (5).

7. The solution preparation device for medical testing experiments according to claim 1, characterized in that, A second valve (22) is installed at the outlet (5).

8. The solution preparation device for medical testing experiments according to claim 1, characterized in that, The liquid preparation tank (3) is provided with a first viewing window (23) with a scale on its body, and a second viewing window (24) is provided on the front side of the shell (1). The second viewing window (24) corresponds one-to-one with the placement slot (2).

9. The solution preparation device for medical testing experiments according to claim 1, characterized in that, The edge of the drain groove (8) is formed with a stepped upper edge, and the drain plate (9) overlaps the stepped upper edge.

10. The solution preparation device for medical testing experiments according to claim 1, characterized in that, The bottom wall of the drain trough (8) is inclined, and the drain pipe (10) is connected to the lowest point of the bottom wall of the drain trough (8).

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