The invention provides a medicine for treating the vascular endothelial injury, the stenosis and the occlusion of the heart, the brain and the kidney mainly, which relates to a medicine of traditional Chinese medicines for treating diseases in the aspect of blood vessels. The medicine for treating the vascular endothelial injury, the stenosis and the occlusion of the heart, the brain and the kidney mainly is prepared by the following raw materials: 1 to 3 parts of radix salviae miltiorrhizae, 0.5 to 2 parts of radix notoginseng, 0.5 to 2 parts of leech, 0.5 to 2 parts of land tortoise plastron, 0.5 to 2 parts of crude turtle shell, 0.5 to 2 parts of scorpio, 0.5 to 2 parts of rhizoma alismatis, 0.5 to 2 parts of sea cucumber, 0.4 to 1.2 parts of ginseng and 0.1 to 0.4 parts of bear gall powder; when the medicine for treating the vascular endothelial injury, the stenosis and the occlusion of the heart, the brain and the kidney mainly is prepared, liquor is obtained after the operations of conventional alcohol extraction and water extraction are carried out on the raw materials except for the radix notoginseng, the sea cucumber and the bear gall; and the liquor is concentrated to clear paste of which the relative density is 1.32 to 1.40 (50 DEG C), then the clear paste is stirred with the pulverized matters of the radix notoginseng, the sea cucumber and the bear gall, and the mixture is dried so as to prepare particulate matters containing 17.4 percent of total sugar, 13.8 percent of protein, 180mg/100g of total flavone and 559mg/100g of total saponin. The medicine for treating the vascular endothelial injury, the stenosis and the occlusion of the heart, the brain and the kidney mainly has the following beneficial effects that the medicine for treating the vascular endothelial injury, the stenosis and the occlusion of the heart, the brain and the kidney mainly has a high curative effect, and no toxic or side effect, and is low in cost, and the phenomenon of relapse does not occur after healing; and by 69 cases of clinical trial, the effective rate is 99 percent, and the cure rate is 65 percent.