The invention relates to an industrial
bioreactor (1) with a
dual cycle-controlled optimization process providing an optimized cultivation process (21) for
cell cultures (5 / 51),
cell components (5 / 512) or metabolic products (5 / 52) of the cells in a
nutrient medium (11). The
bioreactor comprises a reactor vessel (12) providing controlled
bioreactor conditions for the cultivation process (21), a
control unit (13) connected to sensory devices (14) measuring sensory parameter (141) values comprising at least measures related to the composition (1411) of the
nutrient medium (11) and / or concentration (1412) of the
nutrient medium (11) and / or
oxygen (1413) and / or temperature (1414) and / or pH-value (1415) and / or
sterility (1416), and transmitting them to the
control unit (13). The
control unit (13) controls and automatically optimizes the operational parameter of the cultivation process (21) and operational parameters of a treatment process (31) applied to the cells during the cultivation process (21) by adjusting operational parameters of the bioreactor (1) affecting the measured sensory parameter (141) values.