49results about How to "The preparation operation process is simple" patented technology

The invention discloses a diterpenoid compound and the preparing method and application thereof. The diterpenoid compound is obtained by using aralia melanocarpa roots as the raw material through extractum extraction, organic solvent extraction, column chromatography on silica gel and high pressure liquid chromatography separation. The molecular formula of the diterpenoid compound is C20H30O3. The name of the diterpenoid compound is 14-oxygen-ent-8(9),15-(14-oxo-ent-pimara-8(9),15-diene-19-oic acid). The structural formula is as shown in the specification. According to the preparing method, aralia melanocarpa roots are used as the raw material, and extractum extraction, organic solvent extraction, column chromatography on silica gel and high pressure liquid chromatography separation are conducted to generate the diterpenoid compound. The diterpenoid compound can be applied to preparation of anti-inflammatory drugs for prevention and / or treatment. The diterpenoid compound is subjected to in-vitro anti-inflammatory activity testing, and experimental results show a good lipopolysaccharide (LPS) restraining effect and a good effect of inducting pulmonary alveolar macrophages (RAW264.7) to generate NO. A new compound or lead compound with high application value can be provided for the medical industry.

The invention discloses an isoflavone compound with a novel structure, a preparation method and an application thereof. The compound has the structure as shown in the right formula; the invention uses an MCI column for bleaching a papaya liquid extract, uses the silica gel column chromatography for primary separation, and then adopts the semipreparative high-performance liquid chromatography for further separation, thereby obtaining the new compound which is named as 3',4',5'-trihydroxy-5, 7-dimethoxyisoflavone. An effect test of eliminating free radicals in mainstream cigarette smoke is carried out on the compound, and the test result shows that the compound has good effect of eliminating the free radicals.

The invention relates to an isoflavone compound having antibacterial activity and a preparing method and applications thereof, and belongs to the technical field of phytochemistry. The structure of the compound is shown as a formula (I). The formula (I) is shown in the specification. The compound is prepared from kudzu vine root that is a traditional medicinal and edible plant and through steps of extractum extraction, column chromatography on silica gel and separation and purification through high performance liquid chromatography. Activity tests prove that the compound has a good bacteriostatic function; when the compound is added into a tobacco material solution, the compound can effectively inhibit microbe growth in the material solution and can prolong the shelf life of the solution; when the compound is used for cigarette tipping paper, the compound can eliminate or reduce the possibility of bacterium breeding and reproduction in the cigarette tipping paper; and the compound has a wide application prospect.

The invention discloses an application for isobenzofuran type compounds in marine biofouling prevention and a preparation method thereof, which belongs to the field of marine fouling organism repellency and mainly solves the problem of marine biofouling. The application for isobenzofuran type compounds in marine biofouling prevention can be used for preventing underwater structure surfaces from being attached and / or fouled by marine organisms. The sobenzofuran type compounds are all obtained from isolation of fungus which is named cephalosporium cordaAL 031 in the strain classification, and the preservation serial number of the fungus strain is CCTCC Number M2010140. Extracts of secondary metabolites of the fungus and two isobenzofuran type compounds are performed a fouling resistance activity screening, the experiment result indicates that the extracts of secondary metabolites of the fungus and two isobenzofuran compounds show high fouling resistance activity, attachment of marine fouling organisms can be inhibited, and the application for isobenzofuran type compounds in marine biofouling prevention and the preparation method thereof can be used for prevention and treatment of marine biofouling and have a good application perspective.

The invention discloses an isobenzofuran compound. A structure of the isobenzofuran compound is as shown in the specification, and the isobenzofuran compound is named 2-hydroxyl-1-isopentenyl-isobenzofuran-5(3H)-ketone. The invention further discloses a preparation method of the isobenzofuran compound and application of the isobenzofuran compound to cigarette antibacterial tipping paper.

The invention discloses diterpenoid compounds, and a preparation method and application thereof. The diterpenoid compounds are prepared by the following steps: by using Aralia melanocarpa root as a raw material, carrying out extract leaching, organic solvent extraction, silica gel column chromatography and high pressure liquid chromatography separation. The molecular formula of the compounds is C20H28O2 which is named ent-pimar-6,8(14),15-trien-19-oic acid disclosed as the structural formula in the specification. The preparation method comprises the following steps: by using the Aralia melanocarpa root as the raw material, carrying out extract leaching, organic solvent extraction, silica gel column chromatography and high pressure liquid chromatography separation. The invention also discloses application of the diterpenoid compounds in preparing drugs for preventing and / or treating tumor and in preparing drugs for preventing and / or treating human lung adenocarcinoma, human prostatic cancer or human acute medullary system leukaemia. The diterpenoid compounds have obvious inhibiting actions when being applied to drugs for human lung adenocarcinoma, human prostatic cancer or human acute medullary system leukaemia, which indicates that the diterpenoid compounds have favorable anticancer activity and can be used as an anticancer active component or lead compound.

The invention relates to the field of medicines, in particular to a yak skin polypeptide with blood tonifying effect and a preparation method thereof.The molecular weight of the yak skin polypeptide is composed of 17KDa, 34KDa and 43KDa, the maximum ultraviolet absorption wavelength of peptide bonds is at 216nanometer, the amide I band infrared spectrum is at 1600 '-1700' cm <-1>, the amide II band infrared spectrum is at 1560 '-1500' cm <-1>, and the amide III infrared spectrum is at 1234 '-1237' cm <-1>.The preparation method comprises grinding skin, heating, extracting foam, preparing enzymolysis solution, centrifuging, concentrating, separating, and drying.According to the invention, the pure natural pollution-free Qinghai-Tibet plateau yak skin is used as a main raw material, the rawmaterial sources are wide, the nutrition is rich, the economic added value of the yak skin is improved; and meanwhile, a product with the effect of enriching blood is added; the preparation operationflow is simple, and the prior peeling machine is changed into a grinding machine, so that waste caused by different thickness of raw materials is avoided; and the prepared yak skin polypeptide has theblood-enriching bioactive components with three molecular weight sections.

The invention discloses a tetracyclic diterpenoid compound and a preparation method as well as application thereof. The tetracyclic diterpenoid compound is obtained through extractum extracting, organic solvent leaching, column chromatography on silica gel and high pressure liquid chromatography separation by taking Araliadumetorum Hand.-Mazz roots as a material. The compound has a molecular formula of C20H30O3, is named as dumetorumane B, and has the following structural formula as shown in the description. The preparation method means that the tetranuclear diterpenoid is obtained through extractum extracting, organic solvent leaching, column chromatography on silica gel and high pressure liquid chromatography separation by taking the Araliadumetorum Hand.-Mazz roots as the material. The application is application of the tetranuclear diterpenoid to preparation of drugs for preventing and / or treating tumour and to preparation of drugs for preventing and / or treating human lung adenocarcinoma, human acute promyelocytic leukemia or human breast cancer. The tetranuclear diterpenoid has a remarkable inhibiting effect on cell strains of human lung adenocarcinoma, human acute promyelocytic leukemia or human breast cancer, has good antitumor activity indicatively, and can serve as an antitumor activity component or a lead compound.

The invention provides fluosilicic acid for lead electrolysis and a preparation method thereof, and belongs to the technical field of chemistry and chemical engineering. The preparation method comprises the steps that a low-grade fluosilicic acid solution is provided, and the low-grade fluosilicic acid solution is doped with hydrogen fluoride impurities and sulfuric acid impurities; a certain amount of quartz sand is added into the low-grade fluosilicic acid solution for reaction, so that hydrogen fluoride impurities are removed for the first time, and first clear liquid is obtained; and a certain amount of lead oxide is added into the first clear liquid for reaction, so that sulfuric acid impurities are removed, meanwhile, the remaining hydrogen fluoride impurities are removed for the second time, second clear liquid is obtained, and the second clear liquid is fluosilicic acid for lead electrolysis. By adopting the quartz sand with special crystal morphology, hydrogen fluoride impurities can be effectively removed; sulfuric acid impurities and remaining hydrogen fluoride impurities are removed through lead oxide, the total removal rate of the hydrogen fluoride impurities reaches 99% or above, the total removal rate of the sulfuric acid impurities reaches 98% or above, the impurity removal rate is high, the preparation process is simple, and the cost is low.

The invention belongs to the technical field of natural product chemistry, and particularly relates to an indole alkaloid compound as well as a preparation method and application thereof. The molecular formula of the compound is C15H15NO2, and the compound has the following structure shown in the specification. The invention also discloses a preparation method and application of the compound. The compound disclosed by the invention is a novel compound separated from a fermentation product of endogenous aspergillus versicolor of tobacco, and is identified as the indole alkaloid compound through spectrum data such as nuclear magnetic resonance, mass spectrum, infrared and the like. The indole alkaloid compound has good tobacco mosaic virus resisting activity, and it is found through tobacco mosaic virus resisting activity tests that the relative inhibition rate of the indole alkaloid compound to tobacco mosaic viruses reaches 41.2%, and the activity of the indole alkaloid compound is higher than the relative inhibition rate (32.5%) of a reference substance ningnanmycin. The compound disclosed by the invention is simple in structure and good in activity, can be used as a leading compound of the tobacco mosaic virus resisting medicine, and has a good application prospect in preparation of the tobacco mosaic virus resisting medicine.

The invention discloses a soil extracting agent and a preparation method thereof, and application of the soil extracting agent in treatment of cadmium-contaminated soil. The soil extracting agent is formed by compounding biochar and magnetic powder, wherein a mass ratio of the biochar to the magnetic powder (in terms of Fe3O4) is (1.5-2.5): 1. When the adding mass of the soil extracting agent in the soil is 5%, the contamination concentration of cadmium is reduced by 20.1-24.0% in 7 days after the soil extracting agent is used for treating the cadmium-contaminated soil. In 30 days after the soil extracting agent is used for treating the cadmium-contaminated soil, the contamination concentration of cadmium is reduced by 26.2 to 28.3%.

The invention discloses a benzofuran phenylpropanoids compound, a preparation method and application thereof. The compound has a structure of a general formula (I). Waste smashed cigarettes of the industrial production are taken as raw materials, are grinded, and are ultrasonically extracted with 70% ethanol separately, the extracting solutions are mixed, filtered and concentrated into extractum, then a silicagel column is adopted for chromatography and preliminary separation, an efficient liquid phase preparative chromatography is adopted for further separation, i.e. the required compound can be obtained. Antibiotic activity screening is carried out for the compound, and the experimental test shows that the compound has good antibiotic activity. The compound is used for cigarette tipping papers, and can eliminate or reduce the possibilities of bacterial growth and reproduction in the cigarette tipping papers.

The invention discloses a phenylpropanoid compound and a preparation method thereof. The preparation method includes the following steps of: S1, preparing materials are prepared, cleaning up salvia plebeian, and drying the salvia plebeian, wherein the salvia plebeia is widely distributed in China, rich in raw material and low in price, separation and obtaining are easy, the synthesis route is simple, artificial synthesis is easy, and the working efficiency is improved; S2, performing crushing: putting rhizomes of salvia plebeia into preparation equipment, and performing crushing to 30-45 meshes; S3, performing extraction. The present invention provides a preparation device of the phenylpropanoid compound and the preparation method thereof, the preparation device comprises a box body, a feeding pipe is welded to the top of the box body, and a discharging pipe is welded to one side of the box body. The synthetic route is simple, artificial synthesis is easy, the working efficiency is improved, the compound purity is high, subsequent industrial production is easy to realize, the preparation effect is improved, a crushing rod can be driven to rotate and move up and down at the same time to form linkage, and the crushing effect of the device is improved.

The invention relates to a benzodihydropyran compound with effects of resisting hepatitis B virus and coronavirus, especially SARS-CoV-2, and a preparation method and application of the benzodihydropyran compound. Specifically, the invention provides a preparation method and application of a compound as shown in a formula I. The compound is used for preventing, treating or relieving hepatitis B virus infectious diseases and coronavirus infectious diseases. The compound disclosed by the invention has relatively strong activity of resisting hepatitis B virus and coronavirus, especially SARS-CoV-2, and is used as an active component to be prepared into a medicine or a medicine composition for resisting hepatitis B virus or coronavirus together with a pharmaceutically acceptable carrier or auxiliary materials.

The invention belongs to the technical field of roadway wall back filling layers and solid waste recycling, and discloses a high-performance roadway wall back filling layer material with pretreated phosphogypsum as aggregate. According to the ardealite backfill material, ardealite which is pretreated after being dried for 8 hours at the temperature of 130 DEG C is used as aggregate, slag and carbide slag are added, the mixture is stirred with tap water, and no other additive is added. The ardealite, the slag and the carbide slag pretreated by the aggregate used by the wall back filling layer material respectively account for 65-75%, 20-25% and 5-10% of the total solid mass. The ardealite wall back filling layer manufactured according to the mixing ratio can meet the compressive strength requirement, the fluidity requirement and the water permeability requirement of the wall back filling layer in a roadway composite support system, and has the advantages of being low in cost and easy and convenient to manufacture. Meanwhile, the problem that a large amount of industrial solid wastes such as ardealite and the like are accumulated is solved, land resource pressure is released, contribution is made to environmental protection, and certain practical significance is achieved.

The invention provides a high-temperature-resisting nanometer anti-oxidization isolating agent for an oriented silicon steel billet and a production method and application method of the high-temperature-resisting nanometer anti-oxidization isolating agent. The high-temperature-resisting nanometer anti-oxidization isolating agent comprises, by weight percent, 5%-10% of carbon powder, 20%-30% of magnesium aluminate spinel powder, 10%-20% of an inorganic binder, 5%-10% of a suspending agent, 5%-10% of an inorganic reagent and the balance magnesite clinker micro powder and inevitable impurities. Compared with the prior art, the formula of the isolating agent is adjusted, a proper production process is adopted, and the high-temperature-resisting nanometer anti-oxidization isolating agent for the oriented silicon steel billet and with stable high temperature stability is obtained; and after a production test, according to the isolating agent, the performance of an oriented silicon steel product is influenced, and meanwhile the burning loss is reduced by 80% or above. The isolating agent has the advantages of being simple in preparing, low in cost and stable in high temperature stability.

The present invention relates to containers, devices, kits and methods for preparing adipose tissue usable for injection from aspirated fat material. In particular, a washing and separating containerfor the preparation of adipose tissue has a washing chamber for washing the aspirated adipose material, the container having an inlet and an outlet, for admitting fatty material through the inlet intoa washing chamber and exiting the chamber through the outlet from a fluid component of the material, the washing chamber includes at least one stirring assembly for mechanically forming an emulsion of a fluid component, each stirring assembly comprising an elastic member and at least one sphere secured to the elastic member. The method includes a washing step, an emulsification step, and an emulsion removal step, during which the washing and separation vessel is always in a vertical state with the outlet facing downward. Compared with the existing process, the preparation process is relatively simple, which can save time, reduce the complexity of the instrument and reduce the possibility of contamination.

The invention relates to application of a pentacyclic triterpenoid compound in preparation of an anti-migraine drug. Specifically, the invention relates to application of a pentacyclic triterpenoid compound as shown in a formula I which is described in the specification, and the pentacyclic triterpenoid compound is used for treating migraine. In the formula I, R is H or OH. The pentacyclic triterpenoid compound can be a naturally-existing organic compound or a synthesized organic compound, has strong anti-migraine activity, and can be used as an active component for preparation of an anti-migraine drug or a pharmaceutical composition together with a pharmaceutically acceptable carrier or auxiliary material.

The invention discloses an application for isobenzofuran type compounds in marine biofouling prevention and a preparation method thereof, which belongs to the field of marine fouling organism repellency and mainly solves the problem of marine biofouling. The application for isobenzofuran type compounds in marine biofouling prevention can be used for preventing underwater structure surfaces from being attached and / or fouled by marine organisms. The sobenzofuran type compounds are all obtained from isolation of fungus which is named cephalosporium cordaAL 031 in the strain classification, and the preservation serial number of the fungus strain is CCTCC Number M2010140. Extracts of secondary metabolites of the fungus and two isobenzofuran type compounds are performed a fouling resistance activity screening, the experiment result indicates that the extracts of secondary metabolites of the fungus and two isobenzofuran compounds show high fouling resistance activity, attachment of marine fouling organisms can be inhibited, and the application for isobenzofuran type compounds in marine biofouling prevention and the preparation method thereof can be used for prevention and treatment of marine biofouling and have a good application perspective.

The invention discloses a xanthone compound (I) and a preparation method and application thereof. The xanthone compound is separated from swertia atroviolacea, has the molecular formula of C17H16O5 and is named as 6-(2-hydroxymethyl)-1,7-dimethoxy-3-methyl-xanthone which is of the structural formula shown (I) in the description. The preparation method of the xanthone compound comprises the steps that swertia atroviolacea is used as a raw material, extraction, silica-gel column chromatography and high pressure liquid phase chromatography separation are carried out, and the xanthone compound is obtained. Through activity tests, the xanthone compound has good bacteriostasis. The compound is novel in structure, has good bacteriostasis, and can be used as a lead compound for preparing antibacterial drugs. The compound is used for cigarette tipping paper, and the possibility of bacteria growth and reproduction in the cigarette tipping paper can be eliminated or lowered.

The invention discloses a diterpenoid compound and the preparing method and application thereof. The diterpenoid compound is obtained by using aralia melanocarpa roots as the raw material through extractum extraction, organic solvent extraction, column chromatography on silica gel and high pressure liquid chromatography separation. The molecular formula of the diterpenoid compound is C20H30O3. The name of the diterpenoid compound is 14-oxygen-ent-8(9),15-(14-oxo-ent-pimara-8(9),15-diene-19-oic acid). The structural formula is as shown in the specification. According to the preparing method, aralia melanocarpa roots are used as the raw material, and extractum extraction, organic solvent extraction, column chromatography on silica gel and high pressure liquid chromatography separation are conducted to generate the diterpenoid compound. The diterpenoid compound can be applied to preparation of anti-inflammatory drugs for prevention and / or treatment. The diterpenoid compound is subjected to in-vitro anti-inflammatory activity testing, and experimental results show a good lipopolysaccharide (LPS) restraining effect and a good effect of inducting pulmonary alveolar macrophages (RAW264.7) to generate NO. A new compound or lead compound with high application value can be provided for the medical industry.

The invention provides a device and a synthesis method for one-step synthesis of layered hydroxide using solid waste. The device includes a material acidolysis chamber, an ion precipitation chamber and an ion filter chamber. The material acidolysis chamber mainly includes a chemical reaction box, a magnetic stirring controller, a liquid drain hole and an acid injection hole; the ion precipitation chamber mainly includes a solution mixing box, an overflow hole, a liquid addition hole, an air inlet hole and a top cover , the ion precipitation chamber and the material acidolysis chamber are connected by channel-tenon assembly and bolt pre-tightening; the ion filtration chamber mainly includes a liquid inlet bin, a filtrate bin, a circulation bin, a sealing cover and a vacuum filtration device, and the filtrate bin is arranged The discharge pipe controls the liquid inlet valve by floating, so that the filtrate automatically enters the circulation chamber from the filtrate bin, and finally returns to the solution mixing box. The device and the synthesis method of the invention can simplify the operation process of using solid waste as raw material to prepare layered hydroxide, reduce the preparation cost of layered hydroxide, improve the preparation efficiency, and realize one-step synthesis of solid waste layered hydroxide.

The invention discloses the application of a soil extractant in treating lead-contaminated soil. The soil extractant is composed of biomass charcoal and magnetic powder. Among them, biochar and magnetic powder (with Fe 3 o 4 ) has a mass ratio of (1.5‑2.5):1. When the dosing mass of the soil extractant in the soil is 5%, the lead pollution concentration is reduced by 30.8-41.9% after the soil extractant treats the lead-contaminated soil for 7 days. In the above technical solution, when the weight of the soil extractant added to the soil is 5%, after the soil extractant treats lead-contaminated soil for 30 days, the concentration of lead pollution is reduced by 26.8-40.1%.

The invention discloses a composite photocatalyst, which refers to a composite photocatalyst of bismuth molybdate and cadmium sulfide. The composite photocatalyst can enable water to continuously generate hydrogen under visible light irradiation of sunlight, and its preparation method is disclosed. The bismuth molybdate and cadmium sulfide composite photocatalyst prepared by the present invention has a large-area contact interface, which is conducive to carrier separation. The structure of the bismuth molybdate and cadmium sulfide is stable and the band gap is matched, which improves the photocatalytic activity and stabilizes the catalytic effect. It has excellent properties of photolysis of water to produce hydrogen, photodegradation of organic pollutants, heavy metal ions and reduction of carbon dioxide; the synthesis method has common raw materials, simple preparation operation process, easy to realize process parameters, low cost, easy operation, high yield and long cycle life. , has broad application prospects and industrialization prospects in the fields of photolysis of water to produce hydrogen, photodegradation of organic pollutants, reduction of heavy metal ions and carbon dioxide.

The invention discloses diterpenoid compounds, and a preparation method and application thereof. The diterpenoid compounds are prepared by the following steps: by using Aralia melanocarpa root as a raw material, carrying out extract leaching, organic solvent extraction, silica gel column chromatography and high pressure liquid chromatography separation. The molecular formula of the compounds is C20H28O2 which is named ent-pimar-6,8(14),15-trien-19-oic acid disclosed as the structural formula in the specification. The preparation method comprises the following steps: by using the Aralia melanocarpa root as the raw material, carrying out extract leaching, organic solvent extraction, silica gel column chromatography and high pressure liquid chromatography separation. The invention also discloses application of the diterpenoid compounds in preparing drugs for preventing and / or treating tumor and in preparing drugs for preventing and / or treating human lung adenocarcinoma, human prostatic cancer or human acute medullary system leukaemia. The diterpenoid compounds have obvious inhibiting actions when being applied to drugs for human lung adenocarcinoma, human prostatic cancer or human acute medullary system leukaemia, which indicates that the diterpenoid compounds have favorable anticancer activity and can be used as an anticancer active component or lead compound.

The invention belongs to the technical field of phytochemistry, and in particular relates to a compound with antibacterial effect, its preparation method and its use in cigarettes. The molecular formula of the compound is C 16 h 18 o 4 , and has the following structural formula: . The invention also discloses the preparation method and application of the above compound. The present invention for the first time isolates a new benzopyranolactone compound from the genetically improved tobacco stem bark with high resistance to black shank, and no related reports have been seen so far. The compound exhibits good antibacterial activity, and the antibacterial rates against Escherichia coli, Staphylococcus aureus and the like all reach more than 95%.

The present invention relates to containers, devices, kits and methods for preparing injectable adipose tissue from aspirated adipose material. In particular, a washing and separation vessel for preparing adipose tissue has a washing chamber for washing aspirated fatty material, the vessel having an inlet and an outlet for passing the fatty material through the inlet into the washing chamber and allowing the material to enter the washing chamber The fluid component exits the chamber through the outlet, and the washing chamber includes at least one agitation assembly for mechanically forming an emulsion of the fluid component, each agitation assembly comprising an elastic member and an elastic member fixed to the at least one sphere on it. The method comprises a washing step, an emulsifying step and an emulsion removing step, during which the washing and separating vessel is always in a vertical state with the outlet facing downwards. Compared to the existing process, the preparation process is relatively simple, which can save time, reduce the complexity of the device and reduce the possibility of contamination.

The invention discloses an isoquinoline alkaloid compound. The isoquinoline alkaloid compound is characterized by having a structure shown in the specification, and the compound is named as 2-hydroxyl-1-(7-hydroxy-6-methoxyisoquinolin-1-yl) ethanone and has the molecular formula being C12H11NO4. The invention further discloses a preparation method of the isoquinoline alkaloid compound and an application of the isoquinoline alkaloid compound to antibacterial tipping paper of cigarettes.

The invention belongs to the technical field of phytochemistry, and particularly relates to a compound with an antibacterial effect, a preparation method of the compound and application of the compound in cigarettes. The molecular formula of the compound is C16H18O4, and the compound has a structural formula disclosed in the invention. The invention also discloses the preparation method and application of the compound. According to the preparation method, a new benzopyran lactone compound is separated from genetically modified tobacco stem bark with high black shank resistance for the first time for the first time. The compound shows good antibacterial activity, and the antibacterial rates on escherichia coli, staphylococcus aureus and the like all reach 95% or above.