Nutrients replenisher for replenishing folic acid and vitamin B12 and preparation method thereof
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A nutritional supplement and supplement technology, applied in the field of nutritional supplements supplementing small doses of folic acid and vitamin B12, can solve problems such as inapplicability
Inactive Publication Date: 2008-05-14
江西省药物研究所
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[0009] At present, there are many types of preparations containing folic acid on the market, but they are usually preparations containing various nutrients such as multivitamins, calcium and iron, such as Centrum Tablets, Elevit, Iron Folic Acid Tablets, and Fushifu; Single formulation without B vitamins 12 , such as Cirian tablets; contains both folic acid and B vitamins 12 The preparations, all contain large doses of folic acid, clinically used for megaloblastic anemia, such as folic acid vitamin B 12 Tablets, this large dose of folic acid is not suitable for pregnant women to prevent the occurrence of neural tube defects
Method used
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example 1
[0031] prescription:
[0032] Folic acid 0.2g
[0033] Vitamin B 12 0.005g
[0034] Microcrystalline Cellulose 40g
[0035] 20% ethanol solution appropriate amount
[0036]
[0037] Makes 1000 capsules
[0038] Preparation method:
[0039] Folic acid, vitamin B 12 and crystal cellulose were passed through 80-mesh sieve respectively, and folic acid and vitamin B were weighed according to the proportion of the formula 12 and crystal cellulose, mix in a mixer for 10 to 15 minutes, add 20% ethanol solution to make a soft material, and granulate in a granulator. Dry at 55°C, sieve through a 16-mesh sieve, fill the obtained granules into capsules, inspect, and pack to obtain the product.
example 2
[0041] prescription:
[0042] Folic acid 0.3g
[0043] Vitamin B 12 0.006g
[0044] Dextrin 40g
[0045] 5% starch slurry appropriate amount
[0046]
[0047] Makes 1000 capsules
[0048] Preparation method:
[0049] Folic acid, vitamin B 12 and dextrin were passed through an 80-mesh sieve, and folic acid and vitamin B were weighed according to the formula ratio 12 and dextrin, mix in a mixer for 10-15 minutes, add 5% starch slurry in an appropriate amount to make a soft material, and granulate in a granulator. Dry at 55°C, sieve through a 16-mesh sieve, fill the obtained granules into capsules, inspect, and pack to obtain the product.
example 3
[0051] Folic acid 0.2g
[0052] Vitamin B 12 0.005g
[0053] Microcrystalline Cellulose 40g
[0054] 5% polyvinylpyrrolidone appropriate amount
[0055]
[0056] Makes 1000 pieces
[0057] Preparation method:
[0058] Folic acid, vitamin B 12 and crystal cellulose were passed through 80-mesh sieve respectively, and folic acid and vitamin B were weighed according to the proportion of the formula 12 and crystal cellulose, mix in a mixer for 10 to 15 minutes, add 5% polyvinylpyrrolidone in an appropriate amount to make a soft material, and granulate in a granulator. Dry at 55°C, sieve through a 16-mesh sieve, press into tablets, inspect, pack, and get ready.
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Abstract
The invention relates to a nutriment supplement and a preparation method for the small dosage folic acid and vitamin B12. The folic acid cannot be synthesized by the human body, which must rely on the exogenetic supply. The folic acid has close relation with the vitamin B12 on the in vivo metabolism and the function. Although a plurality of preparations containing the folic acid are seld in the market, most of which are the preparation comprising the multivitamins, the calcium iron and other nutrient preparations or the sole preparation comprising the folic acid; the preparation only comprising the folic acid and the vitamin B12 contains the big dosage folic acid and the big dosage folic acid is not suitable for the pregnant women and the crowd lacking of folic acid. The invention is characterized in comprising the folic acid, the vitamin B12 and the medicine carrier according to the weight account matching 10 to 400: 1: 400 to 4000; the nutriment supplement is made into a capsule (tablet) comprising the folic acid 100 to 400 Mug, the vitamin B12 1 to 10 Mug according to the conventional method in the pharmaceutics. The invention has an advantage of capability for supplying the reasonable nutrition supplement to the people lacking of folic acid.
Description
technical field [0001] The invention relates to a nutrient supplement, in particular to a small-dose supplement of folic acid and vitamin B 12 nutrient supplements. The invention also relates to the preparation method of the preparation. Background technique [0002] Folic acid is a heat-labile, low-molecular-weight, water-soluble vitamin. It is composed of pteridine nucleus, p-aminobenzoic acid, and glutamic acid. The human body cannot synthesize it and must be ingested from animal and plant foods. Studies have shown that folic acid deficiency is the main cause of neural tube defects in newborns. [0003] Every year, more than 300,000 newborns suffer from neural tube defects worldwide, causing a huge burden on society and patients' families. Neural tube defects (NTDs) include anencephaly, deencephalia, encephalocele, spina bifida occult, spina bifida, meningocele and meningomyelocele, encephalocele, occipital cleft and encephalocele Although these three deformities are...
Claims
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Application Information
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