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Preparation method of influenze granule for children

A technology for Xiaoergan and granules, applied in the field of preparation of Xiaoerganshu granules, can solve the problems of long production process, incomplete degreasing, and variable volatile oil yield, and achieves the advantages of shortening production cycle, improving production efficiency and improving compliance. Effect

Active Publication Date: 2012-01-25
NANJING ZHONGSHAN PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0013] However, there are many deficiencies in the original Xiao'er Ganmaoshu granule process: (1) the steam distillation method is used to extract the nepeta volatile oil, the yield of the volatile oil is variable, and the nepeta oil has a strong pungent smell, and the children's compliance is poor; 2) Water precipitation method, using paraffin adsorption in the extract solution to degrease the burdock fruit, the efficiency is low and the degreasing is incomplete; (3) the extraction process is complicated, the production process is long, and the yield of paste is high, which is not suitable for industrialized large-scale production

Method used

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  • Preparation method of influenze granule for children
  • Preparation method of influenze granule for children
  • Preparation method of influenze granule for children

Examples

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Effect test

Embodiment 1

[0158] Recipe: Pueraria 400g, Nepeta 300g, Campanulaceae 250g, Scrophulariae 150g, Licorice 100g, Cicada slough 200g, Jianqu 300g, Arctium 300g.

[0159] Preparation Process:

[0160] a. Put the burdock fruit powder into a coarse powder and place it in the extraction kettle for CO 2 Supercritical extraction, the extraction pressure is 32Mpa, the temperature of the extraction kettle is 48°C, the extraction time is 40min, and the CO 2 raffinate of supercritical extraction;

[0161] b. Mix the raw materials kudzu root, nepeta, platycodon, scrophulariaceae, licorice, cicada slough, Jianqu and burdock fruit extract evenly, crush them into coarse powder, add 70% ethanol which is 1 times the weight of the percolated medicinal material and soak for 6 hours , then infiltrate at a percolation rate of 6 mL / min per kilogram of medicinal material, and collect percolation fluid that is 5 times the total weight of medicinal material in percolation; spray granulation after the percolation ...

Embodiment 2

[0163] Recipe: Pueraria 300g, Nepeta 400g, Campanulaceae 300g, Scrophulariae 100g, Licorice 150g, Cicada slough 300g, Jianqu 400g, Arctium 400g;

[0164] Preparation Process:

[0165] The burdock fruit was first ground into a coarse powder and then placed in an extraction kettle for CO 2 Supercritical extraction, the extraction pressure is 36Mpa, the temperature of the extraction kettle is 60°C, the extraction time is 60min, and the CO 2 The raffinate of supercritical extraction; then mix the raffinate of Pueraria root, nepeta, platycodon, scrophulariaceae, licorice, cicada slough, Jianqu and burdock fruit, and grind it into a coarse powder, add the percolated medicinal material to 1 times the weight Soak in 80% ethanol for 10 hours, then infiltrate at a percolation rate of 14mL / min per kilogram of medicinal materials, and collect percolation liquid 5 times the total weight of medicinal materials; take percolation liquid, and perform ultrafiltration at 25°C , ultrafiltratio...

Embodiment 3

[0167] Recipe: Pueraria 500g, Nepeta 200g, Campanulaceae 150g, Scrophulariaceae 200g, Licorice 50g, Cicada slough 150g, Jianqu 200g, Arctium 200g;

[0168] Preparation Process:

[0169] a. Put the burdock fruit powder into a coarse powder and place it in the extraction kettle for CO 2 Supercritical extraction, the extraction pressure is 24Mpa, the temperature of the extraction kettle is 40°C, the extraction time is 20min, and the CO 2 raffinate of supercritical extraction;

[0170] b. Mix the raw materials kudzu root, nepeta, platycodon, scrophulariaceae, licorice, cicada slough, Jianqu and burdock fruit extract evenly, grind them into coarse powder, add 70-90% ethanol of 1 times the weight of the percolated medicinal materials Soak for 2-10h, then infiltrate at a rate of 14mL / min per kilogram of medicinal material, and collect percolation liquid that is 5 times the total weight of the medicinal material; after the percolation liquid is concentrated and dried, it is sprayed...

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Abstract

The invention discloses a preparation method of Ganmaoshu Keli for children, comprising the following steps: degreasing fructus arctii, percolating and extracting degreased fructus arctii, radices puerarire, herba schizeneptae, balloonflower root, figwort, liquorice, periostracum cicadae and massa medicata fermentata fujianensis, and then spraying and pelletizing. The preparation method has simple and stable production and controllable quality standard. The Ganmaoshu Keli for children prepared by using the method has obvious curative effect.

Description

technical field [0001] The invention belongs to the field of traditional Chinese medicine pharmacy, and in particular relates to a preparation method of Xiaoer Ganmaoshu Granules. Background technique [0002] Exogenous fever in children is the most common disease in children, and the incidence rate accounts for the first of pediatric diseases. At present, traditional Chinese medicines for treating colds are mainly divided into two categories. The first category is heat-clearing and detoxifying, such as Folium Folium Isatidis, Radix Isatidis, Forsythia, etc. These are the majority. Those with obvious symptoms of toxic heat; the second category belongs to the pungent and warm category, such as Qianghuo, Fangfeng, Nepeta, etc., which are suitable for those who suffer from cold and evil, which is a minority. According to Professor Jiang Yuren's clinical experience, the actual condition of the clinical manifestations of children with upper cold is not simply a matter of cold an...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K35/64A61K9/16A61K36/808A61P11/00
Inventor 濮存海李鑫鹏赵开军王波陈磊徐云辉
Owner NANJING ZHONGSHAN PHARMA CO LTD
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