Polypeptide composition and application thereof in detecting tuberculosis antibody

Abstract

The invention discloses a polypeptide composition which is formed by combining an antigen Mtb16.3, an antigen 38kD, ESAT-6, CFP 10, MPT 64, Mtb 8 and Mtb 8.4. The antigens Mtb 16.3, 38kD, ESAT-6, CFP 10 and MPT 64 have excellent complementarities in serological detection. The sensitivity for diagnosing tuberculosis is obviously promoted by combining antigen Mtb16.3 with at least one of antigen 38kD, ESAT-6, CFP 10 and MPT 64.

Description

technical field The present invention relates to a polypeptide composition, in particular to a polypeptide composition comprising a Mtb16.3 specific epitope antigen peptide, and more specifically to a Mtb16.3 specific epitope antigen peptide for tuberculosis antibody detection The polypeptide composition. Background technique In recent years, tuberculosis (TB) has become a public health and social issue of global concern. According to statistics, there are currently 20 million tuberculosis patients in the world, 10 million new cases, and 3 million deaths per year, exceeding the sum of other infectious diseases. Pulmonary tuberculosis exhibits all the main features of a global epidemic and is spreading worldwide. About 1 / 3 of the people on the planet are infected with Mycobacterium tuberculosis, resulting in 8 million cases of active tuberculosis and 3 million deaths each year. The emergence of multidrug-resistant strains of Mycobacterium tuberculosis and co-infection wit...

AI Technical Summary

Problems solved by technology

Although scholars have conducted a lot of research in the field of serological detection of tuberculosis, no single antigen, fusion antigen or combination antigens with satisfactory sensitivity and specificity have been found yet.

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