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Preparation method of ginkgolide K

A ginkgolide, reaction technology, applied in the field of compound preparation, can solve the problems of ginkgolide K content scarcity, high cost, lack of practical application value, etc., and achieve the effect of simple reaction conditions and high yield of finished products

Inactive Publication Date: 2010-09-08
广东省中药研究所
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

This patented process allows for production of various compounds called gallium-saccharides (Ga). It involves only one step: making it easier than previous methods that required multiple steps like purification or extraction from natural sources.

Problems solved by technology

The technical problem addressed in this patents relates to finding novel chemical entities from plant sources for use in medicine or biology purposes without being limited by their physicochemistry properties like solubility or stability. This would allow us to develop more useful molecules through various methods involving chemotherapy treatments or gene therapies techniques.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0013] Take 10g of ginkgolide B, add 10ml of concentrated hydrochloric acid, oil bath at 110°C, react for 12 hours, filter to obtain the crude product, add an appropriate amount of ethanol to crystallize, and obtain ginkgolide K.

Embodiment 2

[0015] Take 10g of ginkgolide B, add 15ml of concentrated sulfuric acid, put it in a water bath at 90°C, react for 24 hours, filter to obtain the crude product, add an appropriate amount of methanol to crystallize, and obtain ginkgolide K.

Embodiment 3

[0017] Take 10g of ginkgolide B, add 30ml of concentrated sulfuric acid, put it in a water bath at 100°C, react for 16 hours, filter to obtain the crude product, add NaOH to adjust the pH to 5.0, add an appropriate amount of methanol to crystallize, and obtain ginkgolide K.

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PUM

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Abstract

The invention relates to a ginkgolide K, which is ginkgolide compound, is a receptor antagonist for strengthening platelet activating factors (PAF), and has very wide application prospect in pharmacy; Lou Fengchang et al. prepares trace amount of ginkgolide K by means of preparing liquid phases and the like, but the content of the ginkgolide K in natural product is extremely rare, the preparation method is lack of practical application value due to overhigh cost, and the preparation method prepares the ginkgolide K by synthesis. The preparation method has simple technique and low cost and provides possibility for further developing the compound.

Description

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Claims

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Application Information

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Owner 广东省中药研究所
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